Ramp2 (receptor activity modifying protein 2) - Rat Genome Database

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Gene: Ramp2 (receptor activity modifying protein 2) Rattus norvegicus
Analyze
Symbol: Ramp2
Name: receptor activity modifying protein 2
RGD ID: 61872
Description: Enables coreceptor activity. Involved in several processes, including receptor internalization; response to estradiol; and response to progesterone. Predicted to be located in cytoplasm. Predicted to be part of adrenomedullin receptor complex. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Biomarker of adult respiratory distress syndrome; congestive heart failure; hypertension; kidney disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RAMP2 (receptor activity modifying protein 2); INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: receptor (calcitonin) activity modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; receptor activity modifying protein 2 isoform; receptor activity-modifying protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,689,148 - 86,690,956 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,688,703 - 86,691,231 (+)EnsemblGRCr8
mRatBN7.21086,187,366 - 86,190,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,226,790 - 91,228,598 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,701,301 - 90,703,109 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,094,462 - 86,096,270 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,166,170 - 89,168,962 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,166,890 - 89,168,965 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,965,679 - 88,967,458 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,275,463 - 90,277,242NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.11090,289,832 - 90,291,611NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
calciol  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
desferrioxamine B  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diethyl malate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
indole-3-methanol  (EXP)
isoprenaline  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (EXP)
nitric oxide  (EXP)
nitroprusside  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
adrenomedullin receptor complex  (ISO)
cell surface  (IBA,ISO,ISS)
cytoplasm  (ISO,ISS)
membrane  (IEA)
plasma membrane  (IEA,ISO,ISS)
receptor complex  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs? Barwell J, etal., Br J Pharmacol. 2012 May;166(1):51-65. doi: 10.1111/j.1476-5381.2011.01525.x.
2. Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. Bomberger JM, etal., J Biol Chem. 2005 Mar 11;280(10):9297-307. Epub 2004 Dec 21.
3. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
4. Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts. Dai K, etal., Oncogene. 2020 Feb;39(9):1914-1930. doi: 10.1038/s41388-019-1112-z. Epub 2019 Nov 21.
5. Hypoxic induction of receptor activity-modifying protein 2 alters regulation of pulmonary endothelin-1 by adrenomedullin: induction under normoxia versus inhibition under hypoxia. Dschietzig T, etal., J Pharmacol Exp Ther. 2007 Apr;321(1):409-19. Epub 2007 Jan 24.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. [Changes of intermedin/adrenomedullin 2 and its receptors in the right ventricle of rats with chronic hypoxic pulmonary hypertension.] Gong YS, etal., Sheng Li Xue Bao. 2007 Apr 25;59(2):210-4.
9. CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS. Hay DL, etal., Br J Pharmacol. 2003 Oct;140(3):477-86. Epub 2003 Aug 26.
10. Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9. Hikosaka T, etal., Peptides. 2011 Sep;32(9):1825-31. doi: 10.1016/j.peptides.2011.07.012. Epub 2011 Aug 3.
11. The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats. Hiragushi K, etal., Kidney Int. 2004 Feb;65(2):540-50.
12. The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis. Hwang IS, etal., Regul Pept. 2006 Jul 15;135(1-2):69-77. Epub 2006 May 19.
13. Estrogen and phytoestrogen regulate the mRNA expression of adrenomedullin and adrenomedullin receptor components in the rat uterus. Ikeda K, etal., Mol Cell Endocrinol. 2004 Aug 31;223(1-2):27-34.
14. Intermedin1-53 protects the heart against isoproterenol-induced ischemic injury in rats. Jia YX, etal., Eur J Pharmacol. 2006 Nov 7;549(1-3):117-23. Epub 2006 Aug 17.
15. Alteration of the adrenomedullin receptor components gene expression associated with the blood pressure in pregnancy-induced hypertension. Makino Y, etal., J Clin Endocrinol Metab. 2001 Oct;86(10):5079-82.
16. Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation. Man SY, etal., Neuropeptides. 2007 Jun;41(3):177-87. Epub 2007 Mar 1.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Effects of endothelin on adrenomedullin secretion and expression of adrenomedullin receptors in rat cardiomyocytes. Mishima K, etal., Biochem Biophys Res Commun. 2001 Sep 14;287(1):264-9.
19. Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy. Nagae T, etal., Biochem Biophys Res Commun 2000 Apr 2;270(1):89-93.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Ventricular adrenomedullin system in the transition from LVH to heart failure in rats. Nishikimi T, etal., Hypertension 2003 Mar;41(3):512-8.
22. Novel regulation of adrenomedullin receptor by PDGF: role of receptor activity modifying protein-3. Nowak W, etal., Am J Physiol Cell Physiol 2002 Jun;282(6):C1322-31.
23. Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Oliver KR, etal., Eur J Neurosci 2001 Aug;14(4):618-28.
24. Potentiated response to adrenomedullin in myocardia and aortas in spontaneously hypertensive rat. Pan ChS, etal., Basic Res Cardiol. 2006 May;101(3):193-203. Epub 2006 Feb 6.
25. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Qing X, etal., Am J Physiol Lung Cell Mol Physiol 2001 Mar;280(3):L547-54.
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Comprehensive gene review and curation RGD comprehensive gene curation
29. Association study of calcitonin-receptor-like receptor gene in essential hypertension. Sano M, etal., Am J Hypertens. 2005 Mar;18(3):403-8.
30. Changes in the expression of calcitonin receptor-like receptor, receptor activity-modifying protein (RAMP) 1, RAMP2, and RAMP3 in rat uterus during pregnancy, labor, and by steroid hormone treatments. Thota C, etal., Biol Reprod. 2003 Oct;69(4):1432-7. Epub 2003 Jun 11.
31. Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro. Tomoda Y, etal., Cardiovasc Res 2001 Mar;49(4):721-30.
32. Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats. Yoshihara F, etal., Hypertension 2001 Feb;37(2):216-22.
33. Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy. Yoshihara F, etal., Regul Pept. 2005 Apr 15;127(1-3):239-44.
34. [Alterations of intermedin and its receptor system in oleic acid-induced acute lung injury of rats] Yu XM, etal., Beijing Da Xue Xue Bao. 2006 Oct 18;38(5):496-500.
Additional References at PubMed
PMID:1299115   PMID:8889548   PMID:9620797   PMID:10854696   PMID:10882736   PMID:11099398   PMID:11804624   PMID:12538603   PMID:12732346   PMID:12899678   PMID:14715154   PMID:14722252  
PMID:15193773   PMID:15315911   PMID:15623431   PMID:16040721   PMID:16964401   PMID:18097473   PMID:18434369   PMID:20074556   PMID:20596610   PMID:21034462   PMID:22102369   PMID:22500019  
PMID:24505304   PMID:25061099   PMID:26927337  


Genomics

Comparative Map Data
Ramp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,689,148 - 86,690,956 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,688,703 - 86,691,231 (+)EnsemblGRCr8
mRatBN7.21086,187,366 - 86,190,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,226,790 - 91,228,598 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,701,301 - 90,703,109 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,094,462 - 86,096,270 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,166,170 - 89,168,962 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,166,890 - 89,168,965 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,965,679 - 88,967,458 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,275,463 - 90,277,242NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.11090,289,832 - 90,291,611NCBI
Cytogenetic Map10q31NCBI
RAMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,761,227 - 42,763,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,758,447 - 42,763,041 (+)Ensemblhg38GRCh38
GRCh371740,913,245 - 40,915,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,166,738 - 38,168,585 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341738,166,737 - 38,168,580NCBI
Celera1737,569,491 - 37,571,338 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,678,311 - 36,680,158 (+)NCBIHuRef
CHM1_11741,148,776 - 41,150,623 (+)NCBICHM1_1
T2T-CHM13v2.01743,618,368 - 43,620,182 (+)NCBIT2T-CHM13v2.0
Ramp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,137,160 - 101,139,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,136,854 - 101,150,372 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811101,246,334 - 101,248,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,246,028 - 101,259,546 (+)Ensemblmm10GRCm38
MGSCv3711101,107,648 - 101,109,564 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611101,062,424 - 101,064,340 (+)NCBIMGSCv36mm8
Celera11112,542,561 - 112,544,477 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.47NCBI
Ramp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545116,584,742 - 16,586,093 (+)NCBIChiLan1.0ChiLan1.0
RAMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,222,750 - 22,225,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,112,840 - 24,115,133 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,554,888 - 14,557,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,779,666 - 14,781,481 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,779,666 - 14,781,481 (-)EnsemblpanPan2panpan1.1
RAMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,250,711 - 20,252,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,712,023 - 19,713,795 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0920,969,093 - 20,970,865 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,969,095 - 20,971,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,753,999 - 19,755,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,020,208 - 20,021,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,122,921 - 20,124,693 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ramp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,593,351 - 19,595,280 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,479,650 - 17,482,716 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,479,899 - 17,481,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,092,196 - 20,094,469 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11220,092,204 - 20,094,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,346,948 - 20,349,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,526,915 - 63,529,697 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,526,305 - 63,528,767 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607734,320,238 - 34,322,154 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ramp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,435,121 - 1,436,421 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ramp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1960,550,972 - 60,553,146 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ramp2
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:84
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000043953
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH128282  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,190,466 - 86,190,663 (+)MAPPERmRatBN7.2
Rnor_6.01089,168,745 - 89,168,941NCBIRnor6.0
Rnor_5.01088,967,241 - 88,967,437UniSTSRnor5.0
RGSC_v3.41090,277,025 - 90,277,221UniSTSRGSC3.4
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 79 59 6 343 179 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000043953   ⟹   ENSRNOP00000043210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,688,703 - 86,691,231 (+)Ensembl
Rnor_6.0 Ensembl1089,167,146 - 89,168,965 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088331   ⟹   ENSRNOP00000073785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,166,890 - 89,168,864 (+)Ensembl
RefSeq Acc Id: NM_031646   ⟹   NP_113834
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,689,148 - 86,690,956 (+)NCBI
mRatBN7.21086,188,876 - 86,190,687 (+)NCBI
Rnor_6.01089,167,183 - 89,168,962 (+)NCBI
Rnor_5.01088,965,679 - 88,967,458 (+)NCBI
RGSC_v3.41090,275,463 - 90,277,242 (+)RGD
Sequence:
RefSeq Acc Id: NP_113834   ⟸   NM_031646
- Peptide Label: precursor
- UniProtKB: Q9JHJ1 (UniProtKB/Swiss-Prot),   A0A8L2QNA2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043210   ⟸   ENSRNOT00000043953
Ensembl Acc Id: ENSRNOP00000073785   ⟸   ENSRNOT00000088331

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHJ1-F1-model_v2 AlphaFold Q9JHJ1 1-182 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697748
Promoter ID:EPDNEW_R8271
Type:multiple initiation site
Name:Ramp2_1
Description:receptor activity modifying protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,167,159 - 89,167,219EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61872 AgrOrtholog
BioCyc Gene G2FUF-23189 BioCyc
Ensembl Genes ENSRNOG00000020415 Ensembl
  ENSRNOG00000020441 Ensembl
  ENSRNOG00000085964 Ensembl
Gene3D-CATH 1.10.150.510 UniProtKB/Swiss-Prot
InterPro RAMP UniProtKB/Swiss-Prot
  RAMP_sf UniProtKB/Swiss-Prot
KEGG Report rno:58966 UniProtKB/Swiss-Prot
NCBI Gene 58966 ENTREZGENE
PANTHER PTHR14076 UniProtKB/Swiss-Prot
  RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 UniProtKB/Swiss-Prot
Pfam RAMP UniProtKB/Swiss-Prot
PhenoGen Ramp2 PhenoGen
RatGTEx ENSRNOG00000020415 RatGTEx
  ENSRNOG00000020441 RatGTEx
  ENSRNOG00000085964 RatGTEx
UniProt A0A8L2QNA2 ENTREZGENE, UniProtKB/TrEMBL
  A5YW89_RAT UniProtKB/TrEMBL
  Q9JHJ1 ENTREZGENE
  Q9WVQ3_RAT UniProtKB/TrEMBL
  RAMP2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Ramp2  receptor activity modifying protein 2  Ramp2  receptor (G protein-coupled) activity modifying protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ramp2  receptor (G protein-coupled) activity modifying protein 2  Ramp2  receptor (calcitonin) activity modifying protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ramp2  receptor (calcitonin) activity modifying protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in renal cortex and medulla 68718
gene_expression expressed in atria and ventricles of the heart 625420
gene_expression expressed in quiescent mesangial cells 631307
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determines its glycosylation state 61729
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determines its glycosylation state 68718
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determines its glycosylation state 68902
gene_physical_interaction forms a complex with calcitonin receptor-like receptor (CRLR) to form a functional adrenomedullin receptor 625420
gene_process involved in potentiating adrenomedullin-mediated adenylate cyclase activity and inhibition of DNA synthesis 631307