Prl8a7 (prolactin family 8, subfamily A, member 7) - Rat Genome Database

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Gene: Prl8a7 (prolactin family 8, subfamily A, member 7) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prl8a7
Name: prolactin family 8, subfamily A, member 7
RGD ID: 620115
Description: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease and impulse control disorder. Orthologous to human PRL (prolactin); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ghd10; growth hormone d10; growth hormone-related protein 1; MGC114320; placental prolactin-like protein D; PLP-D; PRL-like protein D; Prlpd; prolactin-8A7; prolactin-like protein D
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81737,767,210 - 37,773,112 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1737,767,271 - 37,773,106 (+)EnsemblGRCr8
mRatBN7.21737,558,822 - 37,564,724 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1737,558,883 - 37,564,718 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1737,427,592 - 37,433,389 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01739,031,614 - 39,037,411 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01737,375,316 - 37,381,113 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01739,509,516 - 39,515,418 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1739,509,516 - 39,515,412 (+)Ensemblrn6Rnor6.0
Rnor_5.01741,426,985 - 41,432,887 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41744,148,437 - 44,154,238 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1737,062,789 - 37,068,590 (+)NCBICelera
RGSC_v3.11744,151,277 - 44,157,079 (+)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein D (PLP-D). Iwatsuki K, etal., Endocrinology 1996 Sep;137(9):3849-55.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2351117   PMID:12477932   PMID:15489334   PMID:26697363   PMID:26862561  


Genomics

Variants

.
Variants in Prl8a7
49 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:75
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000022797
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat

Markers in Region
RH127679  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21737,564,286 - 37,564,481 (+)MAPPERmRatBN7.2
Rnor_6.01739,514,981 - 39,515,175NCBIRnor6.0
Rnor_5.01741,432,450 - 41,432,644UniSTSRnor5.0
RGSC_v3.41744,153,902 - 44,154,096UniSTSRGSC3.4
Celera1737,068,254 - 37,068,448UniSTS
Cytogenetic Map17p11UniSTS
BI284285  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81737,773,286 - 37,773,441 (+)Marker Load Pipeline
mRatBN7.21737,564,898 - 37,565,053 (+)MAPPERmRatBN7.2
Rnor_6.01739,515,593 - 39,515,747NCBIRnor6.0
Rnor_5.01741,433,062 - 41,433,216UniSTSRnor5.0
RGSC_v3.41744,154,514 - 44,154,668UniSTSRGSC3.4
Celera1737,068,866 - 37,069,020UniSTS
RH 3.4 Map17436.89UniSTS
Cytogenetic Map17p11UniSTS


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
18 2 2 2 2 5 1 1 17 2 12

Sequence


Ensembl Acc Id: ENSRNOT00000022797   ⟹   ENSRNOP00000022797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,559,602 - 37,564,718 (+)Ensembl
Rnor_6.0 Ensembl1739,509,516 - 39,515,317 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087330   ⟹   ENSRNOP00000068804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1737,767,271 - 37,773,106 (+)Ensembl
mRatBN7.2 Ensembl1737,558,883 - 37,564,718 (+)Ensembl
Rnor_6.0 Ensembl1739,510,936 - 39,515,412 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108614   ⟹   ENSRNOP00000077020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1737,767,271 - 37,773,106 (+)Ensembl
mRatBN7.2 Ensembl1737,558,883 - 37,564,718 (+)Ensembl
RefSeq Acc Id: NM_022537   ⟹   NP_071982
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81737,767,210 - 37,773,011 (+)NCBI
mRatBN7.21737,558,822 - 37,564,623 (+)NCBI
Rnor_6.01739,509,516 - 39,515,317 (+)NCBI
Rnor_5.01741,426,985 - 41,432,887 (+)NCBI
RGSC_v3.41744,148,437 - 44,154,238 (+)RGD
Celera1737,062,789 - 37,068,590 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253909   ⟹   XP_006253971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81737,767,229 - 37,773,112 (+)NCBI
mRatBN7.21737,558,851 - 37,564,724 (+)NCBI
Rnor_6.01739,509,545 - 39,515,418 (+)NCBI
Rnor_5.01741,426,985 - 41,432,887 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_071982 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253971 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98917 (Get FASTA)   NCBI Sequence Viewer  
  BAA19054 (Get FASTA)   NCBI Sequence Viewer  
  CDW51450 (Get FASTA)   NCBI Sequence Viewer  
  EDL98422 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068804
GenBank Protein P33578 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071982   ⟸   NM_022537
- Peptide Label: precursor
- UniProtKB: P97786 (UniProtKB/Swiss-Prot),   Q4FZY5 (UniProtKB/Swiss-Prot),   P33578 (UniProtKB/Swiss-Prot),   A6J7S2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253971   ⟸   XM_006253909
- Peptide Label: isoform X1
- UniProtKB: A0A0M6L0K4 (UniProtKB/TrEMBL),   A0A0G2JTQ7 (UniProtKB/TrEMBL),   A6J7S2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068804   ⟸   ENSRNOT00000087330
Ensembl Acc Id: ENSRNOP00000022797   ⟸   ENSRNOT00000022797
Ensembl Acc Id: ENSRNOP00000077020   ⟸   ENSRNOT00000108614

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33578-F1-model_v2 AlphaFold P33578 1-240 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620115 AgrOrtholog
BioCyc Gene G2FUF-9454 BioCyc
Ensembl Genes ENSRNOG00000016933 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000087330 ENTREZGENE
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7445772 IMAGE-MGC_LOAD
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  Somatotropin/Prolactin UniProtKB/Swiss-Prot
KEGG Report rno:64368 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114320 IMAGE-MGC_LOAD
NCBI Gene 64368 ENTREZGENE
PANTHER PROLACTIN-8A6-RELATED UniProtKB/Swiss-Prot
  PTHR11417 UniProtKB/Swiss-Prot
Pfam Hormone_1 UniProtKB/Swiss-Prot
PhenoGen Prl8a7 PhenoGen
RatGTEx ENSRNOG00000016933 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A0A0G2JTQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A0M6L0K4 ENTREZGENE
  A0A8I5XVP8_RAT UniProtKB/TrEMBL
  A6J7S2 ENTREZGENE, UniProtKB/TrEMBL
  P33578 ENTREZGENE
  P97786 ENTREZGENE
  PR8A7_RAT UniProtKB/Swiss-Prot
  Q4FZY5 ENTREZGENE
UniProt Secondary P97786 UniProtKB/Swiss-Prot
  Q4FZY5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-07 Prl8a7  prolactin family 8, subfamily A, member 7  Prl8a7  prolactin family 8, subfamily a, member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-05-04 Prl8a7  prolactin family 8, subfamily a, member 7  Prlpd  prolactin-like protein D  Symbol and Name updated 1624237 APPROVED
2002-08-07 Prlpd  prolactin-like protein D      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains one putative N-glycosylation site and six cysteine residues 633800
gene_expression mRNA first appears at day 14 of pregnancy and increased until term 633800