Tjp2 (tight junction protein 2) - Rat Genome Database

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Gene: Tjp2 (tight junction protein 2) Rattus norvegicus
Analyze
Symbol: Tjp2
Name: tight junction protein 2
RGD ID: 619807
Description: Enables transmembrane transporter binding activity. Predicted to be involved in several processes, including establishment of endothelial intestinal barrier; positive regulation of blood-brain barrier permeability; and protein localization to cell-cell junction. Predicted to act upstream of or within negative regulation of osteoclast development and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in bicellular tight junction. Biomarker of hypertension. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2); INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC108349129; MGC124724; tight junction protein ZO-2; uncharacterized LOC108349129; ZO-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81231,136,218 - 231,264,750 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1231,136,243 - 231,264,750 (-)EnsemblGRCr8
mRatBN7.21221,709,745 - 221,838,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,709,745 - 221,838,295 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1230,159,462 - 230,287,384 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,089,516 - 237,217,442 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01229,907,552 - 230,035,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,945,816 - 242,084,044 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,945,841 - 242,083,484 (-)Ensemblrn6Rnor6.0
Rnor_5.01249,224,590 - 249,358,779 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41227,475,386 - 227,574,457 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1218,921,753 - 219,049,897 (-)NCBICelera
RGSC_v3.11227,639,414 - 227,668,771 (-)NCBI
Cytogenetic Map1q51NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Benzo[a]fluorene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[b]fluorene  (ISO)
Benzo[c]fluorene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
corn oil  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
lead(0)  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
malaoxon  (EXP)
malathion  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
nefazodone  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rifampicin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
streptozocin  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenylene  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Histone deacetylase inhibitors up-regulate the expression of tight junction proteins. Bordin M, etal., Mol Cancer Res. 2004 Dec;2(12):692-701.
3. Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. Carlton VE, etal., Nat Genet 2003 May;34(1):91-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats. Hom S, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Jan 18;.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. Singh D, etal., J Biol Chem. 2005 Aug 26;280(34):30416-21. Epub 2005 Jun 26.
Additional References at PubMed
PMID:11090614   PMID:12060405   PMID:12477932   PMID:12507281   PMID:14681019   PMID:15632090   PMID:16931598   PMID:18197414   PMID:18423437   PMID:19148554   PMID:19507189   PMID:20868367  
PMID:20970449   PMID:21679692   PMID:22006950   PMID:22437732   PMID:23885123   PMID:24889144   PMID:25468996   PMID:25486565   PMID:26464396   PMID:26609154   PMID:33450132   PMID:34689705  


Genomics

Comparative Map Data
Tjp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81231,136,218 - 231,264,750 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1231,136,243 - 231,264,750 (-)EnsemblGRCr8
mRatBN7.21221,709,745 - 221,838,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,709,745 - 221,838,295 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1230,159,462 - 230,287,384 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,089,516 - 237,217,442 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01229,907,552 - 230,035,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,945,816 - 242,084,044 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,945,841 - 242,083,484 (-)Ensemblrn6Rnor6.0
Rnor_5.01249,224,590 - 249,358,779 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41227,475,386 - 227,574,457 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1218,921,753 - 219,049,897 (-)NCBICelera
RGSC_v3.11227,639,414 - 227,668,771 (-)NCBI
Cytogenetic Map1q51NCBI
TJP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38969,121,264 - 69,255,208 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl969,121,264 - 69,274,615 (+)Ensemblhg38GRCh38
GRCh37971,736,180 - 71,870,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36970,978,909 - 71,059,940 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34969,018,642 - 69,099,672NCBI
Celera942,332,221 - 42,460,614 (+)NCBICelera
Cytogenetic Map9q21.11NCBI
HuRef941,580,602 - 41,709,784 (+)NCBIHuRef
CHM1_1971,882,855 - 72,016,570 (+)NCBICHM1_1
T2T-CHM13v2.0981,294,639 - 81,423,094 (+)NCBIT2T-CHM13v2.0
Tjp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391924,071,860 - 24,202,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1924,071,869 - 24,202,394 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381924,094,496 - 24,225,128 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1924,094,505 - 24,225,030 (-)Ensemblmm10GRCm38
MGSCv371924,168,992 - 24,299,444 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361924,161,608 - 24,241,085 (-)NCBIMGSCv36mm8
Celera1924,858,437 - 24,990,672 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1919.17NCBI
Tjp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554343,781,113 - 3,923,391 (-)Ensembl
ChiLan1.0NW_0049554343,781,368 - 3,923,240 (-)NCBIChiLan1.0ChiLan1.0
TJP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,311,183 - 68,465,150 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1968,317,161 - 68,471,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0955,536,627 - 55,690,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1967,865,958 - 68,020,569 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl967,886,421 - 68,021,189 (+)EnsemblpanPan2panpan1.1
TJP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1188,126,134 - 88,251,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl188,126,136 - 88,230,654 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha188,593,804 - 88,698,045 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0188,673,963 - 88,797,946 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl188,673,965 - 88,778,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1188,329,360 - 88,433,088 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0188,035,802 - 88,139,746 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0188,799,691 - 88,904,715 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tjp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947135,633,106 - 135,729,071 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365035,497,832 - 5,539,090 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365035,414,330 - 5,539,895 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TJP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,474,639 - 222,612,983 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11222,474,518 - 222,612,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21248,714,644 - 248,883,729 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TJP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11280,224,497 - 80,358,495 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1280,307,380 - 80,358,584 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603868,660,986 - 68,767,811 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tjp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247363,834,548 - 3,878,828 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247363,833,402 - 4,009,385 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tjp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1224,212,230 - 24,290,329 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tjp2
747 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:91
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000065921
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
5508828Leukc3Leukocyte quantity QTL 3eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1227535119233480676Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1221820316234540296Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1223964326236074012Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
RH132524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,774,547 - 221,774,744 (+)MAPPERmRatBN7.2
Rnor_6.01242,010,632 - 242,010,828NCBIRnor6.0
Rnor_5.01249,289,500 - 249,289,696UniSTSRnor5.0
RGSC_v3.41227,540,566 - 227,540,762UniSTSRGSC3.4
Celera1218,986,555 - 218,986,751UniSTS
Cytogenetic Map1q51UniSTS
RH132796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,709,826 - 221,710,014 (+)MAPPERmRatBN7.2
Rnor_6.01241,945,898 - 241,946,085NCBIRnor6.0
Rnor_5.01249,224,672 - 249,224,859UniSTSRnor5.0
RGSC_v3.41227,475,468 - 227,475,655UniSTSRGSC3.4
Celera1218,921,835 - 218,922,022UniSTS
Cytogenetic Map1q51UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 89 59 6 353 189 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000065921   ⟹   ENSRNOP00000062549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1231,136,243 - 231,264,750 (-)Ensembl
mRatBN7.2 Ensembl1221,709,745 - 221,838,295 (-)Ensembl
Rnor_6.0 Ensembl1241,945,841 - 242,083,484 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094702   ⟹   ENSRNOP00000095687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1231,136,243 - 231,264,750 (-)Ensembl
mRatBN7.2 Ensembl1221,709,745 - 221,838,295 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103927   ⟹   ENSRNOP00000096118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1231,136,243 - 231,214,895 (-)Ensembl
mRatBN7.2 Ensembl1221,709,745 - 221,788,493 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104406   ⟹   ENSRNOP00000093930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1231,136,243 - 231,217,396 (-)Ensembl
mRatBN7.2 Ensembl1221,709,745 - 221,807,388 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125106   ⟹   ENSRNOP00000106000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1231,136,243 - 231,214,034 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127207   ⟹   ENSRNOP00000107172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1231,138,883 - 231,183,076 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148636   ⟹   ENSRNOP00000102226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1231,136,243 - 231,247,770 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148916   ⟹   ENSRNOP00000101092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1231,136,243 - 231,183,076 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167191   ⟹   ENSRNOP00000107921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1231,136,243 - 231,214,703 (-)Ensembl
RefSeq Acc Id: NM_001414504   ⟹   NP_001401433
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81231,136,218 - 231,264,750 (-)NCBI
mRatBN7.21221,709,745 - 221,838,291 (-)NCBI
RefSeq Acc Id: NM_053773   ⟹   NP_446225
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81231,136,218 - 231,264,750 (-)NCBI
mRatBN7.21221,709,745 - 221,838,291 (-)NCBI
Rnor_6.01241,945,816 - 242,083,484 (-)NCBI
Rnor_5.01249,224,590 - 249,358,779 (-)NCBI
RGSC_v3.41227,475,386 - 227,574,457 (-)RGD
Celera1218,921,753 - 219,049,897 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231176   ⟹   XP_006231238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81231,136,218 - 231,233,664 (-)NCBI
mRatBN7.21221,709,745 - 221,807,203 (-)NCBI
Rnor_6.01241,945,816 - 242,059,862 (-)NCBI
Rnor_5.01249,224,590 - 249,358,779 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231177   ⟹   XP_006231239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81231,136,218 - 231,186,273 (-)NCBI
mRatBN7.21221,709,745 - 221,756,516 (-)NCBI
Rnor_6.01241,945,816 - 241,992,901 (-)NCBI
Rnor_5.01249,224,590 - 249,358,779 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231178   ⟹   XP_006231240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81231,136,218 - 231,214,912 (-)NCBI
mRatBN7.21221,709,745 - 221,788,426 (-)NCBI
Rnor_6.01241,945,816 - 242,026,725 (-)NCBI
Rnor_5.01249,224,590 - 249,358,779 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231182   ⟹   XP_006231244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81231,136,218 - 231,186,279 (-)NCBI
mRatBN7.21221,709,745 - 221,756,522 (-)NCBI
Rnor_6.01241,945,816 - 241,992,902 (-)NCBI
Rnor_5.01249,224,590 - 249,358,779 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109067   ⟹   XP_038964995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81231,136,218 - 231,214,840 (-)NCBI
mRatBN7.21221,709,745 - 221,788,411 (-)NCBI
RefSeq Acc Id: XM_039109085   ⟹   XP_038965013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81231,136,218 - 231,214,914 (-)NCBI
mRatBN7.21221,709,745 - 221,788,426 (-)NCBI
RefSeq Acc Id: NP_446225   ⟸   NM_053773
- Peptide Label: isoform 2
- UniProtKB: Q3ZB99 (UniProtKB/TrEMBL),   E9PTS1 (UniProtKB/TrEMBL),   A0A8I6ALD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231238   ⟸   XM_006231176
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AP88 (UniProtKB/TrEMBL),   A0A8I6ALD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231240   ⟸   XM_006231178
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GLX8 (UniProtKB/TrEMBL),   A6I0Q0 (UniProtKB/TrEMBL),   A0A8I6ALD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231244   ⟸   XM_006231182
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ALD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231239   ⟸   XM_006231177
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ALD4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062549   ⟸   ENSRNOT00000065921
RefSeq Acc Id: XP_038965013   ⟸   XM_039109085
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ALD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964995   ⟸   XM_039109067
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ALD4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096118   ⟸   ENSRNOT00000103927
Ensembl Acc Id: ENSRNOP00000093930   ⟸   ENSRNOT00000104406
Ensembl Acc Id: ENSRNOP00000095687   ⟸   ENSRNOT00000094702
RefSeq Acc Id: NP_001401433   ⟸   NM_001414504
- Peptide Label: isoform 1
- UniProtKB: A0A8J8Y4W9 (UniProtKB/TrEMBL),   A6I0Q1 (UniProtKB/TrEMBL),   A0A8I6ALD4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106000   ⟸   ENSRNOT00000125106
Ensembl Acc Id: ENSRNOP00000107172   ⟸   ENSRNOT00000127207
Ensembl Acc Id: ENSRNOP00000107921   ⟸   ENSRNOT00000167191
Ensembl Acc Id: ENSRNOP00000101092   ⟸   ENSRNOT00000148916
Ensembl Acc Id: ENSRNOP00000102226   ⟸   ENSRNOT00000148636
Protein Domains
Guanylate kinase-like   PDZ   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3ZB99-F1-model_v2 AlphaFold Q3ZB99 1-1164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690824
Promoter ID:EPDNEW_R1348
Type:initiation region
Name:Tjp2_1
Description:tight junction protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01242,083,480 - 242,083,540EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619807 AgrOrtholog
BioCyc Gene G2FUF-56096 BioCyc
Ensembl Genes ENSRNOG00000015030 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065921 ENTREZGENE
  ENSRNOT00000065921.5 UniProtKB/TrEMBL
  ENSRNOT00000094702 ENTREZGENE
  ENSRNOT00000094702.2 UniProtKB/TrEMBL
  ENSRNOT00000103927 ENTREZGENE
  ENSRNOT00000103927.2 UniProtKB/TrEMBL
  ENSRNOT00000104406.2 UniProtKB/TrEMBL
  ENSRNOT00000125106.1 UniProtKB/TrEMBL
  ENSRNOT00000127207.1 UniProtKB/TrEMBL
  ENSRNOT00000148636.1 UniProtKB/TrEMBL
  ENSRNOT00000148916 ENTREZGENE
  ENSRNOT00000148916.1 UniProtKB/TrEMBL
  ENSRNOT00000167191 ENTREZGENE
  ENSRNOT00000167191.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7936785 IMAGE-MGC_LOAD
InterPro Guanylate_kin UniProtKB/TrEMBL
  Guanylate_kin/L-typ_Ca_channel UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  ZO-2_SH3 UniProtKB/TrEMBL
  ZonOcculdens UniProtKB/TrEMBL
  ZonOcculS2 UniProtKB/TrEMBL
MGC_CLONE MGC:124724 IMAGE-MGC_LOAD
NCBI Gene 115769 ENTREZGENE
PANTHER TIGHT JUNCTION PROTEIN UniProtKB/TrEMBL
  TIGHT JUNCTION PROTEIN ZO-2 UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PhenoGen Tjp2 PhenoGen
PRINTS ZONOCCLUDNS UniProtKB/TrEMBL
  ZONOCCLUDNS2 UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015030 RatGTEx
SMART GuKc UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6ALD4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP88 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLX8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8Y4W9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LAL9_RAT UniProtKB/TrEMBL
  A0ABK0LBF1_RAT UniProtKB/TrEMBL
  A0ABK0LFN1_RAT UniProtKB/TrEMBL
  A0ABK0LUS5_RAT UniProtKB/TrEMBL
  A0ABK0LYM5_RAT UniProtKB/TrEMBL
  A6I0Q0 ENTREZGENE, UniProtKB/TrEMBL
  A6I0Q1 ENTREZGENE, UniProtKB/TrEMBL
  E9PTS1 ENTREZGENE
  Q3ZB99 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9PTS1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tjp2  tight junction protein 2  LOC108349129  uncharacterized LOC108349129  Data merged from RGD:11448097 737654 PROVISIONAL
2016-08-02 LOC108349129  uncharacterized LOC108349129      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Tjp2  tight junction protein 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Tjp2        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation differentially expressed following carotoid injury 631940