Eif2b4 (eukaryotic translation initiation factor 2B subunit delta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Eif2b4 (eukaryotic translation initiation factor 2B subunit delta) Rattus norvegicus
Analyze
Symbol: Eif2b4
Name: eukaryotic translation initiation factor 2B subunit delta
RGD ID: 620208
Description: Enables translation initiation factor binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; response to glucose; and response to heat. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta); PARTICIPATES IN translation initiation pathway; RNA transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eIF-2B GDP-GTP exchange factor subunit delta; Eif2b; eIF2B GDP-GTP exchange factor subunit delta; eukaryotic translation initiation factor 2B; eukaryotic translation initiation factor 2B subunit 4; eukaryotic translation initiation factor 2B, subunit 4 delta; translation initiation factor eIF-2B subunit delta; translation initiation factor eIF2B subunit delta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,903,148 - 30,908,803 (+)NCBIGRCr8
mRatBN7.2625,183,177 - 25,188,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,183,186 - 25,188,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,484,104 - 25,489,668 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,799,997 - 25,805,561 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,279,071 - 25,284,628 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,546,917 - 26,552,474 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,546,924 - 26,552,430 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,364,317 - 36,369,311 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,159,823 - 25,165,561 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,162,775 - 25,168,512 (+)NCBI
Celera624,674,570 - 24,680,134 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. Anthony TG, etal., Biochim Biophys Acta. 2000 Jun 21;1492(1):56-62.
2. Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells. Fabian JR, etal., J Biol Chem. 1997 May 9;272(19):12359-65.
3. Reconstitution and purification of eukaryotic initiation factor 2B (eIF2B) expressed in Sf21 insect cells. Fabian JR, etal., Protein Expr Purif. 1998 Jun;13(1):16-22.
4. Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans. Gilligan M, etal., J Biol Chem. 1996 Jan 26;271(4):2121-5.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The mechanism of eukaryotic translation initiation: new insights and challenges. Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
7. Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus. Inamura N, etal., Neurosci Lett. 2003 Jul 31;346(1-2):117-9.
8. Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats. Karinch AM, etal., Am J Physiol. 1993 Jan;264(1 Pt 1):E101-8.
9. Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. Kashiwagi K, etal., J Struct Funct Genomics. 2016 Mar;17(1):33-8. doi: 10.1007/s10969-016-9203-3. Epub 2016 Mar 29.
10. Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. Kimball SR, etal., J Biol Chem. 1998 Jan 30;273(5):3039-44.
11. Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b. Kimball SR, etal., J Biol Chem. 1998 May 22;273(21):12841-5.
12. Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain. Martin de la Vega C, etal., Biochem J. 2001 Aug 1;357(Pt 3):819-26.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway. Pap M and Cooper GM, Mol Cell Biol 2002 Jan;22(2):578-86.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast. Price NT, etal., Biochem J 1996 Sep 1;318 ( Pt 2):637-43.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Effect of CCK and intracellular calcium to regulate eIF2B and protein synthesis in rat pancreatic acinar cells. Sans MD, etal., Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G267-76.
22. Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells. Scheper GC, etal., J Biol Chem. 1997 Oct 24;272(43):26850-6.
23. Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter. van der Knaap MS, etal., Ann Neurol 2002 Feb;51(2):264-70.
Additional References at PubMed
PMID:8626696   PMID:11323413   PMID:12624094   PMID:14565967   PMID:14566705   PMID:15054402   PMID:15060152   PMID:15217090   PMID:15507143   PMID:16289705  


Genomics

Comparative Map Data
Eif2b4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,903,148 - 30,908,803 (+)NCBIGRCr8
mRatBN7.2625,183,177 - 25,188,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,183,186 - 25,188,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,484,104 - 25,489,668 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,799,997 - 25,805,561 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,279,071 - 25,284,628 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,546,917 - 26,552,474 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,546,924 - 26,552,430 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,364,317 - 36,369,311 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,159,823 - 25,165,561 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,162,775 - 25,168,512 (+)NCBI
Celera624,674,570 - 24,680,134 (+)NCBICelera
Cytogenetic Map6q14NCBI
EIF2B4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,364,352 - 27,370,338 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,364,352 - 27,370,338 (-)EnsemblGRCh38hg38GRCh38
GRCh37227,587,219 - 27,593,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,440,723 - 27,446,828 (-)NCBINCBI36Build 36hg18NCBI36
Build 34227,498,880 - 27,504,570NCBI
Celera227,433,890 - 27,439,990 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,329,223 - 27,335,327 (-)NCBIHuRef
CHM1_1227,517,164 - 27,523,272 (-)NCBICHM1_1
T2T-CHM13v2.0227,406,760 - 27,412,735 (-)NCBIT2T-CHM13v2.0
Eif2b4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,344,902 - 31,350,483 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,344,902 - 31,350,774 (-)EnsemblGRCm39 Ensembl
GRCm38531,187,558 - 31,193,139 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,187,558 - 31,193,430 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,489,931 - 31,495,512 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,464,149 - 31,469,674 (-)NCBIMGSCv36mm8
Celera528,666,608 - 28,672,190 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.24NCBI
Eif2b4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,328,943 - 9,334,315 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,328,900 - 9,334,463 (-)NCBIChiLan1.0ChiLan1.0
EIF2B4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,140,159 - 99,146,332 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,144,139 - 99,150,300 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,368,189 - 27,374,265 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,456,571 - 27,462,706 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,456,457 - 27,462,706 (-)Ensemblpanpan1.1panPan2
EIF2B4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,321,329 - 21,326,357 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,321,349 - 21,326,244 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,213,087 - 21,218,104 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,642,644 - 21,647,661 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,642,644 - 21,647,572 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,329,308 - 21,334,325 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,338,998 - 21,344,015 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,387,006 - 21,392,025 (-)NCBIUU_Cfam_GSD_1.0
Eif2b4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,621,895 - 65,631,786 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,213,055 - 5,217,664 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,213,036 - 5,217,670 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2B4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,781,648 - 111,786,372 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,781,661 - 111,786,377 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,691,182 - 118,692,456 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2B4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,240,874 - 80,247,555 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,240,449 - 80,249,521 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,905,087 - 31,911,385 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2b4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,437,554 - 9,443,747 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,438,484 - 9,443,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif2b4
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:83
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000007763
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
RH134747  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,188,594 - 25,188,806 (+)MAPPERmRatBN7.2
Rnor_6.0626,552,237 - 26,552,448NCBIRnor6.0
Rnor_5.0636,369,074 - 36,369,285UniSTSRnor5.0
RGSC_v3.4625,165,324 - 25,165,535UniSTSRGSC3.4
Celera624,679,897 - 24,680,108UniSTS
Cytogenetic Map6q14UniSTS
AA851483  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21152,583,470 - 52,583,503 (+)MAPPERmRatBN7.2
Rnor_6.0626,550,737 - 26,551,389NCBIRnor6.0
RGSC_v3.4625,163,642 - 25,164,475UniSTSRGSC3.4
Celera624,678,389 - 24,679,048UniSTS
Cytogenetic Map6q14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007763   ⟹   ENSRNOP00000007763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,183,186 - 25,188,829 (+)Ensembl
Rnor_6.0 Ensembl626,546,924 - 26,552,430 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110149   ⟹   ENSRNOP00000092958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,183,322 - 25,188,829 (+)Ensembl
RefSeq Acc Id: NM_053950   ⟹   NP_446402
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,903,239 - 30,908,803 (+)NCBI
mRatBN7.2625,183,268 - 25,188,832 (+)NCBI
Rnor_6.0626,546,917 - 26,552,474 (+)NCBI
Rnor_5.0636,364,317 - 36,369,311 (+)NCBI
RGSC_v3.4625,159,823 - 25,165,561 (+)RGD
Celera624,674,570 - 24,680,134 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111697   ⟹   XP_038967625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,903,148 - 30,908,803 (+)NCBI
mRatBN7.2625,183,177 - 25,188,832 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446402 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967625 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA88256 (Get FASTA)   NCBI Sequence Viewer  
  EDM02925 (Get FASTA)   NCBI Sequence Viewer  
  EDM02926 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007763
  ENSRNOP00000007763.5
  ENSRNOP00000092958.1
GenBank Protein Q63186 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_446402   ⟸   NM_053950
- UniProtKB: Q63186 (UniProtKB/Swiss-Prot),   A6HA70 (UniProtKB/TrEMBL),   A0A096MIS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007763   ⟸   ENSRNOT00000007763
RefSeq Acc Id: XP_038967625   ⟸   XM_039111697
- Peptide Label: isoform X1
- UniProtKB: A0A096MIS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092958   ⟸   ENSRNOT00000110149

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63186-F1-model_v2 AlphaFold Q63186 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694441
Promoter ID:EPDNEW_R4966
Type:multiple initiation site
Name:Eif2b4_1
Description:eukaryotic translation initiation factor 2B subunit delta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,546,912 - 26,546,972EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620208 AgrOrtholog
BioCyc Gene G2FUF-38349 BioCyc
Ensembl Genes ENSRNOG00000005301 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007763 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000007763.6 UniProtKB/Swiss-Prot
  ENSRNOT00000110149.1 UniProtKB/TrEMBL
InterPro IF-2B-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_2B-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117019 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117019 ENTREZGENE
PANTHER TRANSLATION INITIATION FACTOR EIF-2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IF-2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif2b4 PhenoGen
RatGTEx ENSRNOG00000005301 RatGTEx
Superfamily-SCOP SSF100950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MIS3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJA8_RAT UniProtKB/TrEMBL
  A6HA70 ENTREZGENE, UniProtKB/TrEMBL
  A6HA71_RAT UniProtKB/TrEMBL
  EI2BD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-26 Eif2b4  eukaryotic translation initiation factor 2B subunit delta  Eif2b4  eukaryotic translation initiation factor 2B subunit 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Eif2b4  eukaryotic translation initiation factor 2B subunit 4  Eif2b4  eukaryotic translation initiation factor 2B, subunit 4 delta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Eif2b4  eukaryotic translation initiation factor 2B, subunit 4 delta  Eif2b  eukaryotic translation initiation factor 2B  Symbol and Name updated 1299863 APPROVED
2002-08-07 Eif2b  eukaryotic translation initiation factor 2B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process phosphorylation by GSK-3b plays a role in the control of programmed cell death by the PI 3-kinase/Akt signaling pathway 70606