Slc40a1 (solute carrier family 40 member 1) - Rat Genome Database

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Gene: Slc40a1 (solute carrier family 40 member 1) Rattus norvegicus
Analyze
Symbol: Slc40a1
Name: solute carrier family 40 member 1
RGD ID: 620180
Description: Predicted to enable ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Predicted to be involved in intracellular iron ion homeostasis and iron ion export across plasma membrane. Predicted to act upstream of or within several processes, including multicellular organismal-level iron ion homeostasis; positive regulation of transcription by RNA polymerase II; and spleen trabecula formation. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and synaptic vesicle. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1); PARTICIPATES IN iron efflux pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CAR1; cell adhesion regulator; ferroportin; ferroportin 1; ferroportin-1; Fpn1; NEWGENE_620180; Slc11a3; Slc39a1; solute carrier family 39 (iron-regulated transporter), member 1; solute carrier family 40 (iron-regulated transporter), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,525,457 - 55,633,463 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl955,525,532 - 55,543,460 (-)EnsemblGRCr8
mRatBN7.2948,033,526 - 48,053,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,033,526 - 48,051,481 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx956,559,843 - 56,577,824 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,682,660 - 61,700,640 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,978,656 - 59,996,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd959,304,065 - 59,322,045 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive955,079,453 - 55,097,435 (-)NCBILyon_Normotensive
Lyon_Hypertensive955,214,884 - 55,232,864 (-)NCBILyon_Hypertensive
F344_StmMcwi957,130,919 - 57,148,899 (-)NCBIF344_StmMcwi
Rnor_6.0952,819,451 - 52,830,461 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,894,365 - 52,912,293 (-)Ensemblrn6Rnor6.0
Rnor_5.0952,560,116 - 52,579,079 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4944,977,430 - 44,995,358 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera945,700,875 - 45,718,803 (-)NCBICelera
RGSC_v3.1944,979,984 - 44,996,778 (-)NCBI
Cytogenetic Map9q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzoate  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apocynin  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
busulfan  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethyl fumarate  (ISO)
diquat  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erastin  (EXP,ISO)
ethanol  (ISO)
ferric ammonium citrate  (EXP,ISO)
ferrostatin-1  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gadolinium trichloride  (EXP)
gallium nitrate  (ISO)
Gastrodin  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glycidol  (EXP)
hexane  (ISO)
hypochlorous acid  (ISO)
indoline  (ISO)
indometacin  (ISO)
inulin  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (ISO)
L-glutamic acid  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mithramycin  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
omeprazole  (ISO)
oxidopamine  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenacetin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
phorone  (EXP)
Picein  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salvianolic acid A  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sclareol  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiazoles  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
toosendanin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis. di Patti MC, etal., Neurosci Lett 2004 Jun 10;363(2):182-6.
2. Ironing out Ferroportin. Drakesmith H, etal., Cell Metab. 2015 Nov 3;22(5):777-87. doi: 10.1016/j.cmet.2015.09.006. Epub 2015 Oct 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Itoh A, etal., Brain Res Mol Brain Res 1998 Nov 20;62(2):175-86.
5. Distribution of ferroportin1 protein in different regions of developing rat brain. Jiang DH, etal., Dev Neurosci 2002;24(2-3):94-8.
6. DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Leong WI, etal., Am J Physiol Gastrointest Liver Physiol 2003 Dec;285(6):G1153-61. Epub 2003 Sep 04.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. A novel prognostic signature for idiopathic pulmonary fibrosis based on five-immune-related genes. Qiu L, etal., Ann Transl Med. 2021 Oct;9(20):1570. doi: 10.21037/atm-21-4545.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis. Wallace DF, etal., Blood 2002 Jul 15;100(2):692-4.
15. Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Yeh KY, etal., Am J Physiol Gastrointest Liver Physiol 2004 Mar;286(3):G385-94. Epub 2003 Oct 30.
Additional References at PubMed
PMID:8889548   PMID:10477520   PMID:10828623   PMID:12091367   PMID:12431995   PMID:14972659   PMID:15084469   PMID:15114483   PMID:15342464   PMID:15514116   PMID:15888661   PMID:15944915  
PMID:16081696   PMID:17383861   PMID:17561842   PMID:18189270   PMID:18839536   PMID:18974313   PMID:19234114   PMID:19252488   PMID:19596281   PMID:19766498   PMID:19913091   PMID:20007457  
PMID:20019163   PMID:20530874   PMID:20564203   PMID:21473866   PMID:21570398   PMID:21700773   PMID:21785164   PMID:22469696   PMID:22659129   PMID:22682227   PMID:23395172   PMID:23506423  
PMID:24174620   PMID:25115800   PMID:25318588   PMID:25745840   PMID:26617777   PMID:26788496   PMID:28273797   PMID:29757912   PMID:30027341   PMID:34748769  


Genomics

Comparative Map Data
Slc40a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,525,457 - 55,633,463 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl955,525,532 - 55,543,460 (-)EnsemblGRCr8
mRatBN7.2948,033,526 - 48,053,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,033,526 - 48,051,481 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx956,559,843 - 56,577,824 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,682,660 - 61,700,640 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,978,656 - 59,996,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd959,304,065 - 59,322,045 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive955,079,453 - 55,097,435 (-)NCBILyon_Normotensive
Lyon_Hypertensive955,214,884 - 55,232,864 (-)NCBILyon_Hypertensive
F344_StmMcwi957,130,919 - 57,148,899 (-)NCBIF344_StmMcwi
Rnor_6.0952,819,451 - 52,830,461 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,894,365 - 52,912,293 (-)Ensemblrn6Rnor6.0
Rnor_5.0952,560,116 - 52,579,079 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4944,977,430 - 44,995,358 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera945,700,875 - 45,718,803 (-)NCBICelera
RGSC_v3.1944,979,984 - 44,996,778 (-)NCBI
Cytogenetic Map9q22NCBI
SLC40A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382189,560,590 - 189,580,786 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2189,560,538 - 189,583,758 (-)Ensemblhg38GRCh38
GRCh372190,425,316 - 190,445,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,133,561 - 190,153,858 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342190,250,823 - 190,271,119NCBI
Celera2184,020,234 - 184,040,455 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,284,805 - 182,305,032 (-)NCBIHuRef
CHM1_12190,431,102 - 190,451,326 (-)NCBICHM1_1
T2T-CHM13v2.02190,049,828 - 190,070,025 (-)NCBIT2T-CHM13v2.0
Slc40a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39145,947,230 - 45,965,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl145,947,228 - 45,965,683 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38145,908,070 - 45,926,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl145,908,068 - 45,926,523 (-)Ensemblmm10GRCm38
MGSCv37145,964,915 - 45,982,439 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36145,852,630 - 45,870,079 (-)NCBIMGSCv36mm8
Celera146,240,344 - 46,257,933 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.96NCBI
Slc40a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554039,253,734 - 9,271,916 (+)Ensembl
ChiLan1.0NW_0049554039,253,734 - 9,271,732 (+)NCBIChiLan1.0ChiLan1.0
SLC40A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,254,018 - 92,274,565 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,269,001 - 92,289,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B76,867,908 - 76,888,403 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B194,787,575 - 194,808,129 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B194,787,575 - 194,810,993 (-)EnsemblpanPan2panpan1.1
SLC40A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137308,054 - 329,037 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37303,104 - 368,865 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha371,278,631 - 1,299,609 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.037196,731 - 217,705 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37183,743 - 312,839 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137209,278 - 230,249 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037177,455 - 198,429 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037205,666 - 226,640 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc40a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,421,846 - 148,441,474 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365068,396,912 - 8,416,374 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365068,396,593 - 8,415,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC40A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,141,988 - 94,167,408 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11594,140,635 - 94,161,793 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,177,377 - 105,198,528 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC40A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,076,286 - 75,097,742 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,075,971 - 75,096,271 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040124,382,259 - 124,402,681 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc40a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899685,097 - 702,440 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624899685,166 - 701,725 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc40a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14121,772,512 - 121,790,818 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc40a1
508 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:237
Interacting mature miRNAs:285
Transcripts:ENSRNOT00000005228, ENSRNOT00000073557
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
D9Rat60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,035,934 - 48,036,057 (+)MAPPERmRatBN7.2
Rnor_6.0952,896,774 - 52,896,896NCBIRnor6.0
Rnor_6.0952,821,860 - 52,821,982NCBIRnor6.0
Rnor_5.0952,562,590 - 52,562,712UniSTSRnor5.0
Rnor_5.0952,487,676 - 52,487,798UniSTSRnor5.0
RGSC_v3.4944,979,838 - 44,979,961RGDRGSC3.4
RGSC_v3.4944,979,839 - 44,979,961UniSTSRGSC3.4
Celera945,703,284 - 45,703,406UniSTS
RGSC_v3.1944,981,242 - 44,981,612RGD
SHRSP x BN Map941.0698UniSTS
SHRSP x BN Map941.0698RGD
FHH x ACI Map932.43RGD
Cytogenetic Map9q22UniSTS
RH129386  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,033,867 - 48,034,064 (+)MAPPERmRatBN7.2
Rnor_6.0952,894,707 - 52,894,903NCBIRnor6.0
Rnor_6.0952,819,793 - 52,819,989NCBIRnor6.0
Rnor_5.0952,485,609 - 52,485,805UniSTSRnor5.0
Rnor_5.0952,560,523 - 52,560,719UniSTSRnor5.0
RGSC_v3.4944,977,772 - 44,977,968UniSTSRGSC3.4
Celera945,701,217 - 45,701,413UniSTS
Cytogenetic Map9q22UniSTS
RH136898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,034,706 - 48,034,886 (+)MAPPERmRatBN7.2
Rnor_6.0952,820,632 - 52,820,811NCBIRnor6.0
Rnor_6.0952,895,546 - 52,895,725NCBIRnor6.0
Rnor_5.0952,486,448 - 52,486,627UniSTSRnor5.0
Rnor_5.0952,561,362 - 52,561,541UniSTSRnor5.0
RGSC_v3.4944,978,611 - 44,978,790UniSTSRGSC3.4
Celera945,702,056 - 45,702,235UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 88 87 56 92 56 6 352 192 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005228   ⟹   ENSRNOP00000005228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl955,525,532 - 55,543,460 (-)Ensembl
mRatBN7.2 Ensembl948,033,527 - 48,051,481 (-)Ensembl
Rnor_6.0 Ensembl952,894,365 - 52,912,293 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095235   ⟹   ENSRNOP00000086572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,033,526 - 48,049,019 (-)Ensembl
RefSeq Acc Id: NM_133315   ⟹   NP_579849
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,525,532 - 55,543,460 (-)NCBI
mRatBN7.2948,033,526 - 48,051,455 (-)NCBI
Dahl_SR_JrHsd959,304,065 - 59,322,045 (-)NCBI
Lyon_Normotensive955,079,453 - 55,097,435 (-)NCBI
Lyon_Hypertensive955,214,884 - 55,232,864 (-)NCBI
F344_StmMcwi957,130,919 - 57,148,899 (-)NCBI
Rnor_6.0952,819,451 - 52,830,461 (-)NCBI
Rnor_5.0952,560,116 - 52,579,079 (-)NCBI
RGSC_v3.4944,977,430 - 44,995,358 (-)RGD
Celera945,700,875 - 45,718,803 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082988   ⟹   XP_038938916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,525,457 - 55,633,463 (-)NCBI
mRatBN7.2948,033,541 - 48,053,876 (-)NCBI
RefSeq Acc Id: XM_063266613   ⟹   XP_063122683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,525,457 - 55,633,463 (-)NCBI
RefSeq Acc Id: NP_579849   ⟸   NM_133315
- UniProtKB: Q9Z1C9 (UniProtKB/Swiss-Prot),   Q923U9 (UniProtKB/Swiss-Prot),   G3V6H7 (UniProtKB/TrEMBL),   A6INT8 (UniProtKB/TrEMBL),   A0A9M1WP97 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005228   ⟸   ENSRNOT00000005228
RefSeq Acc Id: XP_038938916   ⟸   XM_039082988
- Peptide Label: isoform X1
- UniProtKB: Q923U9 (UniProtKB/Swiss-Prot),   G3V6H7 (UniProtKB/Swiss-Prot),   Q9Z1C9 (UniProtKB/Swiss-Prot),   A6INT8 (UniProtKB/TrEMBL),   A0A9M1WP97 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086572   ⟸   ENSRNOT00000095235
RefSeq Acc Id: XP_063122683   ⟸   XM_063266613
- Peptide Label: isoform X1
- UniProtKB: Q9Z1C9 (UniProtKB/Swiss-Prot),   Q923U9 (UniProtKB/Swiss-Prot),   G3V6H7 (UniProtKB/Swiss-Prot),   A6INT8 (UniProtKB/TrEMBL),   A0A9M1WP97 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923U9-F1-model_v2 AlphaFold Q923U9 1-570 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620180 AgrOrtholog
BioCyc Gene G2FUF-27634 BioCyc
Ensembl Genes ENSRNOG00000003872 Ensembl, ENTREZGENE
  ENSRNOG00055004811 UniProtKB/Swiss-Prot
  ENSRNOG00060016832 UniProtKB/Swiss-Prot
  ENSRNOG00065030099 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005228 ENTREZGENE
  ENSRNOT00055007668 UniProtKB/Swiss-Prot
  ENSRNOT00060028791 UniProtKB/Swiss-Prot
  ENSRNOT00065051968 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro Ferroportin-1 UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
KEGG Report rno:170840 UniProtKB/Swiss-Prot
NCBI Gene 170840 ENTREZGENE
PANTHER PTHR11660 UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 40 MEMBER 1 UniProtKB/Swiss-Prot
Pfam FPN1 UniProtKB/Swiss-Prot
PhenoGen Slc40a1 PhenoGen
RatGTEx ENSRNOG00000003872 RatGTEx
  ENSRNOG00055004811 RatGTEx
  ENSRNOG00060016832 RatGTEx
  ENSRNOG00065030099 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A0A9M1WP97 ENTREZGENE, UniProtKB/TrEMBL
  A6INT8 ENTREZGENE, UniProtKB/TrEMBL
  G3V6H7 ENTREZGENE
  Q923U9 ENTREZGENE
  Q9Z1C9 ENTREZGENE
  S40A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary G3V6H7 UniProtKB/Swiss-Prot
  Q9Z1C9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Slc40a1  solute carrier family 40 member 1  NEWGENE_620180  solute carrier family 40 member 1  Data merged from RGD:11441106 737654 PROVISIONAL
2016-08-02 NEWGENE_620180  solute carrier family 40 member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-03-09 Slc40a1  solute carrier family 40 member 1  Slc40a1  solute carrier family 40 (iron-regulated transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Slc40a1  solute carrier family 40 (iron-regulated transporter), member 1  Slc40a1  solute carrier family 39 (iron-regulated transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc40a1  solute carrier family 39 (iron-regulated transporter), member 1  Slc39a1    Symbol and Name updated 1299863 APPROVED
2002-08-07 Slc39a1  solute carrier family 39 (iron-regulated transporter), member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in many specific regions of the brain 634086
gene_regulation expression downregulated by hepcidin in an LPS-induced manner 1304454