Ereg (epiregulin) - Rat Genome Database

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Gene: Ereg (epiregulin) Rattus norvegicus
Analyze
Symbol: Ereg
Name: epiregulin
RGD ID: 620299
Description: Enables growth factor activity. Involved in several processes, including luteinizing hormone signaling pathway; oogenesis; and positive regulation of mitotic nuclear division. Located in extracellular space. Human ortholog(s) of this gene implicated in extrapulmonary tuberculosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human EREG (epiregulin); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: epiregulin precursor; proepiregulin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,311,485 - 17,325,260 (-)NCBIGRCr8
mRatBN7.21417,027,287 - 17,041,062 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,027,287 - 17,041,062 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,029,016 - 17,042,901 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,347,942 - 18,361,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,040,063 - 17,053,944 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,577,620 - 18,591,395 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,576,355 - 18,591,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,486,956 - 18,500,731 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,521,069 - 18,534,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,521,068 - 18,534,844 (-)NCBI
Celera1416,405,096 - 16,418,803 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-Dinitropyrene  (ISO)
1-nitropyrene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4-aminosalicylic acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
AL 8810  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpidem  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
batimastat  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (EXP)
biperiden  (ISO)
bisphenol A  (EXP,ISO)
bromfenac  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
Chorionic gonadotropin  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
entacapone  (ISO)
esmolol  (ISO)
etodolac  (ISO)
etoposide  (ISO)
ferroheme b  (ISO)
Fexofenadine hydrochloride  (ISO)
flavonoids  (EXP)
fludrocortisone  (ISO)
fluoranthene  (ISO)
flutamide  (EXP,ISO)
fulvestrant  (EXP)
genistein  (EXP)
gentamycin  (EXP)
griseofulvin  (ISO)
heme b  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
Iproniazid  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
ketoconazole  (ISO)
ketorolac tromethamine  (ISO)
lipopolysaccharide  (ISO)
lumiracoxib  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mebendazole  (ISO)
meloxicam  (ISO)
metam  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
microcystin-LR  (ISO)
minoxidil  (ISO)
mirex  (EXP)
monobenzyl phthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalenes  (EXP)
nefazodone  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
Nonylphenol  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
penbutolol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
Phenoxybenzamine  (ISO)
phentolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pioglitazone  (ISO)
pirprofen  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
primaquine  (ISO)
procyclidine  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrins  (ISO)
protriptyline  (ISO)
quercetin  (ISO)
retinyl palmitate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (ISO)
tienilic acid  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
trazodone  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
Trihexyphenidyl  (ISO)
triphenyl phosphate  (ISO)
triprolidine  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinyl carbamate  (ISO)
zafirlukast  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,ISO,ISS)
membrane  (IEA)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Epidermal growth factor family members: endogenous mediators of the ovulatory response. Ashkenazi H, etal., Endocrinology. 2005 Jan;146(1):77-84. Epub 2004 Sep 30.
2. Polymorphism in the EREG gene confers susceptibility to tuberculosis. Cao W, etal., BMC Med Genet. 2019 Jan 11;20(1):7. doi: 10.1186/s12881-018-0729-z.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury. Hsu D, etal., Lab Invest. 2010 Sep;90(9):1295-305. doi: 10.1038/labinvest.2010.100. Epub 2010 May 24.
6. Mechanism of growth promoting activity of epiregulin in primary cultures of rat hepatocytes. Komurasaki T, etal., Growth Factors 2002 Jun;20(2):61-9.
7. Factor Xa induces mitogenesis of vascular smooth muscle cells via autocrine production of epiregulin. Koo BH and Kim DS, J Biol Chem. 2003 Dec 26;278(52):52578-86. Epub 2003 Oct 21.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Transcriptional regulation of the epiregulin gene in the rat ovary. Sekiguchi T, etal., Endocrinology 2002 Dec;143(12):4718-29.
16. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
17. Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin. Taylor DS, etal., Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1633-8.
18. Expression of the epidermal growth factor system in human middle ear cholesteatoma. Thorup MB, etal., Acta Otolaryngol. 2014 Feb;134(2):124-34. doi: 10.3109/00016489.2013.847282. Epub 2013 Nov 21.
19. Epiregulin (EREG) variation is associated with susceptibility to tuberculosis. Thuong NT, etal., Genes Immun. 2012 Apr;13(3):275-81. doi: 10.1038/gene.2011.83. Epub 2011 Dec 15.
20. Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer. Xie Y, etal., PLoS One. 2013 Jun 21;8(6):e67819. doi: 10.1371/journal.pone.0067819. Print 2013.
Additional References at PubMed
PMID:7706296   PMID:9337852   PMID:9419975   PMID:10681561   PMID:12702554   PMID:14581411   PMID:15291759   PMID:16182244   PMID:18653716   PMID:31062344  


Genomics

Comparative Map Data
Ereg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,311,485 - 17,325,260 (-)NCBIGRCr8
mRatBN7.21417,027,287 - 17,041,062 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,027,287 - 17,041,062 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,029,016 - 17,042,901 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,347,942 - 18,361,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,040,063 - 17,053,944 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,577,620 - 18,591,395 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,576,355 - 18,591,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,486,956 - 18,500,731 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,521,069 - 18,534,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,521,068 - 18,534,844 (-)NCBI
Celera1416,405,096 - 16,418,803 (-)NCBICelera
Cytogenetic Map14p22NCBI
EREG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,365,145 - 74,388,749 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,365,145 - 74,388,749 (+)EnsemblGRCh38hg38GRCh38
GRCh37475,230,862 - 75,254,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,449,724 - 75,473,341 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,595,894 - 75,619,512NCBI
Celera472,591,116 - 72,614,730 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef471,041,824 - 71,065,447 (+)NCBIHuRef
CHM1_1475,266,712 - 75,290,347 (+)NCBICHM1_1
T2T-CHM13v2.0477,708,788 - 77,732,398 (+)NCBIT2T-CHM13v2.0
Ereg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,222,476 - 91,241,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,222,481 - 91,241,505 (+)EnsemblGRCm39 Ensembl
GRCm38591,074,617 - 91,093,649 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl591,074,622 - 91,093,646 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,503,643 - 91,522,675 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36592,149,822 - 92,168,846 (+)NCBIMGSCv36mm8
Celera589,212,781 - 89,230,978 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Ereg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474612,440 - 627,606 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474612,440 - 627,606 (+)NCBIChiLan1.0ChiLan1.0
EREG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2355,672,126 - 55,720,786 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1455,861,183 - 55,909,825 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0449,806,505 - 49,827,961 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,641,014 - 55,660,568 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,641,014 - 55,660,568 (-)Ensemblpanpan1.1panPan2
EREG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,857,325 - 62,877,831 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,856,709 - 62,877,760 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,545,018 - 62,568,011 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,687,189 - 63,710,239 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,687,115 - 63,707,828 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11363,301,985 - 63,325,016 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,783,802 - 62,806,817 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,926,759 - 63,949,788 (+)NCBIUU_Cfam_GSD_1.0
Ereg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528512,874,664 - 12,893,710 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,328,803 - 1,344,360 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,328,803 - 1,336,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EREG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,351,311 - 70,372,569 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,351,316 - 70,372,530 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,502,143 - 74,521,363 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EREG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,898,998 - 22,924,922 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,901,862 - 22,920,678 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660371,191,580 - 1,214,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ereg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247301,339,518 - 1,353,429 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247301,339,017 - 1,353,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ereg
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:102
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000003716
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 3 10
Below cutoff 1 2 10 2 15 2 1 1 1 8 14 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003716   ⟹   ENSRNOP00000003716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,027,287 - 17,041,062 (-)Ensembl
Rnor_6.0 Ensembl1418,576,355 - 18,591,394 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106769   ⟹   ENSRNOP00000081571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,027,287 - 17,031,974 (-)Ensembl
RefSeq Acc Id: NM_021689   ⟹   NP_067721
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,311,485 - 17,325,260 (-)NCBI
mRatBN7.21417,027,287 - 17,041,062 (-)NCBI
Rnor_6.01418,577,620 - 18,591,395 (-)NCBI
Rnor_5.01418,486,956 - 18,500,731 (-)NCBI
RGSC_v3.41418,521,069 - 18,534,844 (-)RGD
Celera1416,405,096 - 16,418,803 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_067721   ⟸   NM_021689
- Peptide Label: preproprotein
- UniProtKB: Q9Z0L5 (UniProtKB/TrEMBL),   A0A8I5ZT85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003716   ⟸   ENSRNOT00000003716
RefSeq Acc Id: ENSRNOP00000081571   ⟸   ENSRNOT00000106769
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0L5-F1-model_v2 AlphaFold Q9Z0L5 1-162 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699223
Promoter ID:EPDNEW_R9747
Type:single initiation site
Name:Ereg_1
Description:epiregulin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,591,396 - 18,591,456EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620299 AgrOrtholog
BioCyc Gene G2FUF-16215 BioCyc
Ensembl Genes ENSRNOG00000002771 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006392 UniProtKB/Swiss-Prot
  ENSRNOG00060017986 UniProtKB/Swiss-Prot
  ENSRNOG00065016811 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003716 ENTREZGENE
  ENSRNOT00000003716.4 UniProtKB/Swiss-Prot
  ENSRNOT00000106769.1 UniProtKB/TrEMBL
  ENSRNOT00055010389 UniProtKB/Swiss-Prot
  ENSRNOT00060030933 UniProtKB/Swiss-Prot
  ENSRNOT00065028060 UniProtKB/Swiss-Prot
Gene3D-CATH Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59325 UniProtKB/Swiss-Prot
NCBI Gene 59325 ENTREZGENE
PANTHER PROEPIREGULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EREG RGD
PhenoGen Ereg PhenoGen
PRINTS EGFTGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002771 RatGTEx
  ENSRNOG00055006392 RatGTEx
  ENSRNOG00060017986 RatGTEx
  ENSRNOG00065016811 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZT85 ENTREZGENE, UniProtKB/TrEMBL
  EREG_RAT UniProtKB/Swiss-Prot
  Q2VC84_RAT UniProtKB/TrEMBL
  Q9Z0L5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ereg  epiregulin    epiregulin precursor  Name updated 625702 APPROVED
2002-08-07 Ereg  epiregulin precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in ovarian granulosa cells 628418
gene_process mitogenic for rat aortic smooth muscle (RASM) cells, causing rapid EGF receptor activation, enhancing DNA synthesis 632743
gene_process may play a role in FSH induced growth and maturation of ovarian follicles 628418
gene_process growth factor belonging to epidermal growth factor family 628418
gene_regulation induced by vasoactive GTP-binding protein-coupled receptor agonists such as angiotensin II (AII), endothelin-1 (ET-1), and alpha-thrombin (alpha-Thr) 632743
gene_regulation Sp1/Sp3 proteins regulate via upstream sequence; rapid and strong induction in ovarian granulosa cells by FSH 628418
gene_transcript 5 exons; 125 bp region upstream of the start site important for transcription; one GT and two CT boxes located within this region important for expression 628418