Il10ra (interleukin 10 receptor subunit alpha) - Rat Genome Database

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Gene: Il10ra (interleukin 10 receptor subunit alpha) Rattus norvegicus
Analyze
Symbol: Il10ra
Name: interleukin 10 receptor subunit alpha
RGD ID: 620138
Description: Enables interleukin-10 binding activity and interleukin-10 receptor activity. Involved in regulation of synapse organization and response to lipopolysaccharide. Predicted to be located in several cellular components, including cilium; cytosol; and nucleoplasm. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 28. Orthologous to human IL10RA (interleukin 10 receptor subunit alpha); PARTICIPATES IN Interleukin-10 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: interleukin 10 receptor, alpha; interleukin-10 receptor subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,459,754 - 54,474,786 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl854,459,882 - 54,475,028 (-)EnsemblGRCr8
mRatBN7.2845,563,009 - 45,578,041 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,563,137 - 45,578,061 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx851,059,536 - 51,072,968 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0849,338,295 - 49,351,727 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,208,844 - 47,222,279 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0849,558,062 - 49,573,891 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,560,035 - 49,573,742 (-)Ensemblrn6Rnor6.0
Rnor_5.0848,184,634 - 48,200,343 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4848,211,040 - 48,224,439 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera845,147,695 - 45,161,094 (-)NCBICelera
RGSC_v3.1848,219,805 - 48,233,205 (-)NCBI
Cytogenetic Map8q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrobenzenesulfonic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asperentin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clopidogrel  (ISO)
copper(II) sulfate  (ISO)
dexamethasone  (ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
diuron  (ISO)
ethyl methanesulfonate  (ISO)
ferric oxide  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
glycidol  (EXP)
hydroxychloroquine  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
microcystin-LR  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium stibogluconate  (ISO)
sulfasalazine  (ISO)
teriflunomide  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Site-specific modulation of LPS-induced fever and interleukin-1 beta expression in rats by interleukin-10. Ledeboer A, etal., Am J Physiol Regul Integr Comp Physiol 2002 Jun;282(6):R1762-72.
4. Expression and regulation of interleukin-10 and interleukin-10 receptor in rat astroglial and microglial cells. Ledeboer A, etal., Eur J Neurosci 2002 Oct;16(7):1175-85.
5. Regional and temporal expression patterns of interleukin-10, interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE. Ledeboer A, etal., J Neuroimmunol. 2003 Mar;136(1-2):94-103.
6. Neuronal synapse formation induced by microglia and interleukin 10. Lim SH, etal., PLoS One. 2013 Nov 22;8(11):e81218. doi: 10.1371/journal.pone.0081218. eCollection 2013.
7. IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. Mathurin P, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jun;282(6):G981-90.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Interleukin-10 regulates progenitor differentiation and modulates neurogenesis in adult brain. Perez-Asensio FJ, etal., J Cell Sci. 2013 Sep 15;126(Pt 18):4208-19. doi: 10.1242/jcs.127803. Epub 2013 Jul 10.
12. Interleukin (IL)-10 inhibits RANTES-, tumour necrosis factor (TNF)- and nerve growth factor (NGF)-induced mast cell migratory response but is not a mast cell chemoattractant. Pietrzak A, etal., Immunol Lett. 2009 Mar 24;123(1):46-51. Epub 2009 Feb 14.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Biology of interleukin-10. Sabat R, etal., Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44. doi: 10.1016/j.cytogfr.2010.09.002. Epub 2010 Nov 5.
19. The rat interleukin 10 receptor: cloning and sequencing of cDNA coding for the alpha-chain protein sequence, and demonstration by western blotting of expression in the rat brain. Ward H, etal., Cytokine 2001 Sep 7;15(5):237-40.
Additional References at PubMed
PMID:16086233   PMID:16982608   PMID:22087322   PMID:23185784   PMID:26962683   PMID:31210303  


Genomics

Comparative Map Data
Il10ra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,459,754 - 54,474,786 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl854,459,882 - 54,475,028 (-)EnsemblGRCr8
mRatBN7.2845,563,009 - 45,578,041 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,563,137 - 45,578,061 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx851,059,536 - 51,072,968 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0849,338,295 - 49,351,727 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,208,844 - 47,222,279 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0849,558,062 - 49,573,891 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,560,035 - 49,573,742 (-)Ensemblrn6Rnor6.0
Rnor_5.0848,184,634 - 48,200,343 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4848,211,040 - 48,224,439 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera845,147,695 - 45,161,094 (-)NCBICelera
RGSC_v3.1848,219,805 - 48,233,205 (-)NCBI
Cytogenetic Map8q22NCBI
IL10RA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811117,986,394 - 118,003,037 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11117,986,370 - 118,003,037 (+)Ensemblhg38GRCh38
GRCh3711117,857,109 - 117,873,752 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,362,319 - 117,377,404 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411117,362,318 - 117,377,404NCBI
Celera11115,014,946 - 115,030,037 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11113,790,784 - 113,805,875 (+)NCBIHuRef
CHM1_111117,742,666 - 117,757,757 (+)NCBICHM1_1
T2T-CHM13v2.011118,002,773 - 118,019,416 (+)NCBIT2T-CHM13v2.0
Il10ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,165,135 - 45,180,447 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,165,135 - 45,180,447 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38945,253,837 - 45,269,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,253,837 - 45,269,149 (-)Ensemblmm10GRCm38
MGSCv37945,061,922 - 45,077,229 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36945,004,833 - 45,020,128 (-)NCBIMGSCv36mm8
Celera942,530,039 - 42,545,574 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
Il10ra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541219,182,029 - 19,193,971 (+)Ensembl
ChiLan1.0NW_00495541219,182,536 - 19,197,083 (+)NCBIChiLan1.0ChiLan1.0
IL10RA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29118,686,901 - 118,702,056 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111119,791,876 - 119,807,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011112,820,445 - 112,835,603 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111116,752,619 - 116,767,771 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11116,752,619 - 116,767,771 (+)EnsemblpanPan2panpan1.1
IL10RA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,675,775 - 15,688,935 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,677,547 - 15,682,163 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha515,725,841 - 15,738,336 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0515,617,611 - 15,630,201 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl515,617,622 - 15,630,212 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1515,755,417 - 15,767,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0515,658,874 - 15,671,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0515,700,417 - 15,712,914 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il10ra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,178,025 - 100,191,000 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365423,099,430 - 3,113,210 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365423,099,484 - 3,113,159 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL10RA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl945,310,534 - 45,325,168 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1945,310,527 - 45,324,557 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2950,364,900 - 50,378,929 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL10RA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11109,357,081 - 109,372,557 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1109,357,133 - 109,372,697 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604316,683,781 - 16,699,148 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il10ra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478413,386,965 - 13,403,014 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478413,386,793 - 13,399,871 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Il10ra
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1839,788,184 - 39,802,642 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il10ra
76 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:46
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000021926
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 165 91 90 59 92 59 6 354 190 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021926   ⟹   ENSRNOP00000021926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl854,459,882 - 54,475,028 (-)Ensembl
mRatBN7.2 Ensembl845,563,137 - 45,578,061 (-)Ensembl
Rnor_6.0 Ensembl849,560,035 - 49,573,742 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000129949   ⟹   ENSRNOP00000099887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl854,459,882 - 54,474,990 (-)Ensembl
RefSeq Acc Id: NM_057193   ⟹   NP_476541
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,461,387 - 54,474,786 (-)NCBI
mRatBN7.2845,564,642 - 45,578,041 (-)NCBI
Rnor_6.0849,560,181 - 49,573,710 (-)NCBI
Rnor_5.0848,184,634 - 48,200,343 (-)NCBI
RGSC_v3.4848,211,040 - 48,224,439 (-)RGD
Celera845,147,695 - 45,161,094 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080716   ⟹   XP_038936644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,459,754 - 54,472,224 (-)NCBI
mRatBN7.2845,563,009 - 45,575,481 (-)NCBI
Protein Sequences
Protein RefSeqs NP_476541 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936644 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAC24567 (Get FASTA)   NCBI Sequence Viewer  
  EDL95358 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021926
  ENSRNOP00000021926.2
  ENSRNOP00000099887.1
RefSeq Acc Id: NP_476541   ⟸   NM_057193
- Peptide Label: precursor
- UniProtKB: G3V830 (UniProtKB/TrEMBL),   A6J435 (UniProtKB/TrEMBL),   Q99ND6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021926   ⟸   ENSRNOT00000021926
RefSeq Acc Id: XP_038936644   ⟸   XM_039080716
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000099887   ⟸   ENSRNOT00000129949
Protein Domains
Fibronectin type-III   Interferon/interleukin receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V830-F1-model_v2 AlphaFold G3V830 1-569 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695915
Promoter ID:EPDNEW_R6439
Type:single initiation site
Name:Il10ra_1
Description:interleukin 10 receptor subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0849,573,732 - 49,573,792EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620138 AgrOrtholog
BioCyc Gene G2FUF-30674 BioCyc
Ensembl Genes ENSRNOG00000016308 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021926 ENTREZGENE
  ENSRNOT00000021926.6 UniProtKB/TrEMBL
  ENSRNOT00000129949.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Interferon/interleukin_rcp_dom UniProtKB/TrEMBL
  Type-II_Cytokine-TF_Rcpt UniProtKB/TrEMBL
KEGG Report rno:117539 UniProtKB/TrEMBL
NCBI Gene 117539 ENTREZGENE
PANTHER INTERFERON/INTERLEUKIN RECEPTOR UniProtKB/TrEMBL
  INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam Interfer-bind UniProtKB/TrEMBL
  Tissue_fac UniProtKB/TrEMBL
PharmGKB IL10RA RGD
PhenoGen Il10ra PhenoGen
RatGTEx ENSRNOG00000016308 RatGTEx
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A0ABK0L742_RAT UniProtKB/TrEMBL
  A6J435 ENTREZGENE, UniProtKB/TrEMBL
  G3V830 ENTREZGENE, UniProtKB/TrEMBL
  Q99ND6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il10ra  interleukin 10 receptor subunit alpha  Il10ra  interleukin 10 receptor, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Il10ra  interleukin 10 receptor, alpha      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Il10ra  interleukin 10 receptor, alpha      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the cortex, cerebellum, hippocampus, hypothalamus and pituitary 633102
gene_homology shows 88% and 68% homology with the mouse and human IL-10 receptor 633102
gene_homology nucleotide sequence is 85% identical to the mouse homolog 625762
gene_regulation constitutively expressed after in vitro lipopolysaccharide treatment or cholestatic liver injury in activated hepatic stellate cells (HSC) 625762
gene_transcript RNA transcript is 3.5-kb in hepatic macrophages 625762