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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620180
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc40a1
Name: solute carrier family 40 member 1
Acc ID: CHEBI:28901
Term: busulfan
Definition: A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
Chemical ID: MESH:D002066
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc40a1decreases expressionISOSlc40a1 (Mus musculus)6480464CTDBusulfan results in decreased expression of SLC40A1 proteinPMID:32416107
Slc40a1multiple interactionsISOSlc40a1 (Mus musculus)6480464CTDDeferoxamine inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]PMID:32416107
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