Htr2b (5-hydroxytryptamine receptor 2B) - Rat Genome Database

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Gene: Htr2b (5-hydroxytryptamine receptor 2B) Rattus norvegicus
Analyze
Symbol: Htr2b
Name: 5-hydroxytryptamine receptor 2B
RGD ID: 61801
Description: Enables serotonin binding activity. Involved in several processes, including cellular response to amine stimulus; cellular response to serotonin; and hepatic stellate cell activation. Located in dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-2B; 5-HT-2F; 5-HT2B; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; serotonin receptor 2B; stomach fundus serotonin receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,184,442 - 94,206,851 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl994,190,109 - 94,204,087 (-)EnsemblGRCr8
mRatBN7.2986,735,793 - 86,756,638 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl986,742,102 - 86,755,108 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx995,160,066 - 95,174,072 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,288,563 - 100,302,570 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0998,670,337 - 98,684,343 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,112,781 - 93,130,135 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)Ensemblrn6Rnor6.0
Rnor_5.0992,836,402 - 92,856,220 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4984,840,026 - 84,852,984 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera984,162,612 - 84,175,882 (-)NCBICelera
RGSC_v3.1985,023,439 - 85,036,403 (-)NCBI
Cytogenetic Map9q35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide  (ISO)
(R)-noradrenaline  (EXP)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
ergotamine  (ISO)
fenfluramine  (ISO)
fluoxetine  (ISO)
furan  (EXP)
genistein  (ISO)
glycogen  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
lipopolysaccharide  (ISO)
lysergic acid diethylamide  (ISO)
mercaptopurine  (EXP)
mesulergine  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
Methylergonovine Maleate  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
purine-6-thiol  (EXP)
rac-lactic acid  (ISO)
ritanserin  (ISO)
SB 206553  (EXP)
serotonin  (EXP,ISO)
sodium arsenate  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (ISO)
trichloroethene  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium-mediated signaling  (IEA,ISO,ISS)
cardiac muscle hypertrophy  (IEA,ISO,ISS)
cellular response to amine stimulus  (IDA)
cellular response to serotonin  (IDA)
chemical synaptic transmission  (IBA)
embryonic morphogenesis  (IEA,ISO,ISS)
ERK1 and ERK2 cascade  (IEA,ISO,ISS)
G protein-coupled receptor signaling pathway  (IEA,ISO,ISS)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (IEA,ISO,ISS)
heart development  (IEA,ISO)
heart morphogenesis  (IEA,ISO,ISS)
hepatic stellate cell activation  (IEP)
inositol phosphate metabolic process  (IEP)
intestine smooth muscle contraction  (IEA,ISO,ISS)
intracellular calcium ion homeostasis  (IEA,ISO)
monoatomic ion transmembrane transport  (IDA)
negative regulation of apoptotic process  (IEA,ISO,ISS)
neural crest cell differentiation  (IEA,ISO,ISS)
neural crest cell migration  (IEA,ISO,ISS)
phospholipase C-activating serotonin receptor signaling pathway  (IBA,IEA,ISO,ISS)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
positive regulation of cell division  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of cytokine production  (IEA,ISO,ISS)
positive regulation of endothelial cell proliferation  (IEA,ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
positive regulation of phosphatidylinositol biosynthetic process  (IEA,ISO,ISS)
regulation of behavior  (IEA,ISO,ISS)
release of sequestered calcium ion into cytosol  (IBA,IEA,ISO,ISS)
response to xenobiotic stimulus  (IEA,ISO)
serotonin receptor signaling pathway  (IBA)
signal transduction  (IEA)
smooth muscle contraction  (IEA)
vasoconstriction  (IEA,ISO,ISS)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
dendrite  (IBA,IDA)
G protein-coupled serotonin receptor complex  (IEA,ISO)
membrane  (IEA)
neuron projection  (IEA)
neuronal cell body  (IDA)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO,ISS)
synapse  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. Binetti J, etal., Life (Basel). 2020 Oct 16;10(10):245. doi: 10.3390/life10100245.
2. Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Brattelid T, etal., J Mol Cell Cardiol. 2007 Dec;43(6):767-79. Epub 2007 Sep 5.
3. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
4. Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological study. Droogmans S, etal., Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1940-8. doi: 10.1152/ajpheart.01177.2008. Epub 2009 Apr 3.
5. Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system. Duxon MS, etal., Neuroscience. 1997 Jan;76(2):323-9.
6. Cloning and functional characterization of the rat stomach fundus serotonin receptor. Foguet M, etal., EMBO J 1992 Sep;11(9):3481-7.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Jaffre F, etal., Circ Res. 2009 Jan 2;104(1):113-23. doi: 10.1161/CIRCRESAHA.108.180976. Epub 2008 Nov 20.
10. Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus. Kursar JD, etal., Mol Pharmacol. 1992 Oct;42(4):549-57.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Ruddell RG, etal., Am J Pathol. 2006 Sep;169(3):861-76.
18. 5-Hydroxytryptamine2B receptors stimulate Ca2+ increases in cultured astrocytes from three different brain regions. Sanden N, etal., Neurochem Int. 2000 Apr;36(4-5):427-34.
Additional References at PubMed
PMID:7582481   PMID:7599919   PMID:7926008   PMID:8621713   PMID:8882600   PMID:9165122   PMID:9186750   PMID:10944220   PMID:12761501   PMID:12970106   PMID:15625277   PMID:15831837  
PMID:15862800   PMID:15925089   PMID:16517693   PMID:16758492   PMID:17325130   PMID:17584957   PMID:17609583   PMID:18439428   PMID:18566482   PMID:18604238   PMID:18703043   PMID:19057895  
PMID:19307114   PMID:19308295   PMID:19615378   PMID:20099302   PMID:20374255   PMID:20450948   PMID:20980537   PMID:21179162   PMID:21789169   PMID:22106156   PMID:22476011   PMID:22525520  
PMID:25544272   PMID:26106048   PMID:26804134   PMID:29384698   PMID:32504811   PMID:37747614   PMID:38596485  


Genomics

Comparative Map Data
Htr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,184,442 - 94,206,851 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl994,190,109 - 94,204,087 (-)EnsemblGRCr8
mRatBN7.2986,735,793 - 86,756,638 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl986,742,102 - 86,755,108 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx995,160,066 - 95,174,072 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,288,563 - 100,302,570 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0998,670,337 - 98,684,343 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,112,781 - 93,130,135 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)Ensemblrn6Rnor6.0
Rnor_5.0992,836,402 - 92,856,220 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4984,840,026 - 84,852,984 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera984,162,612 - 84,175,882 (-)NCBICelera
RGSC_v3.1985,023,439 - 85,036,403 (-)NCBI
Cytogenetic Map9q35NCBI
HTR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,108,230 - 231,125,042 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,108,230 - 231,125,080 (-)Ensemblhg38GRCh38
GRCh372231,972,944 - 231,989,756 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,681,199 - 231,698,068 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342231,798,459 - 231,815,329NCBI
Celera2225,748,458 - 225,765,335 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2223,815,006 - 223,831,883 (-)NCBIHuRef
CHM1_12231,978,806 - 231,995,681 (-)NCBICHM1_1
T2T-CHM13v2.02231,592,736 - 231,609,548 (-)NCBIT2T-CHM13v2.0
Htr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,025,268 - 86,043,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,026,748 - 86,039,692 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38186,097,546 - 86,116,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,099,026 - 86,111,970 (-)Ensemblmm10GRCm38
MGSCv37187,995,612 - 88,008,545 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36187,930,442 - 87,942,088 (-)NCBIMGSCv36mm8
Celera189,064,379 - 89,077,312 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.94NCBI
Htr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554534,351,668 - 4,367,807 (+)Ensembl
ChiLan1.0NW_0049554534,352,278 - 4,367,807 (+)NCBIChiLan1.0ChiLan1.0
HTR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213133,720,071 - 133,758,758 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B133,735,036 - 133,773,723 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B118,362,719 - 118,381,253 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B237,153,709 - 237,174,356 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,153,709 - 237,170,591 (-)EnsemblpanPan2panpan1.1
HTR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,042,306 - 43,056,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,042,173 - 43,056,612 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2543,602,608 - 43,616,665 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02543,299,319 - 43,313,380 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,299,186 - 43,314,350 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,227,978 - 43,242,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02543,070,901 - 43,084,964 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,226,286 - 43,240,447 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Htr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,210,647 - 185,227,546 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365255,712,329 - 5,729,831 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365255,711,894 - 5,729,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15131,844,992 - 131,859,277 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115131,844,578 - 131,860,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215145,561,472 - 145,577,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,132,919 - 117,152,132 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10117,133,195 - 117,149,681 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604082,292,351 - 82,310,254 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248434,408,424 - 4,424,168 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248434,407,055 - 4,424,585 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Htr2b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14158,234,305 - 158,246,437 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Htr2b
286 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:45
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000023829
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 51 118 74 73 42 70 42 6 290 154 11 97 70 91 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000023829   ⟹   ENSRNOP00000023829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl994,190,109 - 94,204,087 (-)Ensembl
mRatBN7.2 Ensembl986,742,102 - 86,755,108 (-)Ensembl
Rnor_6.0 Ensembl993,112,805 - 93,125,014 (-)Ensembl
RefSeq Acc Id: NM_017250   ⟹   NP_058946
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,190,083 - 94,204,087 (-)NCBI
mRatBN7.2986,742,076 - 86,756,081 (-)NCBI
Rnor_6.0993,112,781 - 93,125,014 (-)NCBI
Rnor_5.0992,836,402 - 92,856,220 (-)NCBI
RGSC_v3.4984,840,026 - 84,852,984 (-)RGD
Celera984,162,612 - 84,175,882 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083116   ⟹   XP_038939044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,184,442 - 94,206,851 (-)NCBI
mRatBN7.2986,735,793 - 86,756,638 (-)NCBI
RefSeq Acc Id: XM_063266817   ⟹   XP_063122887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,184,555 - 94,206,851 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058946 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939044 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122887 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA47318 (Get FASTA)   NCBI Sequence Viewer  
  EDL75569 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023829
GenBank Protein P30994 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058946   ⟸   NM_017250
- UniProtKB: Q9QW44 (UniProtKB/Swiss-Prot),   P30994 (UniProtKB/Swiss-Prot),   G3V8A0 (UniProtKB/TrEMBL),   A6JWG0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023829   ⟸   ENSRNOT00000023829
RefSeq Acc Id: XP_038939044   ⟸   XM_039083116
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122887   ⟸   XM_063266817
- Peptide Label: isoform X1
- UniProtKB: Q9QW44 (UniProtKB/Swiss-Prot),   P30994 (UniProtKB/Swiss-Prot),   A6JWG0 (UniProtKB/TrEMBL),   G3V8A0 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30994-F1-model_v2 AlphaFold P30994 1-479 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61801 AgrOrtholog
BioCyc Gene G2FUF-26905 BioCyc
Ensembl Genes ENSRNOG00000017625 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023829 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT2B_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:29581 UniProtKB/Swiss-Prot
NCBI Gene 29581 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  PTHR24247:SF31 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Htr2b PhenoGen
PRINTS 5HT2BRECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017625 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT2B_RAT UniProtKB/Swiss-Prot
  A6JWG0 ENTREZGENE, UniProtKB/TrEMBL
  G3V8A0 ENTREZGENE, UniProtKB/TrEMBL
  P30994 ENTREZGENE
  Q9QW44 ENTREZGENE
UniProt Secondary Q9QW44 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr2b  5-hydroxytryptamine receptor 2B  Htr2b  5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr2b  5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled  Htr2b  5-hydroxytryptamine (serotonin) receptor 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Htr2b  5-hydroxytryptamine (serotonin) receptor 2B      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function activation triggered the typical chloride current 61633