Sh3gl2 (SH3 domain containing GRB2 like 2, endophilin A1) - Rat Genome Database

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Gene: Sh3gl2 (SH3 domain containing GRB2 like 2, endophilin A1) Rattus norvegicus
Analyze
Symbol: Sh3gl2
Name: SH3 domain containing GRB2 like 2, endophilin A1
RGD ID: 620276
Description: Enables several functions, including identical protein binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including membrane bending; positive regulation of membrane tubulation; and vesicle scission. Located in several cellular components, including basal dendrite; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH 17beta-estradiol; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endophilin-1; endophilin-A1; SH3 domain protein 2A; SH3 domain-containing GRB2-like 2; SH3 domain-containing GRB2-like protein 2; SH3-domain GRB2-like 2; Sh3d2a; Sh3p4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85104,699,270 - 104,874,724 (+)NCBIGRCr8
mRatBN7.2599,653,189 - 99,827,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl599,653,152 - 100,113,843 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5102,036,367 - 102,216,379 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05103,824,073 - 103,998,825 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05103,847,211 - 104,027,230 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05103,479,767 - 103,654,507 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5103,479,767 - 103,654,247 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05107,479,270 - 107,653,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45104,129,280 - 104,308,317 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15104,300,491 - 104,313,320 (+)NCBI
Celera598,159,729 - 98,334,521 (+)NCBICelera
Cytogenetic Map5q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation. Ambroso MR, etal., Proc Natl Acad Sci U S A. 2014 May 13;111(19):6982-7. doi: 10.1073/pnas.1402233111. Epub 2014 Apr 28.
2. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Intradimer/Intermolecular interactions suggest autoinhibition mechanism in endophilin A1. Chen Z, etal., J Am Chem Soc. 2014 Mar 26;136(12):4557-64. doi: 10.1021/ja411607b. Epub 2014 Mar 13.
4. Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Chowdhury S, etal., Neuron. 2006 Nov 9;52(3):445-59.
5. Identification of endophilins 1 and 3 as selective binding partners for VGLUT1 and their co-localization in neocortical glutamatergic synapses: implications for vesicular glutamate transporter trafficking and excitatory vesicle formation. De Gois S, etal., Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):679-93. doi: 10.1007/s10571-006-9054-8. Epub 2006 May 19.
6. Identification of the major synaptojanin-binding proteins in brain. de Heuvel E, etal., J Biol Chem. 1997 Mar 28;272(13):8710-6.
7. Generation of high curvature membranes mediated by direct endophilin bilayer interactions. Farsad K, etal., J Cell Biol. 2001 Oct 15;155(2):193-200. doi: 10.1083/jcb.200107075. Epub 2001 Oct 15.
8. Mechanism of endophilin N-BAR domain-mediated membrane curvature. Gallop JL, etal., EMBO J. 2006 Jun 21;25(12):2898-910. doi: 10.1038/sj.emboj.7601174. Epub 2006 Jun 8.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Early increase of apoptosis-linked gene-2 interacting protein X in areas of kainate-induced neurodegeneration. Hemming FJ, etal., Neuroscience. 2004;123(4):887-95.
12. Interaction of SPIN90 with dynamin I and its participation in synaptic vesicle endocytosis. Kim Y, etal., J Neurosci. 2005 Oct 12;25(41):9515-23.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. Micheva KD, etal., J Biol Chem. 1997 Oct 24;272(43):27239-45. doi: 10.1074/jbc.272.43.27239.
15. Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Milosevic I, etal., Neuron. 2011 Nov 17;72(4):587-601. doi: 10.1016/j.neuron.2011.08.029.
16. Multiple modes of endophilin-mediated conversion of lipid vesicles into coated tubes: implications for synaptic endocytosis. Mizuno N, etal., J Biol Chem. 2010 Jul 23;285(30):23351-8. doi: 10.1074/jbc.M110.143776. Epub 2010 May 18.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals. Nemoto Y, etal., J Biol Chem 2001 Nov 2;276(44):41133-42.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Differential expression of endophilin 1 and 2 dimers at central nervous system synapses. Ringstad N, etal., J Biol Chem. 2001 Nov 2;276(44):40424-30. doi: 10.1074/jbc.M106338200. Epub 2001 Aug 22.
25. The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. Ringstad N, etal., Proc Natl Acad Sci U S A 1997 Aug 5;94(16):8569-74.
26. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
27. Inhibitory role of endophilin 3 in receptor-mediated endocytosis. Sugiura H, etal., J Biol Chem. 2004 May 28;279(22):23343-8. doi: 10.1074/jbc.M312607200. Epub 2004 Apr 5.
28. Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I. Tian Q, etal., Neurosci Bull. 2012 Oct;28(5):483-92. doi: 10.1007/s12264-012-1257-z. Epub 2012 Jul 13.
29. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Voglmaier SM, etal., Neuron. 2006 Jul 6;51(1):71-84. doi: 10.1016/j.neuron.2006.05.027.
30. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains. Wuertenberger S and Groemping Y, FEBS Lett. 2015 Apr 28;589(10):1156-63. doi: 10.1016/j.febslet.2015.03.014. Epub 2015 Mar 24.
Additional References at PubMed
PMID:10908605   PMID:14704270   PMID:15821731   PMID:16115810   PMID:16164598   PMID:18391417   PMID:18940612   PMID:19481455   PMID:20404169   PMID:20418375   PMID:21849472   PMID:22768939  
PMID:23376485   PMID:23442862   PMID:23482561   PMID:23785143   PMID:24854121   PMID:25517094   PMID:26854628   PMID:28235806   PMID:28933693   PMID:29476059   PMID:31059028  


Genomics

Comparative Map Data
Sh3gl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85104,699,270 - 104,874,724 (+)NCBIGRCr8
mRatBN7.2599,653,189 - 99,827,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl599,653,152 - 100,113,843 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5102,036,367 - 102,216,379 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05103,824,073 - 103,998,825 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05103,847,211 - 104,027,230 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05103,479,767 - 103,654,507 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5103,479,767 - 103,654,247 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05107,479,270 - 107,653,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45104,129,280 - 104,308,317 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15104,300,491 - 104,313,320 (+)NCBI
Celera598,159,729 - 98,334,521 (+)NCBICelera
Cytogenetic Map5q31NCBI
SH3GL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38917,579,066 - 17,797,124 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl917,579,066 - 17,797,124 (+)EnsemblGRCh38hg38GRCh38
GRCh37917,579,064 - 17,797,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36917,569,194 - 17,787,122 (+)NCBINCBI36Build 36hg18NCBI36
Build 34917,569,193 - 17,787,120NCBI
Celera917,507,463 - 17,725,658 (+)NCBICelera
Cytogenetic Map9p22.2NCBI
HuRef917,541,205 - 17,759,965 (+)NCBIHuRef
CHM1_1917,579,359 - 17,797,531 (+)NCBICHM1_1
T2T-CHM13v2.0917,591,797 - 17,809,924 (+)NCBIT2T-CHM13v2.0
Sh3gl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39485,123,663 - 85,307,617 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl485,123,363 - 85,557,432 (+)EnsemblGRCm39 Ensembl
GRCm38485,205,456 - 85,389,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl485,205,126 - 85,639,195 (+)EnsemblGRCm38mm10GRCm38
MGSCv37484,851,360 - 85,035,284 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36484,676,687 - 84,860,611 (+)NCBIMGSCv36mm8
Celera483,721,182 - 83,903,108 (+)NCBICelera
Cytogenetic Map4C4NCBI
cM Map440.23NCBI
Sh3gl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543420,331,779 - 20,381,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543420,332,727 - 20,381,320 (+)NCBIChiLan1.0ChiLan1.0
SH3GL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211106,761,688 - 106,981,117 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19106,767,634 - 106,987,062 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0917,386,298 - 17,605,722 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1917,878,860 - 18,097,579 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl918,045,198 - 18,097,579 (+)Ensemblpanpan1.1panPan2
SH3GL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11137,720,793 - 37,769,027 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1137,577,053 - 37,767,572 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1136,210,473 - 36,429,450 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01138,479,939 - 38,699,050 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1138,479,865 - 38,844,393 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11137,183,251 - 37,402,158 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01136,975,724 - 37,194,721 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01137,613,946 - 37,832,890 (+)NCBIUU_Cfam_GSD_1.0
SH3GL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1205,081,231 - 205,285,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11205,081,227 - 205,285,359 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21228,802,236 - 229,005,151 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH3GL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11261,862,997 - 62,085,254 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1261,862,943 - 61,917,315 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603850,001,458 - 50,229,863 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3gl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473621,554,969 - 21,716,877 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473621,554,950 - 21,715,522 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sh3gl2
1892 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:152
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000008999
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599485997103690167Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat

Markers in Region
D5Rat151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2599,753,548 - 99,753,708 (+)MAPPERmRatBN7.2
Rnor_6.05103,580,245 - 103,580,403NCBIRnor6.0
Rnor_5.05107,580,081 - 107,580,201NCBIRnor5.0
Rnor_5.05107,580,080 - 107,580,201NCBIRnor5.0
RGSC_v3.45104,231,741 - 104,231,900RGDRGSC3.4
RGSC_v3.45104,231,742 - 104,231,900UniSTSRGSC3.4
RGSC_v3.15104,236,968 - 104,237,126RGD
Celera598,259,651 - 98,259,809UniSTS
RH 3.4 Map5742.7UniSTS
RH 3.4 Map5742.7RGD
RH 2.0 Map5653.0RGD
Cytogenetic Map5q31UniSTS
AU047584  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2599,800,893 - 99,801,089 (+)MAPPERmRatBN7.2
mRatBN7.2599,800,932 - 99,801,089 (+)MAPPERmRatBN7.2
Rnor_6.05103,628,140 - 103,628,296NCBIRnor6.0
Rnor_6.05103,628,101 - 103,628,296NCBIRnor6.0
Rnor_5.05107,627,416 - 107,627,572UniSTSRnor5.0
Rnor_5.05107,627,377 - 107,627,572UniSTSRnor5.0
RGSC_v3.45104,281,296 - 104,281,452UniSTSRGSC3.4
RGSC_v3.45104,281,257 - 104,281,452UniSTSRGSC3.4
Celera598,308,162 - 98,308,355UniSTS
Celera598,308,201 - 98,308,355UniSTS
Cytogenetic Map5q31UniSTS
G47071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2599,819,473 - 99,819,695 (+)MAPPERmRatBN7.2
Rnor_6.05103,646,221 - 103,646,442NCBIRnor6.0
Rnor_5.05107,645,497 - 107,645,718UniSTSRnor5.0
RGSC_v3.45104,300,068 - 104,300,289UniSTSRGSC3.4
Celera598,326,495 - 98,326,716UniSTS
Cytogenetic Map5q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 64 25 18 2
Low 1 32 15 18 4 6 10 10 23 9 4
Below cutoff 11 35 34 1 34 4 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008999   ⟹   ENSRNOP00000008999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl599,787,847 - 99,827,500 (+)Ensembl
Rnor_6.0 Ensembl5103,479,767 - 103,654,247 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100135   ⟹   ENSRNOP00000081211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl599,653,189 - 99,825,720 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110787   ⟹   ENSRNOP00000087931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl599,653,152 - 99,827,500 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111420   ⟹   ENSRNOP00000088763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl599,653,189 - 100,113,843 (+)Ensembl
RefSeq Acc Id: NM_053935   ⟹   NP_446387
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85104,699,270 - 104,873,575 (+)NCBI
mRatBN7.2599,653,189 - 99,827,500 (+)NCBI
Rnor_6.05103,479,767 - 103,654,247 (+)NCBI
Rnor_5.05107,479,270 - 107,653,523 (+)NCBI
Celera598,159,729 - 98,334,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238359   ⟹   XP_006238421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85104,816,070 - 104,874,724 (+)NCBI
mRatBN7.2599,770,011 - 99,827,154 (+)NCBI
Rnor_6.05103,595,629 - 103,654,507 (+)NCBI
Rnor_5.05107,479,270 - 107,653,523 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063287074   ⟹   XP_063143144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85104,791,785 - 104,874,724 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446387   ⟸   NM_053935
- UniProtKB: O35179 (UniProtKB/Swiss-Prot),   A6J857 (UniProtKB/TrEMBL),   A0A8L2Q412 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238421   ⟸   XM_006238359
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GFM2 (UniProtKB/TrEMBL),   A0A8L2Q412 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008999   ⟸   ENSRNOT00000008999
RefSeq Acc Id: ENSRNOP00000087931   ⟸   ENSRNOT00000110787
RefSeq Acc Id: ENSRNOP00000088763   ⟸   ENSRNOT00000111420
RefSeq Acc Id: ENSRNOP00000081211   ⟸   ENSRNOT00000100135
RefSeq Acc Id: XP_063143144   ⟸   XM_063287074
- Peptide Label: isoform X2
Protein Domains
BAR   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35179-F1-model_v2 AlphaFold O35179 1-352 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693821
Promoter ID:EPDNEW_R4346
Type:initiation region
Name:Sh3gl2_1
Description:SH3 domain containing GRB2 like 2, endophilin A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05103,479,726 - 103,479,786EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620276 AgrOrtholog
BIND 130461
  130589
  134434
BioCyc Gene G2FUF-40854 BioCyc
Ensembl Genes ENSRNOG00000006761 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008999 ENTREZGENE
  ENSRNOT00000008999.7 UniProtKB/TrEMBL
  ENSRNOT00000100135.1 UniProtKB/TrEMBL
  ENSRNOT00000110787.1 UniProtKB/TrEMBL
  ENSRNOT00000111420.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endophilin_A_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116743 ENTREZGENE
PANTHER ENDOPHILIN-A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sh3gl2 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPECTRNALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006761 RatGTEx
SMART BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZRH7_RAT UniProtKB/TrEMBL
  A0A8I6ABD8_RAT UniProtKB/TrEMBL
  A0A8I6GFM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q412 ENTREZGENE, UniProtKB/TrEMBL
  A6J857 ENTREZGENE, UniProtKB/TrEMBL
  O35179 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-19 Sh3gl2  SH3 domain containing GRB2 like 2, endophilin A1  Sh3gl2  SH3 domain-containing GRB2-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Sh3gl2  SH3 domain-containing GRB2-like 2  Sh3gl2  SH3-domain GRB2-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Sh3gl2  SH3-domain GRB2-like 2    SH3 domain protein 2A  Name updated 1299863 APPROVED
2004-09-10 Sh3gl2  SH3 domain protein 2A  Sh3d2a    Symbol and Name updated 1299863 APPROVED
2002-08-07 Sh3d2a  SH3 domain protein 2A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in brain 633918