Gene:	Lef1 ( Rattus norvegicus ) lymphoid enhancer binding factor 1
Description:	putative transcription factor; member of the high mobility group (HMG) family of regulatory proteins
ArrayIDs:	1370138_at; 1383785_at; 5834161; rc_AI231086_at; 6301792; 5988363; A_43_P13120; rc_AA858877_at; 6494676; 5821917; 6678407; 5706928; A_44_P240702; 6232448; 5698138; 6350296; 6701293; 5871989; GE1287569; 6181982;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Eau5 - Experimental allergic uveoretinitis QTL 5
Homologs
Homo sapiens: LEF1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Lef1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Lef1 genome assembly 3.1 2 228537002 - 228659871     Rat Celera Assembly 2 211924784 - 212018812     RGSC genome assembly v3.4 2 228550263 - 228673131     Cytogenetic 2 q34-q45 Mus musculus Lef1 Mouse genome assembly build 36.1 3 130813389 - 130926252     Cytogenetic 3 3 G3 Homo sapiens LEF1 human genome assembly 4 109326304 - 109447182     Human genome assembly build 36.2 4 109188150 - 109309027     Cytogenetic 4 q23-q25   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology transcription factor activity,  chromatin binding,  RNA polymerase II transcription factor activity, enhancer binding ...  (details...)
Biological Process	Gene Ontology somitogenesis,  mammary gland development,  skin development ...  (details...)
Cellular Component	Gene Ontology transcription factor complex,  nucleus,  nucleolus ...  (details...)
Disease	Ontology Ovarian Neoplasms,  Femoral Fractures (details...)
Pathway	Ontology canonical Wnt signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: HMG IPI PROSITE: HMG_BOX_2 IPI UNIPARC: UPI000021F06B IPI UNIPARC: UPI000012E412 IPI UNIPARC: UPI0001B7BC7E IPI KEGG Report: rno:161452 ENTREZGENE HomoloGene Group ID: 7813 ENTREZGENE Germonline: 620241 Pfam: HMG_box IPI Pfam: CTNNB1_binding IPI KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04916 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05217 ENTREZGENE KEGG Pathway: 05412 ENTREZGENE KEGG Pathway: 04520 ENTREZGENE KEGG Pathway: 05221 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 05216 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE InterPro: HMG_superfamily. IPI InterPro: HMG_HMG1/HMG2. IPI InterPro: CTNNB1_bd_N. IPI IPI: IPI00213373 IPI IPI: IPI00949045 IPI IPI: IPI00392795 IPI Ensembl Protein: ENSRNOP00000059658 IPI Ensembl Protein: ENSRNOP00000013694 IPI Ensembl Protein: ENSRNOP00000035157 IPI Gene3D-CATH: HMG-box IPI Entrez Gene: Lef1 ENTREZGENE UniProt: A5A1E7_RAT IPI UniProt: LEF1_RAT IPI Ensembl Genes: ENSRNOG00000010121 IPI Superfamily-SCOP: HMG-box IPI
Sequences	Nucleotide: CH473952 Get FASTA Search GEO Profiles Nucleotide: AF198533 Get FASTA Search GEO Profiles Nucleotide: NM_130429 Get FASTA Search GEO Profiles Nucleotide: EF519319 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: AAF15601 Get FASTA Protein: EDL82210 Get FASTA Protein: EDL82209 Get FASTA Protein: Q9QXN1 Get FASTA Protein: ABP57804 Get FASTA Protein: NP_569113 Get FASTA Protein: EDL82211 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 21926
References
Curated References	16 references in RGD related to Lef1
Other References	9 other references at PubMed related to Lef1
Database Information
RGD ID	620241
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 26-FEB-04: Lef1 lymphoid enhancer binding factor 1 APPROVED Symbol and Name status set to approved 625702 07-AUG-02: Lef1 PROVISIONAL Symbol and Name status set to provisional 70820