Grb14 (growth factor receptor bound protein 14) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Grb14 (growth factor receptor bound protein 14) Rattus norvegicus
Analyze
Symbol: Grb14
Name: growth factor receptor bound protein 14
RGD ID: 61869
Description: Enables phosphoprotein binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; and negative regulation of meiotic cell cycle process involved in oocyte maturation. Located in endosome. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GRB14 (growth factor receptor bound protein 14); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GRB14 adapter protein; growth factor receptor-bound protein 14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8369,976,331 - 70,091,921 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl369,976,339 - 70,091,921 (-)EnsemblGRCr8
mRatBN7.2349,568,210 - 49,683,805 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl349,568,210 - 49,683,889 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx352,905,764 - 53,021,646 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0361,489,289 - 61,605,158 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0359,273,965 - 59,396,250 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0350,937,403 - 51,054,447 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl350,937,669 - 51,054,378 (-)Ensemblrn6Rnor6.0
Rnor_5.0357,578,226 - 57,619,404 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0357,679,758 - 57,695,025 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4346,832,380 - 46,952,670 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera349,175,830 - 49,290,450 (-)NCBICelera
RGSC_v3.1346,728,757 - 46,849,042 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
flutamide  (EXP)
fonofos  (ISO)
furan  (EXP)
hydroxyurea  (ISO)
imipramine  (EXP)
indometacin  (ISO)
inulin  (ISO)
ketoconazole  (EXP)
methapyrilene  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
endosome  (IDA)
endosome membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Grb14 inhibits FGF receptor signaling through the regulation of PLCgamma recruitment and activation. Browaeys-Poly E, etal., FEBS Lett. 2010 Nov 5;584(21):4383-8. doi: 10.1016/j.febslet.2010.09.048. Epub 2010 Oct 8.
2. Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver. Desbuquois B, etal., FEBS J. 2008 Sep;275(17):4363-77. Epub 2008 Jul 24.
3. Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score. Eze IC, etal., Environ Int. 2016 Sep;94:263-271. doi: 10.1016/j.envint.2016.04.032. Epub 2016 Jun 6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Identification of the rat adapter Grb14 as an inhibitor of insulin actions. Kasus-Jacobi A, etal., J Biol Chem 1998 Oct 2;273(40):26026-35.
7. Endosomal proteolysis of internalised -human insulin at neutral pH generates the mature insulin peptide in rat liver in vivo. Kouach M, etal., Diabetologia. 2009 Dec;52(12):2621-32. Epub 2009 Oct 16.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. SAXS study of the PIR domain from the Grb14 molecular adaptor: a natively unfolded protein with a transient structure primer? Moncoq K, etal., Biophys J. 2004 Dec;87(6):4056-64. doi: 10.1529/biophysj.104.048645. Epub 2004 Oct 1.
10. The PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signaling. Moncoq K, etal., FEBS Lett. 2003 Nov 20;554(3):240-6.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study. Yang HC, etal., PLoS One. 2012;7(3):e32907. doi: 10.1371/journal.pone.0032907. Epub 2012 Mar 29.
18. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
Additional References at PubMed
PMID:10713090   PMID:11278563   PMID:16246733   PMID:20890309   PMID:24350791   PMID:25578860   PMID:25687571  


Genomics

Comparative Map Data
Grb14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8369,976,331 - 70,091,921 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl369,976,339 - 70,091,921 (-)EnsemblGRCr8
mRatBN7.2349,568,210 - 49,683,805 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl349,568,210 - 49,683,889 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx352,905,764 - 53,021,646 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0361,489,289 - 61,605,158 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0359,273,965 - 59,396,250 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0350,937,403 - 51,054,447 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl350,937,669 - 51,054,378 (-)Ensemblrn6Rnor6.0
Rnor_5.0357,578,226 - 57,619,404 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0357,679,758 - 57,695,025 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4346,832,380 - 46,952,670 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera349,175,830 - 49,290,450 (-)NCBICelera
RGSC_v3.1346,728,757 - 46,849,042 (-)NCBI
Cytogenetic Map3q21NCBI
GRB14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382164,492,417 - 164,621,482 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2164,492,417 - 164,622,472 (-)Ensemblhg38GRCh38
GRCh372165,348,927 - 165,477,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362165,057,569 - 165,186,606 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342165,174,839 - 165,303,865NCBI
Celera2158,959,227 - 159,088,293 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2157,231,772 - 157,360,824 (-)NCBIHuRef
CHM1_12165,355,217 - 165,484,258 (-)NCBICHM1_1
T2T-CHM13v2.02164,949,755 - 165,079,884 (-)NCBIT2T-CHM13v2.0
Grb14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39264,742,820 - 64,853,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl264,742,820 - 64,855,331 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38264,912,476 - 65,022,766 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl264,912,476 - 65,024,987 (-)Ensemblmm10GRCm38
MGSCv37264,750,535 - 64,860,823 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36264,713,317 - 64,823,605 (-)NCBIMGSCv36mm8
Celera266,583,155 - 66,693,422 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map238.35NCBI
Grb14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554499,466,706 - 9,591,598 (+)Ensembl
ChiLan1.0NW_0049554499,466,764 - 9,589,559 (+)NCBIChiLan1.0ChiLan1.0
GRB14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21367,158,657 - 67,287,266 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B67,173,633 - 67,302,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B51,773,844 - 51,902,420 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B169,135,019 - 169,262,834 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B169,135,231 - 169,263,874 (-)EnsemblpanPan2panpan1.1
GRB14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1369,711,885 - 9,843,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl369,712,142 - 9,721,769 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha369,856,214 - 9,987,580 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0369,844,049 - 9,975,461 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl369,844,059 - 9,975,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1369,855,062 - 9,986,361 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,897,060 - 10,011,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03610,011,150 - 10,142,536 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grb14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303126,875,121 - 126,989,222 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646914,628,546 - 14,743,916 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646914,628,478 - 14,742,327 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRB14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1571,119,926 - 71,247,383 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11571,119,928 - 71,247,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21579,273,968 - 79,340,255 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRB14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11049,952,835 - 50,085,274 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1049,953,059 - 50,084,869 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040149,415,172 - 149,544,225 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grb14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624732811,484 - 950,343 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624732811,486 - 949,972 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Grb14
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1542,404,574 - 42,513,183 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grb14
690 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:91
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000052395
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)35986366373704481Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)35860129171157804Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)35911940270710963Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
D3Wox38  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8369,976,466 - 69,976,574 (+)Marker Load Pipeline
mRatBN7.2349,568,345 - 49,568,455 (+)MAPPERmRatBN7.2
Rnor_6.0350,937,537 - 50,937,644NCBIRnor6.0
Rnor_5.0357,578,360 - 57,578,467UniSTSRnor5.0
RGSC_v3.4346,832,514 - 46,832,621UniSTSRGSC3.4
Celera349,175,964 - 49,176,071UniSTS
Cytogenetic Map3q21UniSTS
AI505286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2349,568,477 - 49,568,589 (+)MAPPERmRatBN7.2
Rnor_6.0350,937,667 - 50,937,778NCBIRnor6.0
Rnor_5.0357,578,490 - 57,578,601UniSTSRnor5.0
RGSC_v3.4346,832,644 - 46,832,755UniSTSRGSC3.4
Celera349,176,094 - 49,176,205UniSTS
Cytogenetic Map3q21UniSTS
RH137906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2349,684,771 - 49,684,957 (+)MAPPERmRatBN7.2
Rnor_6.0351,066,278 - 51,066,463NCBIRnor6.0
Rnor_5.0357,706,527 - 57,706,712UniSTSRnor5.0
RGSC_v3.4346,953,780 - 46,953,965UniSTSRGSC3.4
Celera349,291,278 - 49,291,463UniSTS
RH 3.4 Map3625.3UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 155 91 90 59 90 59 6 354 190 11 134 81 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000089243   ⟹   ENSRNOP00000072564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl369,976,339 - 70,091,921 (-)Ensembl
mRatBN7.2 Ensembl349,568,213 - 49,683,889 (-)Ensembl
Rnor_6.0 Ensembl350,937,669 - 51,054,378 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097641   ⟹   ENSRNOP00000082236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl369,996,990 - 70,046,606 (-)Ensembl
mRatBN7.2 Ensembl349,588,872 - 49,638,518 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100574   ⟹   ENSRNOP00000083261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl369,976,339 - 70,091,921 (-)Ensembl
mRatBN7.2 Ensembl349,568,210 - 49,683,878 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123263   ⟹   ENSRNOP00000108268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl369,976,628 - 70,091,921 (-)Ensembl
RefSeq Acc Id: NM_031623   ⟹   NP_113811
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,976,333 - 70,091,921 (-)NCBI
mRatBN7.2349,568,212 - 49,683,805 (-)NCBI
Rnor_6.0350,937,403 - 51,054,447 (-)NCBI
Rnor_5.0357,578,226 - 57,619,404 (-)NCBI
Rnor_5.0357,679,758 - 57,695,025 (-)NCBI
RGSC_v3.4346,832,380 - 46,952,670 (-)RGD
Celera349,175,830 - 49,290,450 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105748   ⟹   XP_038961676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,976,331 - 70,046,595 (-)NCBI
mRatBN7.2349,568,210 - 49,638,478 (-)NCBI
RefSeq Acc Id: XM_039105749   ⟹   XP_038961677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,976,331 - 70,032,080 (-)NCBI
mRatBN7.2349,568,210 - 49,623,965 (-)NCBI
Protein Sequences
Protein RefSeqs NP_113811 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961676 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961677 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC61478 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072564
GenBank Protein O88900 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113811   ⟸   NM_031623
- UniProtKB: O88900 (UniProtKB/Swiss-Prot),   A0A0G2K3B0 (UniProtKB/TrEMBL),   A6HLW6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072564   ⟸   ENSRNOT00000089243
RefSeq Acc Id: XP_038961676   ⟸   XM_039105748
- Peptide Label: isoform X1
- UniProtKB: O88900 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038961677   ⟸   XM_039105749
- Peptide Label: isoform X2
- UniProtKB: O88900 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000083261   ⟸   ENSRNOT00000100574
Ensembl Acc Id: ENSRNOP00000082236   ⟸   ENSRNOT00000097641
Ensembl Acc Id: ENSRNOP00000108268   ⟸   ENSRNOT00000123263
Protein Domains
PH   Ras-associating   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88900-F1-model_v2 AlphaFold O88900 1-538 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61869 AgrOrtholog
BioCyc Gene G2FUF-49568 BioCyc
Ensembl Genes ENSRNOG00000052498 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000089243 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro BPS-dom UniProtKB/Swiss-Prot
  GRB/APBB1IP UniProtKB/Swiss-Prot
  Grb14_SH2 UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_APBB1IP UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  RA_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:58844 UniProtKB/Swiss-Prot
NCBI Gene 58844 ENTREZGENE
PANTHER PTHR11243 UniProtKB/Swiss-Prot
  PTHR11243:SF22 UniProtKB/Swiss-Prot
Pfam BPS UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  RA_2 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PhenoGen Grb14 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
  PS50200 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052498 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
  SM00314 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
TIGR TC209084
UniProt A0A0G2K3B0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVQ2_RAT UniProtKB/TrEMBL
  A0A8I5ZWE7_RAT UniProtKB/TrEMBL
  A0ABK0LQH4_RAT UniProtKB/TrEMBL
  A6HLW6 ENTREZGENE, UniProtKB/TrEMBL
  GRB14_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Grb14  growth factor receptor bound protein 14       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression decreases insulin stimulation of both DNA and glycogen synthesis 61620
gene_physical_interaction binds to phosphorylated activation loop of insulin receptor 61620