Dynll2 (dynein light chain LC8-type 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Dynll2 (dynein light chain LC8-type 2) Rattus norvegicus
Analyze
Symbol: Dynll2
Name: dynein light chain LC8-type 2
RGD ID: 619860
Description: Enables identical protein binding activity and scaffold protein binding activity. Predicted to be involved in microtubule-based process. Part of cytoplasmic dynein complex. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human DYNLL2 (dynein light chain LC8-type 2); PARTICIPATES IN mitochondria transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Dlc2; dynein light chain 2, cytoplasmic; dynein light chain-2; MGC72334
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,264,260 - 73,283,042 (-)NCBIGRCr8
mRatBN7.21072,767,035 - 72,785,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,767,035 - 72,785,805 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,377,490 - 77,385,515 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,882,434 - 76,890,459 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,346,936 - 72,354,961 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,262,536 - 75,281,302 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,262,537 - 75,270,561 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01074,819,177 - 74,837,880 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,263,883 - 76,271,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11076,278,253 - 76,286,278 (-)NCBI
Celera1071,677,302 - 71,685,328 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
choline  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Mesaconitine  (EXP)
methapyrilene  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytoplasmic dynein. Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
2. Myotonia congenita with strabismus in a large family with a mutation in the SCN4A gene. Du H, etal., Eye (Lond). 2012 Aug;26(8):1039-43. doi: 10.1038/eye.2012.80. Epub 2012 Jun 1.
3. Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon. Fejtova A, etal., J Cell Biol. 2009 Apr 20;185(2):341-55. doi: 10.1083/jcb.200807155.
4. Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. Fuhrmann JC, etal., J Neurosci 2002 Jul 1;22(13):5393-402.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. King SM, etal., J Biol Chem. 1996 Aug 9;271(32):19358-66.
7. Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. Lo KW, etal., J Biol Chem. 2007 Dec 21;282(51):36871-8. Epub 2007 Oct 27.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. Naisbitt S, etal., J Neurosci. 2000 Jun 15;20(12):4524-34.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Subcellular localization of PMES-2 proteins regulated by their two cytoskeleton-associated domains. Ninomiya K, etal., Cell Mol Neurobiol. 2005 Aug;25(5):899-911. doi: 10.1007/s10571-005-4955-5.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12904292   PMID:14561217   PMID:15489334   PMID:19946888   PMID:21399614   PMID:21630459   PMID:21700703   PMID:22328512   PMID:25002582   PMID:25294941   PMID:26344333  
PMID:31904090  


Genomics

Comparative Map Data
Dynll2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,264,260 - 73,283,042 (-)NCBIGRCr8
mRatBN7.21072,767,035 - 72,785,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,767,035 - 72,785,805 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,377,490 - 77,385,515 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,882,434 - 76,890,459 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,346,936 - 72,354,961 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,262,536 - 75,281,302 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,262,537 - 75,270,561 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01074,819,177 - 74,837,880 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,263,883 - 76,271,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11076,278,253 - 76,286,278 (-)NCBI
Celera1071,677,302 - 71,685,328 (-)NCBICelera
Cytogenetic Map10q26NCBI
DYNLL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,083,419 - 58,095,542 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,083,419 - 58,095,542 (+)EnsemblGRCh38hg38GRCh38
GRCh371756,160,780 - 56,172,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,515,798 - 53,521,810 (+)NCBINCBI36Build 36hg18NCBI36
Build 341753,515,797 - 53,521,812NCBI
Celera1752,622,562 - 52,629,401 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1751,521,612 - 51,528,449 (+)NCBIHuRef
CHM1_11756,225,816 - 56,232,655 (+)NCBICHM1_1
T2T-CHM13v2.01758,957,420 - 58,969,544 (+)NCBIT2T-CHM13v2.0
Dynll2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,870,351 - 87,892,746 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,870,351 - 87,878,359 (-)EnsemblGRCm39 Ensembl
GRCm381187,979,525 - 88,003,817 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,979,525 - 87,987,533 (-)EnsemblGRCm38mm10GRCm38
MGSCv371187,793,027 - 87,811,800 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,795,728 - 87,803,700 (-)NCBIMGSCv36mm8
Celera1197,583,461 - 97,602,228 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.35NCBI
Dynll2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,929,186 - 4,936,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,929,186 - 4,936,027 (-)NCBIChiLan1.0ChiLan1.0
DYNLL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,257,528 - 74,265,364 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11779,068,504 - 79,076,340 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,161,701 - 52,169,538 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11757,021,357 - 57,025,750 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,021,357 - 57,025,750 (+)Ensemblpanpan1.1panPan2
DYNLL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1932,748,229 - 32,768,896 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl932,762,278 - 32,767,103 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha931,986,475 - 32,007,301 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0933,555,947 - 33,576,771 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl933,570,149 - 33,574,978 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,340,575 - 32,361,395 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0932,623,924 - 32,644,951 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0932,707,694 - 32,728,760 (+)NCBIUU_Cfam_GSD_1.0
Dynll2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,097,388 - 32,106,244 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364904,968,806 - 4,977,727 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364904,968,806 - 4,977,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNLL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,349,294 - 34,356,472 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,348,336 - 34,356,478 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21235,383,171 - 35,390,262 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DYNLL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11635,310,154 - 35,317,964 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1635,312,088 - 35,318,018 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660776,127,027 - 6,134,841 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dynll2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479512,932,460 - 12,940,498 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479512,932,425 - 12,940,503 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dynll2
67 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:146
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000012279
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat

Markers in Region
D10Chm200  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01075,272,084 - 75,272,330NCBIRnor6.0
Rnor_5.01074,828,086 - 74,828,332UniSTSRnor5.0
RGSC_v3.41076,273,430 - 76,273,676UniSTSRGSC3.4
Celera1071,686,853 - 71,687,105UniSTS
Cytogenetic Map10q26UniSTS
C87222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,767,110 - 72,767,317 (+)MAPPERmRatBN7.2
Rnor_6.01075,262,612 - 75,262,818NCBIRnor6.0
Rnor_5.01074,837,598 - 74,837,804UniSTSRnor5.0
RGSC_v3.41076,263,959 - 76,264,165UniSTSRGSC3.4
Celera1071,677,378 - 71,677,584UniSTS
Cytogenetic Map10q26UniSTS
RH127756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,767,251 - 72,767,468 (+)MAPPERmRatBN7.2
Rnor_6.01075,262,753 - 75,262,969NCBIRnor6.0
Rnor_5.01074,837,447 - 74,837,663UniSTSRnor5.0
RGSC_v3.41076,264,100 - 76,264,316UniSTSRGSC3.4
Celera1071,677,519 - 71,677,735UniSTS
Cytogenetic Map10q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012279   ⟹   ENSRNOP00000012279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1072,767,035 - 72,775,067 (-)Ensembl
Rnor_6.0 Ensembl1075,262,537 - 75,270,561 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102251   ⟹   ENSRNOP00000088572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1072,770,193 - 72,785,805 (-)Ensembl
RefSeq Acc Id: NM_080697   ⟹   NP_542428
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,264,260 - 73,272,285 (-)NCBI
mRatBN7.21072,767,035 - 72,775,060 (-)NCBI
Rnor_6.01075,262,536 - 75,270,561 (-)NCBI
Rnor_5.01074,819,177 - 74,837,880 (+)NCBI
RGSC_v3.41076,263,883 - 76,271,908 (-)RGD
Celera1071,677,302 - 71,685,328 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247077   ⟹   XP_006247139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,264,260 - 73,283,042 (-)NCBI
mRatBN7.21072,767,035 - 72,785,824 (-)NCBI
Rnor_6.01075,262,536 - 75,281,302 (-)NCBI
Rnor_5.01074,819,177 - 74,837,880 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085093   ⟹   XP_038941021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,264,260 - 73,272,320 (-)NCBI
mRatBN7.21072,767,035 - 72,775,078 (-)NCBI
RefSeq Acc Id: XM_063268351   ⟹   XP_063124421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,264,260 - 73,272,033 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_542428   ⟸   NM_080697
- UniProtKB: Q78P75 (UniProtKB/Swiss-Prot),   A6HHW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247139   ⟸   XM_006247077
- Peptide Label: isoform X1
- UniProtKB: Q78P75 (UniProtKB/Swiss-Prot),   A6HHW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012279   ⟸   ENSRNOT00000012279
RefSeq Acc Id: XP_038941021   ⟸   XM_039085093
- Peptide Label: isoform X1
- UniProtKB: Q78P75 (UniProtKB/Swiss-Prot),   A6HHW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088572   ⟸   ENSRNOT00000102251
RefSeq Acc Id: XP_063124421   ⟸   XM_063268351
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q78P75-F1-model_v2 AlphaFold Q78P75 1-89 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697577
Promoter ID:EPDNEW_R8102
Type:initiation region
Name:Dynll2_1
Description:dynein light chain LC8-type 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01075,270,571 - 75,270,631EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619860 AgrOrtholog
BIND 134401
BioCyc Gene G2FUF-23734 BioCyc
Ensembl Genes ENSRNOG00000008921 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026961 UniProtKB/Swiss-Prot
  ENSRNOG00060030573 UniProtKB/Swiss-Prot
  ENSRNOG00065018451 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012279 ENTREZGENE
  ENSRNOT00000012279.5 UniProtKB/Swiss-Prot
  ENSRNOT00000102251.1 UniProtKB/TrEMBL
  ENSRNOT00055046544 UniProtKB/Swiss-Prot
  ENSRNOT00060053087 UniProtKB/Swiss-Prot
  ENSRNOT00065030957 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598327 IMAGE-MGC_LOAD
InterPro DLC_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_light_1/2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_light_chain_typ-1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140734 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72334 IMAGE-MGC_LOAD
NCBI Gene 140734 ENTREZGENE
PANTHER DYNEIN LIGHT CHAIN 2, CYTOPLASMIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11886 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynein_light UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dynll2 PhenoGen
PROSITE DYNEIN_LIGHT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008921 RatGTEx
  ENSRNOG00055026961 RatGTEx
  ENSRNOG00060030573 RatGTEx
  ENSRNOG00065018451 RatGTEx
SMART Dynein_light UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54648 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AJ49_RAT UniProtKB/TrEMBL
  A6HHW4_RAT UniProtKB/TrEMBL
  A6HHW6 ENTREZGENE, UniProtKB/TrEMBL
  DYL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Dynll2  dynein light chain LC8-type 2  Dlc2  dynein light chain-2  Symbol and Name updated 1299863 APPROVED
2005-01-20 Dlc2  dynein light chain-2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dlc2  dynein light chain-2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization cytoplasmic and synaptic localization in hippocampal cells 628355
gene_expression enriched at synaptic sites 628355
gene_function binds to gephyrin, a tubulin-binding protein 628355
gene_physical_interaction directily interacts with synaptic scaffolding protein gephyrin 628355
gene_process plays a role in postsynaptic targeting of neurotransmitter receptors or scaffolding proteins 628355