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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:733146 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TJP2 mRNA | CTD | PMID:22079256 | 1,3-dinitrobenzene | increases expression | ISO | RGD:619807 | 6480464 | 3-dinitrobenzene results in increased expression of TJP2 mRNA | CTD | PMID:21983209 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:733146 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TJP2 mRNA | CTD | PMID:17101203 PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TJP2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TJP2 mRNA | CTD | PMID:21354282 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:733146 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TJP2 mRNA | CTD | PMID:20106945 PMID:17101203 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TJP2 mRNA | CTD | PMID:19465110 | 2,4-dinitrotoluene | affects expression | ISO | RGD:619807 | 6480464 | 2,4-dinitrotoluene affects the expression of TJP2 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | ISO | RGD:619807 | 6480464 | 2,6-dinitrotoluene affects the expression of TJP2 mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TJP2 mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of TJP2 mRNA | CTD | PMID:18648102 | ammonium chloride | affects expression | ISO | RGD:619807 | 6480464 | Ammonium Chloride affects the expression of TJP2 mRNA | CTD | PMID:16483693 | arsenite(3-) | increases expression | EXP | | 6480464 | arsenite results in increased expression of TJP2 mRNA | CTD | PMID:18191166 | benzo[a]pyrene | increases expression | ISO | RGD:733146 | 6480464 | Benzo(a)pyrene results in increased expression of TJP2 mRNA | CTD | PMID:17879257 | benzo[a]pyrene | decreases expression | ISO | RGD:733146 | 6480464 | Benzo(a)pyrene results in decreased expression of TJP2 mRNA | CTD | PMID:21632981 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of TJP2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of TJP2 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of TJP2 mRNA | CTD | PMID:21715664 | bis(2-chloroethyl) sulfide | increases phosphorylation | ISO | RGD:733146 | 6480464 | Mustard Gas results in increased phosphorylation of TJP2 protein | CTD | PMID:19845377 | cisplatin | multiple interactions | ISO | RGD:733146 | 6480464 | Cisplatin inhibits the reaction [Piroxicam results in increased expression of TJP2 mRNA] | CTD | PMID:21858171 | cobalt dichloride | decreases expression | ISO | RGD:733146 | 6480464 | cobaltous chloride results in decreased expression of TJP2 mRNA | CTD | PMID:19320972 | cocaine | affects expression | ISO | RGD:619807 | 6480464 | Cocaine affects the expression of TJP2 mRNA | CTD | PMID:20187946 | cyclosporin A | decreases expression | ISO | RGD:733146 | 6480464 | Cyclosporine results in decreased expression of TJP2 mRNA | CTD | PMID:20106945 | formaldehyde | decreases expression | ISO | RGD:733146 | 6480464 | Formaldehyde results in decreased expression of TJP2 mRNA | CTD | PMID:20655997 | lead(0) | multiple interactions | ISO | RGD:619807 | 6480464 | [malaoxon co-treated with Lead] results in decreased expression of TJP2 protein; more ... | CTD | PMID:20970449 | lead(0) | decreases expression | ISO | RGD:619807 | 6480464 | Lead results in decreased expression of TJP2 protein | CTD | PMID:20970449 | malathion | multiple interactions | ISO | RGD:619807 | 6480464 | [Malathion co-treated with Lead] results in decreased expression of TJP2 protein | CTD | PMID:20970449 | malathion | decreases expression | ISO | RGD:619807 | 6480464 | Malathion results in decreased expression of TJP2 protein | CTD | PMID:20970449 | menadione | affects expression | ISO | RGD:733146 | 6480464 | Vitamin K 3 affects the expression of TJP2 mRNA | CTD | PMID:20044591 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of TJP2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:733146 | 6480464 | Acetaminophen results in increased expression of TJP2 mRNA | CTD | PMID:21420995 | pirinixic acid | multiple interactions | ISO | RGD:733146 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TJP2 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of TJP2 mRNA | CTD | PMID:18301758 | piroxicam | multiple interactions | ISO | RGD:733146 | 6480464 | Cisplatin inhibits the reaction [Piroxicam results in increased expression of TJP2 mRNA] | CTD | PMID:21858171 | piroxicam | increases expression | ISO | RGD:733146 | 6480464 | Piroxicam results in increased expression of TJP2 mRNA | CTD | PMID:21858171 | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of TJP2 mRNA | CTD | PMID:21278054 | quercetin | decreases expression | ISO | RGD:733146 | 6480464 | Quercetin results in decreased expression of TJP2 mRNA | CTD | PMID:21632981 | rifampicin | decreases expression | EXP | | 6480464 | Rifampin results in decreased expression of TJP2 mRNA | CTD | PMID:19577586 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Tight junction |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional repression (PID:200200) |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Tight junction |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional repression (PID:200200) |
Phenotype Annotations
References - curated| 1. |
Carlton VE, etal., Nat Genet 2003 May;34(1):91-6. |
| 2. |
Hom S, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Jan 18;. |
| 3. |
MGD and Homologene mouse data transfer |
| 4. |
MGD data from the GO Consortium |
| 5. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 6. |
RGD automated import pipeline |
| 7. |
RGD automated import pipeline for gene-chemical interactions |
| 8. |
RGD Automated Pipelines |
References - uncurated| PubMed | 10026224 |
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RGD Disease Portals| Tjp2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Tjp2 (Mus musculus) |
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| TJP2 (Homo sapiens) |
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| Tjp2 (Rattus norvegicus) |
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Position Markers| D19Mit107 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001198985 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_011597 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHY01142617 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01142618 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01142619 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01142620 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01142621 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01142622 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01142623 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01142624 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01142625 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01142626 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01142627 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC107685 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC149224 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF113005 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK028494 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK076689 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK184185 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK194560 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK202211 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK203756 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK204133 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK204857 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK209802 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK213841 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK217702 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK218366 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK218795 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK219931 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC034677 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC039924 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC042695 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BM224980 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BP767126 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BQ033995 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BQ176958 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BY032291 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB724174 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CF736959 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466534 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN527767 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN529621 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_011597 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_035727 | |||||||||||||||||||||||||
| Peptide Label: | isoform 2 | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001198985 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001185914 | ||||||||||||||||||||
| Peptide Label: | isoform 1 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001185914 | (Get FASTA) |
| NP_035727 | (Get FASTA) | |
| GenBank Protein | AAD19964 | (Get FASTA) |
| AAH34677 | (Get FASTA) | |
| AAH39924 | (Get FASTA) | |
| EDL41612 | (Get FASTA) | |
| EDL41613 | (Get FASTA) | |
| EDL41614 | (Get FASTA) | |
| Q9Z0U1 | (Get FASTA) |
Promoters| RGD ID: | 6830472 | ||||||||||
| Promoter ID: | MM_KWN:26693 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Lung | ||||||||||
| Transcripts: | ENSMUST00000099558, UC008HAL.1 | ||||||||||
| Position: |
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| RGD ID: | 6891624 | ||||||||||
| Promoter ID: | EPDNEW_M9263 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Tjp2_1 | ||||||||||
| Description: | tight junction protein 2 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000024812 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000097154 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000099558 | ENTREZGENE |
| Entrez Gene | 21873 | ENTREZGENE |
| Germonline | ENSMUSG00000024812 | |
| HomoloGene Group ID | 3541 | ENTREZGENE |
| InterPro | Guanylate_kin | UniProtKB/Swiss-Prot |
| Guanylate_kin/L-typ_Ca_channel | UniProtKB/Swiss-Prot | |
| PDZ/DHR/GLGF | UniProtKB/Swiss-Prot | |
| SH3_2 | UniProtKB/Swiss-Prot | |
| SH3_domain | UniProtKB/Swiss-Prot | |
| ZonOcculdens | UniProtKB/Swiss-Prot | |
| ZonOcculS2 | UniProtKB/Swiss-Prot | |
| IPI | IPI00323349 | UniProtKB/Swiss-Prot |
| KEGG Report | mmu:21873 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1341872 | ENTREZGENE |
| Pfam | Guanylate_kin | UniProtKB/Swiss-Prot |
| PDZ | UniProtKB/Swiss-Prot | |
| SH3_2 | UniProtKB/Swiss-Prot | |
| PRINTS | ZONOCCLUDNS | UniProtKB/Swiss-Prot |
| ZONOCCLUDNS2 | UniProtKB/Swiss-Prot | |
| PROSITE | GUANYLATE_KINASE_1; FALSE_NEG | UniProtKB/Swiss-Prot |
| GUANYLATE_KINASE_2 | UniProtKB/Swiss-Prot | |
| PDZ | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| SMART | GuKc | UniProtKB/Swiss-Prot |
| PDZ | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | PDZ | UniProtKB/Swiss-Prot |
| SH3 | UniProtKB/Swiss-Prot | |
| UniGene | Mm.104744 | ENTREZGENE |
| UniProt | ZO2_MOUSE | UniProtKB/Swiss-Prot |
| More on Tjp2 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 733147 |
| Created: | 2004-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




