Aldh1a2 (aldehyde dehydrogenase 1 family, member A2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Aldh1a2 (aldehyde dehydrogenase 1 family, member A2) Rattus norvegicus
Analyze
Symbol: Aldh1a2
Name: aldehyde dehydrogenase 1 family, member A2
RGD ID: 620250
Description: Enables retinal binding activity and retinal dehydrogenase (NAD+) activity. Involved in several processes, including response to estradiol; response to vitamin A; and retinoic acid biosynthetic process. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2); PARTICIPATES IN retinoic acid metabolic pathway; retinol metabolic pathway; vitamin A deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde dehydrogenase 1A2; aldehyde dehydrogenase family 1 member A2; aldehyde dehydrogenase family 1, subfamily A2; MGC114283; RALDH 2; RalDH(II); Raldh-2; ralDH2; retinal dehydrogenase 2; retinal dehydrogenase type II; retinal dehydrogenase, type II; retinaldehyde-specific dehydrogenase type 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8880,758,641 - 80,837,891 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl880,758,142 - 80,837,883 (+)EnsemblGRCr8
mRatBN7.2871,877,850 - 71,957,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx877,412,501 - 77,491,856 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0875,685,476 - 75,764,833 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0873,522,516 - 73,601,878 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0877,640,234 - 77,719,488 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,640,222 - 77,719,489 (+)Ensemblrn6Rnor6.0
Rnor_5.0875,363,285 - 75,442,554 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4875,692,099 - 75,771,159 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera869,779,737 - 69,858,993 (-)NCBICelera
RGSC_v3.1875,711,165 - 75,790,204 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-Ethylhexanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
22-Hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(diethylamino)benzaldehyde  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
abacavir  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzaldehydes  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bezafibrate  (ISO)
bictegravir  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chloroprene  (EXP)
choline  (ISO)
citral  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cylindrospermopsin  (ISO)
D-gluconic acid  (EXP)
dabigatran  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
decanal  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dolutegravir  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Doxylamine succinate  (ISO)
elvitegravir  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylene glycol  (ISO)
ethylparaben  (ISO)
fenofibrate  (ISO)
fenpropidin  (ISO)
ferric oxide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
geranial  (EXP)
glycitein  (ISO)
glycitin  (ISO)
hexanal  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
isotretinoin  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoclopramide  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nilotinib  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paraquat  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sotorasib  (ISO)
spiroxamine  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
WIN 18446  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
9-cis-retinoic acid biosynthetic process  (ISO)
aldehyde metabolic process  (IBA)
anterior/posterior pattern specification  (ISO)
blood vessel development  (ISO)
camera-type eye development  (ISO)
cardiac muscle tissue development  (ISO)
cellular response to retinoic acid  (IEA,ISO)
determination of bilateral symmetry  (ISO)
embryonic camera-type eye development  (ISO)
embryonic digestive tract development  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
face development  (ISO)
forebrain development  (ISO)
heart morphogenesis  (ISO)
hindbrain development  (ISO)
kidney development  (IEP)
lipid metabolic process  (IEA)
liver development  (IEP)
lung development  (ISO)
midgut development  (IEP)
morphogenesis of embryonic epithelium  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
neural crest cell development  (ISO)
neural tube development  (IEA,ISO)
neuron differentiation  (ISO)
pancreas development  (ISO)
pituitary gland development  (IEP)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
protein homotetramerization  (IEA,ISO,ISS)
proximal/distal pattern formation  (ISO)
regulation of endothelial cell proliferation  (ISO)
response to cytokine  (IEA,ISO)
response to estradiol  (IEP)
response to retinoic acid  (IEA,ISO,ISS)
response to vitamin A  (IEP)
retinal metabolic process  (ISO)
retinoic acid biosynthetic process  (IEA,IMP,ISO,ISS)
retinoic acid metabolic process  (IDA,IEA,ISO)
retinoic acid receptor signaling pathway  (ISO)
retinol metabolic process  (IEA)
ureter maturation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. Broadhurst MJ, etal., PLoS Pathog. 2012;8(8):e1002883. doi: 10.1371/journal.ppat.1002883. Epub 2012 Aug 23.
2. Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Everts HB, etal., Exp Cell Res. 2005 Aug 15;308(2):309-19.
3. Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats. Fujiwara K, etal., Cell Tissue Res. 2007 Apr;328(1):129-35. Epub 2006 Dec 19.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus. Li XH, etal., Endocrinology. 2004 Oct;145(10):4756-62. Epub 2004 Jun 17.
8. Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation. Liu X, etal., Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2196-206. doi: 10.1161/ATVBAHA.115.306012. Epub 2015 Aug 27.
9. Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Marlier A and Gilbert T, Gene Expr Patterns. 2004 Dec;5(2):179-85.
10. Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents. Mey J, etal., Am J Pathol. 2003 Feb;162(2):673-9.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Cardiovascular malformations in DiGeorge syndrome (congenital absence of hypoplasia of the thymus). Moerman P, etal., Br Heart J 1980 Oct;44(4):452-9.
13. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Retinaldehyde dehydrogenase 2 is down-regulated during duodenal atresia formation in Fgfr2IIIb-/- mice. Nichol PF, etal., J Surg Res. 2012 Jun 1;175(1):82-7. doi: 10.1016/j.jss.2011.02.040. Epub 2011 Mar 21.
16. The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system. Niederreither K, etal., Development 2003 Jun;130(11):2525-34.
17. Postnatal changes in gene expression of retinal dehydrogenase and retinoid receptors in liver of rats. Ogura Y, etal., Life Sci. 2004 Feb 6;74(12):1519-28.
18. Developmental changes of the expression of the genes regulated by retinoic acid in the small intestine of rats. Ogura Y, etal., Life Sci. 2005 Oct 14;77(22):2804-13.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Haploinsufficiency of retinaldehyde dehydrogenase 2 decreases the severity and incidence of duodenal atresia in the fibroblast growth factor receptor 2IIIb-/- mouse model. Reeder AL, etal., Surgery. 2012 Oct;152(4):768-75; discussion 775-6. doi: 10.1016/j.surg.2012.07.022.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Vermot J, etal., Proc Natl Acad Sci U S A 2003 Feb 18;100(4):1763-8. Epub 2003 Jan 31.
26. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.
27. Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate. Wang X, etal., J Biol Chem 1996 Jul 5;271(27):16288-93.
28. Cellular expression of retinal dehydrogenase types 1 and 2: effects of vitamin A status on testis mRNA. Zhai Y, etal., J Cell Physiol. 2001 Feb;186(2):220-32.
Additional References at PubMed
PMID:8797830   PMID:8889548   PMID:9892670   PMID:10320326   PMID:11245568   PMID:11876656   PMID:12477932   PMID:12610736   PMID:14623241   PMID:14627725   PMID:15069081   PMID:15366004  
PMID:15489334   PMID:15652703   PMID:15731404   PMID:15739227   PMID:15753214   PMID:15872003   PMID:15889094   PMID:16026781   PMID:16166285   PMID:16237707   PMID:16368932   PMID:16427040  
PMID:16806149   PMID:17067568   PMID:17184764   PMID:18495959   PMID:18816858   PMID:20034106   PMID:21521737   PMID:29240402  


Genomics

Comparative Map Data
Aldh1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8880,758,641 - 80,837,891 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl880,758,142 - 80,837,883 (+)EnsemblGRCr8
mRatBN7.2871,877,850 - 71,957,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx877,412,501 - 77,491,856 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0875,685,476 - 75,764,833 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0873,522,516 - 73,601,878 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0877,640,234 - 77,719,488 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,640,222 - 77,719,489 (+)Ensemblrn6Rnor6.0
Rnor_5.0875,363,285 - 75,442,554 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4875,692,099 - 75,771,159 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera869,779,737 - 69,858,993 (-)NCBICelera
RGSC_v3.1875,711,165 - 75,790,204 (+)NCBI
Cytogenetic Map8q24NCBI
ALDH1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381557,953,429 - 58,065,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1557,953,424 - 58,497,866 (-)Ensemblhg38GRCh38
GRCh371558,245,627 - 58,357,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,032,919 - 56,145,198 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341556,032,918 - 56,093,527NCBI
Celera1535,135,291 - 35,247,470 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,068,702 - 35,181,099 (-)NCBIHuRef
CHM1_11558,363,582 - 58,476,117 (-)NCBICHM1_1
T2T-CHM13v2.01555,755,851 - 55,868,018 (-)NCBIT2T-CHM13v2.0
Aldh1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39971,123,071 - 71,203,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl971,123,071 - 71,203,525 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38971,215,789 - 71,296,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl971,215,789 - 71,296,243 (+)Ensemblmm10GRCm38
MGSCv37971,063,596 - 71,144,050 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36971,014,409 - 71,094,803 (+)NCBIMGSCv36mm8
Celera968,414,967 - 68,495,534 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.85NCBI
Aldh1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545016,406,436 - 16,453,180 (+)Ensembl
ChiLan1.0NW_00495545016,406,578 - 16,453,048 (+)NCBIChiLan1.0ChiLan1.0
ALDH1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21647,196,709 - 47,377,143 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11551,379,387 - 51,559,409 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01536,925,443 - 37,038,288 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11555,237,101 - 55,349,851 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,237,101 - 55,557,168 (-)EnsemblpanPan2panpan1.1
ALDH1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,074,432 - 23,170,374 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,074,432 - 23,340,030 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3023,045,955 - 23,141,851 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03023,233,206 - 23,329,111 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,233,206 - 23,498,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,164,758 - 23,260,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,250,334 - 23,346,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,392,036 - 23,488,058 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aldh1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,327,905 - 101,415,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647119,175,992 - 19,263,335 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647119,175,997 - 19,263,335 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,932,739 - 114,037,046 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11113,932,722 - 114,037,059 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21126,038,541 - 126,105,080 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12625,439,159 - 25,557,199 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2625,439,360 - 25,557,202 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048115,756,952 - 115,875,731 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,756,390 - 13,845,479 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478113,756,469 - 13,845,253 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aldh1a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1865,525,687 - 65,605,800 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aldh1a2
435 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:72
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000021757
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat

Markers in Region
D8Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,888,146 - 71,888,253 (+)MAPPERmRatBN7.2
Rnor_6.0877,650,530 - 77,650,636NCBIRnor6.0
Rnor_5.0875,432,152 - 75,432,258UniSTSRnor5.0
RGSC_v3.4875,702,394 - 75,702,501RGDRGSC3.4
RGSC_v3.4875,702,395 - 75,702,501UniSTSRGSC3.4
Celera869,848,591 - 69,848,697UniSTS
RGSC_v3.1875,721,448 - 75,721,555RGD
RH 2.0 Map8697.7RGD
Cytogenetic Map8q24UniSTS
RH133490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,956,878 - 71,957,087 (+)MAPPERmRatBN7.2
Rnor_6.0877,719,260 - 77,719,468NCBIRnor6.0
Rnor_5.0875,363,305 - 75,363,513UniSTSRnor5.0
RGSC_v3.4875,770,931 - 75,771,139UniSTSRGSC3.4
Celera869,779,757 - 69,779,965UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 148 91 90 59 34 59 6 298 134 10 126 81 92 31 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000079115   ⟹   ENSRNOP00000073203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl880,758,142 - 80,837,883 (+)Ensembl
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)Ensembl
Rnor_6.0 Ensembl877,640,222 - 77,719,489 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113857   ⟹   ENSRNOP00000076670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl880,758,142 - 80,837,883 (+)Ensembl
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)Ensembl
RefSeq Acc Id: NM_053896   ⟹   NP_446348
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,758,641 - 80,837,891 (+)NCBI
mRatBN7.2871,877,850 - 71,957,107 (+)NCBI
Rnor_6.0877,640,234 - 77,719,488 (+)NCBI
Rnor_5.0875,363,285 - 75,442,554 (-)NCBI
RGSC_v3.4875,692,099 - 75,771,159 (+)RGD
Celera869,779,737 - 69,858,993 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446348 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52637 (Get FASTA)   NCBI Sequence Viewer  
  AAH98910 (Get FASTA)   NCBI Sequence Viewer  
  EDL84165 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073203
  ENSRNOP00000073203.1
GenBank Protein Q63639 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446348   ⟸   NM_053896
- UniProtKB: Q4FZY8 (UniProtKB/Swiss-Prot),   Q63639 (UniProtKB/Swiss-Prot),   A6KER4 (UniProtKB/TrEMBL),   A0A8I5Y0L7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073203   ⟸   ENSRNOT00000079115
Ensembl Acc Id: ENSRNOP00000076670   ⟸   ENSRNOT00000113857
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63639-F1-model_v2 AlphaFold Q63639 1-518 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696110
Promoter ID:EPDNEW_R6635
Type:initiation region
Name:Aldh1a2_1
Description:aldehyde dehydrogenase 1 family, member A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0877,640,211 - 77,640,271EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620250 AgrOrtholog
BioCyc Gene G2FUF-29902 BioCyc
BioCyc Pathway PWY-6872 [retinoate biosynthesis I] BioCyc
BioCyc Pathway Image PWY-6872 BioCyc
Ensembl Genes ENSRNOG00000055049 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079115 ENTREZGENE
  ENSRNOT00000079115.2 UniProtKB/Swiss-Prot
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7455646 IMAGE-MGC_LOAD
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
KEGG Report rno:116676 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114283 IMAGE-MGC_LOAD
NCBI Gene 116676 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PhenoGen Aldh1a2 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055049 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
UniProt A0A8I5Y0L7 ENTREZGENE, UniProtKB/TrEMBL
  A6KER4 ENTREZGENE, UniProtKB/TrEMBL
  AL1A2_RAT UniProtKB/Swiss-Prot
  Q4FZY8 ENTREZGENE
  Q63639 ENTREZGENE
UniProt Secondary Q4FZY8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aldh1a2  aldehyde dehydrogenase 1 family, member A2  Aldh1a2  aldehyde dehydrogenase family 1, subfamily A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Aldh1a2  aldehyde dehydrogenase family 1, subfamily A2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Aldh1a2  aldehyde dehydrogenase family 1, subfamily A2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently 724707