Grk4 (G protein-coupled receptor kinase 4) - Rat Genome Database

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Pathways
Gene: Grk4 (G protein-coupled receptor kinase 4) Rattus norvegicus
Analyze
Symbol: Grk4
Name: G protein-coupled receptor kinase 4
RGD ID: 61858
Description: Enables rhodopsin kinase activity. Involved in G protein-coupled receptor internalization. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; kinin signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor kinase 2, groucho gene related; G protein-coupled receptor kinase 2, groucho gene related (Drosophila); g protein-coupled receptor kinase GRK4; Gprk2l
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,230,699 - 80,305,292 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1480,230,816 - 80,305,292 (-)EnsemblGRCr8
mRatBN7.21475,998,554 - 76,080,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1480,458,931 - 80,533,471 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,699,586 - 81,774,124 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,144,821 - 78,219,352 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,261,708 - 81,339,516 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,265,672 - 81,339,526 (-)Ensemblrn6Rnor6.0
Rnor_5.01481,953,108 - 82,026,972 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41481,648,003 - 81,722,480 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,930,817 - 75,005,219 (-)NCBICelera
RGSC_v3.11481,650,393 - 81,724,871 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IEA)
cytoplasm  (IBA,IEA)
cytosol  (ISO)
dendrite  (IDA)
neuronal cell body  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells. Fraga S, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R772-9. Epub 2004 May 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Role of G protein-coupled receptor kinase 4 and beta-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases. Iacovelli L, etal., J Biol Chem 2003 Apr 4;278(14):12433-42. Epub 2003 Jan 07.
4. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
8. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. Premont RT, etal., J Biol Chem 1999 Oct 8;274(41):29381-9.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1. Sallese M, etal., FASEB J. 2000 Dec;14(15):2569-80.
14. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. Speirs HJ, etal., J Hypertens. 2004 May;22(5):931-6.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Rat G protein-coupled receptor kinase GRK4: identification, functional expression, and differential tissue distribution of two splice variants. Virlon B, etal., Endocrinology 1998 Jun;139(6):2784-95.
17. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30.
Additional References at PubMed
PMID:16636192   PMID:18957817   PMID:20074556   PMID:23839509   PMID:32687659   PMID:32940654  


Genomics

Comparative Map Data
Grk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,230,699 - 80,305,292 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1480,230,816 - 80,305,292 (-)EnsemblGRCr8
mRatBN7.21475,998,554 - 76,080,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1480,458,931 - 80,533,471 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,699,586 - 81,774,124 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,144,821 - 78,219,352 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,261,708 - 81,339,516 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,265,672 - 81,339,526 (-)Ensemblrn6Rnor6.0
Rnor_5.01481,953,108 - 82,026,972 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41481,648,003 - 81,722,480 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,930,817 - 75,005,219 (-)NCBICelera
RGSC_v3.11481,650,393 - 81,724,871 (-)NCBI
Cytogenetic Map14q21NCBI
GRK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,963,571 - 3,040,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl42,963,571 - 3,040,760 (+)Ensemblhg38GRCh38
GRCh3742,965,298 - 3,042,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,935,141 - 3,012,272 (+)NCBIBuild 36Build 36hg18NCBI36
Celera42,876,244 - 2,953,687 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,903,673 - 2,980,923 (+)NCBIHuRef
CHM1_142,963,374 - 3,040,591 (+)NCBICHM1_1
T2T-CHM13v2.042,962,247 - 3,039,448 (+)NCBIT2T-CHM13v2.0
Grk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,817,641 - 34,912,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,817,723 - 34,912,649 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38534,660,250 - 34,755,305 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,660,379 - 34,755,305 (+)Ensemblmm10GRCm38
MGSCv37535,003,028 - 35,097,952 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36534,977,810 - 35,072,160 (+)NCBIMGSCv36mm8
Celera532,133,988 - 32,229,425 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.91NCBI
Grk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,837,141 - 1,895,785 (+)Ensembl
ChiLan1.0NW_0049555141,837,141 - 1,895,785 (+)NCBIChiLan1.0ChiLan1.0
GRK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,299,377 - 3,374,945 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,235,633 - 3,310,914 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,106,064 - 3,181,270 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.143,007,989 - 3,083,215 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,008,126 - 3,083,094 (+)EnsemblpanPan2panpan1.1
GRK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,233,066 - 61,331,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,079,904 - 61,330,290 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha363,816,745 - 63,913,652 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0361,708,736 - 61,805,626 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,708,837 - 61,805,819 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,200,173 - 61,297,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,404,752 - 61,501,823 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,764,513 - 61,861,425 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
GRK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,738,333 - 1,792,374 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.181,737,960 - 1,792,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,370,315 - 1,444,424 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,691,936 - 45,765,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660512,054,185 - 2,131,243 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,742,073 - 24,830,314 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475524,741,985 - 24,789,972 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grk4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11170,325,137 - 70,397,352 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grk4
231 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:81
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000015894, ENSRNOT00000016153
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
Gprk2l  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,048,124 - 76,048,527 (+)MAPPERmRatBN7.2
Rnor_6.01481,306,941 - 81,307,343NCBIRnor6.0
Rnor_5.01481,994,397 - 81,994,799UniSTSRnor5.0
RGSC_v3.41481,689,906 - 81,690,308UniSTSRGSC3.4
Celera1474,972,650 - 74,973,052UniSTS
Cytogenetic Map14q21UniSTS
RH138943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,080,793 - 76,080,920 (+)MAPPERmRatBN7.2
Rnor_6.01481,339,617 - 81,339,743NCBIRnor6.0
Rnor_5.01482,027,073 - 82,027,199UniSTSRnor5.0
RGSC_v3.41481,722,581 - 81,722,707UniSTSRGSC3.4
Celera1475,005,320 - 75,005,446UniSTS
Cytogenetic Map14q21UniSTS
AU049804  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,008,922 - 76,009,082 (+)MAPPERmRatBN7.2
Rnor_6.01481,268,488 - 81,268,647NCBIRnor6.0
Rnor_5.01481,955,944 - 81,956,103UniSTSRnor5.0
RGSC_v3.41481,650,704 - 81,650,863UniSTSRGSC3.4
Celera1474,933,512 - 74,933,671UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001428989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005493008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015894   ⟹   ENSRNOP00000015894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,230,816 - 80,305,292 (-)Ensembl
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)Ensembl
Rnor_6.0 Ensembl1481,265,672 - 81,339,526 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094171   ⟹   ENSRNOP00000088283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,231,755 - 80,305,292 (-)Ensembl
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098753   ⟹   ENSRNOP00000083618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,231,755 - 80,305,292 (-)Ensembl
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103702   ⟹   ENSRNOP00000086910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,232,500 - 80,299,922 (-)Ensembl
mRatBN7.2 Ensembl1476,007,902 - 76,075,325 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168890   ⟹   ENSRNOP00000101234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,231,755 - 80,305,292 (-)Ensembl
RefSeq Acc Id: NM_022928   ⟹   NP_075217
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,816 - 80,305,292 (-)NCBI
mRatBN7.21476,006,218 - 76,080,693 (-)NCBI
Rnor_6.01481,265,784 - 81,339,516 (-)NCBI
Rnor_5.01481,953,108 - 82,026,972 (-)NCBI
RGSC_v3.41481,648,003 - 81,722,480 (-)RGD
Celera1474,930,817 - 75,005,219 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251359   ⟹   XP_006251421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,699 - 80,305,187 (-)NCBI
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
Rnor_6.01481,261,708 - 81,339,359 (-)NCBI
Rnor_5.01481,953,108 - 82,026,972 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251360   ⟹   XP_006251422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,699 - 80,305,187 (-)NCBI
mRatBN7.21476,006,188 - 76,080,808 (-)NCBI
Rnor_6.01481,261,708 - 81,339,359 (-)NCBI
Rnor_5.01481,953,108 - 82,026,972 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599346   ⟹   XP_017454835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,699 - 80,305,187 (-)NCBI
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
Rnor_6.01481,261,708 - 81,339,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599347   ⟹   XP_017454836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,699 - 80,305,187 (-)NCBI
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
Rnor_6.01481,261,708 - 81,339,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092352   ⟹   XP_038948280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,699 - 80,305,187 (-)NCBI
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092356   ⟹   XP_038948284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,245,998 - 80,305,187 (-)NCBI
mRatBN7.21476,021,400 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092357   ⟹   XP_038948285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,258,507 - 80,305,187 (-)NCBI
mRatBN7.21476,033,910 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092360   ⟹   XP_038948288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,245,890 - 80,305,187 (-)NCBI
mRatBN7.21476,021,292 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_063273516   ⟹   XP_063129586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,786 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273517   ⟹   XP_063129587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,786 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273518   ⟹   XP_063129588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,786 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273519   ⟹   XP_063129589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,786 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273520   ⟹   XP_063129590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,786 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273521   ⟹   XP_063129591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,786 - 80,288,470 (-)NCBI
RefSeq Acc Id: XM_063273522   ⟹   XP_063129592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,786 - 80,294,227 (-)NCBI
RefSeq Acc Id: XM_063273523   ⟹   XP_063129593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,699 - 80,260,921 (-)NCBI
RefSeq Acc Id: XM_063273524   ⟹   XP_063129594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,699 - 80,268,563 (-)NCBI
RefSeq Acc Id: XM_063273525   ⟹   XP_063129595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,699 - 80,259,315 (-)NCBI
RefSeq Acc Id: XM_063273526   ⟹   XP_063129596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,786 - 80,288,341 (-)NCBI
RefSeq Acc Id: XM_063273527   ⟹   XP_063129597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,243,600 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273528   ⟹   XP_063129598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,235,660 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273529   ⟹   XP_063129599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,235,660 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273530   ⟹   XP_063129600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,232,959 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273531   ⟹   XP_063129601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,786 - 80,288,341 (-)NCBI
RefSeq Acc Id: XM_063273532   ⟹   XP_063129602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,247,857 - 80,305,187 (-)NCBI
RefSeq Acc Id: XM_063273534   ⟹   XP_063129604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,230,699 - 80,245,844 (-)NCBI
RefSeq Acc Id: XR_005493008
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,235,660 - 80,305,187 (-)NCBI
mRatBN7.21476,011,062 - 76,080,808 (-)NCBI
RefSeq Acc Id: XR_010057402
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,235,660 - 80,305,187 (-)NCBI
RefSeq Acc Id: XR_010057403
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,233,015 - 80,305,187 (-)NCBI
RefSeq Acc Id: XR_010057404
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,243,600 - 80,305,187 (-)NCBI
RefSeq Acc Id: XR_010057405
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,243,600 - 80,305,187 (-)NCBI
RefSeq Acc Id: XR_010057406
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,235,660 - 80,305,187 (-)NCBI
RefSeq Acc Id: XR_010057407
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,232,959 - 80,305,187 (-)NCBI
RefSeq Acc Id: XR_010057408
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,235,660 - 80,305,187 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001415918 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415919 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415920 (Get FASTA)   NCBI Sequence Viewer  
  NP_075217 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251421 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251422 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454835 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454836 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948280 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948284 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948285 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948288 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129586 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129587 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129588 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129589 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129590 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129591 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129592 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129593 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129594 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129595 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129596 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129597 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129598 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129599 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129600 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129601 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129602 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129604 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA66180 (Get FASTA)   NCBI Sequence Viewer  
  CAA66181 (Get FASTA)   NCBI Sequence Viewer  
  EDM00081 (Get FASTA)   NCBI Sequence Viewer  
  EDM00082 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015894
  ENSRNOP00000015894.2
  ENSRNOP00000088283
  ENSRNOP00000088283.1
  ENSRNOP00000101234
GenBank Protein P70507 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_075217   ⟸   NM_022928
- UniProtKB: P70508 (UniProtKB/Swiss-Prot),   P70507 (UniProtKB/Swiss-Prot),   A6IK17 (UniProtKB/TrEMBL),   A0A8I6A4S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251421   ⟸   XM_006251359
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006251422   ⟸   XM_006251360
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_017454836   ⟸   XM_017599347
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A4S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454835   ⟸   XM_017599346
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A4S4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015894   ⟸   ENSRNOT00000015894
RefSeq Acc Id: XP_038948280   ⟸   XM_039092352
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038948288   ⟸   XM_039092360
- Peptide Label: isoform X22
RefSeq Acc Id: XP_038948284   ⟸   XM_039092356
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038948285   ⟸   XM_039092357
- Peptide Label: isoform X18
Ensembl Acc Id: ENSRNOP00000086910   ⟸   ENSRNOT00000103702
Ensembl Acc Id: ENSRNOP00000083618   ⟸   ENSRNOT00000098753
Ensembl Acc Id: ENSRNOP00000088283   ⟸   ENSRNOT00000094171
RefSeq Acc Id: XP_063129594   ⟸   XM_063273524
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063129593   ⟸   XM_063273523
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063129595   ⟸   XM_063273525
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063129604   ⟸   XM_063273534
- Peptide Label: isoform X23
RefSeq Acc Id: XP_063129590   ⟸   XM_063273520
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063129588   ⟸   XM_063273518
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A4S4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129589   ⟸   XM_063273519
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A4S4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129587   ⟸   XM_063273517
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4S4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129586   ⟸   XM_063273516
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A4S4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129592   ⟸   XM_063273522
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063129591   ⟸   XM_063273521
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063129601   ⟸   XM_063273531
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063129596   ⟸   XM_063273526
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063129600   ⟸   XM_063273530
- Peptide Label: isoform X20
RefSeq Acc Id: XP_063129599   ⟸   XM_063273529
- Peptide Label: isoform X19
RefSeq Acc Id: XP_063129598   ⟸   XM_063273528
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063129597   ⟸   XM_063273527
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063129602   ⟸   XM_063273532
- Peptide Label: isoform X21
Ensembl Acc Id: ENSRNOP00000101234   ⟸   ENSRNOT00000168890
Protein Domains
AGC-kinase C-terminal   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70507-F1-model_v2 AlphaFold P70507 1-575 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61858 AgrOrtholog
BioCyc Gene G2FUF-15300 BioCyc
Ensembl Genes ENSRNOG00000011847 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015894 ENTREZGENE
  ENSRNOT00000015894.5 UniProtKB/Swiss-Prot
  ENSRNOT00000094171 ENTREZGENE
  ENSRNOT00000094171.1 UniProtKB/Swiss-Prot
  ENSRNOT00000168890 ENTREZGENE
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  GPCR_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:59077 UniProtKB/Swiss-Prot
NCBI Gene 59077 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR KINASE 4 UniProtKB/Swiss-Prot
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
PhenoGen Grk4 PhenoGen
PRINTS GPCRKINASE UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011847 RatGTEx
SMART RGS UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC219373
UniProt A0A8I5ZVP3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4S4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LEH9_RAT UniProtKB/TrEMBL
  A6IK17 ENTREZGENE, UniProtKB/TrEMBL
  GRK4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70508 ENTREZGENE
UniProt Secondary P70508 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Grk4  G protein-coupled receptor kinase 4  Gprk2l  G protein-coupled receptor kinase 2, groucho gene related (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gprk2l  G protein-coupled receptor kinase 2, groucho gene related (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript has two splicing variants, one which has a 31-amino acid deletion in the N-terminal domain 61617