Ppt1 (palmitoyl-protein thioesterase 1) - Rat Genome Database

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Gene: Ppt1 (palmitoyl-protein thioesterase 1) Rattus norvegicus
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Symbol: Ppt1
Name: palmitoyl-protein thioesterase 1
RGD ID: 61994
Description: Predicted to enable lysophosphatidic acid binding activity; sulfatide binding activity; and thiolester hydrolase activity. Predicted to be involved in several processes, including lysosomal lumen acidification; negative regulation of toll-like receptor 9 signaling pathway; and positive regulation of endocytosis. Predicted to act upstream of or within several processes, including endocytosis; grooming behavior; and regulation of phospholipase A2 activity. Located in neuronal cell body and synaptic vesicle. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1); PARTICIPATES IN fatty acid elongation pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; ammonium chloride; bexarotene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: palmitoyl-protein hydrolase 1; palmitoyl-protein thioesterase; Ppt; PPT-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,406,318 - 140,427,201 (+)NCBIGRCr8
mRatBN7.25135,121,164 - 135,142,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,121,163 - 135,142,048 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,827,992 - 137,847,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,598,471 - 139,618,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,605,087 - 139,624,952 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,538,260 - 140,558,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,538,260 - 140,558,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05144,329,263 - 144,349,162 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,153,498 - 142,173,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15142,158,725 - 142,179,598 (+)NCBI
Celera5133,659,813 - 133,679,711 (+)NCBICelera
RH 3.4 Map5890.0RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Ppt1RatCOVID-19  ISOPPT1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Ppt1Ratneuronal ceroid lipofuscinosis 1  ISOPpt1 (Mus musculus)734785 RGD 
1 to 13 of 13 rows
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Original Reference(s)
Ppt1RatCharcot-Marie-Tooth disease dominant intermediate C  ISOPPT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate CClinVarPMID:28492532
Ppt1Ratcongenital myopathy 1A  ISOPPT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Shy-Magee syndromeClinVarPMID:18414213 more ...
Ppt1Ratgenetic disease  ISOPPT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10191107 more ...
Ppt1Ratintellectual disability  ISOPPT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
Ppt1Ratintellectual disability  ISOPPT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Ppt1RatNervous System Malformations  ISOPPT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Abnormality of the nervous systemClinVarPMID:21990111 and PMID:25741868
Ppt1Ratneurodevelopmental disorder with dysmorphic facies and distal limb anomalies  ISOPPT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesClinVarPMID:25741868 more ...
Ppt1Ratneuronal ceroid lipofuscinosis  ISOPPT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10191107 more ...
Ppt1Ratneuronal ceroid lipofuscinosis  ISOPPT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10191107 more ...
Ppt1Ratneuronal ceroid lipofuscinosis 1  ISOPPT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10191107 more ...
Ppt1Ratprogressive myoclonus epilepsy  ISOPPT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuronal Ceroid-Lipofuscinosis and RecessiveClinVarPMID:10649502 more ...
Ppt1Ratretinitis pigmentosa  ISOPPT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVarPMID:10191107 more ...
Ppt1Ratspastic ataxia  ISOPPT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic ataxiaClinVarPMID:12382155 more ...
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Original Reference(s)
Ppt1Ratdisease of cellular proliferation  ISOPPT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30442709
Ppt1Ratneuronal ceroid lipofuscinosis 1  ISOPPT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7637805 more ...
Ppt1Ratneuronal ceroid lipofuscinosis 1  ISOPPT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9425237
Ppt1RatVision Disorders  ISOPPT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24804307
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Original Reference(s)
Ppt1Ratneuronal ceroid lipofuscinosis 1  ISSPpt1 (Mus musculus)13592920OMIM:256730MouseDO 
Ppt1Ratneuronal ceroid lipofuscinosis 3  ISSPpt1 (Mus musculus)13592920OMIM:204200MouseDO 
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Original Reference(s)
Ppt1Ratneuronal ceroid lipofuscinosis 1  ISOPPT1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Ppt1Rat1,2-dimethylhydrazine increases expressionISOPpt1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PPT1 mRNACTDPMID:22206623
Ppt1Rat1-chloro-2,4-dinitrobenzene affects bindingISOPPT1 (Homo sapiens)6480464Dinitrochlorobenzene binds to PPT1 proteinCTDPMID:32991956
Ppt1Rat17alpha-ethynylestradiol decreases expressionISOPpt1 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of PPT1 mRNACTDPMID:17555576
Ppt1Rat17beta-estradiol decreases expressionISOPpt1 (Mus musculus)6480464Estradiol results in decreased expression of PPT1 mRNACTDPMID:39298647
Ppt1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOPPT1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Ppt1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPpt1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PPT1 mRNACTDPMID:24680724
Ppt1Rat2,4,6-tribromophenol decreases expressionISOPPT1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Ppt1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOPpt1 (Mus musculus)64804642 more ...CTDPMID:38648751
Ppt1Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of PPT1 mRNACTDPMID:19162173
Ppt1Rat4,4'-diaminodiphenylmethane increases expressionISOPpt1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of PPT1 mRNACTDPMID:18648102
Ppt1Rat4,4'-sulfonyldiphenol decreases expressionISOPpt1 (Mus musculus)6480464bisphenol S results in decreased expression of PPT1 mRNACTDPMID:39298647
Ppt1Ratacrolein multiple interactionsISOPPT1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of PPT1 mRNA more ...CTDPMID:32699268 and PMID:32845096
Ppt1Ratall-trans-retinoic acid increases expressionISOPPT1 (Homo sapiens)6480464Tretinoin results in increased expression of PPT1 mRNACTDPMID:33167477
Ppt1Ratalpha-pinene multiple interactionsISOPPT1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of PPT1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of PPT1 mRNACTDPMID:32699268
Ppt1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of PPT1 mRNACTDPMID:16483693
Ppt1Ratantirheumatic drug decreases expressionISOPPT1 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of PPT1 mRNACTDPMID:24449571
Ppt1Rataristolochic acid A decreases expressionISOPPT1 (Homo sapiens)6480464aristolochic acid I results in decreased expression of PPT1 mRNACTDPMID:33212167
Ppt1Ratbeauvericin multiple interactionsISOPPT1 (Homo sapiens)6480464[beauvericin co-treated with enniatins] results in decreased expression of PPT1 proteinCTDPMID:32407736
Ppt1Ratbenzo[a]pyrene increases expressionISOPpt1 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of PPT1 mRNACTDPMID:22228805 and PMID:35678645
Ppt1Ratbenzo[a]pyrene increases expressionISOPPT1 (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of PPT1 mRNACTDPMID:32234424

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Biological Process
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Original Reference(s)
Ppt1Ratadult locomotory behavior acts_upstream_of_or_withinISOPpt1 (Mus musculus)1624291MGI:2176390 more ...RGDPMID:11717424 and PMID:15649713
Ppt1Ratadult locomotory behavior acts_upstream_of_or_withinIEAUniProtKB:O88531 and ensembl:ENSMUSP000000304121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratassociative learning acts_upstream_of_or_withinISOPpt1 (Mus musculus)1624291MGI:2176390 PMID:15885820RGDPMID:15885820
Ppt1Ratassociative learning acts_upstream_of_or_withinIEAUniProtKB:O88531 and ensembl:ENSMUSP000000304121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratbrain development involved_inISSUniProtKB:P508978553248PMID:8895569UniProt 
Ppt1Ratbrain development involved_inIEAUniProtKB:P50897 and ensembl:ENSP000004931531600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratbrain development involved_inISOPPT1 (Homo sapiens)1624291 PMID:7637805RGDPMID:7637805
Ppt1Ratendocytosis involved_inIBAFB:FBgn0030057 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppt1Ratgrooming behavior acts_upstream_of_or_withinISOPpt1 (Mus musculus)1624291MGI:2176390 PMID:11717424RGDPMID:11717424
Ppt1Ratgrooming behavior acts_upstream_of_or_withinIEAUniProtKB:O88531 and ensembl:ENSMUSP000000304121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratlipid catabolic process involved_inISOPPT1 (Homo sapiens)1624291 PMID:8816748RGDPMID:8816748
Ppt1Ratlipid catabolic process involved_inIEAUniProtKB:P50897 and ensembl:ENSP000004931531600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratlipid catabolic process involved_inISSUniProtKB:P508978553248PMID:8895569UniProt 
Ppt1Ratlysosomal lumen acidification involved_inISSUniProtKB:P508978553248PMID:8895569UniProt 
Ppt1Ratlysosomal lumen acidification involved_inIEAUniProtKB:P50897 and ensembl:ENSP000004931531600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratlysosomal lumen acidification involved_inISOPPT1 (Homo sapiens)1624291 PMID:11722572RGDPMID:11722572
Ppt1Ratlysosome organization acts_upstream_of_or_withinISOPpt1 (Mus musculus)1624291MGI:2176390 more ...RGDPMID:16368712 and PMID:16542649
Ppt1Ratlysosome organization acts_upstream_of_or_withinIEAUniProtKB:O88531 and ensembl:ENSMUSP000000304121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratmacromolecule catabolic process acts_upstream_of_or_withinISOPpt1 (Mus musculus)1624291MGI:2176390 PMID:15647513RGDPMID:15647513
Ppt1Ratmacromolecule catabolic process acts_upstream_of_or_withinIEAUniProtKB:O88531 and ensembl:ENSMUSP000000304121600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Ppt1Rataxon located_inISSUniProtKB:P508978553248PMID:8895569UniProt 
Ppt1Rataxon located_inIEAUniProtKB:O88531 and ensembl:ENSMUSP000000304121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Rataxon located_inIEAUniProtKB:P50897 and ensembl:ENSP000004931531600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Rataxon located_inISOPpt1 (Mus musculus)1624291 PMID:12483688RGDPMID:12483688
Ppt1Rataxon located_inISOPPT1 (Homo sapiens)1624291 PMID:12483688RGDPMID:12483688
Ppt1Ratcytosol located_inISSUniProtKB:P454781600115GO_REF:0000024UniProtGO_REF:0000024
Ppt1Ratdendrite located_inISOPpt1 (Mus musculus)1624291 PMID:10611498RGDPMID:10611498
Ppt1Ratdendrite located_inIEAUniProtKB:O88531 and ensembl:ENSMUSP000000304121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratextracellular region located_inISSUniProtKB:P454781600115GO_REF:0000024UniProtGO_REF:0000024
Ppt1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Ppt1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Ppt1Ratextracellular region located_inIEAUniProtKB:P50897 and ensembl:ENSP000004931531600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratextracellular region located_inISSUniProtKB:P508978553248PMID:8895569UniProt 
Ppt1Ratextracellular region is_active_inIBAMGI:1298204 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppt1Ratextracellular region located_inISOPPT1 (Homo sapiens)1624291 PMID:8895569RGDPMID:8895569
Ppt1Ratextracellular space located_inIEAUniProtKB:O88531 and ensembl:ENSMUSP000000304121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratextracellular space located_inISOPpt1 (Mus musculus)1624291 PMID:9685319RGDPMID:9685319
Ppt1RatGolgi apparatus located_inISOPPT1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Ppt1RatGolgi apparatus located_inIEAUniProtKB:P50897 and ensembl:ENSP000004931531600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1RatGolgi apparatus located_inISSUniProtKB:P508978553248PMID:8895569UniProt 
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Molecular Function
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Ppt1Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Ppt1Ratlong-chain fatty acyl-CoA hydrolase activity enablesIBAPANTHER:PTN000882372 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppt1Ratlong-chain fatty acyl-CoA hydrolase activity enablesIEAUniProtKB:P50897 and ensembl:ENSP000004931531600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratlong-chain fatty acyl-CoA hydrolase activity enablesISSUniProtKB:P508978553248PMID:8895569UniProt 
Ppt1Ratlong-chain fatty acyl-CoA hydrolase activity enablesISSUniProtKB:P454781600115GO_REF:0000024UniProtGO_REF:0000024
Ppt1Ratlong-chain fatty acyl-CoA hydrolase activity enablesISOPPT1 (Homo sapiens)1624291 PMID:10658183RGDPMID:10658183
Ppt1Ratlysophosphatidic acid binding enablesISOPPT1 (Homo sapiens)1624291 PMID:18317235RGDPMID:18317235
Ppt1Ratlysophosphatidic acid binding enablesIEAUniProtKB:P50897 and ensembl:ENSP000004931531600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratpalmitoyl hydrolase activity enablesIEAInterPro:IPR0024721600115GO_REF:0000002InterProGO_REF:0000002
Ppt1Ratpalmitoyl-(protein) hydrolase activity enablesISSUniProtKB:P508978553248PMID:8895569UniProt 
Ppt1Ratpalmitoyl-(protein) hydrolase activity enablesIEAUniProtKB:P50897 and ensembl:ENSP000004931531600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratpalmitoyl-(protein) hydrolase activity enablesIEAEC:3.1.2.221600115GO_REF:0000003UniProtGO_REF:0000003
Ppt1Ratpalmitoyl-(protein) hydrolase activity enablesISOPpt1 (Mus musculus)1624291MGI:2176390 PMID:11717424 more ...RGDPMID:11717424 more ...
Ppt1Ratpalmitoyl-(protein) hydrolase activity enablesIBAFB:FBgn0030057 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppt1Ratpalmitoyl-(protein) hydrolase activity enablesIEAUniProtKB:O88531 and ensembl:ENSMUSP000000304121600115GO_REF:0000107EnsemblGO_REF:0000107
Ppt1Ratpalmitoyl-(protein) hydrolase activity enablesIEARHEA:192331600115GO_REF:0000116RHEAGO_REF:0000116
Ppt1Ratpalmitoyl-(protein) hydrolase activity enablesISOPPT1 (Homo sapiens)1624291 PMID:10658183 more ...RGDPMID:10658183 more ...
Ppt1Ratpalmitoyl-(protein) hydrolase activity enablesISSUniProtKB:P454781600115GO_REF:0000024UniProtGO_REF:0000024
Ppt1Ratphospholipase A2 inhibitor activity enablesISOPpt1 (Mus musculus)1624291MGI:2176390 PMID:17341491RGDPMID:17341491
Ppt1Ratprotein binding enablesISOPPT1 (Homo sapiens)1624291UniProtKB:O14773 more ...RGDPMID:17237713 more ...
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Imported Annotations - SMPDB

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Ppt1Ratfatty acid elongation pathway  ISOPPT1 (Homo sapiens)10402751 SMPDBSMP:00054

Imported Annotations - KEGG (archival)

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Original Reference(s)
Ppt1Ratfatty acid elongation pathway  IEA 6907045 KEGGrno:00062

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#
Reference Title
Reference Citation
1. Molecular cloning and expression of palmitoyl-protein thioesterase. Camp LA, etal., J Biol Chem 1994 Sep 16;269(37):23212-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Gupta P, etal., Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13566-71.
5. Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis. Hellsten E, etal., EMBO J. 1996 Oct 1;15(19):5240-5.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Status epilepticus induces changes in the expression and localization of endogenous palmitoyl-protein thioesterase 1. Suopanki J, etal., Neurobiol Dis 2002 Aug;10(3):247-57.
16. Palmitoyl-protein thioesterase, an enzyme implicated in neurodegeneration, is localized in neurons and is developmentally regulated in rat brain. Suopanki J, etal., Neurosci Lett. 1999 Apr 9;265(1):53-6.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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PMID:7637805   PMID:7901201   PMID:8816748   PMID:9685319   PMID:10611498   PMID:10658183   PMID:10737604   PMID:10992246   PMID:11020216   PMID:11722572   PMID:12477932   PMID:12483688  
PMID:15647513   PMID:15649713   PMID:15885820   PMID:15929065   PMID:16242638   PMID:16368712   PMID:16542649   PMID:17341491   PMID:18317235   PMID:19941651   PMID:19946888   PMID:23376485  
PMID:23533145   PMID:24302477  



Ppt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,406,318 - 140,427,201 (+)NCBIGRCr8
mRatBN7.25135,121,164 - 135,142,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,121,163 - 135,142,048 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,827,992 - 137,847,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,598,471 - 139,618,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,605,087 - 139,624,952 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,538,260 - 140,558,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,538,260 - 140,558,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05144,329,263 - 144,349,162 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,153,498 - 142,173,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15142,158,725 - 142,179,598 (+)NCBI
Celera5133,659,813 - 133,679,711 (+)NCBICelera
RH 3.4 Map5890.0RGD
Cytogenetic Map5q36NCBI
PPT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38140,071,461 - 40,097,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,072,710 - 40,097,260 (-)EnsemblGRCh38hg38GRCh38
GRCh37140,537,133 - 40,562,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,310,969 - 40,335,555 (-)NCBINCBI36Build 36hg18NCBI36
Build 34140,207,476 - 40,232,061NCBI
Celera138,820,669 - 38,845,442 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,656,433 - 38,681,192 (-)NCBIHuRef
CHM1_1140,653,983 - 40,678,773 (-)NCBICHM1_1
T2T-CHM13v2.0139,940,889 - 39,966,711 (-)NCBIT2T-CHM13v2.0
Ppt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394122,729,879 - 122,752,968 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4122,730,035 - 122,752,968 (+)EnsemblGRCm39 Ensembl
GRCm384122,836,077 - 122,859,175 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4122,836,242 - 122,859,175 (+)EnsemblGRCm38mm10GRCm38
MGSCv374122,513,485 - 122,536,418 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364122,338,558 - 122,360,685 (+)NCBIMGSCv36mm8
Celera4121,166,717 - 121,189,624 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.27NCBI
Ppt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545217,529,115 - 17,549,664 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545217,518,345 - 17,549,112 (-)NCBIChiLan1.0ChiLan1.0
PPT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21186,729,114 - 186,753,833 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,866,794 - 185,891,455 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,358,424 - 39,383,087 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,683,841 - 40,708,609 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,683,841 - 40,708,609 (-)Ensemblpanpan1.1panPan2
PPT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,815,428 - 2,886,474 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,859,979 - 2,894,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha153,117,325 - 3,143,210 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0152,902,313 - 2,973,313 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,946,653 - 2,981,365 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,854,181 - 2,880,060 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,914,086 - 2,939,964 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,930,482 - 2,956,365 (+)NCBIUU_Cfam_GSD_1.0
Ppt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505856,056,908 - 56,081,782 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647421,881,712 - 21,906,569 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647421,881,692 - 21,906,564 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl695,840,908 - 95,860,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1695,840,906 - 95,860,858 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,280,518 - 89,300,475 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,809,373 - 92,833,048 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,809,552 - 92,833,244 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603324,006,277 - 24,030,955 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,543,857 - 22,577,121 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476422,542,892 - 22,577,077 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ppt1
205 total Variants

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:115
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000017998
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat

1 to 10 of 45 rows
Ppt  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,351 - 135,141,556 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,439 - 140,558,643NCBIRnor6.0
Rnor_5.05144,349,438 - 144,349,642UniSTSRnor5.0
RGSC_v3.45142,173,677 - 142,173,881UniSTSRGSC3.4
Celera5133,679,987 - 133,680,191UniSTS
Cytogenetic Map5q36UniSTS
RH142418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,673 - 135,141,856 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,761 - 140,558,943NCBIRnor6.0
Rnor_5.05144,349,760 - 144,349,942UniSTSRnor5.0
RGSC_v3.45142,173,999 - 142,174,181UniSTSRGSC3.4
Celera5133,680,309 - 133,680,491UniSTS
RH 3.4 Map5890.0UniSTS
Cytogenetic Map5q36UniSTS
RH127550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,796 - 135,142,005 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,884 - 140,559,092NCBIRnor6.0
Rnor_5.05144,349,883 - 144,350,091UniSTSRnor5.0
RGSC_v3.45142,174,122 - 142,174,330UniSTSRGSC3.4
Celera5133,680,432 - 133,680,640UniSTS
RH 3.4 Map5876.9UniSTS
Cytogenetic Map5q36UniSTS
AA851880  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85140,427,338 - 140,427,529 (+)Marker Load Pipeline
mRatBN7.25135,142,185 - 135,142,377 (+)MAPPERmRatBN7.2
Rnor_6.05140,559,273 - 140,559,463NCBIRnor6.0
Rnor_5.05144,350,272 - 144,350,462UniSTSRnor5.0
RGSC_v3.45142,174,511 - 142,174,701UniSTSRGSC3.4
Celera5133,680,821 - 133,681,011UniSTS
RH 3.4 Map5900.7UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000017998   ⟹   ENSRNOP00000017998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,121,173 - 135,141,080 (+)Ensembl
Rnor_6.0 Ensembl5140,538,260 - 140,558,162 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109802   ⟹   ENSRNOP00000084196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,126,095 - 135,142,048 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111724   ⟹   ENSRNOP00000093361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,121,163 - 135,132,782 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112154   ⟹   ENSRNOP00000091845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,121,163 - 135,142,048 (+)Ensembl
RefSeq Acc Id: NM_022502   ⟹   NP_071947
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,406,318 - 140,427,201 (+)NCBI
mRatBN7.25135,121,164 - 135,142,048 (+)NCBI
Rnor_6.05140,538,260 - 140,558,163 (+)NCBI
Rnor_5.05144,329,263 - 144,349,162 (+)NCBI
RGSC_v3.45142,153,498 - 142,173,401 (+)RGD
Celera5133,659,813 - 133,679,711 (+)RGD
Sequence:
Protein RefSeqs NP_071947 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA59358 (Get FASTA)   NCBI Sequence Viewer  
  AAI26090 (Get FASTA)   NCBI Sequence Viewer  
  EDL80359 (Get FASTA)   NCBI Sequence Viewer  
  EDL80360 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091845
  ENSRNOP00000091845.1
GenBank Protein P45479 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071947   ⟸   NM_022502
- Peptide Label: precursor
- UniProtKB: A0JN20 (UniProtKB/Swiss-Prot),   P45479 (UniProtKB/Swiss-Prot),   A6IS08 (UniProtKB/TrEMBL),   A0A8I6A0R6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017998   ⟸   ENSRNOT00000017998
Ensembl Acc Id: ENSRNOP00000093361   ⟸   ENSRNOT00000111724
Ensembl Acc Id: ENSRNOP00000091845   ⟸   ENSRNOT00000112154
Ensembl Acc Id: ENSRNOP00000084196   ⟸   ENSRNOT00000109802

Name Modeler Protein Id AA Range Protein Structure
AF-P45479-F1-model_v2 AlphaFold P45479 1-306 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693998
Promoter ID:EPDNEW_R4523
Type:multiple initiation site
Name:Ppt1_1
Description:palmitoyl-protein thioesterase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05140,538,248 - 140,538,308EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40031 BioCyc
Ensembl Genes ENSRNOG00000012616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000112154 ENTREZGENE
  ENSRNOT00000112154.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8361877 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Palm_thioest UniProtKB/Swiss-Prot
KEGG Report rno:29411 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156647 IMAGE-MGC_LOAD
NCBI Gene 29411 ENTREZGENE
PANTHER PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 UniProtKB/Swiss-Prot
  PTHR11247:SF8 UniProtKB/Swiss-Prot
Pfam Palm_thioest UniProtKB/Swiss-Prot
PhenoGen Ppt1 PhenoGen
PRINTS PPTHIESTRASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012616 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
TIGR TC217109
UniProt A0A8I6A0R6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJP6_RAT UniProtKB/TrEMBL
  A0A8L2Q8Z6_RAT UniProtKB/TrEMBL
  A0JN20 ENTREZGENE
  A6IS08 ENTREZGENE, UniProtKB/TrEMBL
  P45479 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0JN20 UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ppt1  palmitoyl-protein thioesterase 1  Ppt  palmitoyl-protein thioesterase  Name updated 1299863 APPROVED
2002-06-10 Ppt  palmitoyl-protein thioesterase      Name updated 70584 APPROVED

Note Type Note Reference
gene_regulation induced by epileptic seizures 633701