Hnrnpu (heterogeneous nuclear ribonucleoprotein U) - Rat Genome Database

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Gene: Hnrnpu (heterogeneous nuclear ribonucleoprotein U) Rattus norvegicus
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Symbol: Hnrnpu
Name: heterogeneous nuclear ribonucleoprotein U
RGD ID: 620372
Description: Enables poly(G) binding activity; promoter-specific chromatin binding activity; and ribonucleoprotein complex binding activity. Involved in cellular response to dexamethasone stimulus and positive regulation of gene expression. Part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to human HNRNPU (heterogeneous nuclear ribonucleoprotein U); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hnRNP U; Hnrpu; SAF-A; scaffold-attachment factor A; SN1; SP120; system N1 Na+ and H+-coupled glutamine transporter; transporter protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81392,609,791 - 92,618,580 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1392,605,216 - 92,618,612 (-)EnsemblGRCr8
mRatBN7.21390,069,058 - 90,086,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1390,074,181 - 90,086,588 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1392,582,994 - 92,591,782 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01393,983,136 - 93,991,924 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01391,164,719 - 91,173,509 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01396,222,093 - 96,238,845 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)Ensemblrn6Rnor6.0
Rnor_5.013100,663,218 - 100,679,960 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41393,978,865 - 93,987,654 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1389,636,544 - 89,645,333 (-)NCBICelera
RGSC_v3.11394,168,061 - 94,176,568 (-)NCBI
Cytogenetic Map13q25NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic UMP  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
tamoxifen  (EXP,ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (ISO,ISS)
alternative mRNA splicing, via spliceosome  (IBA)
cardiac muscle cell development  (ISO)
cell differentiation  (IEA)
cell division  (IEA)
cellular response to dexamethasone stimulus  (IDA)
cellular response to glucocorticoid stimulus  (IEA,ISO)
cellular response to leukemia inhibitory factor  (ISO,ISS)
chromatin organization  (IEA)
circadian regulation of gene expression  (ISO)
CRD-mediated mRNA stabilization  (IEA,ISO)
dendritic transport of messenger ribonucleoprotein complex  (ISO)
dosage compensation by inactivation of X chromosome  (ISO)
erythrocyte differentiation  (ISO)
maintenance of protein location in nucleus  (IEA,ISO)
mRNA metabolic process  (ISO)
mRNA processing  (IEA)
mRNA stabilization  (IEA,ISO)
negative regulation of kinase activity  (ISO)
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA,ISO)
negative regulation of stem cell differentiation  (IEA,ISO,ISS)
negative regulation of telomere maintenance via telomerase  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transcription elongation by RNA polymerase II  (IEA,ISO)
positive regulation of attachment of mitotic spindle microtubules to kinetochore  (IEA,ISO,ISS)
positive regulation of brown fat cell differentiation  (ISO,ISS)
positive regulation of cytoplasmic translation  (IEA,ISO)
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  (IDA)
positive regulation of gene expression  (IMP)
positive regulation of macromolecule biosynthetic process  (IEA)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO,ISS)
protein localization to spindle microtubule  (IEA,ISO,ISS)
random inactivation of X chromosome  (IEA,ISO)
regulation of alternative mRNA splicing, via spliceosome  (IEA,ISO)
regulation of chromatin organization  (IEA,ISO,ISS)
regulation of gene expression  (IEA)
regulation of mitotic cell cycle  (IEA,ISO,ISS)
regulation of mitotic spindle assembly  (IEA,ISO,ISS)
regulatory ncRNA-mediated heterochromatin formation  (IEA,ISO)
RNA localization to chromatin  (ISO)
RNA splicing  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Highly differential expression of SN1, a bidirectional glutamine transporter, in astroglia and endothelium in the developing rat brain. Boulland JL, etal., Glia 2003 Feb;41(3):260-75.
2. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
3. The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. Cok SJ, etal., J Biol Chem. 2003 Sep 19;278(38):36157-62. Epub 2003 Jul 9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The expression profile of RNA-binding proteins in primary and metastatic colorectal cancer: relationship of heterogeneous nuclear ribonucleoproteins with prognosis. Hope NR and Murray GI, Hum Pathol. 2011 Mar;42(3):393-402. doi: 10.1016/j.humpath.2010.08.006. Epub 2010 Dec 30.
7. Interactions between the nuclear matrix and an enhancer of the tryptophan oxygenase gene. Kaneoka H, etal., Biochem Biophys Res Commun. 2009 Oct 2;387(4):717-22. doi: 10.1016/j.bbrc.2009.07.095. Epub 2009 Jul 24.
8. Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U). Kawano S, etal., J Biol Chem. 2010 Aug 20;285(34):26451-60. doi: 10.1074/jbc.M110.112979. Epub 2010 Jun 16.
9. Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins. Majewski L, etal., Nucleus. 2018 Jan 1;9(1):125-141. doi: 10.1080/19491034.2017.1421881.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
Additional References at PubMed
PMID:1628625   PMID:7993898   PMID:8068679   PMID:8174554   PMID:9105675   PMID:9204873   PMID:9353307   PMID:9405365   PMID:10490622   PMID:11003645   PMID:11909954   PMID:11991638  
PMID:14608463   PMID:15121898   PMID:15312650   PMID:15711563   PMID:16210410   PMID:17174306   PMID:17289661   PMID:18082603   PMID:18332112   PMID:19029303   PMID:19617346   PMID:19946888  
PMID:20833368   PMID:21235343   PMID:21242313   PMID:22082260   PMID:22162999   PMID:22325991   PMID:22658674   PMID:22681889   PMID:22720776   PMID:23811339   PMID:23979707   PMID:24625528  
PMID:25921091   PMID:25931508   PMID:25986610   PMID:26039991   PMID:26244333   PMID:28221134   PMID:28622508   PMID:28784777   PMID:34585626   PMID:35352799   PMID:35659652   PMID:37540655  
PMID:39216234  


Genomics

Comparative Map Data
Hnrnpu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81392,609,791 - 92,618,580 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1392,605,216 - 92,618,612 (-)EnsemblGRCr8
mRatBN7.21390,069,058 - 90,086,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1390,074,181 - 90,086,588 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1392,582,994 - 92,591,782 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01393,983,136 - 93,991,924 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01391,164,719 - 91,173,509 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01396,222,093 - 96,238,845 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)Ensemblrn6Rnor6.0
Rnor_5.013100,663,218 - 100,679,960 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41393,978,865 - 93,987,654 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1389,636,544 - 89,645,333 (-)NCBICelera
RGSC_v3.11394,168,061 - 94,176,568 (-)NCBI
Cytogenetic Map13q25NCBI
HNRNPU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381244,850,297 - 244,864,543 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1244,840,638 - 244,864,560 (-)Ensemblhg38GRCh38
GRCh371245,013,599 - 245,027,845 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361243,080,225 - 243,094,450 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341241,343,003 - 241,353,868NCBI
Celera1218,303,553 - 218,317,021 (-)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1215,396,765 - 215,410,903 (-)NCBIHuRef
CHM1_11246,285,948 - 246,300,167 (-)NCBICHM1_1
T2T-CHM13v2.01244,266,602 - 244,280,849 (-)NCBIT2T-CHM13v2.0
Hnrnpu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,148,673 - 178,170,063 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,148,673 - 178,165,362 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381178,321,108 - 178,338,891 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,321,108 - 178,337,797 (-)Ensemblmm10GRCm38
MGSCv371180,258,431 - 180,267,915 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361180,165,990 - 180,174,387 (-)NCBIMGSCv36mm8
Celera1185,387,923 - 185,397,431 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map183.16NCBI
Hnrnpu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554068,000,269 - 8,021,554 (-)Ensembl
ChiLan1.0NW_0049554068,000,269 - 8,021,554 (-)NCBIChiLan1.0ChiLan1.0
HNRNPU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214,286,070 - 4,300,191 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114,511,584 - 4,522,898 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01220,450,218 - 220,461,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11225,830,663 - 225,842,031 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1225,817,899 - 225,842,031 (-)EnsemblpanPan2panpan1.1
HNRNPU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1735,832,956 - 35,842,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl735,833,988 - 35,843,754 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha735,302,229 - 35,316,897 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0735,653,977 - 35,672,359 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl735,655,401 - 35,672,356 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1735,493,577 - 35,507,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0735,509,582 - 35,522,877 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0735,777,999 - 35,788,402 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hnrnpu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934448,725,125 - 48,767,809 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365266,017,279 - 6,022,124 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365266,014,745 - 6,022,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1017,477,902 - 17,497,030 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11017,475,266 - 17,497,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21019,942,586 - 19,951,287 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12581,879,532 - 81,890,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2581,878,111 - 81,890,701 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605584,093,092 - 84,115,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477114,756,100 - 14,765,832 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477114,756,088 - 14,766,106 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hnrnpu
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11056,668,171 - 56,685,876 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hnrnpu
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:216
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000044477
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH125798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,828 - 90,078,072 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,759 - 96,230,002NCBIRnor6.0
Rnor_5.013100,670,884 - 100,671,127UniSTSRnor5.0
RGSC_v3.41393,978,939 - 93,979,182UniSTSRGSC3.4
Celera1389,636,618 - 89,636,861UniSTS
Cytogenetic Map13q26UniSTS
WI-7584  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,858 - 90,078,195 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,789 - 96,230,125NCBIRnor6.0
Rnor_5.013100,670,914 - 100,671,250UniSTSRnor5.0
RGSC_v3.41393,978,969 - 93,979,305UniSTSRGSC3.4
Celera1389,636,648 - 89,636,984UniSTS
Cytogenetic Map13q26UniSTS
WI-8450  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,858 - 90,078,172 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,789 - 96,230,102NCBIRnor6.0
Rnor_5.013100,670,914 - 100,671,227UniSTSRnor5.0
RGSC_v3.41393,978,969 - 93,979,282UniSTSRGSC3.4
Celera1389,636,648 - 89,636,961UniSTS
Cytogenetic Map13q26UniSTS
RH135335  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,953 - 90,078,144 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,884 - 96,230,074NCBIRnor6.0
Rnor_5.013100,671,009 - 100,671,199UniSTSRnor5.0
RGSC_v3.41393,979,064 - 93,979,254UniSTSRGSC3.4
Celera1389,636,743 - 89,636,933UniSTS
RH 3.4 Map13608.5UniSTS
Cytogenetic Map13q26UniSTS
C86794  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81392,611,411 - 92,611,894 (+)Marker Load Pipeline
mRatBN7.21390,079,375 - 90,079,858 (+)MAPPERmRatBN7.2
Rnor_6.01396,231,306 - 96,231,788NCBIRnor6.0
Rnor_5.013100,672,431 - 100,672,913UniSTSRnor5.0
RGSC_v3.41393,980,486 - 93,980,968UniSTSRGSC3.4
Celera1389,638,165 - 89,638,647UniSTS
Cytogenetic Map13q26UniSTS
MARC_20677-20678:1024509130:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81392,610,463 - 92,611,128 (+)Marker Load Pipeline
mRatBN7.21390,078,427 - 90,079,092 (+)MAPPERmRatBN7.2
Rnor_6.01396,230,358 - 96,231,022NCBIRnor6.0
Rnor_5.013100,671,483 - 100,672,147UniSTSRnor5.0
RGSC_v3.41393,979,538 - 93,980,202UniSTSRGSC3.4
Celera1389,637,217 - 89,637,881UniSTS
Cytogenetic Map13q26UniSTS
MARC_26419-26420:1036768776:5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,852 - 90,078,342 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,783 - 96,230,272NCBIRnor6.0
Rnor_5.013100,670,908 - 100,671,397UniSTSRnor5.0
RGSC_v3.41393,978,963 - 93,979,452UniSTSRGSC3.4
Celera1389,636,642 - 89,637,131UniSTS
Cytogenetic Map13q26UniSTS
ksks277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,078,579 - 90,079,052 (+)MAPPERmRatBN7.2
Rnor_6.01396,230,510 - 96,230,982NCBIRnor6.0
Rnor_5.013100,671,635 - 100,672,107UniSTSRnor5.0
RGSC_v3.41393,979,690 - 93,980,162UniSTSRGSC3.4
Celera1389,637,369 - 89,637,841UniSTS
Cytogenetic Map13q26UniSTS
A007A33  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81392,610,502 - 92,611,120 (+)Marker Load Pipeline
mRatBN7.21390,078,466 - 90,079,084 (+)MAPPERmRatBN7.2
Rnor_6.01396,230,397 - 96,231,014NCBIRnor6.0
Rnor_5.013100,671,522 - 100,672,139UniSTSRnor5.0
RGSC_v3.41393,979,577 - 93,980,194UniSTSRGSC3.4
Celera1389,637,256 - 89,637,873UniSTS
Cytogenetic Map13q26UniSTS
HNRPU_1518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,655 - 90,078,517 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,586 - 96,230,447NCBIRnor6.0
Rnor_5.013100,670,711 - 100,671,572UniSTSRnor5.0
RGSC_v3.41393,978,766 - 93,979,627UniSTSRGSC3.4
Celera1389,636,445 - 89,637,306UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:546820  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81392,610,608 - 92,611,135 (+)Marker Load Pipeline
mRatBN7.21390,078,572 - 90,079,099 (+)MAPPERmRatBN7.2
Rnor_6.01396,230,503 - 96,231,029NCBIRnor6.0
Rnor_5.013100,671,628 - 100,672,154UniSTSRnor5.0
Celera1389,637,362 - 89,637,888UniSTS
Cytogenetic Map13q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000044477   ⟹   ENSRNOP00000046783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1392,609,794 - 92,618,612 (-)Ensembl
mRatBN7.2 Ensembl1390,077,755 - 90,086,588 (-)Ensembl
Rnor_6.0 Ensembl1396,229,688 - 96,238,474 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078061   ⟹   ENSRNOP00000070912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1392,605,216 - 92,618,580 (-)Ensembl
mRatBN7.2 Ensembl1390,074,181 - 90,086,586 (-)Ensembl
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095557   ⟹   ENSRNOP00000093222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1392,609,794 - 92,618,580 (-)Ensembl
mRatBN7.2 Ensembl1390,077,755 - 90,086,588 (-)Ensembl
RefSeq Acc Id: NM_057139   ⟹   NP_476480
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81392,609,791 - 92,618,580 (-)NCBI
mRatBN7.21390,077,755 - 90,086,544 (-)NCBI
Rnor_6.01396,229,685 - 96,238,474 (-)NCBI
Rnor_5.013100,663,218 - 100,679,960 (-)NCBI
RGSC_v3.41393,978,865 - 93,987,654 (-)RGD
Celera1389,636,544 - 89,645,333 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476480 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH72529 (Get FASTA)   NCBI Sequence Viewer  
  BAA03136 (Get FASTA)   NCBI Sequence Viewer  
  EDL94800 (Get FASTA)   NCBI Sequence Viewer  
  EDL94801 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046783
  ENSRNOP00000046783.3
GenBank Protein Q6IMY8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476480   ⟸   NM_057139
- UniProtKB: Q6IMY8 (UniProtKB/TrEMBL),   Q63555 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070912   ⟸   ENSRNOT00000078061
Ensembl Acc Id: ENSRNOP00000046783   ⟸   ENSRNOT00000044477
Ensembl Acc Id: ENSRNOP00000093222   ⟸   ENSRNOT00000095557
Protein Domains
B30.2/SPRY   SAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IMY8-F1-model_v2 AlphaFold Q6IMY8 1-798 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699050
Promoter ID:EPDNEW_R9574
Type:initiation region
Name:Hnrnpu_1
Description:heterogeneous nuclear ribonucleoprotein U
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01396,238,515 - 96,238,575EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620372 AgrOrtholog
BioCyc Gene G2FUF-17173 BioCyc
Ensembl Genes ENSRNOG00000033790 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044477 ENTREZGENE
  ENSRNOT00000044477.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot
  2.60.120.920 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096906 IMAGE-MGC_LOAD
InterPro B30.2/SPRY UniProtKB/Swiss-Prot
  B30.2/SPRY_sf UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  SAP_dom UniProtKB/Swiss-Prot
  SAP_dom_sf UniProtKB/Swiss-Prot
  SPRY_dom UniProtKB/Swiss-Prot
  SPRY_hnRNP_U UniProtKB/Swiss-Prot
KEGG Report rno:117280 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91534 IMAGE-MGC_LOAD
NCBI Gene 117280 ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER UniProtKB/Swiss-Prot
  PTHR12381:SF11 UniProtKB/Swiss-Prot
Pfam AAA_33 UniProtKB/Swiss-Prot
  SAP UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
PhenoGen Hnrnpu PhenoGen
PROSITE B302_SPRY UniProtKB/Swiss-Prot
  SAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033790 RatGTEx
SMART SAP UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF68906 UniProtKB/Swiss-Prot
UniProt A0A0G2JZ52_RAT UniProtKB/TrEMBL
  A0A8I6AI90_RAT UniProtKB/TrEMBL
  A6JGE4_RAT UniProtKB/TrEMBL
  HNRPU_RAT UniProtKB/Swiss-Prot
  Q63555 ENTREZGENE, UniProtKB/TrEMBL
  Q6IMY8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Hnrnpu  heterogeneous nuclear ribonucleoprotein U  Hnrpu  heterogeneous nuclear ribonucleoprotein U  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Hnrpu  heterogeneous nuclear ribonucleoprotein U    transporter protein; system N1 Na+ and H+-coupled glutamine transporter  Name updated 1299863 APPROVED
2002-08-07 Hnrpu  transporter protein; system N1 Na+ and H+-coupled glutamine transporter      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in astroglia, Bergmann glia, and vascular endothelium 632946
gene_expression expressed at high levels in the postnatal period 632946