Pebp1 (phosphatidylethanolamine binding protein 1) - Rat Genome Database

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Gene: Pebp1 (phosphatidylethanolamine binding protein 1) Rattus norvegicus
Analyze
Symbol: Pebp1
Name: phosphatidylethanolamine binding protein 1
RGD ID: 62017
Description: Enables ATP binding activity; mitogen-activated protein kinase binding activity; and receptor serine/threonine kinase binding activity. Involved in several processes, including positive regulation of acetylcholine biosynthetic process; positive regulation of mitotic nuclear division; and regulation of intracellular signal transduction. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and synaptic vesicle. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 23 kDa morphine-binding protein; HCNP; HCNPpp; hippocampal cholinergic neurostimulating peptide; P23K; Pbp; PEBP-1; phosphatidylethanolamine binding protein; phosphatidylethanolamine-binding protein 1; Raf-1 kinase inhibitor protein; Rkip
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Pebp1-ps1  
Candidate Gene For: Bp116
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,946,307 - 44,967,890 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1244,963,675 - 44,971,780 (+)EnsemblGRCr8
mRatBN7.21239,302,864 - 39,307,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1239,302,840 - 39,307,862 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1240,478,140 - 40,482,340 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01241,091,959 - 41,096,159 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,144,930 - 40,149,130 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01245,026,948 - 45,031,148 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1245,026,886 - 45,031,145 (+)Ensemblrn6Rnor6.0
Rnor_5.01246,846,901 - 46,851,101 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41240,491,393 - 40,495,593 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,944,260 - 40,948,460 (+)NCBICelera
RGSC_v3.11240,354,780 - 40,358,980 (+)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2-methoxyethanol  (EXP)
3',5'-cyclic AMP  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-Hydroxythalidomide  (ISO)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
asiaticoside  (EXP)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calycosin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
chrysene  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
Didymin  (ISO)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
FR900359  (ISO)
furfural  (ISO)
glucose  (ISO)
hexadecanoic acid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
inulin  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
malathion  (ISO)
maneb  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nitrates  (ISO)
Nonylphenol  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulfasalazine  (EXP)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The emerging cardioinhibitory role of the hippocampal cholinergic neurostimulating peptide. Angelone T, etal., J Pharmacol Exp Ther. 2006 Jul;318(1):336-44. Epub 2006 Apr 11.
2. Gene expression in early stage cervical cancer. Biewenga P, etal., Gynecol Oncol. 2008 Mar;108(3):520-6. Epub 2008 Jan 11.
3. GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity. Brackley AD, etal., Cell Rep. 2016 Sep 6;16(10):2686-2698. doi: 10.1016/j.celrep.2016.07.084. Epub 2016 Aug 25.
4. Hippocampal signaling cascades are modulated in voluntary and treadmill exercise rats. Chen WQ, etal., Electrophoresis. 2007 Dec;28(23):4392-400.
5. Proteome analysis of conditioned medium from cultured adult hippocampal progenitors. Dahl A, etal., Rapid Commun Mass Spectrom. 2003;17(19):2195-202.
6. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Eves EM, etal., Mol Cell. 2006 Aug;23(4):561-74.
7. Reduction in rat phosphatidylethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: a first study. Feldmann RE Jr, etal., Stress. 2008;11(2):134-47.
8. Localisation of phosphatidylethanolamine-binding protein in the brain and other tissues of the rat. Frayne J, etal., Cell Tissue Res. 1999 Dec;298(3):415-23.
9. Expression of phosphatidylethanolamine-binding protein in the male reproductive tract: immunolocalisation and expression in prepubertal and adult rat testes and epididymides. Frayne J, etal., Mol Reprod Dev 1998 Apr;49(4):454-60.
10. Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. Fu Z, etal., J Natl Cancer Inst. 2003 Jun 18;95(12):878-89.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease. George AJ, etal., Neurobiol Aging. 2006 Apr;27(4):614-23. Epub 2005 Jun 6.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Hagan S, etal., Clin Cancer Res. 2005 Oct 15;11(20):7392-7.
15. The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors. Hengst U, etal., J Biol Chem. 2001 Jan 5;276(1):535-40.
16. A comparative proteomic analysis of the rat brain during rebound hyperphagia induced by space-restriction. Ishihara K, etal., Mol Cell Biochem. 2005 Aug;276(1-2):21-9.
17. Muscarinic cholinergic and glutamatergic reciprocal regulation of expression of hippocampal cholinergic neurostimulating peptide precursor protein gene in rat hippocampus. Iwase T, etal., Neuroscience. 2001;102(2):341-52.
18. Neuronal distribution and subcellular localization of HCNP-like immunoreactivity in rat small intestine. Katada E, etal., J Neurocytol. 2000 Mar;29(3):199-207.
19. Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice. Kazuki Y, etal., Biochem Biophys Res Commun. 2004 Apr 30;317(2):491-9.
20. Psychoproteomic analysis of rat cortex following acute methamphetamine exposure. Kobeissy FH, etal., J Proteome Res. 2008 May;7(5):1971-83. Epub 2008 May 2.
21. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Lorenz K, etal., Nature. 2003 Dec 4;426(6966):574-9.
22. Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease. Maki M, etal., J Neuropathol Exp Neurol. 2002 Feb;61(2):176-85.
23. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. McCubrey JA, etal., Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7.
24. Region-specific alterations of global protein expression in the remodelled rat myocardium. Melle C, etal., Int J Mol Med. 2006 Dec;18(6):1207-15.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Accumulation of hippocampal cholinergic neurostimulating peptide (HCNP)-related components in Hirano bodies. Mitake S, etal., Neuropathol Appl Neurobiol. 1995 Feb;21(1):35-40.
27. Specific binding of 125I-hippocampal cholinergic neurostimulating peptide (HCNP) to rat brain membranes: characterization and regional distribution. Morishita M, etal., Brain Res 2003 Mar 7;965(1-2):194-202.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Demonstration of the biological activity of peptide fragments related to human and rat hippocampal cholinergic neurostimulating peptide (HCNP). Ojika K, etal., Neurosci Lett. 1996 Sep 6;215(2):127-30.
30. Hippocampal cholinergic neurostimulating peptides (HCNP). Ojika K, etal., Prog Neurobiol. 2000 Jan;60(1):37-83.
31. Sequence analysis of a mammalian phospholipid-binding protein from testis and epididymis and its distribution between spermatozoa and extracellular secretions. Perry AC, etal., Biochem J 1994 Jul 1;301 ( Pt 1)(2):235-42.
32. GOA pipeline RGD automated data pipeline
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery. Scholler N, etal., J Transl Med. 2008 Jul 24;6:41.
35. Oxidative stress and protein oxidation in the brain of water drinking and alcohol drinking rats administered the HIV envelope protein, gp120. Singh AK, etal., J Neurochem. 2008 Mar;104(6):1478-93. Epub 2007 Dec 6.
36. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
37. Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein. Tohdoh N, etal., Brain Res Mol Brain Res 1995 Jun;30(2):381-4.
38. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. Trakul N, etal., J Biol Chem. 2005 Jul 1;280(26):24931-40. Epub 2005 May 10.
39. High levels of hippocampal cholinergic neurostimulating peptide (HCNP) in the CSF of some patients with Alzheimer's disease. Tsugu Y, etal., Eur J Neurol. 1998 Nov;5(6):561-569.
40. Detection of germ cell-derived proteins in testicular interstitial fluid: potential for monitoring spermatogenesis in vivo. Turner KJ, etal., J Androl. 1996 Mar-Apr;17(2):127-36.
41. Postvasectomy alterations in protein synthesis and secretion in the rat caput epididymidis are not repaired after vasovasostomy. Turner TT, etal., J Androl. 2000 Mar-Apr;21(2):276-90.
42. Changes of hippocampal signaling protein levels during postnatal brain development in the rat. Weitzdorfer R, etal., Hippocampus. 2008;18(8):807-13.
43. Pituitary adenylate cyclase activating polypeptide can regulate testicular germ cell protein synthesis in vitro. West AP, etal., J Endocrinol. 1995 Feb;144(2):215-23.
44. Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer. Woods Ignatoski KM, etal., Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):153-60.
45. Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants. Yamamoto T, etal., J Toxicol Sci. 2005 May;30(2):111-26.
46. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Yeung K, etal., Nature. 1999 Sep 9;401(6749):173-7.
47. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Yeung KC, etal., Mol Cell Biol. 2001 Nov;21(21):7207-17.
Additional References at PubMed
PMID:1611510   PMID:1932083   PMID:1978248   PMID:9105667   PMID:12551925   PMID:15489334   PMID:15782137   PMID:16183867   PMID:17634366   PMID:18616905   PMID:19056867   PMID:19199708  
PMID:19309582   PMID:19323783   PMID:19705086   PMID:19913121   PMID:20458337   PMID:20510017   PMID:20628086   PMID:21554319   PMID:21630459   PMID:21831839   PMID:22542739   PMID:22610096  
PMID:22658674   PMID:22859298   PMID:23276635   PMID:23376485   PMID:23533145   PMID:24065653   PMID:25108669   PMID:25231108   PMID:25962787   PMID:26316108   PMID:26479924   PMID:27470410  
PMID:28245468   PMID:31875544  


Genomics

Comparative Map Data
Pebp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,946,307 - 44,967,890 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1244,963,675 - 44,971,780 (+)EnsemblGRCr8
mRatBN7.21239,302,864 - 39,307,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1239,302,840 - 39,307,862 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1240,478,140 - 40,482,340 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01241,091,959 - 41,096,159 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,144,930 - 40,149,130 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01245,026,948 - 45,031,148 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1245,026,886 - 45,031,145 (+)Ensemblrn6Rnor6.0
Rnor_5.01246,846,901 - 46,851,101 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41240,491,393 - 40,495,593 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,944,260 - 40,948,460 (+)NCBICelera
RGSC_v3.11240,354,780 - 40,358,980 (+)NCBI
Cytogenetic Map12q16NCBI
PEBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812118,136,124 - 118,145,584 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12118,136,071 - 118,145,584 (+)Ensemblhg38GRCh38
GRCh3712118,573,929 - 118,583,389 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612117,058,253 - 117,067,773 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412117,036,589 - 117,046,110NCBI
Celera12118,204,960 - 118,214,471 (+)NCBICelera
Cytogenetic Map12q24.23NCBI
HuRef12115,583,844 - 115,593,353 (+)NCBIHuRef
CHM1_112118,541,591 - 118,551,104 (+)NCBICHM1_1
T2T-CHM13v2.012118,123,375 - 118,132,824 (+)NCBIT2T-CHM13v2.0
Pebp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395117,420,716 - 117,425,629 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5117,420,719 - 117,425,690 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385117,282,651 - 117,287,564 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,282,654 - 117,287,625 (-)Ensemblmm10GRCm38
MGSCv375117,732,660 - 117,737,573 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365117,543,681 - 117,548,594 (-)NCBIMGSCv36mm8
Celera5114,378,177 - 114,383,080 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.88NCBI
Pebp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,217,767 - 13,223,108 (-)Ensembl
ChiLan1.0NW_00495545513,217,012 - 13,222,370 (-)NCBIChiLan1.0ChiLan1.0
PEBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210126,202,444 - 126,211,940 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112126,198,824 - 126,208,320 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012115,716,953 - 115,726,412 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112119,096,328 - 119,105,832 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12119,093,952 - 119,105,054 (+)EnsemblpanPan2panpan1.1
PEBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12614,522,124 - 14,526,370 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2614,500,074 - 14,529,354 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2614,515,188 - 14,519,426 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02614,784,007 - 14,788,255 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2614,778,114 - 14,791,198 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12614,748,852 - 14,753,083 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02614,821,104 - 14,825,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02614,856,217 - 14,860,448 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pebp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118147,817,772 - 147,824,111 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366682,317,361 - 2,323,067 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366682,316,661 - 2,323,015 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PEBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11434,523,901 - 34,530,238 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21436,685,085 - 36,691,392 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PEBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111113,469,845 - 113,479,177 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037131,619,275 - 131,630,575 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pebp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474715,339,844 - 15,346,970 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474715,340,020 - 15,346,960 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pebp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11636,538,734 - 36,543,050 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pebp1
143 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:123
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000001500
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat

Markers in Region
RH127979  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21239,306,809 - 39,307,012 (+)MAPPERmRatBN7.2
mRatBN7.21633,215,751 - 33,215,956 (+)MAPPERmRatBN7.2
Rnor_6.01636,664,087 - 36,664,291NCBIRnor6.0
Rnor_6.01245,030,894 - 45,031,096NCBIRnor6.0
Rnor_5.01636,471,505 - 36,471,709UniSTSRnor5.0
Rnor_5.01246,850,847 - 46,851,049UniSTSRnor5.0
RGSC_v3.41636,640,530 - 36,640,734UniSTSRGSC3.4
RGSC_v3.41240,495,339 - 40,495,541UniSTSRGSC3.4
Celera1240,948,206 - 40,948,408UniSTS
Celera1633,153,055 - 33,153,259UniSTS
Cytogenetic Map16p11UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001500   ⟹   ENSRNOP00000001500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1239,302,872 - 39,307,862 (+)Ensembl
Rnor_6.0 Ensembl1245,026,886 - 45,031,145 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103520   ⟹   ENSRNOP00000078626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1244,963,675 - 44,967,470 (+)Ensembl
mRatBN7.2 Ensembl1239,302,840 - 39,306,644 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115592   ⟹   ENSRNOP00000080426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1244,963,675 - 44,967,887 (+)Ensembl
mRatBN7.2 Ensembl1239,302,872 - 39,307,862 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123005   ⟹   ENSRNOP00000100431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1244,963,675 - 44,971,780 (+)Ensembl
RefSeq Acc Id: NM_017236   ⟹   NP_058932
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,963,690 - 44,967,890 (+)NCBI
mRatBN7.21239,302,864 - 39,307,064 (+)NCBI
Rnor_6.01245,026,948 - 45,031,148 (+)NCBI
Rnor_5.01246,846,901 - 46,851,101 (+)NCBI
RGSC_v3.41240,491,393 - 40,495,593 (+)RGD
Celera1240,944,260 - 40,948,460 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271232   ⟹   XP_063127302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,963,632 - 44,967,890 (+)NCBI
RefSeq Acc Id: XM_063271233   ⟹   XP_063127303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,963,632 - 44,967,890 (+)NCBI
RefSeq Acc Id: XM_063271234   ⟹   XP_063127304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,946,307 - 44,967,890 (+)NCBI
RefSeq Acc Id: NP_058932   ⟸   NM_017236
- UniProtKB: P31045 (UniProtKB/Swiss-Prot),   P31044 (UniProtKB/Swiss-Prot),   A6J1P0 (UniProtKB/TrEMBL),   A0A8I5ZLC1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001500   ⟸   ENSRNOT00000001500
Ensembl Acc Id: ENSRNOP00000078626   ⟸   ENSRNOT00000103520
Ensembl Acc Id: ENSRNOP00000080426   ⟸   ENSRNOT00000115592
RefSeq Acc Id: XP_063127304   ⟸   XM_063271234
- Peptide Label: isoform X3
- UniProtKB: P31045 (UniProtKB/Swiss-Prot),   P31044 (UniProtKB/Swiss-Prot),   A6J1P0 (UniProtKB/TrEMBL),   A0A8I5ZLC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127302   ⟸   XM_063271232
- Peptide Label: isoform X1
- UniProtKB: A6J1P1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127303   ⟸   XM_063271233
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000100431   ⟸   ENSRNOT00000123005

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31044-F1-model_v2 AlphaFold P31044 1-187 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698677
Promoter ID:EPDNEW_R9202
Type:initiation region
Name:Pebp1_1
Description:phosphatidylethanolamine binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01245,026,956 - 45,027,016EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62017 AgrOrtholog
BioCyc Gene G2FUF-19059 BioCyc
Ensembl Genes ENSRNOG00000001136 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000103520 ENTREZGENE
Gene3D-CATH 3.90.280.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6888051 IMAGE-MGC_LOAD
InterPro PEBP UniProtKB/Swiss-Prot
  PEBP-like_sf UniProtKB/Swiss-Prot
  PEBP_euk UniProtKB/Swiss-Prot
  Phosphatidylethanolamine-bd_CS UniProtKB/Swiss-Prot
KEGG Report rno:29542 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72882 IMAGE-MGC_LOAD
NCBI Gene 29542 ENTREZGENE
PANTHER PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR11362 UniProtKB/Swiss-Prot
Pfam PBP UniProtKB/Swiss-Prot
PhenoGen Pebp1 PhenoGen
PROSITE PBP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001136 RatGTEx
Superfamily-SCOP SSF49777 UniProtKB/Swiss-Prot
UniProt A0A8I5ZLC1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQN0_RAT UniProtKB/TrEMBL
  A0A8L2UH84 ENTREZGENE
  A0ABK0L6X0_RAT UniProtKB/TrEMBL
  A6J1P0 ENTREZGENE, UniProtKB/TrEMBL
  A6J1P1 ENTREZGENE, UniProtKB/TrEMBL
  A6J1P2_RAT UniProtKB/TrEMBL
  P31044 ENTREZGENE
  P31045 ENTREZGENE
  PEBP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P31045 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Pebp1  phosphatidylethanolamine binding protein 1  Pbp  phosphatidylethanolamine binding protein  Symbol and Name updated 1299863 APPROVED
2002-06-10 Pbp  phosphatidylethanolamine binding protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference