Camkk1 (calcium/calmodulin-dependent protein kinase kinase 1) - Rat Genome Database

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Gene: Camkk1 (calcium/calmodulin-dependent protein kinase kinase 1) Rattus norvegicus
Analyze
Symbol: Camkk1
Name: calcium/calmodulin-dependent protein kinase kinase 1
RGD ID: 62023
Description: Enables calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide; allethrin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha CaMKK; calcium/calmodulin-dependent protein kinase kinase 1, alpha; calcium/calmodulin-dependent protein kinase kinase alpha; caM-kinase IV kinase; caM-kinase kinase 1; caM-kinase kinase alpha; caM-KK 1; caM-KK alpha; caMKK 1; caMKK alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81058,135,872 - 58,159,023 (+)NCBIGRCr8
mRatBN7.21057,637,335 - 57,660,498 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1057,637,391 - 57,660,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1062,298,025 - 62,321,091 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,786,503 - 61,809,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01057,285,586 - 57,308,642 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01059,585,023 - 59,608,180 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,585,072 - 59,608,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01059,324,498 - 59,347,649 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,908,749 - 59,932,276 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11059,922,371 - 59,945,899 (+)NCBI
Celera1056,761,642 - 56,784,794 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
nucleoplasm  (TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of calcium/calmodulin-dependent protein kinase kinase by protein 14-3-3. Davare MA, etal., J Biol Chem. 2004 Dec 10;279(50):52191-9. Epub 2004 Oct 6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Hawley SA, etal., Cell Metab. 2005 Jul;2(1):9-19.
4. 14-3-3 Proteins directly regulate Ca(2+)/calmodulin-dependent protein kinase kinase alpha through phosphorylation-dependent multisite binding. Ichimura T, etal., FEBS Lett. 2008 Mar 5;582(5):661-5. doi: 10.1016/j.febslet.2008.01.037. Epub 2008 Jan 31.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Evidence for the existence of Ca2+/calmodulin-dependent protein kinase IV kinase isoforms in rat brain. Okuno S, etal., J Biochem (Tokyo) 1996 Jun;119(6):1176-81.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Differential regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms. Tokumitsu H, etal., Biochemistry 2001 Nov 20;40(46):13925-32.
12. Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase. Tokumitsu H, etal., J Biol Chem 1995 Aug 18;270(33):19320-4.
Additional References at PubMed
PMID:8631893   PMID:8929978   PMID:9195898   PMID:9335539   PMID:9859994   PMID:10187789   PMID:10336483   PMID:10467092   PMID:10651863   PMID:15147908   PMID:15150258   PMID:15262966  
PMID:15308608   PMID:15831494   PMID:16054096   PMID:18710651   PMID:19292454   PMID:26050738   PMID:27151216   PMID:30053369   PMID:33197510   PMID:34875535  


Genomics

Comparative Map Data
Camkk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81058,135,872 - 58,159,023 (+)NCBIGRCr8
mRatBN7.21057,637,335 - 57,660,498 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1057,637,391 - 57,660,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1062,298,025 - 62,321,091 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,786,503 - 61,809,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01057,285,586 - 57,308,642 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01059,585,023 - 59,608,180 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,585,072 - 59,608,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01059,324,498 - 59,347,649 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,908,749 - 59,932,276 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11059,922,371 - 59,945,899 (+)NCBI
Celera1056,761,642 - 56,784,794 (+)NCBICelera
Cytogenetic Map10q24NCBI
CAMKK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38173,860,315 - 3,893,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl173,860,315 - 3,894,891 (-)EnsemblGRCh38hg38GRCh38
GRCh37173,763,609 - 3,796,347 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36173,710,358 - 3,743,086 (-)NCBINCBI36Build 36hg18NCBI36
Build 34173,710,366 - 3,743,086NCBI
Celera173,775,420 - 3,808,149 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef173,653,743 - 3,686,358 (-)NCBIHuRef
CHM1_1173,771,851 - 3,805,088 (-)NCBICHM1_1
T2T-CHM13v2.0173,748,985 - 3,781,678 (-)NCBIT2T-CHM13v2.0
Camkk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,906,869 - 72,932,899 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,909,834 - 72,932,899 (+)EnsemblGRCm39 Ensembl
GRCm381173,016,043 - 73,042,073 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,019,008 - 73,042,073 (+)EnsemblGRCm38mm10GRCm38
MGSCv371172,832,510 - 72,855,575 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,835,248 - 72,858,268 (+)NCBIMGSCv36mm8
Celera1180,547,860 - 80,571,059 (+)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1145.12NCBI
Camkk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546712,976,000 - 13,002,159 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546712,973,667 - 13,002,098 (+)NCBIChiLan1.0ChiLan1.0
CAMKK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21911,470,419 - 11,502,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11713,434,426 - 13,466,545 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,908,598 - 3,941,118 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1173,900,441 - 3,930,061 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl173,900,458 - 3,930,010 (-)Ensemblpanpan1.1panPan2
CAMKK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1947,643,781 - 47,670,536 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl947,645,815 - 47,663,855 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha946,805,691 - 46,832,442 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0948,488,782 - 48,515,740 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl948,488,787 - 48,516,079 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,266,332 - 47,293,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0947,555,150 - 47,582,105 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0947,611,601 - 47,638,362 (-)NCBIUU_Cfam_GSD_1.0
Camkk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560255,374,431 - 55,399,959 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936677499,034 - 526,594 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936677499,897 - 526,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAMKK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1249,922,855 - 49,950,605 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11249,922,837 - 49,950,668 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,043,981 - 52,063,677 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAMKK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,341,236 - 3,374,728 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,341,243 - 3,366,741 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605918,339,468 - 18,441,719 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Camkk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247866,473,618 - 6,499,644 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247866,469,057 - 6,499,671 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Camkk1
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:273
Count of miRNA genes:171
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000025009
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 64 11 11
Low 3 43 54 41 17 41 8 11 10 35 30 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000025009   ⟹   ENSRNOP00000025009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1057,637,410 - 57,660,485 (+)Ensembl
Rnor_6.0 Ensembl1059,585,072 - 59,608,165 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104077   ⟹   ENSRNOP00000076910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1057,637,391 - 57,660,498 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106120   ⟹   ENSRNOP00000091768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1057,637,410 - 57,660,485 (+)Ensembl
RefSeq Acc Id: NM_031662   ⟹   NP_113850
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81058,135,935 - 58,159,010 (+)NCBI
mRatBN7.21057,637,410 - 57,660,485 (+)NCBI
Rnor_6.01059,585,092 - 59,608,167 (+)NCBI
Rnor_5.01059,324,498 - 59,347,649 (+)NCBI
RGSC_v3.41059,908,749 - 59,932,276 (+)RGD
Celera1056,761,642 - 56,784,794 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246799   ⟹   XP_006246861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81058,135,872 - 58,159,023 (+)NCBI
mRatBN7.21057,637,335 - 57,660,498 (+)NCBI
Rnor_6.01059,585,023 - 59,608,180 (+)NCBI
Rnor_5.01059,324,498 - 59,347,649 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246801   ⟹   XP_006246863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81058,135,910 - 58,159,023 (+)NCBI
mRatBN7.21057,637,357 - 57,660,498 (+)NCBI
Rnor_6.01059,585,023 - 59,608,180 (+)NCBI
Rnor_5.01059,324,498 - 59,347,649 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767866   ⟹   XP_008766088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81058,135,872 - 58,159,023 (+)NCBI
mRatBN7.21057,637,335 - 57,660,498 (+)NCBI
Rnor_6.01059,585,023 - 59,608,180 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113850   ⟸   NM_031662
- UniProtKB: Q64572 (UniProtKB/Swiss-Prot),   Q794E3 (UniProtKB/Swiss-Prot),   P97756 (UniProtKB/Swiss-Prot),   A0A8I5YBZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246861   ⟸   XM_006246799
- Peptide Label: isoform X1
- UniProtKB: A6HGH7 (UniProtKB/TrEMBL),   A0A8I5YBZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246863   ⟸   XM_006246801
- Peptide Label: isoform X1
- UniProtKB: A6HGH7 (UniProtKB/TrEMBL),   A0A8I5YBZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766088   ⟸   XM_008767866
- Peptide Label: isoform X1
- UniProtKB: A6HGH7 (UniProtKB/TrEMBL),   A0A8I5YBZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025009   ⟸   ENSRNOT00000025009
RefSeq Acc Id: ENSRNOP00000076910   ⟸   ENSRNOT00000104077
RefSeq Acc Id: ENSRNOP00000091768   ⟸   ENSRNOT00000106120
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97756-F1-model_v2 AlphaFold P97756 1-505 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697398
Promoter ID:EPDNEW_R7923
Type:single initiation site
Name:Camkk1_1
Description:calcium/calmodulin-dependent protein kinase kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01059,585,073 - 59,585,133EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62023 AgrOrtholog
BioCyc Gene G2FUF-24342 BioCyc
Ensembl Genes ENSRNOG00000018242 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055027466 UniProtKB/Swiss-Prot
  ENSRNOG00060018674 UniProtKB/Swiss-Prot
  ENSRNOG00065025095 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025009.7 UniProtKB/TrEMBL
  ENSRNOT00000104077 ENTREZGENE
  ENSRNOT00000104077.1 UniProtKB/TrEMBL
  ENSRNOT00000106120.1 UniProtKB/TrEMBL
  ENSRNOT00055047594 UniProtKB/Swiss-Prot
  ENSRNOT00060032174 UniProtKB/Swiss-Prot
  ENSRNOT00065043172 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60341 UniProtKB/Swiss-Prot
NCBI Gene 60341 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1 UniProtKB/TrEMBL
  CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Camkk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018242 RatGTEx
  ENSRNOG00055027466 RatGTEx
  ENSRNOG00060018674 RatGTEx
  ENSRNOG00065025095 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5YBZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEA0_RAT UniProtKB/TrEMBL
  A6HGH7 ENTREZGENE, UniProtKB/TrEMBL
  F1LQD2_RAT UniProtKB/TrEMBL
  KKCC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64572 ENTREZGENE
  Q794E3 ENTREZGENE
UniProt Secondary Q64572 UniProtKB/Swiss-Prot
  Q794E3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Camkk1  calcium/calmodulin-dependent protein kinase kinase 1  Camkk1  calcium/calmodulin-dependent protein kinase kinase 1, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Camkk1  calcium/calmodulin-dependent protein kinase kinase 1, alpha       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain, thymus, and spleen 632489