Phb2 (prohibitin 2) - Rat Genome Database

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Gene: Phb2 (prohibitin 2) Rattus norvegicus
Analyze
Symbol: Phb2
Name: prohibitin 2
RGD ID: 620203
Description: Predicted to enable amide binding activity; protein dimerization activity; and sphingolipid binding activity. Involved in cellular response to hypoxia; cellular response to retinoic acid; and negative regulation of apoptotic process. Located in axon and mitochondrion. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Orthologous to human PHB2 (prohibitin 2); PARTICIPATES IN estrogen signaling pathway; mitochondria fusion pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell receptor associated protein 37; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; Bap; Bap-37; Bap37; Bcap27; Bcap37; prohibitin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,203,948 - 159,208,561 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,203,926 - 159,209,231 (+)EnsemblGRCr8
mRatBN7.24157,517,662 - 157,522,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,517,577 - 157,522,272 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,746,152 - 163,750,758 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,529,057 - 159,533,663 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,170,622 - 158,175,227 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,230,769 - 157,235,375 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,230,769 - 157,235,367 (+)Ensemblrn6Rnor6.0
Rnor_5.04224,248,365 - 224,252,971 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,835,328 - 160,839,933 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,256,324 - 146,260,930 (+)NCBICelera
RGSC_v3.14161,080,337 - 161,084,834 (+)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
CU-O LINKAGE  (ISO)
D-glucose  (EXP)
DDE  (ISO)
Dibutyl phosphate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (EXP)
inositol  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
mitoxantrone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
Propiverine  (EXP)
rotenone  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tungsten  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
3. Composition of the synaptic PSD-95 complex. Dosemeci A, etal., Mol Cell Proteomics. 2007 Oct;6(10):1749-60. doi: 10.1074/mcp.M700040-MCP200. Epub 2007 Jul 9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer. Girault I, etal., Maturitas. 2006 Jul 20;54(4):342-51. Epub 2006 Jul 5.
6. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
7. Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus. Kuramori C, etal., Biochem Biophys Res Commun. 2009 Feb 6;379(2):519-25. doi: 10.1016/j.bbrc.2008.12.103. Epub 2008 Dec 29.
8. Dynamic change of Prohibitin2 expression in rat sciatic nerve after crush. Long L, etal., Cell Mol Neurobiol. 2013 Jul;33(5):689-98. doi: 10.1007/s10571-013-9935-6. Epub 2013 Apr 9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Expression of PHB2 in rat brain cortex following traumatic brain injury. Xu T, etal., Int J Mol Sci. 2014 Feb 21;15(2):3299-318. doi: 10.3390/ijms15023299.
16. Effect of all-trans retinoic acid treatment on prohibitin and renin-angiotensin-aldosterone system expression in hypoxia-induced renal tubular epithelial cell injury. Zhou TB, etal., J Renin Angiotensin Aldosterone Syst. 2014 Sep;15(3):243-9. doi: 10.1177/1470320314542727. Epub 2014 Jul 16.
Additional References at PubMed
PMID:10359819   PMID:11302691   PMID:12477932   PMID:14651853   PMID:15140878   PMID:15489334   PMID:17008324   PMID:17065319   PMID:17070910   PMID:17785450   PMID:18504258   PMID:18614015  
PMID:18629613   PMID:19906925   PMID:20833797   PMID:20959514   PMID:21328542   PMID:21630459   PMID:22082260   PMID:22417827   PMID:23376485   PMID:23548868   PMID:24625528   PMID:25002582  
PMID:29476059   PMID:29867124   PMID:32357304   PMID:33450132   PMID:37046989   PMID:37958902   PMID:38260951  


Genomics

Comparative Map Data
Phb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,203,948 - 159,208,561 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,203,926 - 159,209,231 (+)EnsemblGRCr8
mRatBN7.24157,517,662 - 157,522,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,517,577 - 157,522,272 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,746,152 - 163,750,758 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,529,057 - 159,533,663 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,170,622 - 158,175,227 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,230,769 - 157,235,375 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,230,769 - 157,235,367 (+)Ensemblrn6Rnor6.0
Rnor_5.04224,248,365 - 224,252,971 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,835,328 - 160,839,933 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,256,324 - 146,260,930 (+)NCBICelera
RGSC_v3.14161,080,337 - 161,084,834 (+)NCBI
Cytogenetic Map4q42NCBI
PHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,965,327 - 6,970,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,965,327 - 6,970,841 (-)Ensemblhg38GRCh38
GRCh37127,074,490 - 7,079,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,944,778 - 6,950,152 (-)NCBIBuild 36Build 36hg18NCBI36
Celera128,695,534 - 8,700,935 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,932,980 - 6,938,381 (-)NCBIHuRef
CHM1_1127,073,468 - 7,078,869 (-)NCBICHM1_1
T2T-CHM13v2.0126,978,802 - 6,984,228 (-)NCBIT2T-CHM13v2.0
Phb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,689,252 - 124,693,908 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,689,299 - 124,693,913 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386124,712,289 - 124,716,945 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,712,336 - 124,716,950 (+)Ensemblmm10GRCm38
MGSCv376124,662,307 - 124,666,963 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366124,677,955 - 124,682,537 (+)NCBIMGSCv36mm8
Celera6126,394,014 - 126,398,670 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Phb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,558,259 - 4,563,582 (-)Ensembl
ChiLan1.0NW_0049554134,557,969 - 4,563,697 (-)NCBIChiLan1.0ChiLan1.0
PHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,531,341 - 12,536,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,528,100 - 12,533,303 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,097,073 - 7,102,474 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,012,862 - 7,018,303 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,013,195 - 7,018,053 (-)EnsemblpanPan2panpan1.1
PHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,075,769 - 38,080,440 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,075,652 - 38,080,109 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha278,536,250 - 8,540,926 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02738,428,364 - 38,433,040 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,428,395 - 38,433,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,303,246 - 38,307,922 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,344,227 - 38,348,903 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,015,013 - 8,019,689 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Phb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,186,944 - 102,191,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709854,698 - 858,851 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936709854,493 - 859,182 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,751,558 - 63,756,478 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1563,751,566 - 63,756,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,187,707 - 66,192,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,998,517 - 7,004,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660631,213,103 - 1,219,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,599,687 - 3,604,872 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248603,599,435 - 3,605,016 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Phb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1623,167,153 - 23,171,925 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Phb2
59 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:74
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000017472
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4150095743159267220Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
RH128209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,521,941 - 157,522,145 (+)MAPPERmRatBN7.2
Rnor_6.04157,235,049 - 157,235,252NCBIRnor6.0
Rnor_5.04224,252,645 - 224,252,848UniSTSRnor5.0
RGSC_v3.44160,839,607 - 160,839,810UniSTSRGSC3.4
Celera4146,260,604 - 146,260,807UniSTS
Cytogenetic Map4q42UniSTS
RH142323  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,522,041 - 157,522,208 (+)MAPPERmRatBN7.2
Rnor_6.04157,235,149 - 157,235,315NCBIRnor6.0
Rnor_6.02196,052,665 - 196,052,847NCBIRnor6.0
Rnor_5.04224,252,745 - 224,252,911UniSTSRnor5.0
Rnor_5.02215,545,992 - 215,546,174UniSTSRnor5.0
RGSC_v3.44160,839,707 - 160,839,873UniSTSRGSC3.4
RGSC_v3.42189,787,523 - 189,787,705UniSTSRGSC3.4
Celera4146,260,704 - 146,260,870UniSTS
Cytogenetic Map4q42UniSTS
MARC_4161-4162:996679469:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84159,205,698 - 159,206,534 (+)Marker Load Pipeline
mRatBN7.24157,519,411 - 157,520,248 (+)MAPPERmRatBN7.2
Rnor_6.04157,232,519 - 157,233,355NCBIRnor6.0
Rnor_5.04224,250,115 - 224,250,951UniSTSRnor5.0
RGSC_v3.44160,837,078 - 160,837,913UniSTSRGSC3.4
Celera4146,258,074 - 146,258,910UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017472   ⟹   ENSRNOP00000017472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,203,926 - 159,208,019 (+)Ensembl
mRatBN7.2 Ensembl4157,517,577 - 157,522,269 (+)Ensembl
Rnor_6.0 Ensembl4157,230,895 - 157,235,051 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091464   ⟹   ENSRNOP00000075668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,203,926 - 159,208,551 (+)Ensembl
mRatBN7.2 Ensembl4157,517,577 - 157,522,272 (+)Ensembl
Rnor_6.0 Ensembl4157,230,769 - 157,235,367 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104665   ⟹   ENSRNOP00000093330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,203,926 - 159,209,231 (+)Ensembl
mRatBN7.2 Ensembl4157,517,751 - 157,522,235 (+)Ensembl
RefSeq Acc Id: NM_001013035   ⟹   NP_001013053
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,203,948 - 159,208,554 (+)NCBI
mRatBN7.24157,517,662 - 157,522,268 (+)NCBI
Rnor_6.04157,230,769 - 157,235,375 (+)NCBI
Rnor_5.04224,248,365 - 224,252,971 (+)NCBI
RGSC_v3.44160,835,328 - 160,839,933 (+)RGD
Celera4146,256,324 - 146,260,930 (+)RGD
Sequence:
RefSeq Acc Id: XM_063285401   ⟹   XP_063141471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,203,997 - 159,208,561 (+)NCBI
RefSeq Acc Id: NP_001013053   ⟸   NM_001013035
- UniProtKB: P70629 (UniProtKB/Swiss-Prot),   P70630 (UniProtKB/Swiss-Prot),   Q5XIH7 (UniProtKB/Swiss-Prot),   A0A0G2KB63 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017472   ⟸   ENSRNOT00000017472
Ensembl Acc Id: ENSRNOP00000075668   ⟸   ENSRNOT00000091464
Ensembl Acc Id: ENSRNOP00000093330   ⟸   ENSRNOT00000104665
RefSeq Acc Id: XP_063141471   ⟸   XM_063285401
- Peptide Label: isoform X1
- UniProtKB: A6ILJ3 (UniProtKB/TrEMBL),   A0A8L2Q8H9 (UniProtKB/TrEMBL)
Protein Domains
Band

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIH7-F1-model_v2 AlphaFold Q5XIH7 1-299 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693394
Promoter ID:EPDNEW_R3910
Type:initiation region
Name:Phb2_1
Description:prohibitin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,230,785 - 157,230,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620203 AgrOrtholog
BioCyc Gene G2FUF-43089 BioCyc
Ensembl Genes ENSRNOG00000012999 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017472 ENTREZGENE
  ENSRNOT00000091464.2 UniProtKB/Swiss-Prot
  ENSRNOT00000104665 ENTREZGENE
Gene3D-CATH 3.30.479.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190294 IMAGE-MGC_LOAD
InterPro Band_7 UniProtKB/Swiss-Prot
  Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot
  Prohibitin UniProtKB/Swiss-Prot
KEGG Report rno:114766 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94585 IMAGE-MGC_LOAD
NCBI Gene 114766 ENTREZGENE
PANTHER PROHIBITIN-2 UniProtKB/Swiss-Prot
  PTHR23222 UniProtKB/Swiss-Prot
Pfam Band_7 UniProtKB/Swiss-Prot
PhenoGen Phb2 PhenoGen
PRINTS PROHIBITIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012999 RatGTEx
SMART PHB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117892 UniProtKB/Swiss-Prot
UniProt A0A0G2KB63 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK88_RAT UniProtKB/TrEMBL
  A0A8L2Q8H9 ENTREZGENE, UniProtKB/TrEMBL
  A6ILJ3 ENTREZGENE, UniProtKB/TrEMBL
  P70629 ENTREZGENE
  P70630 ENTREZGENE
  PHB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P70629 UniProtKB/Swiss-Prot
  P70630 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Phb2  prohibitin 2  Bcap37  B-cell receptor-associated protein 37  Symbol and Name updated 1299863 APPROVED
2004-09-10 Bcap37  B-cell receptor-associated protein 37  Bcap27    Symbol updated 1299863 APPROVED
2002-08-07 Bcap27  B-cell receptor-associated protein 37      Symbol and Name status set to provisional 70820 PROVISIONAL