RGD Reference Report - Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. - Rat Genome Database

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Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD.

Authors: Binetti, Jessica  Bertran, Laia  Riesco, David  Aguilar, Carmen  Martínez, Salomé  Sabench, Fàtima  Porras, Jose Antonio  Camaron, Javier  Castillo, Daniel Del  Richart, Cristóbal  Auguet, Teresa 
Citation: Binetti J, etal., Life (Basel). 2020 Oct 16;10(10):245. doi: 10.3390/life10100245.
RGD ID: 401900305
Pubmed: PMID:33081272   (View Abstract at PubMed)
PMCID: PMC7603041   (View Article at PubMed Central)
DOI: DOI:10.3390/life10100245   (Journal Full-text)

Non-alcoholic fatty liver disease (NAFLD) extends from simple steatosis (SS) to non-alcoholic steatohepatitis (NASH). Peripheral serotonin (5-HT) has become as an important regulator of different metabolic pathways. 5-HT has been related to obesity and lipid accumulation in the liver. The objective of this study was to assess the relationship between the 5-HT signaling pathway and the degree of NAFLD, as well as to investigate whether peripheral 5-HT levels are related to the hepatic and jejunal mRNA abundance of serotonin receptors (HTR) in a cohort of women with morbid obesity (MO) and NAFLD. ELISA was used to quantify the serum 5-HT from normal-weight subjects (n = 26) and patients with MO (n = 58). We used RTq-PCR analysis to evaluate the relative expression of HTR in women with MO with normal liver (n = 22), SS (n = 21), and NASH (n = 15). The 5-HT was diminished in women with MO under a hypocaloric diet, regardless of the presence of NAFLD. Additionally, we report a negative correlation of 5-HT levels with metabolic syndrome criteria, suggesting that serotonin may have a protective role in obesity. Additionally, the hepatic expression of HTR2A and HTR2B were decreased in women with MO and NAFLD, but no significant differences in the HTR jejunal expression according to the presence of NAFLD were found.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HTR2BHumanmetabolic dysfunction-associated steatohepatitis  IAGP associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2bRatmetabolic dysfunction-associated steatohepatitis  ISOHTR2B (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2bMousemetabolic dysfunction-associated steatohepatitis  ISOHTR2B (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 
HTR2AHumannon-alcoholic fatty liver  IEP associated with morbid obesity and mRNA:decreased expression:liverRGD 
HTR2BHumannon-alcoholic fatty liver  IEP associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2aRatnon-alcoholic fatty liver  ISOHTR2A (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2aMousenon-alcoholic fatty liver  ISOHTR2A (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2bRatnon-alcoholic fatty liver  ISOHTR2B (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2bMousenon-alcoholic fatty liver  ISOHTR2B (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 
HTR2AHumansteatotic liver disease  IAGP associated with morbid obesity and mRNA:decreased expression:liverRGD 
HTR2BHumansteatotic liver disease  IAGP associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2aMousesteatotic liver disease  ISOHTR2A (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2aRatsteatotic liver disease  ISOHTR2A (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2bRatsteatotic liver disease  ISOHTR2B (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 
Htr2bMousesteatotic liver disease  ISOHTR2B (Homo sapiens)associated with morbid obesity and mRNA:decreased expression:liverRGD 

Objects Annotated

Genes (Rattus norvegicus)
Htr2a  (5-hydroxytryptamine receptor 2A)
Htr2b  (5-hydroxytryptamine receptor 2B)

Genes (Mus musculus)
Htr2a  (5-hydroxytryptamine (serotonin) receptor 2A)
Htr2b  (5-hydroxytryptamine (serotonin) receptor 2B)

Genes (Homo sapiens)
HTR2A  (5-hydroxytryptamine receptor 2A)
HTR2B  (5-hydroxytryptamine receptor 2B)


Additional Information