HNRNPU (heterogeneous nuclear ribonucleoprotein U) - Rat Genome Database

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Gene: HNRNPU (heterogeneous nuclear ribonucleoprotein U) Chlorocebus sabaeus
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Symbol: HNRNPU
Name: heterogeneous nuclear ribonucleoprotein U
RGD ID: 18468338
Description: ENCODES a protein that exhibits poly(G) binding (ortholog); promoter-specific chromatin binding (ortholog); ribonucleoprotein complex binding (ortholog); INVOLVED IN cardiac muscle cell development (ortholog); cellular response to dexamethasone stimulus (ortholog); mRNA metabolic process (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); colorectal cancer (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN CRD-mediated mRNA stability complex (ortholog); dendrite (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12581,879,532 - 81,890,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2581,878,111 - 81,890,701 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605584,093,092 - 84,115,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (IEA)
cardiac muscle cell development  (IEA,ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucocorticoid stimulus  (IEA)
cellular response to leukemia inhibitory factor  (IEA)
circadian regulation of gene expression  (IEA)
CRD-mediated mRNA stabilization  (IEA)
dendritic transport of messenger ribonucleoprotein complex  (IEA)
dosage compensation by inactivation of X chromosome  (IEA)
maintenance of protein location in nucleus  (IEA)
mRNA metabolic process  (IEA,ISO)
mRNA stabilization  (IEA)
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA)
negative regulation of stem cell differentiation  (IEA)
negative regulation of telomere maintenance via telomerase  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription elongation by RNA polymerase II  (IEA)
positive regulation of attachment of mitotic spindle microtubules to kinetochore  (IEA)
positive regulation of brown fat cell differentiation  (IEA)
positive regulation of cytoplasmic translation  (IEA)
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of stem cell proliferation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
protein localization to spindle microtubule  (IEA)
regulation of alternative mRNA splicing, via spliceosome  (IEA)
regulation of chromatin organization  (IEA)
regulation of mitotic cell cycle  (IEA)
regulation of mitotic spindle assembly  (IEA)
RNA localization to chromatin  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
HNRNPU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12581,879,532 - 81,890,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2581,878,111 - 81,890,701 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605584,093,092 - 84,115,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HNRNPU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381244,850,297 - 244,864,543 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1244,840,638 - 244,864,560 (-)EnsemblGRCh38hg38GRCh38
GRCh371245,013,599 - 245,027,845 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361243,080,225 - 243,094,450 (-)NCBINCBI36Build 36hg18NCBI36
Build 341241,343,003 - 241,353,868NCBI
Celera1218,303,553 - 218,317,021 (-)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1215,396,765 - 215,410,903 (-)NCBIHuRef
CHM1_11246,285,948 - 246,300,167 (-)NCBICHM1_1
T2T-CHM13v2.01244,266,602 - 244,280,849 (-)NCBIT2T-CHM13v2.0
Hnrnpu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,148,673 - 178,170,063 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,148,673 - 178,165,362 (-)EnsemblGRCm39 Ensembl
GRCm381178,321,108 - 178,338,891 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,321,108 - 178,337,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371180,258,431 - 180,267,915 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361180,165,990 - 180,174,387 (-)NCBIMGSCv36mm8
Celera1185,387,923 - 185,397,431 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map183.16NCBI
Hnrnpu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81392,609,791 - 92,618,580 (-)NCBIGRCr8
mRatBN7.21390,069,058 - 90,086,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1390,074,181 - 90,086,588 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1392,582,994 - 92,591,782 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01393,983,136 - 93,991,924 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01391,164,719 - 91,173,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01396,222,093 - 96,238,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,663,218 - 100,679,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41393,978,865 - 93,987,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11394,168,061 - 94,176,568 (-)NCBI
Celera1389,636,544 - 89,645,333 (-)NCBICelera
Cytogenetic Map13q25NCBI
Hnrnpu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554068,000,269 - 8,021,554 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554068,000,269 - 8,021,554 (-)NCBIChiLan1.0ChiLan1.0
HNRNPU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214,286,070 - 4,300,191 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114,511,584 - 4,522,898 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01220,450,218 - 220,461,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11225,830,663 - 225,842,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1225,817,899 - 225,842,031 (-)Ensemblpanpan1.1panPan2
HNRNPU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1735,832,956 - 35,842,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl735,833,988 - 35,843,754 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha735,302,229 - 35,316,897 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0735,653,977 - 35,672,359 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl735,655,401 - 35,672,356 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1735,493,577 - 35,507,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0735,509,582 - 35,522,877 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0735,777,999 - 35,788,402 (-)NCBIUU_Cfam_GSD_1.0
Hnrnpu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934448,725,125 - 48,767,809 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365266,014,745 - 6,022,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1017,477,902 - 17,497,030 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11017,475,266 - 17,497,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21019,942,586 - 19,951,287 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Hnrnpu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477114,756,100 - 14,765,832 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477114,756,088 - 14,766,106 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 60
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000007286   ⟹   ENSCSAP00000005471
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2581,878,111 - 81,890,701 (-)Ensembl
RefSeq Acc Id: XM_007990009   ⟹   XP_007988200
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12581,879,532 - 81,890,684 (-)NCBI
Vero_WHO_p1.0NW_02366605584,104,481 - 84,115,743 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990010   ⟹   XP_007988201
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12581,879,532 - 81,890,684 (-)NCBI
Vero_WHO_p1.0NW_02366605584,102,434 - 84,115,605 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005236215
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605584,093,092 - 84,115,623 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007988200 (Get FASTA)   NCBI Sequence Viewer  
  XP_007988201 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005471
  ENSCSAP00000005471.1
RefSeq Acc Id: XP_007988201   ⟸   XM_007990010
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RA32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007988200   ⟸   XM_007990009
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCSAP00000005471   ⟸   ENSCSAT00000007286


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009219 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007286.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  SAP_dom UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
  SPRY_dom UniProtKB/TrEMBL
  SPRY_hnRNP_U UniProtKB/TrEMBL
NCBI Gene HNRNPU ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER UniProtKB/TrEMBL
  PTHR12381:SF11 UniProtKB/TrEMBL
Pfam AAA_33 UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
SMART SAP UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF68906 UniProtKB/TrEMBL
UniProt A0A0D9RA32 ENTREZGENE, UniProtKB/TrEMBL