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Gene: Gdf7 (growth differentiation factor 7) Rattus norvegicus

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Symbol:

Gdf7

Name:

growth differentiation factor 7

RGD ID:

620105

Description:

Predicted to enable cytokine activity and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of SMAD protein signal transduction; positive regulation of macromolecule biosynthetic process; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within several processes, including morphogenesis of an epithelium; nervous system development; and positive regulation of neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human GDF7 (growth differentiation factor 7); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; C60 fullerene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

growth/differentiation factor 7; LOC366572

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GDF7 (growth differentiation factor 7)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gdf7 (growth differentiation factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gdf7 (growth differentiation factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GDF7 (growth differentiation factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GDF7 (growth differentiation factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gdf7 (growth differentiation factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GDF7 (growth differentiation factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GDF7 (growth differentiation factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gdf7 (growth differentiation factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gdf7 (growth differentiation factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GDF7 (growth differentiation factor 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gdf7 (growth differentiation factor 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gdf7 (growth differentiation factor 7)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gdf7	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	36,890,799 - 36,901,783 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	36,890,799 - 36,901,783 (-)	Ensembl				GRCr8
mRatBN7.2	6	31,171,495 - 31,182,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	31,178,119 - 31,182,447 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	31,463,589 - 31,474,571 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	31,779,510 - 31,790,492 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	31,254,019 - 31,265,005 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	33,496,596 - 33,507,626 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	33,503,217 - 33,507,542 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	43,281,722 - 43,292,667 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	31,857,104 - 31,861,428 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	30,628,297 - 30,632,622 (-)	NCBI		Celera
RGSC_v3.1	6	31,860,390 - 31,860,592 (-)	NCBI
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

C60 fullerene (EXP)

CGP 52608 (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

decabromodiphenyl ether (ISO)

dioxygen (ISO)

fonofos (ISO)

fructose (ISO)

glucose (ISO)

lidocaine (EXP)

okadaic acid (ISO)

parathion (ISO)

rotenone (ISO)

sodium arsenite (ISO)

terbufos (ISO)

testosterone (ISO)

Tetrachlorobisphenol A (ISO)

titanium dioxide (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activin receptor signaling pathway (ISO)

axon guidance (ISO)

BMP signaling pathway (ISO)

branching morphogenesis of an epithelial tube (ISO)

cell fate commitment (ISO)

epithelial cell differentiation (ISO)

forebrain morphogenesis (ISO)

gland morphogenesis (ISO)

midbrain development (ISO)

morphogenesis of an epithelial fold (ISO)

neural tube development (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of gene expression (ISO)

positive regulation of neuron differentiation (ISO)

positive regulation of SMAD protein signal transduction (ISO)

positive regulation of tendon cell differentiation (ISO)

reproductive structure development (ISO)

roof plate formation (ISO)

spinal cord association neuron differentiation (ISO)

Cellular Component

extracellular region (IEA,ISO)

extracellular space (NAS)

Molecular Function

growth factor activity (IEA)

identical protein binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

transforming growth factor-beta superfamily mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Gene expression of growth differentiation factors in the developing periodontium of rat molars.	Sena K, etal., J Dent Res 2003 Mar;82(3):166-71.

Additional References at PubMed

PMID:9786991	PMID:10693795	PMID:11356021	PMID:11356025	PMID:12639970	PMID:12741987	PMID:15883363	PMID:16049014	PMID:21412429	PMID:21469182

Genomics

Comparative Map Data

Gdf7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	36,890,799 - 36,901,783 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	36,890,799 - 36,901,783 (-)	Ensembl				GRCr8
mRatBN7.2	6	31,171,495 - 31,182,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	31,178,119 - 31,182,447 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	31,463,589 - 31,474,571 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	31,779,510 - 31,790,492 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	31,254,019 - 31,265,005 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	33,496,596 - 33,507,626 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	33,503,217 - 33,507,542 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	43,281,722 - 43,292,667 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	31,857,104 - 31,861,428 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	30,628,297 - 30,632,622 (-)	NCBI		Celera
RGSC_v3.1	6	31,860,390 - 31,860,592 (-)	NCBI
Cytogenetic Map	6	q14	NCBI

GDF7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	20,667,144 - 20,679,243 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	20,667,144 - 20,679,243 (+)	Ensembl			hg38	GRCh38
GRCh37	2	20,866,904 - 20,879,003 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	20,729,905 - 20,734,731 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	20,788,051 - 20,792,878	NCBI
Celera	2	20,728,800 - 20,733,639 (+)	NCBI		Celera
Cytogenetic Map	2	p24.1	NCBI
HuRef	2	20,623,337 - 20,628,206 (+)	NCBI		HuRef
CHM1_1	2	20,795,793 - 20,800,641 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	20,700,448 - 20,712,559 (+)	NCBI		T2T-CHM13v2.0

Gdf7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	8,347,918 - 8,351,954 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	8,347,918 - 8,351,954 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	8,297,918 - 8,301,954 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	8,297,918 - 8,301,954 (-)	Ensembl			mm10	GRCm38
MGSCv37	12	8,304,724 - 8,308,760 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	8,323,926 - 8,327,962 (-)	NCBI		MGSCv36	mm8
Celera	12	8,691,764 - 8,695,838 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	3.85	NCBI

Gdf7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955469	3,134,355 - 3,149,177 (+)	NCBI	ChiLan1.0	ChiLan1.0

GDF7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	105,850,267 - 105,862,341 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	105,859,696 - 105,866,313 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	20,651,617 - 20,664,586 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	20,766,776 - 20,773,082 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

GDF7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	15,627,739 - 15,636,513 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	15,589,160 - 15,593,215 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	15,776,555 - 15,780,607 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	15,776,555 - 15,780,607 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	15,630,398 - 15,634,442 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	15,637,476 - 15,641,523 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	15,669,550 - 15,673,607 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gdf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	60,026,695 - 60,039,004 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	10,808,714 - 10,812,761 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	10,808,714 - 10,812,761 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GDF7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	117,587,430 - 117,592,466 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	117,586,188 - 117,592,541 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	125,548,358 - 125,553,115 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GDF7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	87,013,821 - 87,027,977 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	87,023,028 - 87,027,194 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	25,180,063 - 25,192,565 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gdf7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624738	3,281,828 - 3,286,627 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gdf7
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	28,638,565 - 28,642,879 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gdf7
65 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	216
Count of miRNA genes:	157
Interacting mature miRNAs:	174
Transcripts:	ENSRNOT00000007928
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	44788383	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	33328841	78328841	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	1	40163351	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	33328841	78328841	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
14	7	40	126	36	33	9	32	9	4	188	99	7	109	61	76	24	6	6

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001170350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB087406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC142360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007928 ⟹ ENSRNOP00000007928

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	31,178,119 - 31,182,447 (-)	Ensembl
Rnor_6.0 Ensembl	6	33,503,217 - 33,507,542 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000155630 ⟹ ENSRNOP00000101233

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	36,890,799 - 36,901,783 (-)	Ensembl

RefSeq Acc Id:

NM_001170350 ⟹ NP_001163821

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	36,890,799 - 36,901,783 (-)	NCBI
mRatBN7.2	6	31,171,495 - 31,182,484 (-)	NCBI
Rnor_6.0	6	33,503,217 - 33,507,542 (-)	NCBI
Rnor_5.0	6	43,281,722 - 43,292,667 (-)	NCBI
RGSC_v3.4	6	31,857,104 - 31,861,428 (-)	RGD
Celera	6	30,628,297 - 30,632,622 (-)	RGD

Sequence:

show sequence

GCCGGCCGGCCCACGGAGCCCATGGACCTGAGCGCTGCCGCCGCGCTGTGTCTCTGGCTGCTGA
GCGCTTGCCGTCCCCGCGACGGGCTGGAAGCTGCCGCGGTGCTCCGAGCGGCGGGAGCAGGACC
AGCCTGGAGCCCGGGGGGCGGCGGCGGCGGGCGGACCCTCGCCCCAGCTCCAGGCCCTTCAGCT
CTCCAGGCCGCTGCGGTTCCCGGTCCCCGCGCTGTGCGCCGCGCCGCGGGCTCCGGCTTCAGGA
ACGGCTCGGTGGTGCCACACCACTTCATGATGTCGCTTTACCGGAGCCTGGCGGGGAGGGCTCC
TGCCGCGGCAACTTCAGGGCACGGGCGCGTGGACACGATCACCGGCTTCACAGACCAAGCAACT
CAAGGCCAGAGCTTCTTATTCGACGTATCCAGCCTCTCGGACTCCGACGAGGTGGTGAATGCCG
AGCTGCGCGTGCTGCGCCGGAGGTCTCCGGAGCCAGACAGGGACAGTGCGACCCTCCCTCCGCT
GCTGCTGCTGTCCACGTGCCCGGACGAGGCCGGCACAGCTCACTTGCTGCACTCGCGGGCCGCC
GAGCCCCTAGACAGCGCGCGCTGGGAAGCGTTCGACGTGACGGACGCGGTGCAGAGTCACCGCC
GCTGGCCGCGCACCTCCCGCAAGTTCTGCCTGGTGCTGCGCGCGGTGACGGGCGCCGAGAGCAG
CCCGCTGGCCCTGAGAAGACTGGGCTTCGGCTGGCCTGGCGGTGGCGACGGCGGCGGCACGGCA
GCCGAGGAGCGCGCGCTGTTGGTGATCTCCTCCCGCACGCACAGGAAAGAGAGTCTGTTCCGGG
AGATACGCGCCCAGGCCCGCGCTCTCCGGGCCGCCGCAGAGCTGCCACCAGATCCAGGACTAGG
CGCTGGATCTCGGAAAGCCACCCCGGGCGGTCGCAGGCGGCGACGGACCGCGCTGGCTGGGACT
CGGGGAGCGCAGGGAAGCGGTGGCGGCGGTGGGGGCGGTGGCGGCGGCGGCGGCGGCGGCGGTG
GCGCAGGCAGGGGCCACGGGCGCAGAGGCAGGAGCCGCTGCAGTCGCAAGCCACTGCATGTGGA
CTTTAAGGAGCTGGGCTGGGACGACTGGATCATCGCGCCATTAGACTACGAGGCATACCACTGC
GAGGGCGTTTGCGACTTTCCTCTGCGCTCGCACCTGGAGCCTACCAACCACGCCATCATCCAGA
CGCTGCTCAACTCCATGGCGCCGGATGCGGCGCCAGCCTCCTGCTGCGTGCCCGCACGTCTCAG
CCCCATCAGCATCCTCTACATCGACGCCGCCAACAACGTGGTCTACAAGCAGTACGAGGACATG
GTGGTAGAGGCCTGCGGCTGCAGGTAGCATGAGGTCTGGGGAGGGTTTTGCTGCCCAGGACCCT
AGCCGAAGAGCGTGAGTCACCAGGCCCGAGGGAAGGCGGACAATGTTCTCTGCCAGCAGAGGAG
AGCACACAGTTAACACTCACATTTACACACTCCTTCACTCGCGCACATGTTTACTGTGGATGCC
AGGCGCTGAAAGCCTTGGACAGAGATAGTATGCAGCGACTTGATGTCATAGCCGTGTTCGTTTG
CTGACGTTGATACAAACCTCTGTCCCTTTGGGGAGAGGGAAGGGTGTCTGTGTTTATGTT

hide sequence

RefSeq Acc Id:

NM_001399290 ⟹ NP_001386219

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	36,890,799 - 36,901,783 (-)	NCBI
mRatBN7.2	6	31,171,495 - 31,182,484 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001163821	(Get FASTA)	NCBI Sequence Viewer
	NP_001386219	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC02715	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000101233
	ENSRNOP00000101233.1

RefSeq Acc Id:	NP_001163821 ⟸ NM_001170350
- Peptide Label:	isoform 2 precursor
- UniProtKB:	F1MAE8 (UniProtKB/TrEMBL), A6HAL5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPAWSPGGGGGGRTLAPAPGPSALQAAAVP GPRAVRRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAAATSGHGRVDTITGFTDQATQGQSFLF DVSSLSDSDEVVNAELRVLRRRSPEPDRDSATLPPLLLLSTCPDEAGTAHLLHSRAAEPLDSAR WEAFDVTDAVQSHRRWPRTSRKFCLVLRAVTGAESSPLALRRLGFGWPGGGDGGGTAAEERALL VISSRTHRKESLFREIRAQARALRAAAELPPDPGLGAGSRKATPGGRRRRRTALAGTRGAQGSG GGGGGGGGGGGGGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGVCDFP LRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC R hide sequence

Ensembl Acc Id:

ENSRNOP00000007928 ⟸ ENSRNOT00000007928

RefSeq Acc Id:	NP_001386219 ⟸ NM_001399290
- Peptide Label:	isoform 1 precursor
- UniProtKB:	A6HAL5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000101233 ⟸ ENSRNOT00000155630

Protein Domains

TGF-beta family profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1MAE8-F1-model_v2	AlphaFold	F1MAE8	1-449	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620105	AgrOrtholog
BioCyc Gene	G2FUF-38198	BioCyc
Ensembl Genes	ENSRNOG00000006046	Ensembl
	ENSRNOG00000088409	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000155630	ENTREZGENE
	ENSRNOT00000155630.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
	2.60.120.970	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-b_N	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
NCBI Gene	252833	ENTREZGENE
PANTHER	GROWTH/DIFFERENTIATION FACTOR 7	UniProtKB/TrEMBL
	TGFbeta	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TGFb_propeptide	UniProtKB/TrEMBL
PhenoGen	Gdf7	PhenoGen
PROSITE	TGF_BETA_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006046	RatGTEx
	ENSRNOG00000088409	RatGTEx
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0ABK0LI89_RAT	UniProtKB/TrEMBL
	A6HAL5	ENTREZGENE, UniProtKB/TrEMBL
	F1MAE8	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-02	Gdf7	growth differentiation factor 7	Gdf7_predicted	growth differentiation factor 7 (predicted)	Data merged from RGD:1311179	737654	APPROVED
2005-01-20	Gdf7	growth differentiation factor 7			Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	Gdf7_predicted	growth differentiation factor 7 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-08-07	Gdf7	growth differentiation factor 7			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)