Abcc9 (ATP binding cassette subfamily C member 9) - Rat Genome Database

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Gene: Abcc9 (ATP binding cassette subfamily C member 9) Rattus norvegicus
Analyze
Symbol: Abcc9
Name: ATP binding cassette subfamily C member 9
RGD ID: 3787
Description: Enables several functions, including identical protein binding activity; potassium channel activator activity; and sulfonylurea receptor activity. Involved in potassium ion import across plasma membrane; response to ATP; and response to xenobiotic stimulus. Located in T-tubule and acrosomal vesicle. Part of inward rectifying potassium channel. Biomarker of Parkinsonism; hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1O; familial atrial fibrillation; and hypertrichotic osteochondrodysplasia Cantu type. Orthologous to human ABCC9 (ATP binding cassette subfamily C member 9); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; ATP-binding cassette, sub-family C, member 9-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 9; LOC100360403; Sulfonylurea receptor 2; Sur2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Abcc9_v1   Abcc9_v2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,262,848 - 177,386,837 (-)NCBIGRCr8
mRatBN7.24175,531,854 - 175,655,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,532,547 - 175,655,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,826,663 - 181,950,019 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,610,938 - 177,734,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,231,509 - 176,354,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,806,098 - 176,928,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,805,431 - 176,922,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04241,019,980 - 241,139,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,165,979 - 180,236,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,877,146 - 33,883,992NCBI
Celera4164,064,977 - 164,186,502 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
adenosine 5'-monophosphate  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
ATP  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
cantharidin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
creatine  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dibenzofurans  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
folic acid  (ISO)
genistein  (EXP,ISO)
glyburide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
kojic acid  (ISO)
lipopolysaccharide  (ISO)
MeIQx  (ISO)
metformin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
niclosamide  (ISO)
nicorandil  (ISO)
O-methyleugenol  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
Pinacidil  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP,ISO)
resveratrol  (ISO)
riddelliine  (EXP)
rubidium atom  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium disulfite  (EXP)
sulfur dioxide  (EXP)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)
vinclozolin  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IEA,ISO)
ATP metabolic process  (IEA,ISO)
blood circulation  (ISO)
blood vessel development  (ISO)
blood vessel diameter maintenance  (ISO)
cardiac conduction  (IEA,ISO)
cardiac muscle cell contraction  (IEA,ISO)
cellular respiration  (IEA,ISO)
cellular response to ATP  (IEA,ISO)
cellular response to calcium ion  (IEA,ISO)
cellular response to chemical stress  (IEA,ISO)
cellular response to potassium ion  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
circulatory system development  (ISO)
coronary vasculature development  (IEA,ISO)
defense response to virus  (IEA,ISO)
fatty acid oxidation  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
gene expression  (IEA,ISO)
heart development  (ISO)
heart morphogenesis  (IEA,ISO)
inorganic cation transmembrane transport  (IGI)
MAPK cascade  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
monoatomic cation transmembrane transport  (IMP)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of blood pressure  (IEA,ISO)
oxygen metabolic process  (IEA,ISO)
potassium ion import across plasma membrane  (IDA)
potassium ion transmembrane transport  (IDA,IEA,ISO)
potassium ion transport  (IDA)
reactive oxygen species biosynthetic process  (IEA,ISO)
regulation of blood pressure  (ISO)
regulation of cation channel activity  (ISO)
regulation of membrane potential  (ISO)
regulation of potassium ion transmembrane transport  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  (ISO)
response to activity  (IEA,ISO)
response to ATP  (IGI,ISO)
response to decreased oxygen levels  (ISO)
response to estrogen  (IEA,ISO)
response to hydrogen peroxide  (IEA,ISO)
response to hydrogen sulfide  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to oxygen levels  (ISO)
response to peptide  (IEA,ISO)
response to potassium ion  (ISO)
response to stress  (ISO)
response to xenobiotic stimulus  (IEP,ISO)
skeletal muscle tissue development  (IEA,ISO)
substrate-dependent cell migration, cell contraction  (NAS)
transmembrane transport  (IBA)
vascular process in circulatory system  (ISO)
vasodilation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Bienengraeber M, etal., Nat Genet 2004 Apr;36(4):382-7. Epub 2004 Mar 21.
2. Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channels. Blanco-Rivero J, etal., Eur J Pharmacol. 2008 Jun 10;587(1-3):204-8. Epub 2008 Mar 30.
3. Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles. Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9.
4. Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats. Chen ZC, etal., Cardiovasc Diabetol. 2012 Jan 18;11:8. doi: 10.1186/1475-2840-11-8.
5. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. Cooper PE, etal., J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.
6. Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel. Cooper PE, etal., J Gen Physiol. 2015 Dec;146(6):527-40. doi: 10.1085/jgp.201511495.
7. Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts. Cuong DV, etal., Mitochondrion. 2005 Apr;5(2):121-33.
8. An amino acid triplet in the NH2 terminus of rat ROMK1 determines interaction with SUR2B. Dong K, etal., J Biol Chem 2001 Nov 23;276(47):44347-53.
9. Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure. Dorschner H, etal., Mol Pharmacol. 1999 Jun;55(6):1060-6.
10. Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles. Fotinou C, etal., FEBS J. 2013 Feb;280(4):1051-63. doi: 10.1111/febs.12097. Epub 2013 Jan 27.
11. Iptakalim, opener of K(ATP), reverses the enhanced expression of genes encoding K(ATP) subunits in spontaneously hypertensive rats. Gao M, etal., Life Sci. 2005 Oct 14;77(22):2743-51.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction. Horinaka S, etal., Cardiovasc Drugs Ther. 2004 Jan;18(1):13-22.
15. A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Inagaki N, etal., Neuron. 1996 May;16(5):1011-7.
16. Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A. Kang Y, etal., J Biol Chem. 2004 Nov 5;279(45):47125-31. Epub 2004 Aug 31.
17. Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge. Lodwick D, etal., Biochem J. 2014 Dec 15;464(3):343-54. doi: 10.1042/BJ20140273.
18. Detection of K(ATP) channels subunits in human term placental explants and evaluation of their implication in human placental lactogen (hPL) and human chorionic gonadotropin (hCG) release. Lybaert P, etal., Placenta. 2013 Jun;34(6):467-73. doi: 10.1016/j.placenta.2013.03.006. Epub 2013 Apr 13.
19. NMR and fluorescence studies of drug binding to the first nucleotide binding domain of SUR2A. López-Alonso JP, etal., Biochemistry. 2012 Nov 13;51(45):9211-22. doi: 10.1021/bi301019e. Epub 2012 Nov 1.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Morrissey A, etal., BMC Physiol. 2005 Jan 12;5(1):1.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels. Purves GI, etal., J Physiol. 2009 Jul 15;587(Pt 14):3639-50. doi: 10.1113/jphysiol.2009.173534.
26. Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Rainbow RD, etal., Biochem J. 2004 Apr 1;379(Pt 1):173-81.
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. ATP-sensitive potassium channels mediate dilatation of basilar artery in response to intracellular acidification in vivo. Santa N, etal., Stroke 2003 May;34(5):1276-80.
30. Putative subunits of the rat mesangial KATP: a type 2B sulfonylurea receptor and an inwardly rectifying K+ channel. Szamosfalvi B, etal., Kidney Int 2002 May;61(5):1739-49.
31. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease? Wang S, etal., Neuropharmacology. 2005 Jun;48(7):984-92.
32. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Wu XF, etal., Pain. 2011 Nov;152(11):2605-15. doi: 10.1016/j.pain.2011.08.003. Epub 2011 Sep 9.
33. Different localization of ATP sensitive K+ channel subunits in rat testis. Zhou M, etal., Anat Rec (Hoboken). 2011 Apr;294(4):729-37. doi: 10.1002/ar.21348. Epub 2011 Feb 15.
Additional References at PubMed
PMID:11927600   PMID:14724757   PMID:16085792   PMID:16672225   PMID:16820413   PMID:17294036   PMID:17395632   PMID:17438353   PMID:17510180   PMID:17596331   PMID:17656102   PMID:17855752  
PMID:17942071   PMID:18026101   PMID:18198173   PMID:18323694   PMID:19224154   PMID:19464385   PMID:20123112   PMID:20332621   PMID:20456845   PMID:20553499   PMID:20610380   PMID:20656890  
PMID:21479273   PMID:21527399   PMID:21714514   PMID:22144717   PMID:22960600   PMID:23085378   PMID:24035941   PMID:24439875   PMID:25073062   PMID:25599573   PMID:26181369   PMID:26198630  
PMID:27035370   PMID:29275331   PMID:30074836   PMID:34455535   PMID:36336713  


Genomics

Comparative Map Data
Abcc9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,262,848 - 177,386,837 (-)NCBIGRCr8
mRatBN7.24175,531,854 - 175,655,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,532,547 - 175,655,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,826,663 - 181,950,019 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,610,938 - 177,734,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,231,509 - 176,354,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,806,098 - 176,928,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,805,431 - 176,922,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04241,019,980 - 241,139,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,165,979 - 180,236,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,877,146 - 33,883,992NCBI
Celera4164,064,977 - 164,186,502 (-)NCBICelera
Cytogenetic Map4q44NCBI
ABCC9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,797,389 - 21,941,426 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,797,389 - 21,942,543 (-)EnsemblGRCh38hg38GRCh38
GRCh371221,950,323 - 22,094,360 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,841,590 - 21,980,895 (-)NCBINCBI36Build 36hg18NCBI36
Build 341221,849,374 - 21,980,875NCBI
Celera1227,105,336 - 27,244,581 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,723,876 - 21,863,675 (-)NCBIHuRef
CHM1_11221,915,604 - 22,054,751 (-)NCBICHM1_1
T2T-CHM13v2.01221,676,073 - 21,820,886 (-)NCBIT2T-CHM13v2.0
Abcc9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,533,592 - 142,648,472 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,533,588 - 142,648,041 (-)EnsemblGRCm39 Ensembl
GRCm386142,587,862 - 142,702,766 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,587,862 - 142,702,315 (-)EnsemblGRCm38mm10GRCm38
MGSCv376142,536,382 - 142,650,794 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366142,546,355 - 142,659,495 (-)NCBIMGSCv36mm8
Celera6145,649,701 - 145,764,495 (-)NCBICelera
Cytogenetic Map6G2NCBI
cM Map674.35NCBI
Abcc9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541317,382,564 - 17,510,132 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541317,385,966 - 17,510,220 (-)NCBIChiLan1.0ChiLan1.0
ABCC9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21074,851,373 - 75,004,445 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11274,856,027 - 75,000,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,357,176 - 64,500,358 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11266,960,888 - 67,102,496 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1266,960,888 - 67,102,496 (+)Ensemblpanpan1.1panPan2
ABCC9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12725,199,580 - 25,352,637 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2725,200,418 - 25,388,477 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2721,008,307 - 21,161,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02725,419,340 - 25,572,249 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,419,332 - 25,572,207 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12725,218,211 - 25,370,572 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02725,241,668 - 25,394,276 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02721,179,155 - 21,329,671 (-)NCBIUU_Cfam_GSD_1.0
Abcc9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,079,120 - 87,187,785 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365484,987,847 - 5,108,104 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365484,983,461 - 5,110,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl551,536,526 - 51,691,595 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1551,536,531 - 51,673,583 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2554,818,859 - 54,944,118 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,658,804 - 21,797,851 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,658,794 - 21,797,263 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606913,343,449 - 13,484,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475216,792,165 - 16,927,293 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475216,792,202 - 16,926,552 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcc9
872 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:94
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000055540, ENSRNOT00000067489
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat

Markers in Region
D4Got140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24176,734,862 - 176,735,053 (+)MAPPERmRatBN7.2
Rnor_6.04178,015,760 - 178,015,950NCBIRnor6.0
Rnor_5.04242,219,183 - 242,219,373UniSTSRnor5.0
RGSC_v3.44180,347,915 - 180,348,106RGDRGSC3.4
RGSC_v3.44180,347,916 - 180,348,106UniSTSRGSC3.4
RGSC_v3.14180,593,040 - 180,593,230RGD
Celera4165,262,255 - 165,262,445UniSTS
RH 3.4 Map41060.3RGD
RH 3.4 Map41060.3UniSTS
Cytogenetic Map4q44UniSTS
BE108803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24176,860,248 - 176,860,432 (+)MAPPERmRatBN7.2
Rnor_6.04178,141,125 - 178,141,308NCBIRnor6.0
Rnor_5.04242,344,099 - 242,344,282UniSTSRnor5.0
RGSC_v3.44180,472,699 - 180,472,882UniSTSRGSC3.4
Celera4165,387,487 - 165,387,670UniSTS
RH 3.4 Map41057.9UniSTS
Cytogenetic Map4q44UniSTS
RH134712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24176,786,011 - 176,786,169 (+)MAPPERmRatBN7.2
Rnor_6.04178,066,907 - 178,067,064NCBIRnor6.0
Rnor_5.04242,270,935 - 242,271,092UniSTSRnor5.0
RGSC_v3.44180,399,064 - 180,399,221UniSTSRGSC3.4
Celera4165,313,400 - 165,313,557UniSTS
RH 3.4 Map41057.9UniSTS
Cytogenetic Map4q44UniSTS
RH139436  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24176,781,873 - 176,782,078 (+)MAPPERmRatBN7.2
Rnor_6.04178,062,769 - 178,062,973NCBIRnor6.0
Rnor_5.04242,266,797 - 242,267,001UniSTSRnor5.0
RGSC_v3.44180,394,926 - 180,395,130UniSTSRGSC3.4
Celera4165,309,262 - 165,309,466UniSTS
RH 3.4 Map41057.1UniSTS
Cytogenetic Map4q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB045281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF019628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF087838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000055540   ⟹   ENSRNOP00000052402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4176,807,804 - 176,922,424 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067489   ⟹   ENSRNOP00000063326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4175,532,547 - 175,655,356 (-)Ensembl
Rnor_6.0 Ensembl4176,805,431 - 176,909,075 (-)Ensembl
RefSeq Acc Id: NM_013040   ⟹   NP_037172
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,262,848 - 177,386,348 (-)NCBI
mRatBN7.24175,531,854 - 175,655,356 (-)NCBI
Rnor_6.04176,806,098 - 176,928,540 (-)NCBI
Rnor_5.04241,019,980 - 241,139,051 (-)NCBI
Celera4164,064,977 - 164,186,502 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107117   ⟹   XP_038963045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,265,205 - 177,386,433 (-)NCBI
mRatBN7.24175,534,211 - 175,655,299 (-)NCBI
RefSeq Acc Id: XM_039107119   ⟹   XP_038963047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,262,848 - 177,386,837 (-)NCBI
mRatBN7.24175,534,046 - 175,655,849 (-)NCBI
RefSeq Acc Id: XM_039107120   ⟹   XP_038963048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,262,848 - 177,386,556 (-)NCBI
mRatBN7.24175,534,046 - 175,655,548 (-)NCBI
RefSeq Acc Id: XM_039107122   ⟹   XP_038963050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,262,848 - 177,386,434 (-)NCBI
mRatBN7.24175,534,212 - 175,655,452 (-)NCBI
RefSeq Acc Id: XM_039107123   ⟹   XP_038963051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,265,205 - 177,386,434 (-)NCBI
mRatBN7.24175,534,211 - 175,655,451 (-)NCBI
RefSeq Acc Id: XM_039107124   ⟹   XP_038963052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,262,848 - 177,386,433 (-)NCBI
mRatBN7.24175,534,212 - 175,655,451 (-)NCBI
RefSeq Acc Id: XM_063285616   ⟹   XP_063141686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,262,848 - 177,342,130 (-)NCBI
RefSeq Acc Id: XM_063285617   ⟹   XP_063141687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,265,205 - 177,386,435 (-)NCBI
RefSeq Acc Id: XM_063285618   ⟹   XP_063141688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,265,205 - 177,386,435 (-)NCBI
RefSeq Acc Id: NP_037172   ⟸   NM_013040
- UniProtKB: A6IMV7 (UniProtKB/TrEMBL),   Q9JJ67 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052402   ⟸   ENSRNOT00000055540
Ensembl Acc Id: ENSRNOP00000063326   ⟸   ENSRNOT00000067489
RefSeq Acc Id: XP_038963047   ⟸   XM_039107119
- Peptide Label: isoform X1
- UniProtKB: A6IMV7 (UniProtKB/TrEMBL),   Q9JJ67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963048   ⟸   XM_039107120
- Peptide Label: isoform X1
- UniProtKB: A6IMV7 (UniProtKB/TrEMBL),   Q9JJ67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963051   ⟸   XM_039107123
- Peptide Label: isoform X5
- UniProtKB: Q9JJ67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963045   ⟸   XM_039107117
- Peptide Label: isoform X2
- UniProtKB: Q63563 (UniProtKB/Swiss-Prot),   O89115 (UniProtKB/Swiss-Prot),   A6IMW1 (UniProtKB/TrEMBL),   Q9JJ67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963050   ⟸   XM_039107122
- Peptide Label: isoform X3
- UniProtKB: Q9JJ67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963052   ⟸   XM_039107124
- Peptide Label: isoform X4
- UniProtKB: Q9JJ67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141686   ⟸   XM_063285616
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063141688   ⟸   XM_063285618
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063141687   ⟸   XM_063285617
- Peptide Label: isoform X7
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63563-F1-model_v2 AlphaFold Q63563 1-1545 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3787 AgrOrtholog
BioCyc Gene G2FUF-42489 BioCyc
Ensembl Genes ENSRNOG00000036960 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067489.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABCC9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABCC9_ATP-bd_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulphorea_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25560 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25560 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24223:SF173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCC9 RGD
PhenoGen Abcc9 PhenoGen
PRINTS SULFNYLUR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SULFNYLUREAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036960 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IMV7 ENTREZGENE, UniProtKB/TrEMBL
  A6IMW1 ENTREZGENE, UniProtKB/TrEMBL
  ABCC9_RAT UniProtKB/Swiss-Prot
  D3ZZ00_RAT UniProtKB/TrEMBL
  O89115 ENTREZGENE
  Q63563 ENTREZGENE
  Q9JJ67 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O89115 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcc9  ATP binding cassette subfamily C member 9  Abcc9  ATP-binding cassette, subfamily C (CFTR/MRP), member 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Abcc9  ATP-binding cassette, subfamily C (CFTR/MRP), member 9  LOC100360403  ATP-binding cassette, sub-family C, member 9-like  Data merged from RGD:2322153 737654 PROVISIONAL
2010-11-16 Abcc9  ATP-binding cassette, subfamily C (CFTR/MRP), member 9  Abcc9  ATP-binding cassette, sub-family C (CFTR/MRP), member 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100360403  ATP-binding cassette, sub-family C, member 9-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-02-27 Abcc9  ATP-binding cassette, sub-family C (CFTR/MRP), member 9      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function can form cardiac and smooth muscle-type K(ATP) channels with Kir6.2. Kir6.2 forms the channel pore while Sur2 is required for activation and regulation 724707
gene_function subunit of ATP-sensitve potassium channels (KATP). 724707