Btc (betacellulin) - Rat Genome Database

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Gene: Btc (betacellulin) Rattus norvegicus
Analyze
Symbol: Btc
Name: betacellulin
RGD ID: 620275
Description: Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including positive regulation of fibroblast proliferation; positive regulation of mitotic nuclear division; and positive regulation of urine volume. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of otitis media. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human BTC (betacellulin); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: probetacellulin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,992,668 - 17,031,178 (+)NCBIGRCr8
mRatBN7.21416,708,447 - 16,746,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,707,982 - 16,747,049 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1416,716,086 - 16,754,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,035,002 - 18,073,595 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01416,727,133 - 16,765,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,231,854 - 18,270,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,231,860 - 18,272,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,121,506 - 18,182,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,194,470 - 18,235,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,214,004 - 18,235,228 (+)NCBI
Celera1416,107,460 - 16,127,465 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Term
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Original Reference(s)
BtcRatExperimental Diabetes Mellitus  ISOBtc (Mus musculus)2313774 RGD 
BtcRatExperimental Diabetes Mellitus  ISOBTC (Homo sapiens)2306965 RGD 
BtcRatExperimental Diabetes Mellitus  ISOBTC (Homo sapiens)1357906 RGD 
BtcRatGlucagonoma  ISOBTC (Homo sapiens)2326087protein:increased expression:pancreasRGD 
BtcRatinsulinoma  ISOBTC (Homo sapiens)2326087protein:increased expression:pancreasRGD 
BtcRatotitis media  IEP 2306978mRNA:decreased expression:middle earRGD 
BtcRattype 1 diabetes mellitus susceptibilityISOBTC (Homo sapiens)2306966DNA:polymorphism:intron:IVS4-4C>T (human)RGD 
BtcRattype 2 diabetes mellitus  ISOBTC (Homo sapiens)2306967DNA:polymorphism:promoter:-226A/G (human)RGD 
BtcRattype 2 diabetes mellitus susceptibilityISOBTC (Homo sapiens)2306973DNA:polymorphism:exon:p.C7G (human)RGD 
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Original Reference(s)
BtcRaterythropoietic protoporphyria  ISOBTC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19267999

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Original Reference(s)
BtcRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BTC mRNA]CTDPMID:31150632
BtcRat(1->4)-beta-D-glucan multiple interactionsISOBtc (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of BTC mRNACTDPMID:36331819
BtcRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of BTC mRNACTDPMID:30723492
BtcRat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of BTC mRNACTDPMID:26496021
BtcRat17beta-estradiol increases expressionISOBTC (Homo sapiens)6480464Estradiol results in increased expression of BTC mRNACTDPMID:31614463
BtcRat17beta-estradiol multiple interactionsISOBTC (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of BTC mRNACTDPMID:30165855
BtcRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOBtc (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of BTC mRNACTDPMID:19933214
BtcRat2,3,7,8-Tetrachlorodibenzofuran increases expressionEXP 64804642 more ...CTDPMID:32109520
BtcRat2-hydroxypropanoic acid decreases expressionISOBTC (Homo sapiens)6480464Lactic Acid results in decreased expression of BTC mRNACTDPMID:30851411
BtcRat2-palmitoylglycerol increases expressionISOBTC (Homo sapiens)64804642-palmitoylglycerol results in increased expression of BTC mRNACTDPMID:37199045
BtcRat3,4-methylenedioxymethamphetamine increases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of BTC mRNACTDPMID:30071829
BtcRat4,4'-diaminodiphenylmethane increases expressionISOBtc (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of BTC mRNACTDPMID:18648102
BtcRat4-hydroxyphenyl retinamide decreases expressionISOBtc (Mus musculus)6480464Fenretinide results in decreased expression of BTC mRNACTDPMID:28973697
BtcRat4-methylcatechol multiple interactionsEXP 64804644-methylcatechol results in decreased expression of and results in decreased secretion of BTC proteinCTDPMID:29473434
BtcRat4-methylcatechol decreases expressionEXP 64804644-methylcatechol results in decreased expression of BTC mRNACTDPMID:29473434
BtcRat4-nonylphenol multiple interactionsISOBtc (Mus musculus)6480464[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein more ...CTDPMID:28703301
BtcRataflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of BTC mRNACTDPMID:23630614
BtcRatall-trans-retinal decreases expressionISOBTC (Homo sapiens)6480464Retinaldehyde results in decreased expression of BTC mRNACTDPMID:16470170
BtcRatall-trans-retinoic acid decreases expressionISOBTC (Homo sapiens)6480464Tretinoin results in decreased expression of BTC mRNACTDPMID:16470170
BtcRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of BTC mRNACTDPMID:16483693

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Biological Process
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Original Reference(s)
BtcRatapoptotic process acts_upstream_ofISOBtc (Mus musculus)1624291 PMID:18656477RGDPMID:18656477
BtcRatcell differentiation  TAS 1357906 RGD 
BtcRatcell population proliferation acts_upstream_ofISOBtc (Mus musculus)1624291MGI:88039 more ...RGDPMID:18656477
BtcRatDNA replication  TAS 1357906 RGD 
BtcRatepidermal growth factor receptor signaling pathway  IDA 2324625 RGD 
BtcRatepidermal growth factor receptor signaling pathway involved_inIEAUniProtKB:P35070 and ensembl:ENSP000003790921600115GO_REF:0000107EnsemblGO_REF:0000107
BtcRatepidermal growth factor receptor signaling pathway involved_inISOBtc (Mus musculus)1624291MGI:95294 PMID:18656477 and PMID:8456283RGDPMID:18656477 and PMID:8456283
BtcRatepidermal growth factor receptor signaling pathway involved_inISOBTC (Homo sapiens)1624291 PMID:8144591RGDPMID:8144591
BtcRatepidermal growth factor receptor signaling pathway involved_inIBAMGI:107508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
BtcRatepithelial cell apoptotic process acts_upstream_ofISOBtc (Mus musculus)1624291 PMID:18656477RGDPMID:18656477
BtcRatERBB2-EGFR signaling pathway involved_inISOBtc (Mus musculus)1624291 PMID:21897861RGDPMID:21897861
BtcRatERBB4-ERBB4 signaling pathway involved_inISOBTC (Homo sapiens)1624291 PMID:9168114RGDPMID:9168114
BtcRatERBB4-ERBB4 signaling pathway involved_inIEAUniProtKB:P35070 and ensembl:ENSP000003790921600115GO_REF:0000107EnsemblGO_REF:0000107
BtcRatnegative regulation of epithelial cell apoptotic process acts_upstream_of_or_withinISOBtc (Mus musculus)1624291 PMID:18656477RGDPMID:18656477
BtcRatpositive regulation of cell differentiation  IMP 2306975 RGD 
BtcRatpositive regulation of cell population proliferation involved_inIBAMGI:107508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
BtcRatpositive regulation of cell population proliferation acts_upstream_of_or_withinISOBtc (Mus musculus)1624291MGI:88039 more ...RGDPMID:18656477
BtcRatpositive regulation of fibroblast proliferation  IDA 2306976 RGD 
BtcRatpositive regulation of mitotic nuclear division involved_inIBAMGI:107508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
BtcRatpositive regulation of mitotic nuclear division  IDA 631927 RGD 
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Cellular Component

  
Object Symbol
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Original Reference(s)
BtcRatextracellular space is_active_inISOBTC (Homo sapiens)1624291 PMID:12399441 and PMID:9168114RGDPMID:12399441 and PMID:9168114
BtcRatextracellular space is_active_inIEAUniProtKB:P35070 and ensembl:ENSP000003790921600115GO_REF:0000107EnsemblGO_REF:0000107
BtcRatextracellular space is_active_inIBAMGI:107508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
BtcRatextracellular space is_active_inISOBtc (Mus musculus)1624291 PMID:21897861 and PMID:8456283RGDPMID:21897861 and PMID:8456283
BtcRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
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Original Reference(s)
BtcRatepidermal growth factor receptor binding  IDA 2324625 RGD 
BtcRatepidermal growth factor receptor binding enablesIBAMGI:107508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
BtcRatgrowth factor activity  IDA 2324625 RGD 
BtcRatgrowth factor activity enablesIBAMGI:1919170 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
BtcRatgrowth factor activity enablesIEAUniProtKB-KW:KW-03391600115GO_REF:0000043UniProtGO_REF:0000043
BtcRatprotein binding enablesISOBTC (Homo sapiens)1624291UniProtKB:O43765 more ...RGDPMID:19740107 more ...
BtcRatreceptor ligand activity enablesISOBtc (Mus musculus)1624291MGI:95294 PMID:18656477 more ...RGDPMID:18656477 more ...
BtcRatreceptor ligand activity enablesIEAUniProtKB:P35070 and ensembl:ENSP000003790921600115GO_REF:0000107EnsemblGO_REF:0000107
BtcRatreceptor ligand activity enablesISOBTC (Homo sapiens)1624291 PMID:12399441 and PMID:9168114RGDPMID:12399441 and PMID:9168114
BtcRatsignaling receptor binding enablesIEAARBA:ARBA000272391600115GO_REF:0000117UniProtGO_REF:0000117
BtcRattransmembrane receptor protein tyrosine kinase activator activity enablesISOBTC (Homo sapiens)1624291 PMID:12399441 and PMID:9168114RGDPMID:12399441 and PMID:9168114
BtcRattransmembrane receptor protein tyrosine kinase activator activity enablesIEAUniProtKB:P35070 and ensembl:ENSP000003790921600115GO_REF:0000107EnsemblGO_REF:0000107
BtcRattransmembrane receptor protein tyrosine kinase activator activity enablesISOBtc (Mus musculus)1624291MGI:95294 PMID:18656477 more ...RGDPMID:18656477 more ...
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RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
BtcRatepidermal growth factor/neuregulin signaling pathway   ISOBTC (Homo sapiens)2317963 RGD 
BtcRatepidermal growth factor/neuregulin signaling pathway   IDA 2324625 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
BtcRatepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012

Imported Annotations - PID (archival)

Object Symbol
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Evidence
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Original Reference(s)
BtcRatepidermal growth factor/neuregulin signaling pathway   ISOBTC (Homo sapiens)6484113 PIDPID:200159

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#
Reference Title
Reference Citation
1. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology An JZ, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2005 May;21(3):284-6.
2. Purification and molecular characterization of recombinant rat betacellulin. Dunbar AJ, etal., J Mol Endocrinol. 2001 Oct;27(2):239-47.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Betacellulin promotes growth of the gastrointestinal organs and effects a diuresis in normal rats. Howarth GS, etal., Growth Factors. 2003 Jun;21(2):79-86.
6. Cloning of rat betacellulin and characterization of its expression in the gastrointestinal tract. Kallincos NC, etal., Growth Factors 2000;18(3):203-13.
7. Genomic structure and promoter characterization of the gene encoding the ErbB ligand betacellulin. Lawson J, etal., Biochim Biophys Acta 2002 Jun 7;1576(1-2):183-90.
8. Activin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats. Li L, etal., Diabetes 2004 Mar;53(3):608-15.
9. Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids. Li L, etal., Stem Cells Dev. 2008 Aug;17(4):815-23.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells. Miyagawa J, etal., Endocr J. 1999 Dec;46(6):755-64.
12. A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes. Nakano Y, etal., Diabetes. 2005 Dec;54(12):3560-6.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Growth factors and their receptors in the middle ear mucosa during otitis media. Palacios SD, etal., Laryngoscope. 2002 Mar;112(3):420-3.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
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PMID:18656477   PMID:25401376  



Btc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,992,668 - 17,031,178 (+)NCBIGRCr8
mRatBN7.21416,708,447 - 16,746,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,707,982 - 16,747,049 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1416,716,086 - 16,754,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,035,002 - 18,073,595 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01416,727,133 - 16,765,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,231,854 - 18,270,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,231,860 - 18,272,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,121,506 - 18,182,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,194,470 - 18,235,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,214,004 - 18,235,228 (+)NCBI
Celera1416,107,460 - 16,127,465 (+)NCBICelera
Cytogenetic Map14p22NCBI
BTC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,744,759 - 74,794,523 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,744,759 - 74,794,523 (-)EnsemblGRCh38hg38GRCh38
GRCh37475,669,969 - 75,719,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,890,472 - 75,938,853 (-)NCBINCBI36Build 36hg18NCBI36
Build 34476,028,626 - 76,077,008NCBI
Celera472,966,514 - 73,015,096 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef471,418,290 - 71,466,739 (-)NCBIHuRef
CHM1_1475,647,936 - 75,696,367 (-)NCBICHM1_1
T2T-CHM13v2.0478,084,851 - 78,134,624 (-)NCBIT2T-CHM13v2.0
Btc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,505,120 - 91,550,853 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,505,120 - 91,550,853 (-)EnsemblGRCm39 Ensembl
GRCm38591,357,261 - 91,402,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl591,357,261 - 91,402,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37591,786,287 - 91,831,939 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36592,432,461 - 92,478,113 (-)NCBIMGSCv36mm8
Celera589,495,391 - 89,540,704 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map544.78NCBI
Btc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474895,573 - 946,894 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955474895,573 - 946,152 (-)NCBIChiLan1.0ChiLan1.0
BTC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2355,275,033 - 55,330,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1455,464,444 - 55,519,925 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0449,329,413 - 49,462,891 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,242,885 - 55,296,894 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,242,899 - 55,298,773 (+)Ensemblpanpan1.1panPan2
BTC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11564,133,051 - 64,159,155 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1564,135,920 - 64,158,970 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1564,312,700 - 64,355,835 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01564,987,534 - 65,030,737 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1564,987,299 - 65,028,910 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11564,211,939 - 64,255,151 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01564,205,431 - 64,248,581 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01564,595,864 - 64,639,083 (+)NCBIUU_Cfam_GSD_1.0
Btc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528512,519,199 - 12,570,403 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936598971,241 - 1,019,121 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936598971,253 - 1,019,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,649,317 - 70,697,420 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,645,721 - 70,697,538 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,799,009 - 74,832,278 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BTC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1723,283,269 - 23,333,373 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl723,281,862 - 23,308,287 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660371,584,706 - 1,636,334 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624730917,630 - 976,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624730917,514 - 975,159 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Btc
300 total Variants

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:29
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000003686
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 17 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 90 89 58 25 58 6 217 97 93 45 55 31



Ensembl Acc Id: ENSRNOT00000003686   ⟹   ENSRNOP00000003686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,726,459 - 16,747,049 (+)Ensembl
Rnor_6.0 Ensembl1418,231,860 - 18,272,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109549   ⟹   ENSRNOP00000095979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,707,982 - 16,747,049 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113734   ⟹   ENSRNOP00000082218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,708,128 - 16,747,049 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116022   ⟹   ENSRNOP00000081813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,708,710 - 16,747,049 (+)Ensembl
RefSeq Acc Id: NM_022256   ⟹   NP_071592
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,992,668 - 17,031,178 (+)NCBI
mRatBN7.21416,708,447 - 16,746,961 (+)NCBI
Rnor_6.01418,231,854 - 18,270,621 (+)NCBI
Rnor_5.01418,121,506 - 18,182,171 (+)NCBI
RGSC_v3.41418,194,470 - 18,235,228 (+)RGD
Celera1416,107,460 - 16,127,465 (+)RGD
Sequence:
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Protein RefSeqs NP_071592 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA96731 (Get FASTA)   NCBI Sequence Viewer  
  EDL88582 (Get FASTA)   NCBI Sequence Viewer  
  EDL88583 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003686.7
  ENSRNOP00000081813.1
  ENSRNOP00000082218
  ENSRNOP00000082218.1
  ENSRNOP00000095979.1
1 to 9 of 9 rows
RefSeq Acc Id: NP_071592   ⟸   NM_022256
- Peptide Label: precursor
- UniProtKB: Q9JJM4 (UniProtKB/TrEMBL),   F1LPG4 (UniProtKB/TrEMBL),   A0A8J8YRH0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003686   ⟸   ENSRNOT00000003686
Ensembl Acc Id: ENSRNOP00000095979   ⟸   ENSRNOT00000109549
Ensembl Acc Id: ENSRNOP00000082218   ⟸   ENSRNOT00000113734
Ensembl Acc Id: ENSRNOP00000081813   ⟸   ENSRNOT00000116022
EGF-like

Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJM4-F1-model_v2 AlphaFold Q9JJM4 1-177 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16217 BioCyc
Ensembl Genes ENSRNOG00000002728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003686.8 UniProtKB/TrEMBL
  ENSRNOT00000109549.1 UniProtKB/TrEMBL
  ENSRNOT00000113734 ENTREZGENE
  ENSRNOT00000113734.1 UniProtKB/TrEMBL
  ENSRNOT00000116022.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro EGF_3 UniProtKB/TrEMBL
KEGG Report rno:64022 UniProtKB/TrEMBL
NCBI Gene 64022 ENTREZGENE
PANTHER PROBETACELLULIN UniProtKB/TrEMBL
  PTHR10740 UniProtKB/TrEMBL
PhenoGen Btc PhenoGen
PRINTS EGFTGF UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002728 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0A8I5ZSF9_RAT UniProtKB/TrEMBL
  A0A8I6AQ55_RAT UniProtKB/TrEMBL
  A0A8J8YRH0 ENTREZGENE, UniProtKB/TrEMBL
  A6KKC7_RAT UniProtKB/TrEMBL
  A6KKC8_RAT UniProtKB/TrEMBL
  F1LPG4 ENTREZGENE
  Q9JJM4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LPG4 UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Btc  betacellulin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Btc  betacellulin      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in kidney 631927