Vtn (vitronectin) - Rat Genome Database

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Gene: Vtn (vitronectin) Rattus norvegicus
Analyze
Symbol: Vtn
Name: vitronectin
RGD ID: 3967
Description: Enables collagen binding activity; heparin binding activity; and identical protein binding activity. Involved in liver regeneration and protein polymerization. Located in several cellular components, including Golgi lumen; basement membrane; and rough endoplasmic reticulum lumen. Used to study proteinuria. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin); PARTICIPATES IN forkhead class A signaling pathway; vascular endothelial growth factor signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Aa1018; MGC124961; Vn
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,892,782 - 63,895,862 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1063,892,766 - 63,895,860 (+)EnsemblGRCr8
mRatBN7.21063,394,732 - 63,397,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,394,719 - 63,397,810 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1068,027,371 - 68,030,455 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,532,702 - 67,535,786 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,002,232 - 63,005,314 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,767,960 - 65,771,040 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,767,053 - 65,771,038 (+)Ensemblrn6Rnor6.0
Rnor_5.01065,872,580 - 65,875,660 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41064,609,242 - 64,612,322 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1062,371,307 - 62,374,387 (+)NCBICelera
RGSC_v3.11064,622,874 - 64,625,943 (+)NCBI
Cytogenetic Map10q25NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
diazepam  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP)
glycidyl methacrylate  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
isoniazide  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotinic acid  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
pioglitazone  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
telmisartan  (EXP)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trametinib  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Vitronectin at sites of cell-substrate contact in cultures of rat myotubes. Baetscher M, etal., J Cell Biol. 1986 Aug;103(2):369-78.
2. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
3. Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. Cai XW, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):867-76.
4. Fibronectin, laminin, vitronectin and their receptors at newly-formed capillaries in proliferative diabetic retinopathy. Casaroli Marano RP, etal., Exp Eye Res. 1995 Jan;60(1):5-17.
5. Evaluation of fibronectin, vitronectin, and leptin levels in coronary artery disease: impacts on thrombosis and thrombolysis. Ekmekci H, etal., Clin Appl Thromb Hemost. 2005 Jan;11(1):63-70.
6. Plasma vitronectin levels in patients with coronary atherosclerosis are increased and correlate with extent of disease. Ekmekci H, etal., J Thromb Thrombolysis. 2002 Dec;14(3):221-5.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Modification of vitronectin by advanced glycation alters functional properties in vitro and in the diabetic retina. Hammes HP, etal., Lab Invest. 1996 Sep;75(3):325-38.
10. Ultrastructural localization and biochemical characterization of vitronectin in developing rat bone. Kumagai T, etal., Histochem J. 1998 Feb;30(2):111-9.
11. Vitronectin- and fibronectin-containing immune complexes in primary systemic vasculitis. Maehnss K, etal., J Autoimmun. 2002 May;18(3):239-50.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Reactive glial cells express a vitronectin-like protein in the hippocampus of epileptic rats. Niquet J, etal., Glia. 1996 Apr;16(4):359-67.
15. Hepatocellular localisation of biosynthesis of vitronectin. Characterisation of the primary structure of rat vitronectin. Otter M, etal., Biochem Mol Biol Int 1995 Oct;37(3):563-72.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Changes in glycosylation of vitronectin modulate multimerization and collagen binding during liver regeneration. Sano K, etal., Glycobiology. 2007 Jul;17(7):784-94. Epub 2007 Mar 16.
20. Vitronectin in the cytoplasm of Leydig cells in the rat testis. Sawada H, etal., Biol Reprod. 1996 Jan;54(1):29-35.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. The changes in glycosylation after partial hepatectomy enhance collagen binding of vitronectin in plasma. Uchibori-Iwaki H, etal., Glycobiology. 2000 Sep;10(9):865-74.
23. Anti-vitronectin antibodies enhance anti-Thy-1-induced proteinuria in PVG/c, but not in Wistar rats. Van Dixhoorn MG, etal., J Am Soc Nephrol. 1998 Jun;9(6):994-1007.
24. The composition of complexes between plasminogen activator inhibitor 1, vitronectin and either thrombin or tissue-type plasminogen activator. van Meijer M, etal., Thromb Haemost 1997 Mar;77(3):516-21.
25. Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin. Wu YP, etal., Blood. 2004 Aug 15;104(4):1034-41. Epub 2004 Apr 6.
26. Alterations of vitronectin and its receptor alpha(v) integrin in the rat renal glomerular wall during diabetes. Yoon S, etal., Am J Kidney Dis. 2001 Dec;38(6):1298-306.
27. Functional structure of the somatomedin B domain of vitronectin. Zhou A Protein Sci. 2007 Jul;16(7):1502-8. Epub 2007 Jun 13.
Additional References at PubMed
PMID:1632457   PMID:1695900   PMID:8626514   PMID:8837777   PMID:10022831   PMID:12477932   PMID:15728191   PMID:15982861   PMID:16502470   PMID:17110906   PMID:18757743   PMID:19199708  
PMID:19574558   PMID:20335177   PMID:20551380   PMID:22505472   PMID:22516433   PMID:23154389   PMID:23155445   PMID:23376485   PMID:23533145   PMID:26979432   PMID:27068509   PMID:27559042  
PMID:29567995   PMID:31010681  


Genomics

Comparative Map Data
Vtn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,892,782 - 63,895,862 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1063,892,766 - 63,895,860 (+)EnsemblGRCr8
mRatBN7.21063,394,732 - 63,397,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,394,719 - 63,397,810 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1068,027,371 - 68,030,455 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,532,702 - 67,535,786 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,002,232 - 63,005,314 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,767,960 - 65,771,040 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,767,053 - 65,771,038 (+)Ensemblrn6Rnor6.0
Rnor_5.01065,872,580 - 65,875,660 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41064,609,242 - 64,612,322 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1062,371,307 - 62,374,387 (+)NCBICelera
RGSC_v3.11064,622,874 - 64,625,943 (+)NCBI
Cytogenetic Map10q25NCBI
VTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,367,284 - 28,370,307 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,367,265 - 28,373,091 (-)Ensemblhg38GRCh38
GRCh371726,694,305 - 26,697,328 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,718,425 - 23,721,500 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341723,718,424 - 23,721,844NCBI
Celera1723,556,056 - 23,559,131 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,902,707 - 22,905,782 (-)NCBIHuRef
CHM1_11726,757,231 - 26,760,306 (-)NCBICHM1_1
T2T-CHM13v2.01729,309,135 - 29,312,158 (-)NCBIT2T-CHM13v2.0
Vtn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,389,946 - 78,393,151 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,389,917 - 78,393,150 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381178,499,120 - 78,502,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,499,091 - 78,502,324 (+)Ensemblmm10GRCm38
MGSCv371178,312,622 - 78,315,827 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361178,315,481 - 78,318,519 (+)NCBIMGSCv36mm8
Celera1188,131,193 - 88,134,398 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Vtn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,765,193 - 4,771,019 (+)Ensembl
ChiLan1.0NW_0049554814,765,078 - 4,768,027 (+)NCBIChiLan1.0ChiLan1.0
VTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,085,584 - 36,091,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,965,973 - 37,971,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,403,813 - 28,407,202 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,906,508 - 28,909,583 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,906,508 - 28,909,583 (+)EnsemblpanPan2panpan1.1
VTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,617,860 - 42,620,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,614,941 - 42,630,864 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha941,774,787 - 41,777,752 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0943,437,036 - 43,440,001 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,434,650 - 43,439,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,221,266 - 42,224,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,512,485 - 42,515,450 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,589,551 - 42,592,516 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vtn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,644,330 - 41,647,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,522,074 - 4,525,336 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,522,275 - 4,525,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,650,534 - 44,655,355 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11244,650,532 - 44,653,916 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,021 - 8,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,133,903 - 22,138,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,133,138 - 22,136,815 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660757,990,668 - 7,994,840 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vtn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624786966,452 - 973,337 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624786970,288 - 973,344 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vtn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1991,940,483 - 91,943,634 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vtn
91 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:64
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000039954
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106174653268282731Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106184363367241334Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AA956238  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,397,651 - 63,397,805 (+)MAPPERmRatBN7.2
Rnor_6.01065,770,880 - 65,771,033NCBIRnor6.0
Rnor_5.01065,872,587 - 65,872,740UniSTSRnor5.0
RGSC_v3.41064,612,162 - 64,612,315UniSTSRGSC3.4
Celera1062,374,227 - 62,374,380UniSTS
Cytogenetic Map10q25UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 57 159 91 90 59 39 59 6 266 129 11 137 57 92 31 15 15

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY318963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000039954   ⟹   ENSRNOP00000046415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1063,892,766 - 63,895,860 (+)Ensembl
mRatBN7.2 Ensembl1063,394,719 - 63,397,810 (+)Ensembl
Rnor_6.0 Ensembl1065,767,930 - 65,771,038 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078897   ⟹   ENSRNOP00000075508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1065,767,053 - 65,770,959 (+)Ensembl
RefSeq Acc Id: NM_019156   ⟹   NP_062029
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,892,782 - 63,895,862 (+)NCBI
mRatBN7.21063,394,732 - 63,397,812 (+)NCBI
Rnor_6.01065,767,960 - 65,771,040 (+)NCBI
Rnor_5.01065,872,580 - 65,875,660 (-)NCBI
RGSC_v3.41064,609,242 - 64,612,322 (+)RGD
Celera1062,371,307 - 62,374,387 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062029 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB01090 (Get FASTA)   NCBI Sequence Viewer  
  AAI05822 (Get FASTA)   NCBI Sequence Viewer  
  AAP85374 (Get FASTA)   NCBI Sequence Viewer  
  EDM05358 (Get FASTA)   NCBI Sequence Viewer  
  EDM05359 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046415
  ENSRNOP00000046415.5
RefSeq Acc Id: NP_062029   ⟸   NM_019156
- Peptide Label: precursor
- UniProtKB: Q3KR94 (UniProtKB/TrEMBL),   Q62905 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046415   ⟸   ENSRNOT00000039954
Ensembl Acc Id: ENSRNOP00000075508   ⟸   ENSRNOT00000078897
Protein Domains
SMB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TQ11-F1-model_v2 AlphaFold Q7TQ11 1-490 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697481
Promoter ID:EPDNEW_R8006
Type:initiation region
Name:Vtn_1
Description:vitronectin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01065,767,945 - 65,768,005EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3967 AgrOrtholog
BioCyc Gene G2FUF-24059 BioCyc
Ensembl Genes ENSRNOG00000010031 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039954 ENTREZGENE
  ENSRNOT00000039954.7 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/TrEMBL
  4.10.410.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121023 IMAGE-MGC_LOAD
  IMAGE:7371104 IMAGE-MGC_LOAD
InterPro Heme_transport/Cell_adhesion UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin/matrixin UniProtKB/TrEMBL
  Hemopexin/matrixin_CS UniProtKB/TrEMBL
  Hemopexin/matrixin_repeat UniProtKB/TrEMBL
  Somatomedin_B UniProtKB/TrEMBL
  Somatomedin_B-like_dom UniProtKB/TrEMBL
  Somatomedin_B_chordata UniProtKB/TrEMBL
KEGG Report rno:29169 UniProtKB/TrEMBL
MGC_CLONE MGC:124961 IMAGE-MGC_LOAD
  MGC:93477 IMAGE-MGC_LOAD
NCBI Gene 29169 ENTREZGENE
PANTHER HEMOPEXIN DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  VITRONECTIN UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/TrEMBL
  Somatomedin_B UniProtKB/TrEMBL
PhenoGen Vtn PhenoGen
PRINTS SOMATOMEDINB UniProtKB/TrEMBL
PROSITE HEMOPEXIN UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/TrEMBL
  SMB_1 UniProtKB/TrEMBL
  SMB_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010031 RatGTEx
SMART SM00120 UniProtKB/TrEMBL
  SM00201 UniProtKB/TrEMBL
Superfamily-SCOP Hemopexin UniProtKB/TrEMBL
  SSF90188 UniProtKB/TrEMBL
TIGR TC221797
UniProt A6HH54_RAT UniProtKB/TrEMBL
  Q3KR94 ENTREZGENE, UniProtKB/TrEMBL
  Q62905 ENTREZGENE, UniProtKB/TrEMBL
  Q7TQ11_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Vtn  vitronectin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hepatocytes 70056