Cib1 (calcium and integrin binding 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cib1 (calcium and integrin binding 1) Rattus norvegicus
Analyze
Symbol: Cib1
Name: calcium and integrin binding 1
RGD ID: 620133
Description: Enables protein kinase binding activity. Involved in positive regulation of calcineurin-NFAT signaling cascade. Located in axon; dendrite; and neuronal cell body. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human CIB1 (calcium and integrin binding 1); INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium and integrin binding 1 (calmyrin); calcium and integrin-binding protein 1; calcium- and integrin-binding protein; calmyrin; Cib; DNA-PKcs-interacting protein; kinase-interacting protein; KIP; Sip2-28
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,587,591 - 143,593,153 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,587,021 - 143,593,326 (-)EnsemblGRCr8
mRatBN7.21134,178,331 - 134,183,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,178,331 - 134,213,423 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1142,087,063 - 142,092,596 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,256,463 - 149,261,996 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,174,501 - 142,180,032 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,014,962 - 142,020,461 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,014,958 - 142,020,525 (-)Ensemblrn6Rnor6.0
Rnor_5.01142,969,357 - 142,974,856 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41136,031,865 - 136,045,153 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,238,471 - 126,243,970 (-)NCBICelera
RGSC_v3.11136,110,270 - 136,123,559 (-)NCBI
Cytogenetic Map1q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
capecitabine  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
fenthion  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
hydralazine  (ISO)
ibuprofen  (ISO)
methidathion  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nicotine  (ISO)
nitrates  (ISO)
ochratoxin A  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
parathion  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
apoptotic process  (IEA,ISO,ISS)
cell adhesion  (IEA)
cell differentiation  (IEA)
cell division  (IEA)
cellular response to growth factor stimulus  (IBA,ISO,ISS)
cellular response to nerve growth factor stimulus  (IEA,ISO,ISS)
cellular response to tumor necrosis factor  (IEA,ISO,ISS)
cytoplasmic microtubule organization  (IEA,ISO,ISS)
DNA damage response  (IEA,ISO,ISS)
endomitotic cell cycle  (IEA,ISO,ISS)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of megakaryocyte differentiation  (ISO,ISS)
negative regulation of microtubule depolymerization  (IEA,ISO,ISS)
negative regulation of neuron projection development  (IEA,ISO,ISS)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
negative regulation of protein phosphorylation  (ISO,ISS)
platelet formation  (ISO,ISS)
positive regulation of calcineurin-NFAT signaling cascade  (IBA,IEA,IMP,ISO)
positive regulation of catalytic activity  (ISO,ISS)
positive regulation of cell adhesion mediated by integrin  (IEA,ISO,ISS)
positive regulation of cell growth  (ISO,ISS)
positive regulation of cell migration  (ISO,ISS)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO,ISS)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of cell-matrix adhesion  (ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (ISO,ISS)
positive regulation of male germ cell proliferation  (ISO,ISS)
positive regulation of protein localization to plasma membrane  (IBA,IEA,ISO)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of protein serine/threonine kinase activity  (ISO,ISS)
positive regulation of protein targeting to membrane  (IEA,ISO,ISS)
positive regulation of substrate adhesion-dependent cell spreading  (IEA,ISO,ISS)
regulation of cell division  (IEA,ISO,ISS)
regulation of cell population proliferation  (IEA,ISO,ISS)
response to ischemia  (ISO,ISS)
spermatid development  (ISO,ISS)
spermatogenesis  (IEA)
thrombopoietin-mediated signaling pathway  (ISO,ISS)

Cellular Component
apical plasma membrane  (IEA)
axon  (IBA,IDA)
cell periphery  (IEA,ISO,ISS)
centrosome  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO,ISS)
cytoskeleton  (IEA)
dendrite  (IDA)
endoplasmic reticulum  (IEA,ISO,ISS)
filopodium tip  (IEA,ISO,ISS)
growth cone  (IEA,ISO,ISS)
lamellipodium  (IEA,ISO,ISS)
membrane  (IEA,ISO,ISS)
neuron projection  (IEA,ISO,ISS)
neuronal cell body  (IBA,IDA,IEA,ISO,ISS)
nucleoplasm  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,ISS)
perikaryon  (IEA)
perinuclear region of cytoplasm  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)
ruffle membrane  (IEA)
sarcolemma  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. The Alzheimer disease-related calcium-binding protein Calmyrin is present in human forebrain with an altered distribution in Alzheimer's as compared to normal ageing brains. Bernstein HG, etal., Neuropathol Appl Neurobiol. 2005 Jun;31(3):314-24.
2. Ca2+-independent binding and cellular expression profiles question a significant role of calmyrin in transduction of Ca2+-signals to Alzheimer's disease-related presenilin 2 in forebrain. Blazejczyk M, etal., Biochim Biophys Acta. 2006 Jan;1762(1):66-72. Epub 2005 Oct 14.
3. Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. Czeredys M, etal., Front Mol Neurosci. 2013 Nov 25;6:42. doi: 10.3389/fnmol.2013.00042. eCollection 2013.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. CIB1 is a regulator of pathological cardiac hypertrophy. Heineke J, etal., Nat Med. 2010 Aug;16(8):872-9. doi: 10.1038/nm.2181. Epub 2010 Jul 18.
7. The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. Kauselmann G, etal., EMBO J 1999 Oct 15;18(20):5528-39.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10366599   PMID:11756406   PMID:12011095   PMID:12477932   PMID:15475008   PMID:16723353   PMID:16982698   PMID:17975111   PMID:17994197   PMID:19056867   PMID:19190083   PMID:19854831  
PMID:20458337   PMID:20473878   PMID:20951827   PMID:21215777   PMID:21264284   PMID:22128142   PMID:23376485   PMID:23533145   PMID:30068544  


Genomics

Comparative Map Data
Cib1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,587,591 - 143,593,153 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,587,021 - 143,593,326 (-)EnsemblGRCr8
mRatBN7.21134,178,331 - 134,183,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,178,331 - 134,213,423 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1142,087,063 - 142,092,596 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,256,463 - 149,261,996 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,174,501 - 142,180,032 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,014,962 - 142,020,461 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,014,958 - 142,020,525 (-)Ensemblrn6Rnor6.0
Rnor_5.01142,969,357 - 142,974,856 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41136,031,865 - 136,045,153 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,238,471 - 126,243,970 (-)NCBICelera
RGSC_v3.11136,110,270 - 136,123,559 (-)NCBI
Cytogenetic Map1q31NCBI
CIB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,229,975 - 90,265,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,229,975 - 90,234,047 (-)Ensemblhg38GRCh38
GRCh371590,773,207 - 90,808,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,574,481 - 88,578,168 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341588,574,481 - 88,578,164NCBI
Celera1567,177,856 - 67,181,658 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,885,466 - 66,920,950 (-)NCBIHuRef
CHM1_11590,615,325 - 90,650,739 (-)NCBICHM1_1
T2T-CHM13v2.01587,985,982 - 88,021,749 (-)NCBIT2T-CHM13v2.0
Cib1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,876,904 - 79,882,367 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,876,895 - 79,882,561 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38780,227,156 - 80,232,805 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,227,147 - 80,232,813 (-)Ensemblmm10GRCm38
MGSCv37787,372,046 - 87,377,502 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36780,100,673 - 80,106,129 (-)NCBIMGSCv36mm8
Celera777,628,499 - 77,633,950 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.55NCBI
Cib1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,102,632 - 15,106,372 (+)Ensembl
ChiLan1.0NW_00495541615,102,632 - 15,106,372 (+)NCBIChiLan1.0ChiLan1.0
CIB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,778,580 - 79,782,540 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,478,015 - 83,481,975 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,919,377 - 68,923,213 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,121,309 - 88,125,120 (-)NCBIPanPan1.1PanPan1.1panPan2
CIB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,184,713 - 53,209,195 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,184,714 - 53,188,224 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha355,822,517 - 55,847,781 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0353,600,749 - 53,626,017 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,600,750 - 53,625,109 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,120,852 - 53,146,101 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,331,988 - 53,357,228 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,672,463 - 53,697,717 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cib1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,366,977 - 130,370,657 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,960,036 - 15,968,094 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,963,863 - 15,967,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,794,836 - 55,798,590 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1755,794,834 - 55,798,666 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,656,933 - 60,659,823 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CIB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,777,202 - 8,781,027 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,777,436 - 8,781,030 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605937,949,545 - 37,953,393 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cib1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,209,639 - 17,213,114 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476817,209,639 - 17,212,996 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cib1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12120,019,396 - 120,025,013 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cib1
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:151
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000042558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
RH138766  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,185,287 - 134,185,488 (+)MAPPERmRatBN7.2
Rnor_6.01142,021,911 - 142,022,111NCBIRnor6.0
Rnor_5.01142,976,306 - 142,976,506UniSTSRnor5.0
RGSC_v3.41136,046,603 - 136,046,803UniSTSRGSC3.4
Celera1126,245,420 - 126,245,620UniSTS
RH 3.4 Map11068.9UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000042558   ⟹   ENSRNOP00000047025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,587,021 - 143,593,115 (-)Ensembl
mRatBN7.2 Ensembl1134,178,341 - 134,183,864 (-)Ensembl
Rnor_6.0 Ensembl1142,014,958 - 142,020,525 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107481   ⟹   ENSRNOP00000091119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,587,599 - 143,593,115 (-)Ensembl
mRatBN7.2 Ensembl1134,178,341 - 134,213,423 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109833   ⟹   ENSRNOP00000090872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,587,591 - 143,591,636 (-)Ensembl
mRatBN7.2 Ensembl1134,178,331 - 134,182,376 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116201   ⟹   ENSRNOP00000085818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,587,599 - 143,593,110 (-)Ensembl
mRatBN7.2 Ensembl1134,178,339 - 134,183,850 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119387   ⟹   ENSRNOP00000085326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,587,591 - 143,593,326 (-)Ensembl
mRatBN7.2 Ensembl1134,178,331 - 134,183,867 (-)Ensembl
RefSeq Acc Id: NM_031145   ⟹   NP_112407
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,587,591 - 143,593,115 (-)NCBI
mRatBN7.21134,178,331 - 134,183,855 (-)NCBI
Rnor_6.01142,014,962 - 142,020,461 (-)NCBI
Rnor_5.01142,969,357 - 142,974,856 (-)NCBI
RGSC_v3.41136,031,865 - 136,045,153 (-)RGD
Celera1126,238,471 - 126,243,970 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092343   ⟹   XP_038948271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,587,599 - 143,593,117 (-)NCBI
mRatBN7.21134,178,336 - 134,183,895 (-)NCBI
RefSeq Acc Id: XM_039092348   ⟹   XP_038948276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,587,599 - 143,593,153 (-)NCBI
mRatBN7.21134,178,336 - 134,183,893 (-)NCBI
RefSeq Acc Id: NP_112407   ⟸   NM_031145
- UniProtKB: Q5BKA8 (UniProtKB/Swiss-Prot),   Q9R010 (UniProtKB/Swiss-Prot),   A6JC88 (UniProtKB/TrEMBL),   A0A8L2QMR3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047025   ⟸   ENSRNOT00000042558
RefSeq Acc Id: XP_038948271   ⟸   XM_039092343
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2I0 (UniProtKB/TrEMBL),   A0A8L2QMR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948276   ⟸   XM_039092348
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GD04 (UniProtKB/TrEMBL),   A6JC87 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085326   ⟸   ENSRNOT00000119387
Ensembl Acc Id: ENSRNOP00000090872   ⟸   ENSRNOT00000109833
Ensembl Acc Id: ENSRNOP00000091119   ⟸   ENSRNOT00000107481
Ensembl Acc Id: ENSRNOP00000085818   ⟸   ENSRNOT00000116201
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R010-F1-model_v2 AlphaFold Q9R010 1-191 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690139
Promoter ID:EPDNEW_R663
Type:initiation region
Name:Cib1_1
Description:calcium and integrin binding 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01142,020,491 - 142,020,551EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620133 AgrOrtholog
BioCyc Gene G2FUF-58755 BioCyc
Ensembl Genes ENSRNOG00000033498 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000109833 ENTREZGENE
  ENSRNOT00000116201 ENTREZGENE
  ENSRNOT00000119387 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7308828 IMAGE-MGC_LOAD
InterPro CIBP UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
KEGG Report rno:81823 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108662 IMAGE-MGC_LOAD
NCBI Gene 81823 ENTREZGENE
PANTHER CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2 UniProtKB/Swiss-Prot
  CALCIUM AND INTEGRIN-BINDING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
PhenoGen Cib1 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033498 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8I6A2I0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACA7_RAT UniProtKB/TrEMBL
  A0A8I6AF54_RAT UniProtKB/TrEMBL
  A0A8I6GD04 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QMR3 ENTREZGENE, UniProtKB/TrEMBL
  A6JC87 ENTREZGENE, UniProtKB/TrEMBL
  A6JC88 ENTREZGENE, UniProtKB/TrEMBL
  A6JC89_RAT UniProtKB/TrEMBL
  CIB1_RAT UniProtKB/Swiss-Prot
  Q5BKA8 ENTREZGENE
  Q9R010 ENTREZGENE
UniProt Secondary Q5BKA8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Cib1  calcium and integrin binding 1  Cib1  calcium and integrin binding 1 (calmyrin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Cib1  calcium and integrin binding 1 (calmyrin)  Sip2-28  calcium- and integrin-binding protein  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Sip2-28  calcium- and integrin-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL