Klk1c2 (kallikrein 1-related peptidase C2) - Rat Genome Database

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Gene: Klk1c2 (kallikrein 1-related peptidase C2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Klk1c2
Name: kallikrein 1-related peptidase C2 (Ensembl:kallikrein 1-related peptidase C2)
RGD ID: 3888
Description: Enables serine-type peptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1); INTERACTS WITH ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: esterase 1; glandular kallikrein-2; kallikrein 1-related peptidase C2; kallikrein a1; KLK2; Klna1; rGK-2; RSKG-5; S2 kallikrein; Ton; tonin
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,628,854 - 103,633,000 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1103,628,854 - 103,633,001 (-)EnsemblGRCr8
mRatBN7.2194,492,332 - 94,496,480 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,492,332 - 94,496,481 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,877,721 - 99,881,867 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,350,346 - 108,354,494 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,640,795 - 101,644,875 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,981,045 - 99,985,422 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,981,045 - 99,985,422 (-)Ensemblrn6Rnor6.0
Rnor_5.01101,046,494 - 101,050,871 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4194,471,693 - 94,475,839 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,759,439 - 88,763,585 (-)NCBICelera
RGSC_v3.1194,549,803 - 94,553,950 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Tonin expression in the rat brain and tonin-mediated central production of angiotensin II. Araujo RC, etal., Physiol Behav 2002 Jun 1;76(2):327-33.
2. Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin. Ashley PL and MacDonald RJ, Biochemistry 1985 Aug 13;24(17):4512-20.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Characterization of genes encoding rat tonin and a kallikrein-like serine protease. Shai SY, etal., Biochemistry 1989 Jun 27;28(13):5334-43.
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. Organization and expression of the rat kallikrein gene family. Wines DR, etal., J Biol Chem 1989 May 5;264(13):7653-62.
Additional References at PubMed
PMID:1315752   PMID:2302205   PMID:2821276   PMID:3038148   PMID:6320014   PMID:12543632   PMID:15203212   PMID:17366701   PMID:20180641   PMID:26216430  


Genomics

Variants

.
Variants in Klk1c2
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:78
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000025701
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
D1Mit30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2194,494,440 - 94,494,763 (+)MAPPERmRatBN7.2
mRatBN7.2194,494,579 - 94,494,763 (+)MAPPERmRatBN7.2
Rnor_6.0199,983,524 - 99,983,705NCBIRnor6.0
Rnor_6.0199,983,293 - 99,983,705NCBIRnor6.0
Rnor_5.01101,048,742 - 101,049,154UniSTSRnor5.0
Rnor_5.01101,048,973 - 101,049,154UniSTSRnor5.0
RGSC_v3.4194,473,941 - 94,474,122UniSTSRGSC3.4
RGSC_v3.4194,473,940 - 94,474,122RGDRGSC3.4
Celera188,761,687 - 88,761,868UniSTS
RGSC_v3.1194,552,051 - 94,552,233RGD
RH 3.4 Map1904.9UniSTS
RH 3.4 Map1904.9RGD
RH 2.0 Map1595.2RGD
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
3 2 8 18 12 1 8 1 1 43 15 1 4 24 27 11

Sequence


Ensembl Acc Id: ENSRNOT00000025701   ⟹   ENSRNOP00000025701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl199,981,045 - 99,985,422 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081095   ⟹   ENSRNOP00000070080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,628,854 - 103,631,248 (-)Ensembl
mRatBN7.2 Ensembl194,492,332 - 94,494,728 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107012   ⟹   ENSRNOP00000081904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,628,854 - 103,633,001 (-)Ensembl
mRatBN7.2 Ensembl194,492,332 - 94,496,481 (-)Ensembl
RefSeq Acc Id: NM_012677   ⟹   NP_036809
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,628,854 - 103,633,000 (-)NCBI
mRatBN7.2194,492,332 - 94,496,480 (-)NCBI
Rnor_6.0199,981,045 - 99,985,422 (-)NCBI
Rnor_5.01101,046,494 - 101,050,871 (-)NCBI
RGSC_v3.4194,471,693 - 94,475,839 (-)RGD
Celera188,759,439 - 88,763,585 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036809 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41466 (Get FASTA)   NCBI Sequence Viewer  
  AAA42081 (Get FASTA)   NCBI Sequence Viewer  
  AAA42259 (Get FASTA)   NCBI Sequence Viewer  
  EDM07523 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081904
  ENSRNOP00000081904.1
GenBank Protein P00759 (Get FASTA)   NCBI Sequence Viewer  
  SFW93257 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036809   ⟸   NM_012677
- Peptide Label: precursor
- UniProtKB: P00759 (UniProtKB/Swiss-Prot),   A0A1R3UCJ3 (UniProtKB/TrEMBL),   A0A0G2JX00 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025701   ⟸   ENSRNOT00000025701
Ensembl Acc Id: ENSRNOP00000081904   ⟸   ENSRNOT00000107012
Ensembl Acc Id: ENSRNOP00000070080   ⟸   ENSRNOT00000081095
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00759-F1-model_v2 AlphaFold P00759 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3888 AgrOrtholog
BioCyc Gene G2FUF-59808 BioCyc
Ensembl Genes ENSRNOG00000029237 Ensembl
  ENSRNOG00000068685 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000107012 ENTREZGENE
  ENSRNOT00000107012.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:24841 UniProtKB/Swiss-Prot
NCBI Gene 24841 ENTREZGENE
PANTHER KALLIKREIN-1 UniProtKB/Swiss-Prot
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Klk1c2 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029237 RatGTEx
  ENSRNOG00000068685 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
TIGR TC229150
UniProt A0A0G2JX00 ENTREZGENE, UniProtKB/TrEMBL
  A0A1R3UCJ3 ENTREZGENE, UniProtKB/TrEMBL
  KLK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-29 Klk1c2  kallikrein 1-related peptidase C2  Ton  tonin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ton  Tonin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the submandibular gland 634504
gene_process mediates central production of angiotensin II in brain 634504