Gene: GDF7 (growth differentiation factor 7)
Homo sapiens
Symbol:
GDF7
Name:
growth differentiation factor 7
Description:
This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
BMP12; GDF-7; growth/differentiation factor 7; OTTHUMP00000115986
Orthologs:
Mus musculus : Gdf7
(growth differentiation factor 7)
MGI
Gdf7
(growth differentiation factor 7)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 2 20,807,496 - 20,812,187 + NCBI Human Genome Assembly HuRef 2 20,623,337 - 20,628,206 + NCBI Human Genome Assembly GRCh37 2 20,866,424 - 20,871,250 + NCBI Human Celera Assembly 2 20,728,800 - 20,733,639 + NCBI Human Genome Assembly Build 36 2 20,729,905 - 20,734,731 + NCBI Human Cytogenetic Map 2 p24.1 NCBI Human Genome Assembly 2 20,788,051 - 20,792,878 NCBI
Model
Gene Ontology Annotations
Biological Process activin receptor signaling pathway IDA 2290271 PMID:16049014 BHF-UCL PMID:16049014 axon guidance IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 BMP signaling pathway IDA 2290271 PMID:16049014 BHF-UCL PMID:16049014 branching morphogenesis of an epithelial tube IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cell fate commitment IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 epithelial cell differentiation IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 forebrain morphogenesis IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 gland morphogenesis IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 growth IEA InterPro:IPR001111 2290271 GO_REF:0000002 InterPro GO_REF:0000002 midbrain development IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 morphogenesis of an epithelial fold IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 pathway-restricted SMAD protein phosphorylation IDA 2290271 PMID:16049014 BHF-UCL PMID:16049014 positive regulation of neuron differentiation IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of pathway-restricted SMAD protein phosphorylation IDA 2290271 PMID:16049014 BHF-UCL PMID:16049014 positive regulation of tendon cell differentiation IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of transcription, DNA-dependent IDA 2290271 PMID:16049014 BHF-UCL PMID:16049014 reproductive structure development IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 roof plate formation IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 spinal cord association neuron differentiation IEA Ensembl:ENSMUSP00000038301 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019
1643271 BW214_H Body weight QTL 214 (human) 2.12 .0021 Body weight BMI 2 1 21078135 Human 1643370 BW334_H Body weight QTL 334 (human) 2 Body morphometry waist circumference 2 1 21078135 Human 2316730 GLUCO280_H Glucose level QTL 280 (human) 1.9 .00278 Glucose level 2 1 24445579 Human 1643381 BW335_H Body weight QTL 335 (human) 2.45 Body weight BMI 2 1 24606996 Human 1559122 SCL42_H Serum cholesterol level QTL 42 (human) 2.3 .09 Lipid level LDL cholesterol 2 367703 26367703 Human 1559340 SCL85_H Serum cholesterol level QTL 85 (human) 2.17 .0008 Lipid level LDL cholesterol 2 2227411 28227411 Human 1643262 BW207_H Body weight QTL 207 (human) 1.7 .003 Body weight BMI 2 4492026 30492026 Human 2292859 PRSTS25_H Prostate tumor susceptibility QTL 25 (human) Prostate tumor susceptibility early onset 2 4492026 30492026 Human 2316727 GLUCO281_H Glucose level QTL 281 (human) 1.98 .0023 Glucose level 2 6418587 32418587 Human 1559337 SCL86_H Serum cholesterol level QTL 86 (human) 1.54 .004 Lipid level total cholesterol 2 8086103 34086103 Human 2315784 GLUCO164_H Glucose level QTL 164 (human) 1.77 .0022 Glucose level 2 15227294 21086187 Human 2289642 BW507_H Body weight QTL 507 (human) 2.91 Body weight BMI 2 15603469 41603469 Human 2289647 INSUL1_H Insulin level QTL 1 (human) 3 Insulin level fasting 2 15603469 41603469 Human 2289649 BW508_H Body weight QTL 508 (human) 3.43 Body fat amount none 2 15603469 41603469 Human 1357382 SLEP2_H Serum leptin level QTL 2 (human) 4.95 .0000009 Hormone level leptin 2 17491957 68239157 Human 1298419 OSTEAR20_H Osteoarthritis QTL 20 (human) 1.48 Joint/bone inflammation ideopathic hand osteoarthritis 2 19941942 21576170 Human
Gene Ontology Annotations
