RGD Reference Report - Status epilepticus induces changes in the expression and localization of endogenous palmitoyl-protein thioesterase 1. - Rat Genome Database

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Status epilepticus induces changes in the expression and localization of endogenous palmitoyl-protein thioesterase 1.

Authors: Suopanki, J  Lintunen, M  Lahtinen, H  Haltia, M  Panula, P  Baumann, M  Tyynela, J 
Citation: Suopanki J, etal., Neurobiol Dis 2002 Aug;10(3):247-57.
RGD ID: 633701
Pubmed: PMID:12270687   (View Abstract at PubMed)

Kainic acid (KA)-induced experimental epilepsy, a model of excitotoxicity, leads to selective neuronal death and synaptic restructuring. We used this model to investigate the effects of neuronal hyperactivation on palmitoyl-protein thioesterase 1 (PPT1), the deficiency of which causes drastic neurodegeneration. Immunological stainings showed that epileptic seizures in adult rats led to a progressive and remarkable increase of PPT1 in limbic areas of the brain. Within 1 week, the maximal expression was observed in CA3 and CA1 pyramidal neurons of the hippocampus. In the surviving pyramidal neurons, PPT1 localized in vesicular structures in cell soma and neuritic extensions. After seizures, colocalization of PPT1 with synaptic membrane marker (NMDAR2B) was enhanced. Further, synaptic fractionation revealed that after seizures PPT1 was readily observed on the presynaptic side of synaptic junction. These data suggest that PPT1 may protect neurons from excitotoxicity and have a role in synaptic plasticity.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of synaptic plasticity  TAS 633701 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuronal cell body  IDA 633701 RGD 
synaptic vesicle  IDA 633701 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ppt1  (palmitoyl-protein thioesterase 1)


Additional Information