Ocln (occludin) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Ocln (occludin) Rattus norvegicus
Analyze
Symbol: Ocln
Name: occludin
RGD ID: 620089
Description: Predicted to enable protein domain specific binding activity. Involved in several processes, including cellular response to tumor necrosis factor; response to Gram-positive bacterium; and response to interleukin-18. Located in apical plasma membrane and lateral plasma membrane. Biomarker of diabetic retinopathy; metabolic dysfunction and alcohol associated liver disease; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; hepatitis C pathway; INTERACTS WITH (R)-carnitine; 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,391,303 - 33,442,207 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl233,391,303 - 33,430,411 (-)EnsemblGRCr8
mRatBN7.2231,657,217 - 31,707,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,657,220 - 31,764,150 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx238,791,782 - 38,841,944 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,819,361 - 36,869,279 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,690,347 - 31,739,905 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,527,327 - 30,577,218 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,527,715 - 30,577,218 (-)Ensemblrn6Rnor6.0
Rnor_5.0249,686,707 - 49,737,380 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4231,317,090 - 31,367,485 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera227,670,881 - 27,719,967 (-)NCBICelera
RGSC_v3.1231,237,461 - 31,287,854 (-)NCBI
Cytogenetic Map2q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (ISO)
(R)-carnitine  (EXP)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-estradiol 3-benzoate  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
4-tert-Octylphenol  (EXP)
5-azacytidine  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-O-alpha-D-glucopyranosyl-D-fructofuranose  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-dihydroxycoumarin  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acrylonitrile  (ISO)
actinidine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (ISO)
Alpinetin  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
ampicillin  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
chlorogenic acid  (EXP)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corn oil  (EXP)
corticosterone  (ISO)
cortisol  (ISO)
CU-CPT22  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
Dictamnine  (ISO)
diethyl phthalate  (ISO)
diiodine  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
dizocilpine maleate  (ISO)
dodecanoic acid  (ISO)
doramapimod  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylene glycol  (EXP)
excitatory amino acid agonist  (ISO)
ferrostatin-1  (ISO)
ferulic acid  (ISO)
flutamide  (EXP)
folic acid  (ISO)
Forsythiaside  (ISO)
FR900359  (ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
galactose  (ISO)
gamma-linolenic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgolide A  (ISO)
ginsenoside Re  (ISO)
glabridin  (ISO)
glucose  (ISO)
glycine  (ISO)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
hydroxychloroquine  (ISO)
hydroxysafflor yellow A  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprene  (ISO)
isovitexin  (EXP)
kaempferol  (EXP,ISO)
ketamine  (ISO)
kynurenic acid  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactulose  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
malaoxon  (EXP)
malathion  (EXP)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
metronidazole  (ISO)
microcystin-LR  (EXP,ISO)
minocycline  (EXP)
Mitoquinone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP,ISO)
mycophenolic acid  (ISO)
myricetin  (EXP)
N(6),N(6)-dimethyladenine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
Neoisoliquiritin  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
NMN zwitterion  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oxybenzone  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
papaverine  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
patulin  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phoxim  (EXP)
pirinixic acid  (ISO)
poly(vinylpyrrolidone)  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
probenecid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
Salidroside  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium propionate  (ISO)
sodium sulfide (anhydrous)  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulfasalazine  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (EXP)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tectorigenin  (ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
tioguanine  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
Torularhodin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
uranium atom  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
zafirlukast  (ISO)
zileuton  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression. Chehade JM, etal., Neurochem Res 2002 Mar;27(3):249-52.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Protective Effect of 4-Methoxy Benzyl Alcohol on the Blood-Brain Barrier after Cerebral Ischemia Reperfusion Injury. He F, etal., J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1258-1265. doi: 10.1016/j.jstrokecerebrovasdis.2017.01.018. Epub 2017 Apr 7.
5. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. Hori S, etal., J Neurochem 2004 Apr;89(2):503-13.
6. The glucose transporter GLUT1 and the tight junction protein occludin in nasal olfactory mucosa. Hussar P, etal., Chem Senses 2002 Jan;27(1):7-11.
7. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Khailova L, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug 27.
8. S-methylation of 2-mercaptopyrazine in rat liver microsomes and cytosol. Lee DH and Kim DH, Xenobiotica 1999 Sep;29(9):909-16.
9. Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Li X, etal., Biochim Biophys Acta. 2012 Feb;1822(2):196-203. doi: 10.1016/j.bbadis.2011.09.019. Epub 2011 Oct 7.
10. Linderae radix ethanol extract attenuates alcoholic liver injury via attenuating inflammation and regulating gut microbiota in rats. Lou Z, etal., Braz J Med Biol Res. 2019;52(6):e7628. doi: 10.1590/1414-431X20197628. Epub 2019 May 16.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Increase in the tight junction protein claudin-1 in intestinal inflammation. Poritz LS, etal., Dig Dis Sci. 2011 Oct;56(10):2802-9. doi: 10.1007/s10620-011-1688-9. Epub 2011 Jul 12.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Focal adhesion kinase is a blood-testis barrier regulator. Siu ER, etal., Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9298-303. doi: 10.1073/pnas.0813113106. Epub 2009 May 21.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK). Su L, etal., Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19623-8. doi: 10.1073/pnas.1111414108. Epub 2011 Nov 21.
22. Bile canalicular barrier function and expression of tight-junctional molecules in rat hepatocytes during common bile duct ligation. Takakuwa Y, etal., Cell Tissue Res 2002 Feb;307(2):181-9.
23. Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury. Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24.
24. Dendrobium chrysotoxum Lindl. alleviates diabetic retinopathy by preventing retinal inflammation and tight junction protein decrease. Yu Z, etal., J Diabetes Res. 2015;2015:518317. doi: 10.1155/2015/518317. Epub 2015 Jan 1.
Additional References at PubMed
PMID:9647647   PMID:11025210   PMID:11090614   PMID:11782481   PMID:11810420   PMID:12060405   PMID:12498716   PMID:12507281   PMID:12734665   PMID:14685273   PMID:15052661   PMID:15489334  
PMID:15528189   PMID:15605377   PMID:15775979   PMID:16365161   PMID:16510873   PMID:16520537   PMID:16651389   PMID:17000770   PMID:17065217   PMID:17130295   PMID:17245419   PMID:17666436  
PMID:17825302   PMID:18183615   PMID:18279593   PMID:18647175   PMID:18706176   PMID:18855986   PMID:19017651   PMID:19129494   PMID:19213829   PMID:19319148   PMID:19332538   PMID:19457074  
PMID:19507189   PMID:19555995   PMID:20028514   PMID:20089884   PMID:20152177   PMID:20164257   PMID:20170644   PMID:20180397   PMID:20473716   PMID:20970449   PMID:21192956   PMID:21257729  
PMID:21318404   PMID:21334421   PMID:21336719   PMID:21415414   PMID:22378877   PMID:22559818   PMID:22946046   PMID:23018187   PMID:23171401   PMID:23288152   PMID:23297502   PMID:23345400  
PMID:23417864   PMID:23708107   PMID:24008412   PMID:24081143   PMID:24398936   PMID:24567356   PMID:24854121   PMID:24889144   PMID:25278303   PMID:25304966   PMID:25617501   PMID:25649016  
PMID:26585695   PMID:26607202   PMID:28079139   PMID:28718701   PMID:29179201   PMID:29258088   PMID:29845266   PMID:30452951   PMID:30734065   PMID:31506421   PMID:32716860   PMID:32807750  
PMID:33343804   PMID:34359845   PMID:35908134  


Genomics

Comparative Map Data
Ocln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,391,303 - 33,442,207 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl233,391,303 - 33,430,411 (-)EnsemblGRCr8
mRatBN7.2231,657,217 - 31,707,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,657,220 - 31,764,150 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx238,791,782 - 38,841,944 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,819,361 - 36,869,279 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,690,347 - 31,739,905 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,527,327 - 30,577,218 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,527,715 - 30,577,218 (-)Ensemblrn6Rnor6.0
Rnor_5.0249,686,707 - 49,737,380 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4231,317,090 - 31,367,485 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera227,670,881 - 27,719,967 (-)NCBICelera
RGSC_v3.1231,237,461 - 31,287,854 (-)NCBI
Cytogenetic Map2q12NCBI
OCLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,492,547 - 69,558,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl569,492,184 - 69,558,104 (+)Ensemblhg38GRCh38
GRCh37568,788,374 - 68,853,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,823,875 - 68,885,889 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34568,823,874 - 68,885,887NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,744,381 - 65,800,380 (+)NCBIHuRef
HuRef565,800,577 - 65,803,347 (+)NCBIHuRef
CHM1_1568,787,783 - 68,853,763 (+)NCBICHM1_1
T2T-CHM13v2.0570,318,187 - 70,383,882 (+)NCBIT2T-CHM13v2.0
Ocln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,633,012 - 100,689,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,633,015 - 100,689,226 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3813100,496,504 - 100,552,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,496,507 - 100,552,718 (-)Ensemblmm10GRCm38
MGSCv3713101,267,322 - 101,322,453 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613101,597,624 - 101,652,755 (-)NCBIMGSCv36mm8
Celera13104,112,684 - 104,167,697 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ocln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955575163,646 - 210,379 (+)Ensembl
ChiLan1.0NW_004955575163,646 - 210,379 (+)NCBIChiLan1.0ChiLan1.0
OCLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,366,263 - 44,428,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,519,888 - 42,582,278 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,447,230 - 44,509,637 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1546,022,538 - 46,080,549 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,023,437 - 46,069,342 (-)EnsemblpanPan2panpan1.1
OCLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,500,299 - 54,545,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,500,299 - 54,545,430 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha251,466,637 - 51,511,781 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0255,004,936 - 55,058,838 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,005,004 - 55,058,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,076,201 - 52,121,488 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,843,313 - 52,888,432 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,733,721 - 53,779,092 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ocln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,162,311 - 191,216,242 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648098,371 - 152,413 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648099,516 - 152,834 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OCLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,600,212 - 47,654,033 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11647,600,175 - 47,652,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,547,473 - 51,598,116 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OCLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,581,943 - 65,641,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,582,460 - 65,644,787 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604914,326,566 - 14,386,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ocln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905333,864 - 388,880 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624905333,853 - 388,990 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ocln
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13157,902,627 - 157,949,884 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ocln
329 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:819
Count of miRNA genes:316
Interacting mature miRNAs:410
Transcripts:ENSRNOT00000024674
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
D2Rat193  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8233,419,884 - 33,419,991 (+)Marker Load Pipeline
mRatBN7.2231,685,805 - 31,685,914 (+)MAPPERmRatBN7.2
Rnor_6.0230,555,907 - 30,556,013NCBIRnor6.0
Rnor_5.0249,715,234 - 49,715,340UniSTSRnor5.0
RGSC_v3.4231,346,067 - 31,346,173UniSTSRGSC3.4
RGSC_v3.4231,346,066 - 31,346,173RGDRGSC3.4
Celera227,699,448 - 27,699,554UniSTS
RGSC_v3.1231,266,436 - 31,266,542RGD
RH 3.4 Map277.5UniSTS
RH 3.4 Map277.5RGD
SHRSP x BN Map210.5399RGD
SHRSP x BN Map210.5399UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 163 91 90 59 91 59 6 354 190 11 140 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000024674   ⟹   ENSRNOP00000024674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl233,391,303 - 33,430,411 (-)Ensembl
mRatBN7.2 Ensembl231,657,220 - 31,707,120 (-)Ensembl
Rnor_6.0 Ensembl230,527,715 - 30,577,218 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077537   ⟹   ENSRNOP00000070680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,742,653 - 31,759,468 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084667   ⟹   ENSRNOP00000068691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,657,220 - 31,760,321 (-)Ensembl
Rnor_6.0 Ensembl230,528,242 - 30,576,591 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085488   ⟹   ENSRNOP00000073691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,725,984 - 31,764,150 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106737   ⟹   ENSRNOP00000078336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,742,653 - 31,764,002 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000121036   ⟹   ENSRNOP00000098588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl233,391,303 - 33,430,411 (-)Ensembl
RefSeq Acc Id: NM_031329   ⟹   NP_112619
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,391,303 - 33,441,198 (-)NCBI
mRatBN7.2231,657,217 - 31,707,120 (-)NCBI
Rnor_6.0230,527,327 - 30,577,218 (-)NCBI
Rnor_5.0249,686,707 - 49,737,380 (-)NCBI
RGSC_v3.4231,317,090 - 31,367,485 (-)RGD
Celera227,670,881 - 27,719,967 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231853   ⟹   XP_006231915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,441,117 (-)NCBI
mRatBN7.2231,658,558 - 31,707,019 (-)NCBI
Rnor_6.0230,528,283 - 30,577,084 (-)NCBI
Rnor_5.0249,686,707 - 49,737,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231854   ⟹   XP_006231916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,441,043 (-)NCBI
mRatBN7.2231,658,558 - 31,706,965 (-)NCBI
Rnor_6.0230,528,283 - 30,577,061 (-)NCBI
Rnor_5.0249,686,707 - 49,737,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231855   ⟹   XP_006231917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,440,628 (-)NCBI
mRatBN7.2231,658,558 - 31,706,508 (-)NCBI
Rnor_6.0230,528,283 - 30,576,129 (-)NCBI
Rnor_5.0249,686,707 - 49,737,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103242   ⟹   XP_038959170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,442,207 (-)NCBI
mRatBN7.2231,658,558 - 31,707,466 (-)NCBI
RefSeq Acc Id: XM_039103244   ⟹   XP_038959172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,440,628 (-)NCBI
mRatBN7.2231,658,558 - 31,706,508 (-)NCBI
RefSeq Acc Id: XM_039103245   ⟹   XP_038959173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,441,058 (-)NCBI
mRatBN7.2231,658,558 - 31,707,019 (-)NCBI
RefSeq Acc Id: XM_063282636   ⟹   XP_063138706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,437,874 (-)NCBI
RefSeq Acc Id: XM_063282637   ⟹   XP_063138707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,442,207 (-)NCBI
RefSeq Acc Id: NP_112619   ⟸   NM_031329
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231915   ⟸   XM_006231853
- Peptide Label: isoform X1
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231916   ⟸   XM_006231854
- Peptide Label: isoform X1
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231917   ⟸   XM_006231855
- Peptide Label: isoform X1
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068691   ⟸   ENSRNOT00000084667
Ensembl Acc Id: ENSRNOP00000024674   ⟸   ENSRNOT00000024674
RefSeq Acc Id: XP_038959170   ⟸   XM_039103242
- Peptide Label: isoform X1
- UniProtKB: Q6P6T5 (UniProtKB/Swiss-Prot),   Q9Z303 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959173   ⟸   XM_039103245
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QZI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959172   ⟸   XM_039103244
- Peptide Label: isoform X1
- UniProtKB: Q6P6T5 (UniProtKB/Swiss-Prot),   Q9Z303 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000070680   ⟸   ENSRNOT00000077537
Ensembl Acc Id: ENSRNOP00000078336   ⟸   ENSRNOT00000106737
Ensembl Acc Id: ENSRNOP00000073691   ⟸   ENSRNOT00000085488
RefSeq Acc Id: XP_063138707   ⟸   XM_063282637
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QZI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138706   ⟸   XM_063282636
- Peptide Label: isoform X1
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098588   ⟸   ENSRNOT00000121036
Protein Domains
MARVEL   OCEL

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6T5-F1-model_v2 AlphaFold Q6P6T5 1-523 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620089 AgrOrtholog
BioCyc Gene G2FUF-54668 BioCyc
Ensembl Genes ENSRNOG00000018297 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000071323 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024674.6 UniProtKB/Swiss-Prot
  ENSRNOT00000121036 ENTREZGENE
Gene3D-CATH 6.10.140.340 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623744 IMAGE-MGC_LOAD
InterPro ELL/occludin UniProtKB/Swiss-Prot
  Marvel UniProtKB/Swiss-Prot
  Occludin UniProtKB/Swiss-Prot
  Occludin_ELL UniProtKB/Swiss-Prot
KEGG Report rno:83497 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72407 IMAGE-MGC_LOAD
NCBI Gene 83497 ENTREZGENE
PANTHER PTHR23288 UniProtKB/Swiss-Prot
  PTHR23288:SF4 UniProtKB/Swiss-Prot
Pfam MARVEL UniProtKB/Swiss-Prot
  Occludin_ELL UniProtKB/Swiss-Prot
PhenoGen Ocln PhenoGen
PIRSF Occludin UniProtKB/Swiss-Prot
PRINTS OCCLUDIN UniProtKB/Swiss-Prot
PROSITE MARVEL UniProtKB/Swiss-Prot
  OCEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018297 RatGTEx
  ENSRNOG00000071323 RatGTEx
Superfamily-SCOP occludin/ELL-like UniProtKB/Swiss-Prot
UniProt A0A8L2QZI9 ENTREZGENE
  A0ABK0KYY0_RAT UniProtKB/TrEMBL
  A0ABK0L5C4_RAT UniProtKB/TrEMBL
  A0ABK0L7U1_RAT UniProtKB/TrEMBL
  A0ABK0LD49_RAT UniProtKB/TrEMBL
  A0ABK0LEZ2_RAT UniProtKB/TrEMBL
  A6I594 ENTREZGENE, UniProtKB/TrEMBL
  OCLN_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z303 ENTREZGENE
UniProt Secondary Q9Z303 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-09-11 Ocln  occludin  Tpmt  thiopurine methyltransferase  Symbol and Name updated 1299863 APPROVED
2005-01-20 Tpmt  thiopurine methyltransferase  Ocln  occludin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ocln  occludin      Symbol and Name status set to provisional 70820 PROVISIONAL