Gpr182 (G protein-coupled receptor 182) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Gpr182 (G protein-coupled receptor 182) Mus musculus
Analyze
Symbol: Gpr182
Name: G protein-coupled receptor 182
RGD ID: 62196
MGI Page MGI
Description: Predicted to enable adrenomedullin receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including central nervous system; gut; heart; reproductive system; and retina. Orthologous to human GPR182 (G protein-coupled receptor 182).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ad; Admr; adrenomedullin receptor; AM; AM-R; G-protein coupled receptor 182; G10-D; G10D; Gpcr; Gpcr17; Gpcr22; MB10; N; NOW
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,585,471 - 127,587,667 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,583,145 - 127,587,601 (-)EnsemblGRCm39 Ensembl
GRCm3810127,749,602 - 127,751,798 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,747,276 - 127,751,732 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,186,658 - 127,188,854 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,152,571 - 127,154,642 (-)NCBIMGSCv36mm8
Celera10130,144,200 - 130,146,396 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1075.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of adrenomedullin and its receptor in lungs of rats with hypoxic pulmonary hypertension. Cheng D, etal., Chin Med J (Engl). 2002 Dec;115(12):1806-8.
2. Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells. Makino I, etal., Biochem Biophys Res Commun 2001 Nov 2;288(3):515-20.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. Saeki Y, etal., FEBS Lett 1993 Dec 27;336(2):317-22.
Additional References at PubMed
PMID:7592696   PMID:8288218   PMID:8889548   PMID:8977434   PMID:9460649   PMID:9808778   PMID:10349636   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11921355  
PMID:12477932   PMID:16141072   PMID:16141073   PMID:16602821   PMID:19847298   PMID:21267068   PMID:21677750   PMID:22535667   PMID:24194600   PMID:26839965   PMID:27626380   PMID:28094771  
PMID:32832870   PMID:33875597   PMID:35013216   PMID:35364055   PMID:37159457   PMID:37554323   PMID:38026988   PMID:38355793  


Genomics

Comparative Map Data
Gpr182
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,585,471 - 127,587,667 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,583,145 - 127,587,601 (-)EnsemblGRCm39 Ensembl
GRCm3810127,749,602 - 127,751,798 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,747,276 - 127,751,732 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,186,658 - 127,188,854 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,152,571 - 127,154,642 (-)NCBIMGSCv36mm8
Celera10130,144,200 - 130,146,396 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1075.07NCBI
GPR182
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,994,492 - 56,998,877 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,994,492 - 56,998,447 (+)EnsemblGRCh38hg38GRCh38
GRCh371257,388,276 - 57,392,231 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,674,622 - 55,676,736 (+)NCBINCBI36Build 36hg18NCBI36
Build 341255,674,621 - 55,676,735NCBI
Celera1257,042,285 - 57,044,399 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,427,154 - 54,444,914 (+)NCBIHuRef
CHM1_11257,356,105 - 57,358,219 (+)NCBICHM1_1
T2T-CHM13v2.01256,962,361 - 56,966,316 (+)NCBIT2T-CHM13v2.0
Gpr182
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,471,254 - 65,474,110 (-)NCBIGRCr8
mRatBN7.2763,585,997 - 63,589,088 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,578,750 - 63,589,210 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,475,217 - 65,478,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,677,507 - 67,680,363 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,478,809 - 67,481,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0771,044,786 - 71,048,713 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl771,045,543 - 71,048,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0771,215,382 - 71,221,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,740,500 - 67,743,356 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,762,225 - 67,763,422 (-)NCBI
Celera760,725,039 - 60,727,895 (-)NCBICelera
Cytogenetic Map7q22NCBI
Gpr182
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,749,869 - 4,753,930 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,749,966 - 4,754,314 (+)NCBIChiLan1.0ChiLan1.0
GPR182
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,343,357 - 37,346,597 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,340,127 - 37,346,859 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,929,288 - 31,933,243 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,182,572 - 32,186,571 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,184,592 - 32,185,806 (-)Ensemblpanpan1.1panPan2
GPR182
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,142,961 - 1,144,357 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,142,937 - 1,144,091 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,206,121 - 1,208,785 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,152,670 - 1,155,074 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,152,834 - 1,155,338 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,129,573 - 1,132,238 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,371,434 - 1,376,076 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,496,202 - 1,500,845 (+)NCBIUU_Cfam_GSD_1.0
Gpr182
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,657,545 - 57,661,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,210,757 - 1,212,425 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,210,711 - 1,212,746 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR182
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,304,588 - 22,311,028 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,303,466 - 22,309,652 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,073,604 - 24,078,011 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR182
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,904,691 - 52,908,786 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,905,582 - 52,906,796 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,064,884 - 193,068,858 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr182
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,936,619 - 10,939,603 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,936,114 - 10,939,614 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr182
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:983
Count of miRNA genes:579
Interacting mature miRNAs:678
Transcripts:ENSMUST00000079692
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse

Markers in Region
RH129954  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,749,622 - 127,749,774UniSTSGRCm38
MGSCv3710127,186,678 - 127,186,830UniSTSGRCm37
Celera10130,144,220 - 130,144,372UniSTS
Cytogenetic Map10D3UniSTS
cM Map1072.0UniSTS
Admr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10D3UniSTS
cM Map1072.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079692   ⟹   ENSMUSP00000100882
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,583,145 - 127,587,601 (-)Ensembl
GRCm38.p6 Ensembl10127,747,276 - 127,751,732 (-)Ensembl
RefSeq Acc Id: NM_007412   ⟹   NP_031438
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,585,471 - 127,587,667 (-)NCBI
GRCm3810127,749,602 - 127,751,798 (-)ENTREZGENE
MGSCv3710127,186,658 - 127,188,854 (-)RGD
Celera10130,144,200 - 130,146,396 (-)RGD
cM Map10 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_031438 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16849 (Get FASTA)   NCBI Sequence Viewer  
  BAA04125 (Get FASTA)   NCBI Sequence Viewer  
  EDL24522 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000100882
  ENSMUSP00000100882.3
GenBank Protein P43142 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_031438   ⟸   NM_007412
- UniProtKB: P43142 (UniProtKB/Swiss-Prot),   G3X9R9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000100882   ⟸   ENSMUST00000079692
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43142-F1-model_v2 AlphaFold P43142 1-395 view protein structure

Promoters
RGD ID:6819398
Promoter ID:MM_KWN:5931
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:OTTMUST00000068436
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,188,514 - 127,189,014 (-)MPROMDB
RGD ID:8673534
Promoter ID:EPDNEW_M14798
Type:initiation region
Name:Gpr182_1
Description:Mus musculus G protein-coupled receptor 182 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810127,751,715 - 127,751,775EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109545 AgrOrtholog
Ensembl Genes ENSMUSG00000058396 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079692 ENTREZGENE
  ENSMUST00000079692.6 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro G10D_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPER1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11536 UniProtKB/TrEMBL
MGD MGI:109545 ENTREZGENE
NCBI Gene 11536 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 182 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr182 PhenoGen
PRINTS G10DORPHANR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3X9R9 ENTREZGENE, UniProtKB/TrEMBL
  GP182_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE