RGD Reference Report - Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation. - Rat Genome Database

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Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation.

Authors: Man, SY  Hwang, IS  Li, YY  O, WS  Sheng, HP  Tang, F 
Citation: Man SY, etal., Neuropeptides. 2007 Jun;41(3):177-87. Epub 2007 Mar 1.
RGD ID: 1625307
Pubmed: PMID:17335899   (View Abstract at PubMed)
DOI: DOI:10.1016/j.npep.2006.12.006   (Journal Full-text)

Adrenomedullin (AM) has been shown to be present in the stomach but the role of gastric AM is obscure. To investigate the effects of starvation on AM in the stomach, we studied the changes in gene expression of preproadrenomedullin (preproAM) and AM receptors by reverse transcription-polymerase chain reaction (RT-PCR), and tissue AM concentrations by radioimmunoassay (RIA) in the fundus and pylorus of the stomach of rats subjected to either acute (1-day) or chronic (4-day) starvation. An up-regulation of preproAM gene expression was observed in the fundus after acute starvation, and in the pylorus after chronic starvation. Immunoreactive AM (ir-AM) levels were increased in both fundus and pylorus after chronic starvation. In addition, marked reductions in the gene expression of fundic calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP) 3 as well as the pyloric CRLR and RAMP2 were observed in the chronically starved rats. The present study suggests that the gene expression of preproadrenomedullin mRNA is differentially regulated by starvation in the different parts of the stomach.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Starvation  ISOAdm (Rattus norvegicus)1625307; 1625307mRNA and protein:increased expression:stomachRGD 
Starvation  IEP 1625307mRNA and protein:increased expression:stomachRGD 
Starvation  ISORamp2 (Rattus norvegicus)1625307; 1625307 RGD 
Starvation  IEP 1625307 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to starvation  IEP 1625307 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adm  (adrenomedullin)
Ramp2  (receptor activity modifying protein 2)

Genes (Mus musculus)
Adm  (adrenomedullin)
Ramp2  (receptor (calcitonin) activity modifying protein 2)

Genes (Homo sapiens)
ADM  (adrenomedullin)
RAMP2  (receptor activity modifying protein 2)


Additional Information