CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1) - Rat Genome Database

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Gene: CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1) Canis lupus familiaris
Analyze
Symbol: CAMKK1
Name: calcium/calmodulin dependent protein kinase kinase 1
RGD ID: 12237235
Description: ENCODES a protein that exhibits calmodulin binding (ortholog); calmodulin-dependent protein kinase activity (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); positive regulation of protein kinase activity (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH Canavan disease (ortholog); genetic disease (ortholog); nervous system disease (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium/calmodulin-dependent protein kinase kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1947,643,781 - 47,670,536 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl947,645,815 - 47,663,855 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha946,805,691 - 46,832,442 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0948,488,782 - 48,515,740 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl948,488,787 - 48,516,079 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,266,332 - 47,293,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0947,555,150 - 47,582,105 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0947,611,601 - 47,638,362 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CAMKK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1947,643,781 - 47,670,536 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl947,645,815 - 47,663,855 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha946,805,691 - 46,832,442 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0948,488,782 - 48,515,740 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl948,488,787 - 48,516,079 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,266,332 - 47,293,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0947,555,150 - 47,582,105 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0947,611,601 - 47,638,362 (-)NCBIUU_Cfam_GSD_1.0
CAMKK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38173,860,315 - 3,893,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl173,860,315 - 3,894,891 (-)EnsemblGRCh38hg38GRCh38
GRCh37173,763,609 - 3,796,347 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36173,710,358 - 3,743,086 (-)NCBINCBI36Build 36hg18NCBI36
Build 34173,710,366 - 3,743,086NCBI
Celera173,775,420 - 3,808,149 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef173,653,743 - 3,686,358 (-)NCBIHuRef
CHM1_1173,771,851 - 3,805,088 (-)NCBICHM1_1
T2T-CHM13v2.0173,748,985 - 3,781,678 (-)NCBIT2T-CHM13v2.0
Camkk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,906,869 - 72,932,899 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,909,834 - 72,932,899 (+)EnsemblGRCm39 Ensembl
GRCm381173,016,043 - 73,042,073 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,019,008 - 73,042,073 (+)EnsemblGRCm38mm10GRCm38
MGSCv371172,832,510 - 72,855,575 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,835,248 - 72,858,268 (+)NCBIMGSCv36mm8
Celera1180,547,860 - 80,571,059 (+)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1145.12NCBI
Camkk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81058,135,872 - 58,159,023 (+)NCBIGRCr8
mRatBN7.21057,637,335 - 57,660,498 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1057,637,391 - 57,660,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1062,298,025 - 62,321,091 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,786,503 - 61,809,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01057,285,586 - 57,308,642 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01059,585,023 - 59,608,180 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,585,072 - 59,608,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01059,324,498 - 59,347,649 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,908,749 - 59,932,276 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11059,922,371 - 59,945,899 (+)NCBI
Celera1056,761,642 - 56,784,794 (+)NCBICelera
Cytogenetic Map10q24NCBI
Camkk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546712,976,000 - 13,002,159 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546712,973,667 - 13,002,098 (+)NCBIChiLan1.0ChiLan1.0
CAMKK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21911,470,419 - 11,502,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11713,434,426 - 13,466,545 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,908,598 - 3,941,118 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1173,900,441 - 3,930,061 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl173,900,458 - 3,930,010 (-)Ensemblpanpan1.1panPan2
Camkk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560255,374,431 - 55,399,959 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936677499,034 - 526,594 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936677499,897 - 526,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAMKK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1249,922,855 - 49,950,605 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11249,922,837 - 49,950,668 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,043,981 - 52,063,677 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAMKK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,341,236 - 3,374,728 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,341,243 - 3,366,741 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605918,339,468 - 18,441,719 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Camkk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247866,473,618 - 6,499,644 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247866,469,057 - 6,499,671 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CAMKK1
230 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8 6 9
Low 5 5 14 6 6 6 3 3 7 10 6
Below cutoff 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000030794   ⟹   ENSCAFP00000028628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl947,645,815 - 47,663,855 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000060163   ⟹   ENSCAFP00000046511
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl947,648,067 - 47,663,855 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030638   ⟹   ENSCAFP00845024040
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl948,488,787 - 48,515,746 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030762   ⟹   ENSCAFP00845024124
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl948,488,794 - 48,516,079 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030927   ⟹   ENSCAFP00845024237
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl948,488,794 - 48,516,079 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845031071   ⟹   ENSCAFP00845024340
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl948,488,794 - 48,510,033 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845031233   ⟹   ENSCAFP00845024449
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl948,488,802 - 48,515,734 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845031357   ⟹   ENSCAFP00845024550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl948,493,070 - 48,515,757 (-)Ensembl
RefSeq Acc Id: XM_038486705   ⟹   XP_038342633
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1947,266,332 - 47,293,082 (-)NCBI
RefSeq Acc Id: XM_038548572   ⟹   XP_038404500
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0947,611,601 - 47,638,362 (-)NCBI
RefSeq Acc Id: XM_038612513   ⟹   XP_038468441
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0947,555,150 - 47,582,105 (-)NCBI
RefSeq Acc Id: XM_038677789   ⟹   XP_038533717
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0948,488,782 - 48,515,740 (-)NCBI
RefSeq Acc Id: XM_863461   ⟹   XP_868554
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1947,643,781 - 47,670,536 (-)NCBI
Dog10K_Boxer_Tasha946,805,691 - 46,832,442 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_868554   ⟸   XM_863461
- UniProtKB: A0A8C0MUP7 (UniProtKB/TrEMBL),   A0A8C0QDU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000028628   ⟸   ENSCAFT00000030794
RefSeq Acc Id: ENSCAFP00000046511   ⟸   ENSCAFT00000060163
RefSeq Acc Id: XP_038342633   ⟸   XM_038486705
RefSeq Acc Id: XP_038468441   ⟸   XM_038612513
RefSeq Acc Id: XP_038533717   ⟸   XM_038677789
- UniProtKB: A0A8C0MUP7 (UniProtKB/TrEMBL),   A0A8C0QDU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038404500   ⟸   XM_038548572
- UniProtKB: A0A8C0MUP7 (UniProtKB/TrEMBL),   A0A8C0QDU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845024124   ⟸   ENSCAFT00845030762
RefSeq Acc Id: ENSCAFP00845024040   ⟸   ENSCAFT00845030638
RefSeq Acc Id: ENSCAFP00845024449   ⟸   ENSCAFT00845031233
RefSeq Acc Id: ENSCAFP00845024550   ⟸   ENSCAFT00845031357
RefSeq Acc Id: ENSCAFP00845024340   ⟸   ENSCAFT00845031071
RefSeq Acc Id: ENSCAFP00845024237   ⟸   ENSCAFT00845030927
Protein Domains
Protein kinase

Promoters
RGD ID:13684734
Promoter ID:EPDNEW_C2801
Type:initiation region
Name:CAMKK1_1
Description:calcium/calmodulin dependent protein kinase kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1947,670,501 - 47,670,561EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019377 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009134 UniProtKB/TrEMBL
  ENSCAFG00040006619 UniProtKB/TrEMBL
  ENSCAFG00845017304 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000030794.5 UniProtKB/TrEMBL
  ENSCAFT00000060163.2 UniProtKB/TrEMBL
  ENSCAFT00000098373.1 UniProtKB/TrEMBL
  ENSCAFT00000104358.1 UniProtKB/TrEMBL
  ENSCAFT00000108100.1 UniProtKB/TrEMBL
  ENSCAFT00030016895.1 UniProtKB/TrEMBL
  ENSCAFT00030017046.1 UniProtKB/TrEMBL
  ENSCAFT00040012395.1 UniProtKB/TrEMBL
  ENSCAFT00845030638.1 UniProtKB/TrEMBL
  ENSCAFT00845030762.1 UniProtKB/TrEMBL
  ENSCAFT00845030927.1 UniProtKB/TrEMBL
  ENSCAFT00845031071.1 UniProtKB/TrEMBL
  ENSCAFT00845031233 ENTREZGENE
  ENSCAFT00845031233.1 UniProtKB/TrEMBL
  ENSCAFT00845031357.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report cfa:611124 UniProtKB/TrEMBL
NCBI Gene CAMKK1 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1 UniProtKB/TrEMBL
  MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0MUP7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QDU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RG99_CANLF UniProtKB/TrEMBL
  A0A8I3NT19_CANLF UniProtKB/TrEMBL
  A0A8I3P298_CANLF UniProtKB/TrEMBL
  A0A8I3P374_CANLF UniProtKB/TrEMBL
  A0A8I3P3N7_CANLF UniProtKB/TrEMBL
  A0A8I3S2M6_CANLF UniProtKB/TrEMBL
  A0A8I3S2T1_CANLF UniProtKB/TrEMBL
  A0A8P0NKI4_CANLF UniProtKB/TrEMBL
  A0A8P0PIV7_CANLF UniProtKB/TrEMBL
  A0A8P0PRL9_CANLF UniProtKB/TrEMBL
  A0A8P0TSR6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38683 ENTREZGENE