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Gene: Grb7 (growth factor receptor bound protein 7) Rattus norvegicus

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Symbol:

Grb7

Name:

growth factor receptor bound protein 7

RGD ID:

619759

Description:

Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of translation; positive regulation of cell migration; and stress granule assembly. Predicted to be located in cytoplasmic stress granule; cytosol; and focal adhesion. Human ortholog(s) of this gene implicated in esophagus adenocarcinoma. Orthologous to human GRB7 (growth factor receptor bound protein 7); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

epidermal growth factor receptor GRB-7; GRB7 adapter protein; growth factor receptor binding protein GRB7; growth factor receptor-bound protein 7; MGC93307

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GRB7 (growth factor receptor bound protein 7)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Grb7 (growth factor receptor bound protein 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Grb7 (growth factor receptor bound protein 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GRB7 (growth factor receptor bound protein 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GRB7 (growth factor receptor bound protein 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Grb7 (growth factor receptor bound protein 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GRB7 (growth factor receptor bound protein 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GRB7 (growth factor receptor bound protein 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Grb7 (growth factor receptor bound protein 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Grb7 (growth factor receptor bound protein 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AIFM3 (AIF family member 3)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GRB7 (growth factor receptor bound protein 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Grb7 (growth factor receptor bound protein 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grb7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	grb7	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	grb7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	83,936,538 - 83,949,344 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	83,939,299 - 83,949,382 (+)	Ensembl				GRCr8
mRatBN7.2	10	83,443,387 - 83,453,057 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	83,444,004 - 83,453,052 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	88,388,376 - 88,397,418 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	87,886,462 - 87,895,504 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	83,279,113 - 83,288,155 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	86,393,186 - 86,408,893 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	86,399,827 - 86,409,348 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	86,195,239 - 86,204,828 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	87,252,571 - 87,261,619 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	82,191,697 - 82,200,731 (+)	NCBI		Celera
RGSC_v3.1	10	87,266,940 - 87,275,988 (+)	NCBI
Cytogenetic Map	10	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

Breast Neoplasms (ISO)

esophageal carcinoma (ISO)

esophagus adenocarcinoma (ISO)

esophagus squamous cell carcinoma (ISO)

gastrointestinal carcinoma (ISO)

hepatocellular carcinoma (ISO)

High Myopia (ISO)

Lung Neoplasms (ISO)

Prostatic Neoplasms (ISO)

renal cell carcinoma (ISO)

stomach cancer (ISO)

stomach carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

9-cis-retinoic acid (ISO)

acrolein (ISO)

afimoxifene (ISO)

all-trans-4-oxoretinoic acid (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

arsenous acid (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromochloroacetic acid (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

carmustine (ISO)

chlordecone (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

DDE (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

endosulfan (EXP)

fenthion (ISO)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

graphene oxide (ISO)

inulin (ISO)

isotretinoin (ISO)

lead diacetate (ISO)

leflunomide (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quinolin-8-ol (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sodium dodecyl sulfate (ISO)

sotorasib (ISO)

sunitinib (ISO)

tamoxifen (ISO)

Tanshinone I (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trametinib (ISO)

trichloroethene (EXP)

triclosan (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

troglitazone (ISO)

tungsten (ISO)

valproic acid (ISO)

zearalenone (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

insulin receptor signaling pathway (IBA,IEA)

intracellular signal transduction (IBA)

negative regulation of insulin receptor signaling pathway (IBA)

negative regulation of translation (IEA,ISO,ISS)

positive regulation of cell migration (IEA,ISO,ISS)

signal transduction (IEA)

stress granule assembly (IEA,ISO,ISS)

Cellular Component

cell projection (IEA)

cytoplasm (IEA)

cytoplasmic stress granule (IEA,ISO,ISS)

cytosol (IEA,ISO,ISS)

focal adhesion (IEA,ISO,ISS)

plasma membrane (IEA,ISO)

Molecular Function

identical protein binding (IEA,ISO)

lipid binding (IEA)

phosphatidylinositol binding (IEA,ISO,ISS)

protein binding (IPI,ISO)

protein kinase binding (IEA,ISO)

protein-macromolecule adaptor activity (IBA)

RNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ephrin - ephrin receptor bidirectional signaling axis (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.	Gotovac JR, etal., J Pathol. 2020 Nov;252(3):317-329. doi: 10.1002/path.5528. Epub 2020 Sep 15.
4.	Role of growth factor receptor bound protein 7 in hepatocellular carcinoma.	Itoh S, etal., Mol Cancer Res. 2007 Jul;5(7):667-73. doi: 10.1158/1541-7786.MCR-06-0282.
5.	Identification of the rat adapter Grb14 as an inhibitor of insulin actions.	Kasus-Jacobi A, etal., J Biol Chem 1998 Oct 2;273(40):26026-35.
6.	Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2.	Kasus-Jacobi A, etal., Oncogene 2000 Apr 13;19(16):2052-9.
7.	Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer.	Kishi T, etal., Biochem Biophys Res Commun. 1997 Mar 6;232(1):5-9. doi: 10.1006/bbrc.1997.6218.
8.	Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.	Lundby A, etal., Cell. 2019 Oct 3;179(2):543-560.e26. doi: 10.1016/j.cell.2019.09.008.
9.	Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas.	Maqani N, etal., Mol Cancer Res. 2006 Jul;4(7):449-55. doi: 10.1158/1541-7786.MCR-06-0058.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17.	Phase II Feasibility and Biomarker Study of Neoadjuvant Trastuzumab and Pertuzumab With Chemoradiotherapy for Resectable Human Epidermal Growth Factor Receptor 2-Positive Esophageal Adenocarcinoma: TRAP Study.	Stroes CI, etal., J Clin Oncol. 2020 Feb 10;38(5):462-471. doi: 10.1200/JCO.19.01814. Epub 2019 Dec 6.
18.	Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma.	Tanaka S, etal., Cancer Res. 1997 Jan 1;57(1):28-31.
19.	Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma.	Tanaka S, etal., J Cell Physiol. 2000 Jun;183(3):411-5. doi: 10.1002/(SICI)1097-4652(200006)183:3<411::AID-JCP14>3.0.CO;2-Z.

Additional References at PubMed

PMID:10893408	PMID:12021278	PMID:15841400	PMID:18273060	PMID:20142421	PMID:32360748

Genomics

Comparative Map Data

Grb7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	83,936,538 - 83,949,344 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	83,939,299 - 83,949,382 (+)	Ensembl				GRCr8
mRatBN7.2	10	83,443,387 - 83,453,057 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	83,444,004 - 83,453,052 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	88,388,376 - 88,397,418 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	87,886,462 - 87,895,504 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	83,279,113 - 83,288,155 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	86,393,186 - 86,408,893 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	86,399,827 - 86,409,348 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	86,195,239 - 86,204,828 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	87,252,571 - 87,261,619 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	82,191,697 - 82,200,731 (+)	NCBI		Celera
RGSC_v3.1	10	87,266,940 - 87,275,988 (+)	NCBI
Cytogenetic Map	10	q31	NCBI

GRB7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	39,737,938 - 39,747,285 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	39,737,490 - 39,747,292 (+)	Ensembl			hg38	GRCh38
GRCh37	17	37,894,191 - 37,903,538 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	35,147,713 - 35,157,064 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	17	35,147,743 - 35,157,063	NCBI
Celera	17	34,553,923 - 34,563,612 (+)	NCBI		Celera
Cytogenetic Map	17	q12	NCBI
HuRef	17	33,687,978 - 33,697,340 (+)	NCBI		HuRef
CHM1_1	17	38,129,890 - 38,139,267 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	40,601,500 - 40,610,848 (+)	NCBI		T2T-CHM13v2.0

Grb7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	98,337,660 - 98,346,199 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	98,337,220 - 98,346,199 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	98,446,834 - 98,455,373 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	98,446,394 - 98,455,373 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	98,308,148 - 98,316,687 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	98,262,981 - 98,271,463 (+)	NCBI		MGSCv36	mm8
Celera	11	108,101,038 - 108,109,577 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	61.75	NCBI

Grb7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	14,464,541 - 14,474,070 (+)	Ensembl
ChiLan1.0	NW_004955451	14,463,032 - 14,470,392 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRB7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	25,207,628 - 25,217,597 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	27,102,480 - 27,112,404 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	17,541,771 - 17,551,049 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	17,758,992 - 17,768,290 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	17,758,992 - 17,768,290 (-)	Ensembl			panPan2	panpan1.1

GRB7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	22,743,370 - 22,751,936 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	22,743,402 - 22,750,896 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	22,215,830 - 22,224,392 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	23,536,867 - 23,545,435 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	23,536,899 - 23,552,360 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	22,309,656 - 22,318,216 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	22,570,695 - 22,579,250 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	22,695,812 - 22,704,377 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Grb7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	22,149,759 - 22,163,208 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	14,917,372 - 14,925,337 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	14,912,010 - 14,925,380 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRB7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	22,574,584 - 22,582,345 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	12	22,574,579 - 22,583,386 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	23,031,754 - 23,036,626 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRB7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	66,416,978 - 66,427,035 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	66,416,904 - 66,426,300 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666077	37,326,500 - 37,335,782 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grb7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	3,357,469 - 3,365,425 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624795	3,359,119 - 3,366,802 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Grb7
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	55,940,519 - 55,949,429 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Grb7
119 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	40
Count of miRNA genes:	40
Interacting mature miRNAs:	40
Transcripts:	ENSRNOT00000009299
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	51071897	96071897	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
8657410	Bp374	Blood pressure QTL 374			heart left ventricle size trait (VT:0002753)	heart left ventricle end-diastolic diameter (CMO:0000982)	10	67476608	107713808	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	35509383	91417879	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63719161	107713808	Rat
631555	Bp134	Blood pressure QTL 134		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	81012077	91729860	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	58073360	103073360	Rat
12903252	Cm113	Cardiac mass QTL 113		0.047	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	54296336	99451733	Rat
4889948	Bss91	Bone structure and strength QTL 91	4		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	10	83061236	92869129	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41831278	86831278	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50464802	95464802	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	64939013	107713808	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76951790	107713808	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	79272424	102982300	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44939359	89939359	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45529164	96099749	Rat
70168	Eae12	Experimental allergic encephalomyelitis QTL 12		0.0009	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	73599825	107713808	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
10450495	Bp383	Blood pressure QTL 383		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76743133	95464802	Rat
12903269	Am15	Aortic mass QTL 15		0.042	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
10450493	Bp382	Blood pressure QTL 382		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50860288	95860288	Rat
12903266	Cm114	Cardiac mass QTL 114		0.02	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	66817119	107713808	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73950353	96620293	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62556066	107556066	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42823274	87823274	Rat
724516	Uae17	Urinary albumin excretion QTL 17	3.6		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	78707585	85720738	Rat
12880372	Am12	Aortic mass QTL 12		0.003	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62556066	107556066	Rat
12880375	Kidm66	Kidney mass QTL 66		0.009	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44939359	89939359	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	67241334	98502431	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
12880370	Cm105	Cardiac mass QTL 105		0.008	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42823274	87823274	Rat
12880371	Cm106	Cardiac mass QTL 106		0.007	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61843496	98710773	Rat
11565453	Kidm58	Kidney mass QTL 58		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	73695339	97272278	Rat
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	65390777	107713808	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	81012077	101828297	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
2306793	Ean5	Experimental allergic neuritis QTL 5	4.7		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	73049656	94495280	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	49495492	94495492	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68920187	107713808	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	65307813	107713808	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61843496	106843496	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70698731	107713808	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	55307972	93608131	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61843496	100198886	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	43608793	88608793	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
7207811	Bmd90	Bone mineral density QTL 90	5.2		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	10	49943710	94943710	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44939359	89939359	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	66108888	107555881	Rat
2325836	Bp346	Blood pressure QTL 346		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76743133	84503487	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61843496	100198886	Rat
12880053	Cm104	Cardiac mass QTL 104		0.009	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	73950209	83959619	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47869129	92869129	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76743133	95604677	Rat
12880050	Am10	Aortic mass QTL 10		0.016	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	39503487	84503487	Rat
2292436	Bp310	Blood pressure QTL 310			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50604677	95604677	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	35509383	88177745	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73950353	96620293	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	76128947	107713808	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	61997479	106997479	Rat
2301405	Cm69	Cardiac mass QTL 69		0.031	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

RH135048

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	83,452,821 - 83,453,009 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	86,408,659 - 86,408,846	NCBI	Rnor6.0
Rnor_5.0	10	86,204,594 - 86,204,781	UniSTS	Rnor5.0
RGSC_v3.4	10	87,261,389 - 87,261,576	UniSTS	RGSC3.4
Celera	10	82,200,501 - 82,200,688	UniSTS
RH 3.4 Map	10	850.9	UniSTS
Cytogenetic Map	10	q31	UniSTS

GRB7_4323

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	83,452,558 - 83,453,022 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	86,408,396 - 86,408,859	NCBI	Rnor6.0
Rnor_5.0	10	86,204,331 - 86,204,794	UniSTS	Rnor5.0
RGSC_v3.4	10	87,261,126 - 87,261,589	UniSTS	RGSC3.4
Celera	10	82,200,238 - 82,200,701	UniSTS
Cytogenetic Map	10	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	6	51	128	91	90	59	90	59	6	328	166	5	109	81	92	31	8	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053403	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768125	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF190121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009299 ⟹ ENSRNOP00000009299

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	83,939,299 - 83,949,382 (+)	Ensembl
mRatBN7.2 Ensembl	10	83,444,004 - 83,453,052 (+)	Ensembl
Rnor_6.0 Ensembl	10	86,399,827 - 86,409,348 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117229 ⟹ ENSRNOP00000090166

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	83,939,299 - 83,949,336 (+)	Ensembl
mRatBN7.2 Ensembl	10	83,444,004 - 83,453,049 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000140324 ⟹ ENSRNOP00000105096

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	83,939,299 - 83,949,344 (+)	Ensembl

RefSeq Acc Id:

NM_053403 ⟹ NP_445855

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	83,940,289 - 83,949,337 (+)	NCBI
mRatBN7.2	10	83,444,004 - 83,453,052 (+)	NCBI
Rnor_6.0	10	86,399,841 - 86,408,889 (+)	NCBI
Rnor_5.0	10	86,195,239 - 86,204,828 (+)	NCBI
RGSC_v3.4	10	87,252,571 - 87,261,619 (+)	RGD
Celera	10	82,191,697 - 82,200,731 (+)	RGD

Sequence:

show sequence

AACAGCCTCCAAACTCCCCTTCCCATGTAGTCAGGATTCTAGATTTTTCTCTTTCCAGCCTGTT
CTCTTTGACTCTTCCTTGCCTCTGCCGGGCACCTGCTCTCTCTCCTAGCACCTGCTGCCCTGTA
GGAAGGGCAAGAGCCAATTCCAGGCGGTGCACAGTGAGGAGTCTCCACCCCTCCTCCTGCGCTT
CCTTCTCCAGGGCGCCTCTCAGGCCCCGCCCTCACCTGCCCAAGATAATTTTAGTTTCCCTGGG
CCTGGAATCTGGATACGCAGGGCTCGCTCCATATTCTCCCGCCTCAACATCCAAAGGCGGGCTA
ACCCTCCTACCACCTGGAGAGAAGAGAGAGAGGGTTCGAAATCAAATCCAAGGGTCTGGGACCT
CTAGACAGAGCCAGCCTTTGGGTCCCGGTGTCCCGCTCCTTCTGCTGGAGTTCCTCCAGGTGCC
ATGGAACTGGATCTGAGCCCGTCTCATCTCAGCAGCTCCCCAGAAGATGTGTGCCCAACTCCTG
GGACCCCTCCCGAGACTCCTCCGCCCCCGGATAACCCTCCGCCCGGCGATGTGAAGCGGTCTCA
GCCTTTGCCCATCCCAAGTAGCAGGAAACTTCGAGAAGAGGAGTTTCAGGCAACCTCTCTACCC
TCCATCCCCAACCCCTTCCCCGAGCTCTGCAGCCCACCTTCACAGAAACCCATTCTTGGTGGTT
CCTCCGGTGCTAGGGGGTTGCTTCCTCGAGACTCCAGCCGCCTCTGTGTGGTGAAGGTGTACAG
TGAAGATGGAGCCTGCCGGTCTGTGGAAGTGGCGGCAGGTGCGACGGCTCGCCATGTGTGTGAG
ATGCTGGTGCAGCGAGCTCACGCCCTGAGCGATGAGAACTGGGGCCTGGTGGAGTGCCACCCCT
ATTTGGCTCTGGAGCGGGGTTTGGAGGACCATGAGTCTGTGGTAGAAGTGCAGGAGGCCTGGCC
TGTGGGTGGAGACAGCCGCTTCATCTTCCGTAAAAACTTCGCCAAGTATGAACTCTTCAAGAGC
CCTCCGCACACCCTGTTCCCAGAAAAGATGGTTTCCAGCTGTCTGGATACACCAACAGGCATAT
CCCATGAAGACCTCATCCAGAACTTCCTGAATGCTGGCAGCTTCCCTGAGATCCAGGGCTTCCT
GCAGCTTCGGGGATCAGGCCGGGGGTCAGGTCGAAAGCTTTGGAAACGATTCTTCTGCTTCCTG
CGTCGGTCTGGCCTCTATTACTCGACCAAGGGCACCTCTAAGGACCCGAGACACCTACAGTACG
TGGCAGATATAAATGAGTCCAATGTGTATGTGGTGACCCAGGGCCGCAAGCTGTATGGGATACC
CACCGACTTCGGCTTTTGTGTCAAGCCCAACAAGCTTCGAAATGGCCACAAGGGGCTCCACATC
TTCTGCAGCGAGGATGAGCAGAGTCGGACTTGCTGGCTGTCCGCCTTCCGGCTCTTCAAGTACG
GGGTACAGCTATATAAGAATTATCAGCAGGCCCAGTCTCGTCACCTGCGCTTATCGTATTTGGG
GTCTCCACCCTTGAGGAGTGTCTCAGATAATACCCTGGTGGCCATGGACTTCTCTGGCCATGCT
GGGCGTGTCATTGAGAACCCCCAGGAAGCTCTGAGTGCTGCCACGGAGGAAGCCCAGGCCTGGA
GGAAGAAGACAAACCACCGTCTCAGCCTGCCCACCCCGTGCTCCGGCCTGAGCCTCAGTGCAGC
TATCCATCGCACCCAGCCCTGGTTTCATGGACGAATCTCCCGGGAGGAGAGCCAGCGGCTAATT
GGACAGCAGGGCCTGGTGGATGGTGTATTCCTGGTCCGGGAGAGCCAGCGGAACCCACAGGGCT
TCGTTCTGTCTCTGTGCCATCTGCAGAAAGTCAAACATTATCTCATCTTGCCAAGCGAAGATGA
AGGCTGCCTTTACTTCAGCATGGATGACGGCCAGACCCGTTTCACAGACCTGCTGCAGCTGGTG
GAATTCCACCAGCTGAACCGAGGCATCCTGCCCTGCTTGCTGCGCCACTGCTGTGCCCGTGTGG
CCCTCTGAGGCCACACAAGCTGTTACAGCCATGGGGCTGCTTATCGCCCTTCTGCTCCGTTCAG
TGGACTCGGTGCAGATGGGTGGGATGATAAACAGATGAAGAGCTCCCCCCACTTTTCTCCCACT
TTTTTTTTTACCTCCCTCAGGTAATGAAACATCCCCCAGCCCTGTTCATCCCTGACTCCTGTCC
CCAAAGGAGGCATTGTGGTCCTCTCCCCTTGGTAGAGCTCCTGAGGCAGTGAAGGGCATTATGA
GAGGAGTAGGGGCAGCCCGGGTGGTCTCATGCCCCACCCACACTCTGTACAGACTGAGAGGCCA
GTTGATCTGCTCTGTTTTATACCAGTGATAATAAAGATTATTTTTTGATACAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006247433 ⟹ XP_006247495

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	83,937,624 - 83,949,344 (+)	NCBI
mRatBN7.2	10	83,443,387 - 83,453,057 (+)	NCBI
Rnor_6.0	10	86,399,292 - 86,408,893 (+)	NCBI
Rnor_5.0	10	86,195,239 - 86,204,828 (+)	NCBI

Sequence:

show sequence

AGCAGAAAAGATGGGGGGGGGAGGCTGTGCTTCCTCAGGGCAGACCCCTTATCACCCCTCGGCT
TGTTTGTTTTCTTAACTCTCACCCGTGGGAAGCTGGGAGGTGGCCCACTGCCTTTGATCCGGGT
CTCTCAACTCCTCTTCCTGATCCTCAGATGTTTGCTGTGGGCTGAACCAGAAAGCTGGAGTAAC
TGCTGCAATAGTCATCTGCACCAGGCCACAACGGTCGCCAGAACACCGTGGCCCCTCCCACCAG
GCCACCTTGCTGCGCTTAGATTTGAAACTGGAGAGGTGCCATGGAACTGGATCTGAGCCCGTCT
CATCTCAGCAGCTCCCCAGAAGATGTGTGCCCAACTCCTGGGACCCCTCCCGAGACTCCTCCGC
CCCCGGATAACCCTCCGCCCGGCGATGTGAAGCGGTCTCAGCCTTTGCCCATCCCAAGTAGCAG
GAAACTTCGAGAAGAGGAGTTTCAGGCAACCTCTCTACCCTCCATCCCCAACCCCTTCCCCGAG
CTCTGCAGCCCACCTTCACAGAAACCCATTCTTGGTGGTTCCTCCGGTGCTAGGGGGTTGCTTC
CTCGAGACTCCAGCCGCCTCTGTGTGGTGAAGGTGTACAGTGAAGATGGAGCCTGCCGGTCTGT
GGAAGTGGCGGCAGGTGCGACGGCTCGCCATGTGTGTGAGATGCTGGTGCAGCGAGCTCACGCC
CTGAGCGATGAGAACTGGGGCCTGGTGGAGTGCCACCCCTATTTGGCTCTGGAGCGGGGTTTGG
AGGACCATGAGTCTGTGGTAGAAGTGCAGGAGGCCTGGCCTGTGGGTGGAGACAGCCGCTTCAT
CTTCCGTAAAAACTTCGCCAAGTATGAACTCTTCAAGAGCCCTCCGCACACCCTGTTCCCAGAA
AAGATGGTTTCCAGCTGTCTGGATACACCAACAGGCATATCCCATGAAGACCTCATCCAGAACT
TCCTGAATGCTGGCAGCTTCCCTGAGATCCAGGGCTTCCTGCAGCTTCGGGGATCAGGCCGGGG
GTCAGGTCGAAAGCTTTGGAAACGATTCTTCTGCTTCCTGCGTCGGTCTGGCCTCTATTACTCG
ACCAAGGGCACCTCTAAGGACCCGAGACACCTACAGTACGTGGCAGATATAAATGAGTCCAATG
TGTATGTGGTGACCCAGGGCCGCAAGCTGTATGGGATACCCACCGACTTCGGCTTTTGTGTCAA
GCCCAACAAGCTTCGAAATGGCCACAAGGGGCTCCACATCTTCTGCAGCGAGGATGAGCAGAGT
CGGACTTGCTGGCTGTCCGCCTTCCGGCTCTTCAAGTACGGGGTACAGCTATATAAGAATTATC
AGCAGGCCCAGTCTCGTCACCTGCGCTTATCGTATTTGGGGTCTCCACCCTTGAGGAGTGTCTC
AGATAATACCCTGGTGGCCATGGACTTCTCTGGCCATGCTGGGCGTGTCATTGAGAACCCCCAG
GAAGCTCTGAGTGCTGCCACGGAGGAAGCCCAGGCCTGGAGGAAGAAGACAAACCACCGTCTCA
GCCTGCCCACCCCGTGCTCCGGCCTGAGCCTCAGTGCAGCTATCCATCGCACCCAGCCCTGGTT
TCATGGACGAATCTCCCGGGAGGAGAGCCAGCGGCTAATTGGACAGCAGGGCCTGGTGGATGGT
GTATTCCTGGTCCGGGAGAGCCAGCGGAACCCACAGGGCTTCGTTCTGTCTCTGTGCCATCTGC
AGAAAGTCAAACATTATCTCATCTTGCCAAGCGAAGATGAAGGCTGCCTTTACTTCAGCATGGA
TGACGGCCAGACCCGTTTCACAGACCTGCTGCAGCTGGTGGAATTCCACCAGCTGAACCGAGGC
ATCCTGCCCTGCTTGCTGCGCCACTGCTGTGCCCGTGTGGCCCTCTGAGGCCACACAAGCTGTT
ACAGCCATGGGGCTGCTTATCGCCCTTCTGCTCCGTTCAGTGGACTCGGTGCAGATGGGTGGGA
TGATAAACAGATGAAGAGCTCCCCCCACTTTTCTCCCACTTTTTTTTTTACCTCCCTCAGGTAA
TGAAACATCCCCCAGCCCTGTTCATCCCTGACTCCTGTCCCCAAAGGAGGCATTGTGGTCCTCT
CCCCTTGGTAGAGCTCCTGAGGCAGTGAAGGGCATTATGAGAGGAGTAGGGGCAGCCCGGGTGG
TCTCATGCCCCACCCACACTCTGTACAGACTGAGAGGCCAGTTGATCTGCTCTGTTTTATACCA
GTGATAATAAAGATTATTTTTTGATACACCCA

hide sequence

RefSeq Acc Id:

XM_039086969 ⟹ XP_038942897

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	83,937,424 - 83,949,344 (+)	NCBI
mRatBN7.2	10	83,443,389 - 83,453,057 (+)	NCBI

RefSeq Acc Id:

XM_063269991 ⟹ XP_063126061

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	83,936,538 - 83,949,344 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_445855	(Get FASTA)	NCBI Sequence Viewer
	XP_006247495	(Get FASTA)	NCBI Sequence Viewer
	XP_038942897	(Get FASTA)	NCBI Sequence Viewer
	XP_063126061	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF01776	(Get FASTA)	NCBI Sequence Viewer
	AAH81757	(Get FASTA)	NCBI Sequence Viewer
	EDM05933	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009299
GenBank Protein	Q9QZC5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445855 ⟸ NM_053403

- UniProtKB:

Q9QZC5 (UniProtKB/Swiss-Prot), A0A8I6AA75 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELDLSPSHLSSSPEDVCPTPGTPPETPPPPDNPPPGDVKRSQPLPIPSSRKLREEEFQATSLP
SIPNPFPELCSPPSQKPILGGSSGARGLLPRDSSRLCVVKVYSEDGACRSVEVAAGATARHVCE
MLVQRAHALSDENWGLVECHPYLALERGLEDHESVVEVQEAWPVGGDSRFIFRKNFAKYELFKS
PPHTLFPEKMVSSCLDTPTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRGSGRKLWKRFFCFL
RRSGLYYSTKGTSKDPRHLQYVADINESNVYVVTQGRKLYGIPTDFGFCVKPNKLRNGHKGLHI
FCSEDEQSRTCWLSAFRLFKYGVQLYKNYQQAQSRHLRLSYLGSPPLRSVSDNTLVAMDFSGHA
GRVIENPQEALSAATEEAQAWRKKTNHRLSLPTPCSGLSLSAAIHRTQPWFHGRISREESQRLI
GQQGLVDGVFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEDEGCLYFSMDDGQTRFTDLLQLV
EFHQLNRGILPCLLRHCCARVAL

hide sequence

RefSeq Acc Id:	XP_006247495 ⟸ XM_006247433
- Peptide Label:	isoform X1
- UniProtKB:	Q9QZC5 (UniProtKB/Swiss-Prot), A0A8I6AA75 (UniProtKB/TrEMBL)
- Sequence:	show sequence MELDLSPSHLSSSPEDVCPTPGTPPETPPPPDNPPPGDVKRSQPLPIPSSRKLREEEFQATSLP SIPNPFPELCSPPSQKPILGGSSGARGLLPRDSSRLCVVKVYSEDGACRSVEVAAGATARHVCE MLVQRAHALSDENWGLVECHPYLALERGLEDHESVVEVQEAWPVGGDSRFIFRKNFAKYELFKS PPHTLFPEKMVSSCLDTPTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRGSGRKLWKRFFCFL RRSGLYYSTKGTSKDPRHLQYVADINESNVYVVTQGRKLYGIPTDFGFCVKPNKLRNGHKGLHI FCSEDEQSRTCWLSAFRLFKYGVQLYKNYQQAQSRHLRLSYLGSPPLRSVSDNTLVAMDFSGHA GRVIENPQEALSAATEEAQAWRKKTNHRLSLPTPCSGLSLSAAIHRTQPWFHGRISREESQRLI GQQGLVDGVFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEDEGCLYFSMDDGQTRFTDLLQLV EFHQLNRGILPCLLRHCCARVAL hide sequence

Ensembl Acc Id:

ENSRNOP00000009299 ⟸ ENSRNOT00000009299

RefSeq Acc Id:	XP_038942897 ⟸ XM_039086969
- Peptide Label:	isoform X1
- UniProtKB:	Q9QZC5 (UniProtKB/Swiss-Prot), A0A8I6AA75 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000090166 ⟸ ENSRNOT00000117229

RefSeq Acc Id:	XP_063126061 ⟸ XM_063269991
- Peptide Label:	isoform X1
- UniProtKB:	Q9QZC5 (UniProtKB/Swiss-Prot), A0A8I6AA75 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000105096 ⟸ ENSRNOT00000140324

Protein Domains

PH Ras-associating SH2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QZC5-F1-model_v2	AlphaFold	Q9QZC5	1-535	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697662

Promoter ID:

EPDNEW_R8187

Type:

initiation region

Name:

Grb7_1

Description:

growth factor receptor bound protein 7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R8188

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	86,399,867 - 86,399,927	EPDNEW

RGD ID:

13697663

Promoter ID:

EPDNEW_R8188

Type:

initiation region

Name:

Grb7_2

Description:

growth factor receptor bound protein 7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R8187

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	86,400,085 - 86,400,145	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619759	AgrOrtholog
BioCyc Gene	G2FUF-23364	BioCyc
Ensembl Genes	ENSRNOG00000006990	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000009299	ENTREZGENE
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot
	3.30.505.10	UniProtKB/Swiss-Prot
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7109771	IMAGE-MGC_LOAD
InterPro	BPS-dom	UniProtKB/Swiss-Prot
	GRB/APBB1IP	UniProtKB/Swiss-Prot
	Grb7	UniProtKB/Swiss-Prot
	GRB7_RA	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	PH_APBB1IP	UniProtKB/Swiss-Prot
	PH_domain	UniProtKB/Swiss-Prot
	RA_dom	UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot
	SH2_dom_sf	UniProtKB/Swiss-Prot
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot
KEGG Report	rno:84427	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93307	IMAGE-MGC_LOAD
NCBI Gene	84427	ENTREZGENE
PANTHER	PTHR11243	UniProtKB/Swiss-Prot
	PTHR11243:SF25	UniProtKB/Swiss-Prot
Pfam	BPS	UniProtKB/Swiss-Prot
	PF00169	UniProtKB/Swiss-Prot
	RA_2	UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot
PhenoGen	Grb7	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot
PROSITE	PH_DOMAIN	UniProtKB/Swiss-Prot
	PS50200	UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000006990	RatGTEx
SMART	SH2	UniProtKB/Swiss-Prot
	SM00233	UniProtKB/Swiss-Prot
	SM00314	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF54236	UniProtKB/Swiss-Prot
	SSF55550	UniProtKB/Swiss-Prot
UniProt	A0A8I6AA75	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q3T0_RAT	UniProtKB/TrEMBL
	A0ABK0LTR7_RAT	UniProtKB/TrEMBL
	GRB7_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Grb7	growth factor receptor bound protein 7		growth factor receptor binding protein GRB7	Name updated	1299863	APPROVED
2002-08-07	Grb7	growth factor receptor binding protein GRB7			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains the SH2 domain and the PIR (phosphotyrosine interacting region) domain	632867
gene_physical_interaction	binds to insulin receptor via the SH2 domain and the PIR (phosphotyrosine interacting region)	632867

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)