Tjp2 (tight junction protein 2) - Rat Genome Database

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Gene: Tjp2 (tight junction protein 2) Chinchilla lanigera
Analyze
Symbol: Tjp2
Name: tight junction protein 2
RGD ID: 8962504
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); protein tyrosine kinase binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN establishment of endothelial intestinal barrier (ortholog); homotypic cell-cell adhesion (ortholog); intestinal absorption (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant nonsyndromic deafness 51 (ortholog); branchiootorenal syndrome (ortholog); FOUND IN bicellular tight junction (ortholog); cell junction (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tight junction protein ZO-2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554343,781,113 - 3,923,391 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554343,781,368 - 3,923,240 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tjp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554343,781,113 - 3,923,391 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554343,781,368 - 3,923,240 (-)NCBIChiLan1.0ChiLan1.0
TJP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38969,121,264 - 69,255,208 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl969,121,264 - 69,274,615 (+)EnsemblGRCh38hg38GRCh38
GRCh37971,736,180 - 71,870,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36970,978,909 - 71,059,940 (+)NCBINCBI36Build 36hg18NCBI36
Build 34969,018,642 - 69,099,672NCBI
Celera942,332,221 - 42,460,614 (+)NCBICelera
Cytogenetic Map9q21.11NCBI
HuRef941,580,602 - 41,709,784 (+)NCBIHuRef
CHM1_1971,882,855 - 72,016,570 (+)NCBICHM1_1
T2T-CHM13v2.0981,294,639 - 81,423,094 (+)NCBIT2T-CHM13v2.0
Tjp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391924,071,860 - 24,202,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1924,071,869 - 24,202,394 (-)EnsemblGRCm39 Ensembl
GRCm381924,094,496 - 24,225,128 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1924,094,505 - 24,225,030 (-)EnsemblGRCm38mm10GRCm38
MGSCv371924,168,992 - 24,299,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361924,161,608 - 24,241,085 (-)NCBIMGSCv36mm8
Celera1924,858,437 - 24,990,672 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1919.17NCBI
Tjp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81231,136,218 - 231,264,750 (-)NCBIGRCr8
mRatBN7.21221,709,745 - 221,838,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,709,745 - 221,838,295 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1230,159,462 - 230,287,384 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,089,516 - 237,217,442 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01229,907,552 - 230,035,465 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,945,816 - 242,084,044 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,945,841 - 242,083,484 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,224,590 - 249,358,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,475,386 - 227,574,457 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,639,414 - 227,668,771 (-)NCBI
Celera1218,921,753 - 219,049,897 (-)NCBICelera
Cytogenetic Map1q51NCBI
TJP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,311,183 - 68,465,150 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1968,317,161 - 68,471,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0955,536,627 - 55,690,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1967,865,958 - 68,020,569 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl967,886,421 - 68,021,189 (+)Ensemblpanpan1.1panPan2
TJP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1188,126,134 - 88,251,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl188,126,136 - 88,230,654 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha188,593,804 - 88,698,045 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0188,673,963 - 88,797,946 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl188,673,965 - 88,778,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1188,329,360 - 88,433,088 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0188,035,802 - 88,139,746 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0188,799,691 - 88,904,715 (-)NCBIUU_Cfam_GSD_1.0
Tjp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947135,633,106 - 135,729,071 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365035,497,832 - 5,539,090 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365035,414,330 - 5,539,895 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TJP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,474,639 - 222,612,983 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,474,518 - 222,612,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21248,714,644 - 248,883,729 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TJP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11280,224,497 - 80,358,495 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1280,307,380 - 80,358,584 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603868,660,986 - 68,767,811 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tjp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247363,834,548 - 3,878,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247363,833,402 - 4,009,385 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000018912   ⟹   ENSCLAP00000018727
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554343,781,113 - 3,923,391 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000018913   ⟹   ENSCLAP00000018728
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554343,781,113 - 3,869,178 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000018914   ⟹   ENSCLAP00000018729
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554343,781,113 - 3,858,014 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000018915   ⟹   ENSCLAP00000018730
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554343,781,113 - 3,837,056 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000018916   ⟹   ENSCLAP00000018731
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554343,782,137 - 3,828,074 (-)Ensembl
RefSeq Acc Id: XM_005388570   ⟹   XP_005388627
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554343,781,368 - 3,923,240 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013516340   ⟹   XP_013371794
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554343,781,368 - 3,923,240 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005388627 (Get FASTA)   NCBI Sequence Viewer  
  XP_013371794 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018727
  ENSCLAP00000018727.1
  ENSCLAP00000018728.1
  ENSCLAP00000018729.1
  ENSCLAP00000018730.1
  ENSCLAP00000018731.1
Reference Protein Sequences
RefSeq Acc Id: XP_005388627   ⟸   XM_005388570
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VPS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013371794   ⟸   XM_013516340
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VPS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000018731   ⟸   ENSCLAT00000018916
RefSeq Acc Id: ENSCLAP00000018730   ⟸   ENSCLAT00000018915
RefSeq Acc Id: ENSCLAP00000018728   ⟸   ENSCLAT00000018913
RefSeq Acc Id: ENSCLAP00000018727   ⟸   ENSCLAT00000018912
RefSeq Acc Id: ENSCLAP00000018729   ⟸   ENSCLAT00000018914
Protein Domains
Guanylate kinase-like   PDZ   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012841 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAG00000025397 ENTREZGENE
Ensembl Transcript ENSCLAT00000018912 ENTREZGENE
  ENSCLAT00000018912.1 UniProtKB/TrEMBL
  ENSCLAT00000018913.1 UniProtKB/TrEMBL
  ENSCLAT00000018914.1 UniProtKB/TrEMBL
  ENSCLAT00000018915.1 UniProtKB/TrEMBL
  ENSCLAT00000018916.1 UniProtKB/TrEMBL
  ENSCLAT00000034394 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro GK/Ca_channel_bsu UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/TrEMBL
  IPR005417 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  ZO-2 UniProtKB/TrEMBL
  ZO-2_SH3 UniProtKB/TrEMBL
NCBI Gene Tjp2 ENTREZGENE
PANTHER TIGHT JUNCTION PROTEIN UniProtKB/TrEMBL
  TIGHT JUNCTION PROTEIN ZO-2 UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PRINTS ZONOCCLUDNS UniProtKB/TrEMBL
  ZONOCCLUDNS2 UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART GuKc UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2VPS0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VRV3_CHILA UniProtKB/TrEMBL
  A0A8C2VTR7_CHILA UniProtKB/TrEMBL
  A0A8C2VWM5_CHILA UniProtKB/TrEMBL
  A0A8C2VWY6_CHILA UniProtKB/TrEMBL