Gdf7 (growth differentiation factor 7) - Rat Genome Database

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Gene: Gdf7 (growth differentiation factor 7) Rattus norvegicus
Analyze
Symbol: Gdf7
Name: growth differentiation factor 7
RGD ID: 620105
Description: Predicted to enable cytokine activity and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of SMAD protein signal transduction; positive regulation of macromolecule biosynthetic process; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within several processes, including morphogenesis of an epithelium; nervous system development; and positive regulation of neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human GDF7 (growth differentiation factor 7); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: growth/differentiation factor 7; LOC366572
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8636,890,799 - 36,901,783 (-)NCBIGRCr8
mRatBN7.2631,171,495 - 31,182,484 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl631,178,119 - 31,182,447 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx631,463,589 - 31,474,571 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0631,779,510 - 31,790,492 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0631,254,019 - 31,265,005 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0633,496,596 - 33,507,626 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,503,217 - 33,507,542 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0643,281,722 - 43,292,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4631,857,104 - 31,861,428 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1631,860,390 - 31,860,592 (-)NCBI
Celera630,628,297 - 30,632,622 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Gene expression of growth differentiation factors in the developing periodontium of rat molars. Sena K, etal., J Dent Res 2003 Mar;82(3):166-71.
Additional References at PubMed
PMID:9786991   PMID:10693795   PMID:11356021   PMID:11356025   PMID:12639970   PMID:12741987   PMID:15883363   PMID:16049014   PMID:21412429   PMID:21469182  


Genomics

Comparative Map Data
Gdf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8636,890,799 - 36,901,783 (-)NCBIGRCr8
mRatBN7.2631,171,495 - 31,182,484 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl631,178,119 - 31,182,447 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx631,463,589 - 31,474,571 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0631,779,510 - 31,790,492 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0631,254,019 - 31,265,005 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0633,496,596 - 33,507,626 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,503,217 - 33,507,542 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0643,281,722 - 43,292,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4631,857,104 - 31,861,428 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1631,860,390 - 31,860,592 (-)NCBI
Celera630,628,297 - 30,632,622 (-)NCBICelera
Cytogenetic Map6q14NCBI
GDF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38220,667,144 - 20,679,243 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl220,667,144 - 20,679,243 (+)EnsemblGRCh38hg38GRCh38
GRCh37220,866,904 - 20,879,003 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36220,729,905 - 20,734,731 (+)NCBINCBI36Build 36hg18NCBI36
Build 34220,788,051 - 20,792,878NCBI
Celera220,728,800 - 20,733,639 (+)NCBICelera
Cytogenetic Map2p24.1NCBI
HuRef220,623,337 - 20,628,206 (+)NCBIHuRef
CHM1_1220,795,793 - 20,800,641 (+)NCBICHM1_1
T2T-CHM13v2.0220,700,448 - 20,712,559 (+)NCBIT2T-CHM13v2.0
Gdf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39128,347,918 - 8,351,954 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl128,347,918 - 8,351,954 (-)EnsemblGRCm39 Ensembl
GRCm38128,297,918 - 8,301,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl128,297,918 - 8,301,954 (-)EnsemblGRCm38mm10GRCm38
MGSCv37128,304,724 - 8,308,760 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36128,323,926 - 8,327,962 (-)NCBIMGSCv36mm8
Celera128,691,764 - 8,695,838 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map123.85NCBI
Gdf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554693,134,355 - 3,149,177 (+)NCBIChiLan1.0ChiLan1.0
GDF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212105,850,267 - 105,862,341 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A105,859,696 - 105,866,313 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A20,651,617 - 20,664,586 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A20,766,776 - 20,773,082 (+)NCBIpanpan1.1PanPan1.1panPan2
GDF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11715,627,739 - 15,636,513 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1715,589,160 - 15,593,215 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01715,776,555 - 15,780,607 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1715,776,555 - 15,780,607 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11715,630,398 - 15,634,442 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01715,637,476 - 15,641,523 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01715,669,550 - 15,673,607 (+)NCBIUU_Cfam_GSD_1.0
Gdf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629260,026,695 - 60,039,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649310,808,714 - 10,812,761 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649310,808,714 - 10,812,761 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3117,587,430 - 117,592,466 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13117,586,188 - 117,592,541 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23125,548,358 - 125,553,115 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11487,013,821 - 87,027,977 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1487,023,028 - 87,027,194 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604525,180,063 - 25,192,565 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247383,281,828 - 3,286,627 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gdf7
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:157
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000007928
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4
Low 2 17 15 7 2
Below cutoff 2 23 10 4 5 6 44 14 18 7 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007928   ⟹   ENSRNOP00000007928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl631,178,119 - 31,182,447 (-)Ensembl
Rnor_6.0 Ensembl633,503,217 - 33,507,542 (-)Ensembl
RefSeq Acc Id: NM_001170350   ⟹   NP_001163821
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8636,890,799 - 36,901,783 (-)NCBI
mRatBN7.2631,171,495 - 31,182,484 (-)NCBI
Rnor_6.0633,503,217 - 33,507,542 (-)NCBI
Rnor_5.0643,281,722 - 43,292,667 (-)NCBI
RGSC_v3.4631,857,104 - 31,861,428 (-)RGD
Celera630,628,297 - 30,632,622 (-)RGD
Sequence:
RefSeq Acc Id: NM_001399290   ⟹   NP_001386219
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8636,890,799 - 36,901,783 (-)NCBI
mRatBN7.2631,171,495 - 31,182,484 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001163821 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386219 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC02715 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007928
  ENSRNOP00000007928.5
Reference Protein Sequences
RefSeq Acc Id: NP_001163821   ⟸   NM_001170350
- Peptide Label: isoform 2 precursor
- UniProtKB: F1MAE8 (UniProtKB/TrEMBL),   A6HAL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007928   ⟸   ENSRNOT00000007928
RefSeq Acc Id: NP_001386219   ⟸   NM_001399290
- Peptide Label: isoform 1 precursor
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAE8-F1-model_v2 AlphaFold F1MAE8 1-449 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620105 AgrOrtholog
BioCyc Gene G2FUF-38198 BioCyc
Ensembl Genes ENSRNOG00000006046 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007928 ENTREZGENE
  ENSRNOT00000007928.6 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_N UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report rno:252833 UniProtKB/TrEMBL
NCBI Gene 252833 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 7 UniProtKB/TrEMBL
  TGFbeta UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PhenoGen Gdf7 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006046 RatGTEx
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A6HAL5 ENTREZGENE, UniProtKB/TrEMBL
  F1MAE8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-02 Gdf7  growth differentiation factor 7  Gdf7_predicted  growth differentiation factor 7 (predicted)  Data merged from RGD:1311179 737654 APPROVED
2005-01-20 Gdf7  growth differentiation factor 7      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Gdf7_predicted  growth differentiation factor 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Gdf7  growth differentiation factor 7      Symbol and Name status set to provisional 70820 PROVISIONAL