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Gene: Ackr5 (atypical chemokine receptor 5) Rattus norvegicus

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Symbol:

Ackr5 (Ensembl: Gpr182)

Name:

atypical chemokine receptor 5 (Ensembl:G protein-coupled receptor 182)

RGD ID:

61903

Description:

Enables adrenomedullin receptor activity. Involved in response to hypoxia. Predicted to be located in endosome and plasma membrane. Biomarker of pulmonary hypertension. Orthologous to human GPR182 (G protein-coupled receptor 182); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; all-trans-retinoic acid.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Admr; adrenomedullin receptor; G protein-coupled receptor 182; G-protein coupled receptor 182; G10D; Gpr182; NOW

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACKR5 (atypical chemokine receptor 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gpr182 (G protein-coupled receptor 182)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ackr5 (atypical chemokine receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACKR5 (atypical chemokine receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR182 (G protein-coupled receptor 182)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ackr5 (atypical chemokine receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPR182 (G protein-coupled receptor 182)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACKR5 (atypical chemokine receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ackr5 (atypical chemokine receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ackr5 (atypical chemokine receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZBTB39 (zinc finger and BTB domain containing 39)	HGNC	EggNOG, PhylomeDB, Treefam
Alliance orthologs ³
Mus musculus (house mouse):	Gpr182 (G protein-coupled receptor 182)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACKR5 (atypical chemokine receptor 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gpr182 (G protein-coupled receptor 182)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gpr182	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gpr182	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	65,471,254 - 65,474,110 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	65,452,965 - 65,474,998 (-)	Ensembl				GRCr8
mRatBN7.2	7	63,585,997 - 63,589,088 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	63,578,750 - 63,589,210 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	65,475,217 - 65,478,073 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	67,677,507 - 67,680,363 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	67,478,809 - 67,481,665 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	71,044,786 - 71,048,713 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	71,045,543 - 71,048,383 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	71,215,382 - 71,221,364 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	67,740,500 - 67,743,356 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	60,725,039 - 60,727,895 (-)	NCBI		Celera
RGSC_v3.1	7	67,762,225 - 67,763,422 (-)	NCBI
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

pulmonary hypertension (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (EXP)

ammonium chloride (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

carbon monoxide (EXP)

carbon nanotube (ISO)

chloroquine (EXP)

chlorpyrifos (ISO)

cobalt dichloride (EXP)

dibutyl phthalate (EXP,ISO)

dioxygen (EXP,ISO)

genistein (ISO)

gold atom (ISO)

gold(0) (ISO)

isoprenaline (ISO)

lidocaine (EXP)

methidathion (ISO)

Moniliformin (ISO)

naphthalene (ISO)

nitrofen (EXP)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

rotenone (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IEA)

response to hypoxia (IEP)

Cellular Component

endosome (ISO,ISS)

endosome membrane (IEA)

membrane (IEA)

plasma membrane (IEA,ISO,ISS)

Molecular Function

adrenomedullin receptor activity (IDA)

C-C chemokine binding (ISO,ISS)

C-X-C chemokine binding (ISO,ISS)

G protein-coupled receptor activity (IEA)

receptor decoy activity (ISS)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal vasodilation (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression of adrenomedullin and its receptor in lungs of rats with hypoxic pulmonary hypertension.	Cheng D, etal., Chin Med J (Engl). 2002 Dec;115(12):1806-8.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung, adrenal, and liver.	Harrison JK, etal., FEBS Lett 1993 Feb 22;318(1):17-22.
5.	Cloning and expression of cDNA encoding a rat adrenomedullin receptor.	Kapas S, etal., J Biol Chem 1995 Oct 27;270(43):25344-7.
6.	Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells.	Makino I, etal., Biochem Biophys Res Commun 2001 Nov 2;288(3):515-20.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: evidences of upregulation of ADM system in immature glands.	Rebuffat P, etal., Int J Mol Med 2002 Jul;10(1):85-8.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:8390839	PMID:11967020	PMID:12477932	PMID:12606469	PMID:15245869	PMID:17898545	PMID:17982694	PMID:18401014	PMID:20431304	PMID:25061099

Genomics

Comparative Map Data

Ackr5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	65,471,254 - 65,474,110 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	65,452,965 - 65,474,998 (-)	Ensembl				GRCr8
mRatBN7.2	7	63,585,997 - 63,589,088 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	63,578,750 - 63,589,210 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	65,475,217 - 65,478,073 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	67,677,507 - 67,680,363 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	67,478,809 - 67,481,665 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	71,044,786 - 71,048,713 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	71,045,543 - 71,048,383 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	71,215,382 - 71,221,364 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	67,740,500 - 67,743,356 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	60,725,039 - 60,727,895 (-)	NCBI		Celera
RGSC_v3.1	7	67,762,225 - 67,763,422 (-)	NCBI
Cytogenetic Map	7	q22	NCBI

ACKR5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	56,994,492 - 56,998,877 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	56,994,492 - 56,998,889 (+)	Ensembl			hg38	GRCh38
GRCh37	12	57,388,276 - 57,392,231 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	55,674,622 - 55,676,736 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	55,674,621 - 55,676,735	NCBI
Celera	12	57,042,285 - 57,044,399 (+)	NCBI		Celera
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	54,427,154 - 54,444,914 (+)	NCBI		HuRef
CHM1_1	12	57,356,105 - 57,358,219 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	56,962,361 - 56,966,316 (+)	NCBI		T2T-CHM13v2.0

Gpr182
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	127,585,471 - 127,587,667 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	127,583,145 - 127,587,601 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	127,749,602 - 127,751,798 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	127,747,276 - 127,751,732 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	127,186,658 - 127,188,854 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	127,152,571 - 127,154,642 (-)	NCBI		MGSCv36	mm8
Celera	10	130,144,200 - 130,146,396 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	75.07	NCBI

Ackr5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	4,749,869 - 4,753,930 (+)	Ensembl
ChiLan1.0	NW_004955458	4,749,966 - 4,754,314 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACKR5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	37,343,357 - 37,346,597 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	37,340,127 - 37,346,859 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	31,929,288 - 31,933,243 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	32,182,572 - 32,186,571 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	32,184,592 - 32,185,806 (-)	Ensembl			panPan2	panpan1.1

GPR182
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	1,142,961 - 1,144,357 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	1,142,937 - 1,144,091 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	1,206,121 - 1,208,785 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	1,152,670 - 1,155,074 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	1,152,834 - 1,155,338 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	1,129,573 - 1,132,238 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	1,371,434 - 1,376,076 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	1,496,202 - 1,500,845 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ackr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	57,657,545 - 57,661,429 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	1,210,757 - 1,212,425 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	1,210,711 - 1,212,746 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR182
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	22,304,588 - 22,311,028 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	22,303,466 - 22,309,652 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	24,073,604 - 24,078,011 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACKR5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	52,904,691 - 52,908,786 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	52,905,582 - 52,906,796 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	193,064,884 - 193,068,858 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ackr5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	10,936,619 - 10,939,603 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624802	10,936,114 - 10,939,614 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ackr5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	206,196,282 - 206,199,132 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ackr5
12 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	51
Count of miRNA genes:	45
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000005693
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	23807606	68807606	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	45113903	90113903	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	26638057	71638057	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	24179478	86817926	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	49137999	67614020	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	51700643	96700643	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	31770293	110435881	Rat
1298525	Cm1	Cardiac mass QTL 1	2.7		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	7	56625161	101625161	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	39845902	84845902	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	32998702	77998702	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	36178764	81178764	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	55498584	105834451	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	63889858	108889858	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	10112916	99900612	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	48475049	93475049	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	36178764	81178764	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	28624575	65788017	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	49682832	115766396	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	62963207	107963207	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	21541977	86817926	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	63889858	108889858	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	49682832	115766396	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	49682832	115766396	Rat
2303582	Gluco53	Glucose level QTL 53	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	7	48603087	93603087	Rat
61439	Cia8	Collagen induced arthritis QTL 8	5.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	7	27182914	72182914	Rat

Markers in Region

RH129954

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,586,732 - 63,586,882 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	71,046,263 - 71,046,412	NCBI	Rnor6.0
Rnor_5.0	7	71,218,932 - 71,219,081	UniSTS	Rnor5.0
RGSC_v3.4	7	67,741,236 - 67,741,385	UniSTS	RGSC3.4
Celera	7	60,725,775 - 60,725,924	UniSTS
Cytogenetic Map	7	q22	UniSTS

BE097830

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,586,089 - 63,586,249 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	71,045,620 - 71,045,779	NCBI	Rnor6.0
Rnor_5.0	7	71,218,289 - 71,218,448	UniSTS	Rnor5.0
RGSC_v3.4	7	67,740,593 - 67,740,752	UniSTS	RGSC3.4
Celera	7	60,725,132 - 60,725,291	UniSTS
Cytogenetic Map	7	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	87	59	6	349	187	11	139	79	92	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053302	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC129072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L09249	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S79811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005685 ⟹ ENSRNOP00000005685

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	65,452,965 - 65,474,998 (-)	Ensembl
mRatBN7.2 Ensembl	7	63,578,750 - 63,589,210 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000005693 ⟹ ENSRNOP00000054500

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	65,469,731 - 65,474,204 (-)	Ensembl
mRatBN7.2 Ensembl	7	63,585,743 - 63,589,210 (-)	Ensembl
Rnor_6.0 Ensembl	7	71,045,543 - 71,048,383 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107610 ⟹ ENSRNOP00000096328

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	63,586,018 - 63,588,205 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000160445 ⟹ ENSRNOP00000108988

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	65,463,951 - 65,474,466 (-)	Ensembl

RefSeq Acc Id:

NM_053302 ⟹ NP_445754

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	65,471,254 - 65,474,110 (-)	NCBI
mRatBN7.2	7	63,585,997 - 63,588,853 (-)	NCBI
Rnor_6.0	7	71,045,527 - 71,048,383 (-)	NCBI
Rnor_5.0	7	71,215,382 - 71,221,364 (-)	NCBI
RGSC_v3.4	7	67,740,500 - 67,743,356 (-)	RGD
Celera	7	60,725,039 - 60,727,895 (-)	RGD

Sequence:

show sequence

CAGCTACTTCCCGCAGGCAAGCAGAGCTGCCTGAAGCCAGCAACAGAGCCTGCTCCACAAAGCT
GCCTCTGCAGCCTCCTGGTGGCTCACAGCCCCATCCATAGGCTCTCCCGGACAGGTGCTCCCCA
GAGAAATCCAGACACTAGCTGGCCCTCATGTCAGTCATACCCAGCTCCAGGCCGGTCTCCACCT
TGGCACCTGACAATGATTTTAGAGAGATCCACAACTGGACAGAGCTGCTCCATCTCTTCAACCA
AACCTTTTCTGATTGCCACATGGAACTCAATGAGAACACCAAACAAGTGGTCCTCTTTGTCTTC
TACCTGGCCATCTTTGTGGTAGGGTTAGTGGAGAACGTCCTGGTGATATGTGTCAACTGCCGCC
GCTCAGGCCGGGTGGGGATGCTGAACTTATACATCCTCAACATGGCCGTCGCGGACCTGGGCAT
CATCCTGTCTCTGCCTGTTTGGATGCTGGAGGTCATGCTGGAGTACACCTGGCTCTGGGGCAGC
TTCTCCTGTCGCTTCATTCATTATTTCTACCTTGCCAACATGTACAGCAGCATCTTCTTCCTCA
CCTGCCTCAGCATTGACCGCTACGTCACCCTCACCAATACCTCTCCCTCCTGGCAGCGCCACCA
GCACCGAATACGGAGGGCCGTGTGCGCAGGCGTCTGGGTCCTCTCCGCCATCATCCCACTGCCT
GAGGTGGTACATATCCAGCTGCTGGATGGCTCCGAGCCCATGTGCCTCTTCCTAGCACCTTTTG
AAACGTACAGCGCCTGGGCCCTGGCAGTGGCCCTGTCGGCTACCATCCTGGGCTTCCTACTGCC
TTTTCCTCTCATCGCAGTGTTTAATATCCTGTCAGCCTGCCGGCTTCGGAGGCAAGGGCAGACA
GAGAGCAGGCGCCACTGTCTGTTGATGTGGGCTTACATAGCTGTCTTTGTCATCTGCTGGCTGC
CCTACCACGTGACTATGCTGCTGCTCACTCTGCACACAACCCACATCTTCCTTCACTGCAACCT
GGTTAACTTCCTCTACTTCTTCTACGAAATCATTGACTGCTTCTCCATGCTACACTGTGTCGCC
AACCCCATCCTCTACAACTTTCTCAGCCCGAGCTTCCGGGGCCGACTGCTGAGCCTTGTGGTCC
GTTACCTTCCCAAGGAGCAGGCCAGGGCAGCAGGCGGTCGAGCCTCCTCTTCATCTTCCACCCA
GCACTCCATCATCATTACCAAAGAGGGCAGCCTGCCCGCTGCAGCGGATCTGCACACCCACGCC
ATCAGAAACGTGCAGGCCTCCTCTCTGCCTCCGAACACCTCACCTACACTCTGCAATTCCATAG
CCAGCTAAGCTCACTATGCAAGTTGTGAGGACAAGAGGCCAGAGGCCAAGGACCCAGGAGGCTC
CGGCAGGACGTTCCGTAGCTGTGCCTCATCCCTGGCCCTGAGTTCGATAAATCAAGGGGGTGAG
GATTACAGCCAGCTGGGTCTTGGGCAGGCACCCGGCAGCTGGCTCAGCAGGATGGCTCCTCCAC
CCAGTCATCCAGGAAATGTGGCTCCATTTCCCTGTGGCATCCTCCCCTCCCCCAACTCATCCTG
CCCCCTCCTCCCCTAAAGCGGAGGCCTCCTCACAAATGACCTCCCTCTCCAAGGGAGATACAGC
CACTAGTGATTCCACGCCCATCTTATTTCTCCAGATCTTGGCAATGTCAGGGAACAGCCATTCT
TCAGAGGACACCTTGGGAGCTGCTGTAGGTACTCCTCCTCCCATGCAGGGAGAGGGGAGGCCAA
AGACTGATTTCCAGAACACTACAGTTGAGTTCTCTCTAGTCGAGCCTTTCCCGAGTCCCCCTAC
CCAACAATCTGTCTATTAAAACTATGGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445754	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB05356	(Get FASTA)	NCBI Sequence Viewer
	AAB35457	(Get FASTA)	NCBI Sequence Viewer
	AAI29073	(Get FASTA)	NCBI Sequence Viewer
	EDM16449	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000054500
GenBank Protein	P31392	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445754 ⟸ NM_053302

- UniProtKB:

Q64166 (UniProtKB/Swiss-Prot), P31392 (UniProtKB/Swiss-Prot), A1L1I2 (UniProtKB/TrEMBL), D3ZC02 (UniProtKB/TrEMBL), A6HQX3 (UniProtKB/TrEMBL), A0A8I6AT50 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLFVFYLAIFVVGL
VENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYF
YLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLD
GSEPMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLM
WAYIAVFVICWLPYHVTMLLLTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLS
PSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPAAADLHTHAIRNVQASSL
PPNTSPTLCNSIAS

hide sequence

Ensembl Acc Id:

ENSRNOP00000054500 ⟸ ENSRNOT00000005693

Ensembl Acc Id:

ENSRNOP00000005685 ⟸ ENSRNOT00000005685

Ensembl Acc Id:

ENSRNOP00000096328 ⟸ ENSRNOT00000107610

Ensembl Acc Id:

ENSRNOP00000108988 ⟸ ENSRNOT00000160445

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P31392-F1-model_v2	AlphaFold	P31392	1-395	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695272

Promoter ID:

EPDNEW_R5795

Type:

initiation region

Name:

Gpr182_1

Description:

G protein-coupled receptor 182

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	71,048,392 - 71,048,452	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61903	AgrOrtholog
BioCyc Gene	G2FUF-33723	BioCyc
Ensembl Genes	ENSRNOG00000004311	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000005693	ENTREZGENE
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7096756	IMAGE-MGC_LOAD
InterPro	G10D_rcpt	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
	GPER1-like	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156507	IMAGE-MGC_LOAD
NCBI Gene	29307	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR 182	UniProtKB/Swiss-Prot
	G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PhenoGen	Ackr5	PhenoGen
PRINTS	G10DORPHANR	UniProtKB/Swiss-Prot
	GPCRRHODOPSN	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004311	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	A0A8I6AT50	ENTREZGENE, UniProtKB/TrEMBL
	A1L1I2	ENTREZGENE, UniProtKB/TrEMBL
	A6HQX3	ENTREZGENE
	D3ZC02	ENTREZGENE
	GP182_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q64166	ENTREZGENE
UniProt Secondary	Q64166	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-11-13	Ackr5	atypical chemokine receptor 5	Gpr182	G protein-coupled receptor 182	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Gpr182	G protein-coupled receptor 182	Admr	adrenomedullin receptor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Admr	adrenomedullin receptor			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	activity is mediated by g proteins which activate adenylate cyclase	724707

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Mammalian Phenotype