Cd79b (CD79b molecule) - Rat Genome Database

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Gene: Cd79b (CD79b molecule) Rattus norvegicus
Analyze
Symbol: Cd79b
Name: CD79b molecule
RGD ID: 620012
Description: Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in B cell differentiation and B cell receptor signaling pathway. Predicted to act upstream of or within response to bacterium. Predicted to be located in plasma membrane. Predicted to be part of IgM B cell receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia 6 and lymphoma (multiple). Orthologous to human CD79B (CD79b molecule); PARTICIPATES IN B cell receptor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell antigen receptor complex-associated protein beta chain; B29; CD79B antigen; Cd79b molecule, immunoglobulin-associated beta; Igb; immunoglobulin-associated beta; MGC108607
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,739,134 - 91,742,312 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1091,739,137 - 91,742,405 (-)EnsemblGRCr8
mRatBN7.21091,239,354 - 91,242,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,239,356 - 91,242,625 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,293,979 - 96,297,125 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,757,144 - 95,760,290 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,167,742 - 91,170,888 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,497,445 - 94,500,591 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,497,448 - 94,500,591 (-)Ensemblrn6Rnor6.0
Rnor_5.01094,248,655 - 94,251,801 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41095,703,129 - 95,706,275 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1089,914,837 - 89,917,983 (-)NCBICelera
RGSC_v3.11095,717,499 - 95,720,645 (-)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetohydrazide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aluminium trifluoride  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
cyclophosphamide  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
furan  (EXP)
gardiquimod  (ISO)
genistein  (ISO)
gentamycin  (EXP)
lipopolysaccharide  (EXP,ISO)
mercaptopurine  (EXP)
methylarsonic acid  (ISO)
morphine  (ISO)
nitrates  (ISO)
nitrobenzenes  (EXP)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylarsine oxide  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
purine-6-thiol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia. Alfarano A, etal., Blood. 1999 Apr 1;93(7):2327-35.
2. Quantitative analysis of CD79b, CD5 and CD19 in mature B-cell lymphoproliferative disorders. Cabezudo E, etal., Haematologica. 1999 May;84(5):413-8.
3. Patients with primary breast and primary female genital tract diffuse large B cell lymphoma have a high frequency of MYD88 and CD79B mutations. Cao XX, etal., Ann Hematol. 2017 Nov;96(11):1867-1871. doi: 10.1007/s00277-017-3094-7. Epub 2017 Aug 12.
4. Morphologic Patterns and the Correlation With MYD88 L265P, CD79B Mutations in Primary Adrenal Diffuse Large B-Cell Lymphoma. Chen Z, etal., Am J Surg Pathol. 2020 Apr;44(4):444-455. doi: 10.1097/PAS.0000000000001386.
5. New markers for minimal residual disease detection in acute lymphoblastic leukemia. Coustan-Smith E, etal., Blood. 2011 Jun 9;117(23):6267-76. doi: 10.1182/blood-2010-12-324004. Epub 2011 Apr 12.
6. Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma. Dornan D, etal., Blood. 2009 Sep 24;114(13):2721-9. doi: 10.1182/blood-2009-02-205500. Epub 2009 Jul 24.
7. CD79b expression in B cell chronic lymphocytic leukemia: its implication for minimal residual disease detection. Garcia Vela J, etal., Leukemia. 1999 Oct;13(10):1501-5. doi: 10.1038/sj.leu.2401511.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. Grommes C, etal., Cancer Discov. 2017 Sep;7(9):1018-1029. doi: 10.1158/2159-8290.CD-17-0613. Epub 2017 Jun 15.
11. Novel regulatory regions found downstream of the rat B29/Ig-beta gene. Komatsu A, etal., Eur J Biochem 2002 Feb;269(4):1227-36.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Physical linkage of the B29/Ig-beta (CD79B) gene to the skeletal muscle, sodium-channel, and growth hormone genes in rat and human. Nakazato S, etal., Genomics 1998 Mar 15;48(3):363-8.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic leukemia. Payelle-Brogard B, etal., Blood. 1999 Nov 15;94(10):3516-22.
17. Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes. Pfeifer M, etal., Leukemia. 2015 Jul;29(7):1578-86. doi: 10.1038/leu.2015.48. Epub 2015 Feb 24.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma. Polson AG, etal., Blood. 2007 Jul 15;110(2):616-23. doi: 10.1182/blood-2007-01-066704. Epub 2007 Mar 20.
20. Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion. Rassenti LZ and Kipps TJ, Blood. 2000 Apr 15;95(8):2725-7.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia. Thompson AA, etal., Blood. 1997 Aug 15;90(4):1387-94.
26. Primary diffuse large B-cell lymphomas of central nervous system exhibit remarkably high prevalence of oncogenic MYD88 and CD79B mutations. Yamada S, etal., Leuk Lymphoma. 2015 Jul;56(7):2141-5. doi: 10.3109/10428194.2014.979413. Epub 2015 Jan 14.
Additional References at PubMed
PMID:1373499   PMID:8626447   PMID:12477932   PMID:14967045   PMID:16920149   PMID:20458337   PMID:20696394   PMID:23012479  


Genomics

Comparative Map Data
Cd79b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,739,134 - 91,742,312 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1091,739,137 - 91,742,405 (-)EnsemblGRCr8
mRatBN7.21091,239,354 - 91,242,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,239,356 - 91,242,625 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,293,979 - 96,297,125 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,757,144 - 95,760,290 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,167,742 - 91,170,888 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,497,445 - 94,500,591 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,497,448 - 94,500,591 (-)Ensemblrn6Rnor6.0
Rnor_5.01094,248,655 - 94,251,801 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41095,703,129 - 95,706,275 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1089,914,837 - 89,917,983 (-)NCBICelera
RGSC_v3.11095,717,499 - 95,720,645 (-)NCBI
Cytogenetic Map10q32.1NCBI
CD79B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,928,740 - 63,932,331 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,928,738 - 63,932,629 (-)Ensemblhg38GRCh38
GRCh371762,006,100 - 62,009,691 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,359,830 - 59,363,436 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341759,359,831 - 59,363,446NCBI
Celera1756,394,160 - 56,397,766 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,373,817 - 57,377,419 (-)NCBIHuRef
CHM1_11762,070,017 - 62,073,623 (-)NCBICHM1_1
T2T-CHM13v2.01764,799,505 - 64,803,094 (-)NCBIT2T-CHM13v2.0
Cd79b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,202,167 - 106,205,388 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,202,167 - 106,205,588 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811106,311,341 - 106,314,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,311,341 - 106,314,762 (-)Ensemblmm10GRCm38
MGSCv3711106,172,655 - 106,175,843 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611106,127,431 - 106,130,760 (-)NCBIMGSCv36mm8
Celera11118,042,026 - 118,045,214 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
Cd79b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,909,153 - 7,913,166 (+)Ensembl
ChiLan1.0NW_0049554787,909,353 - 7,912,814 (+)NCBIChiLan1.0ChiLan1.0
CD79B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,111,641 - 80,115,624 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,931,947 - 84,935,931 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,022,375 - 58,026,359 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,116,722 - 63,120,335 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,116,722 - 63,120,335 (-)EnsemblpanPan2panpan1.1
CD79B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,834,230 - 11,844,946 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,842,190 - 11,844,843 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha912,801,263 - 12,804,585 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0913,502,931 - 13,506,253 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,502,935 - 13,506,208 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,449,684 - 12,453,001 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,079,310 - 15,082,632 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,081,786 - 15,085,109 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd79b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,657,115 - 14,660,367 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,534,246 - 4,537,590 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,534,233 - 4,537,448 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD79B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,053,007 - 15,056,438 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11215,052,966 - 15,056,441 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,044,369 - 15,047,831 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD79B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,339,492 - 57,343,085 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,339,457 - 57,343,358 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607727,952,012 - 27,955,604 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd79b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,429,912 - 1,432,955 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248491,429,446 - 1,432,835 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cd79b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1972,810,492 - 72,813,639 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd79b
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:232
Count of miRNA genes:164
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000015976
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109090424595604677Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109112727095604677Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)9090424595604677Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)9090424595604677Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)109090424595604677Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)109090424595604677Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)109090424595604677Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)108890050196620484Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 58 152 91 90 59 92 59 6 345 183 11 123 81 89 31 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB004831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC133055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015976   ⟹   ENSRNOP00000015977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1091,739,137 - 91,742,405 (-)Ensembl
mRatBN7.2 Ensembl1091,239,357 - 91,242,625 (-)Ensembl
Rnor_6.0 Ensembl1094,497,448 - 94,500,591 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102931   ⟹   ENSRNOP00000077025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,239,356 - 91,242,514 (-)Ensembl
RefSeq Acc Id: NM_133533   ⟹   NP_598217
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,739,134 - 91,742,280 (-)NCBI
mRatBN7.21091,239,354 - 91,242,500 (-)NCBI
Rnor_6.01094,497,445 - 94,500,591 (-)NCBI
Rnor_5.01094,248,655 - 94,251,801 (-)NCBI
RGSC_v3.41095,703,129 - 95,706,275 (-)RGD
Celera1089,914,837 - 89,917,983 (-)RGD
Sequence:
RefSeq Acc Id: XM_063268365   ⟹   XP_063124435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,739,134 - 91,742,312 (-)NCBI
Protein Sequences
Protein RefSeqs NP_598217 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88115 (Get FASTA)   NCBI Sequence Viewer  
  BAA25652 (Get FASTA)   NCBI Sequence Viewer  
  EDM06394 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015977.6
RefSeq Acc Id: NP_598217   ⟸   NM_133533
- Peptide Label: precursor
- UniProtKB: O70153 (UniProtKB/TrEMBL),   F1MAP5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015977   ⟸   ENSRNOT00000015976
Ensembl Acc Id: ENSRNOP00000077025   ⟸   ENSRNOT00000102931
RefSeq Acc Id: XP_063124435   ⟸   XM_063268365
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y5U3 (UniProtKB/TrEMBL)
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70153-F1-model_v2 AlphaFold O70153 1-228 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697843
Promoter ID:EPDNEW_R8368
Type:initiation region
Name:Cd79b_1
Description:CD79b molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,500,586 - 94,500,646EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620012 AgrOrtholog
BioCyc Gene G2FUF-22952 BioCyc
Ensembl Genes ENSRNOG00000011917 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015976.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325406 IMAGE-MGC_LOAD
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Phos_immunorcpt_sig_ITAM UniProtKB/TrEMBL
KEGG Report rno:171055 UniProtKB/TrEMBL
MGC_CLONE MGC:108607 IMAGE-MGC_LOAD
NCBI Gene 171055 ENTREZGENE
PANTHER B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN BETA CHAIN UniProtKB/TrEMBL
  PTHR14334 UniProtKB/TrEMBL
Pfam ITAM UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Cd79b PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
  ITAM_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011917 RatGTEx
SMART ITAM UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8I5Y5U3 ENTREZGENE
  A0A8J8XPU7_RAT UniProtKB/TrEMBL
  A6HK39_RAT UniProtKB/TrEMBL
  F1MAP5 ENTREZGENE
  O70153 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1MAP5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Cd79b  CD79b molecule  Cd79b  Cd79b molecule, immunoglobulin-associated beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cd79b  Cd79b molecule, immunoglobulin-associated beta  Cd79b  CD79B antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cd79b  CD79B antigen  Igb  immunoglobulin-associated beta  Symbol and Name updated 1299863 APPROVED
2002-08-07 Igb  immunoglobulin-associated beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains immunoglobulin, membrane proximal, transmembrane, and cytoplasmic 625627
gene_expression expressed early in B-cell development 625627
gene_homology 85% similar to the mouse and 69% similar to mouse and human amino acids 633033
gene_other located between the polyadenylation site of Scn4a and the 5 end of Gh1 633033
gene_physical_interaction forms a Iga(mb1)/Igb heterodimer to mediate signal transduction 625627
gene_protein 228 amino acids 625627
gene_transcript gene is 3.1 kb in size and has 6 exons 633033
gene_transcript a regulatory enhancer region was identified downstream of the gene and lacks the TATA box and has multiple transcriptional initiation sites 625627