Serpina3n (serine (or cysteine) peptidase inhibitor, clade A, member 3N) - Rat Genome Database

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Gene: Serpina3n (serine (or cysteine) peptidase inhibitor, clade A, member 3N) Rattus norvegicus
Analyze
Symbol: Serpina3n (Ensembl: Serpina3a)
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N (Ensembl:serine (or cysteine) peptidase inhibitor, clade A, member 3A)
RGD ID: 3747
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to organic cyclic compound; and response to vitamin B6. Located in extracellular space. Used to study adult respiratory distress syndrome. Biomarker of uveitis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: contrapsin-like protease inhibitor 6; CPi-26; MGC93363; serine protease inhibitor; serine protease inhibitor 2c; serine protease inhibitor 3; serine protease inhibitor A3N; serpin A3N; serpina3n-like protein; Spi-2.2; SPI-3; SPI3; Spin2c; Spin3
RGD Orthologs
Human
Mouse
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,088,392 - 129,095,950 (+)NCBIGRCr8
mRatBN7.26123,323,623 - 123,331,181 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,323,629 - 123,332,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,454,436 - 123,462,011 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,749,728 - 123,757,302 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,120,847 - 123,128,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06128,073,344 - 128,080,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,941,526 - 128,080,889 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06137,283,367 - 137,290,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,461,775 - 128,469,309 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,465,521 - 128,473,056 (+)NCBI
Celera6120,800,865 - 120,808,399 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chloroquine  (EXP)
chlorpromazine  (ISO)
citalopram  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
clothianidin  (ISO)
clozapine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
doxepin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
elemental selenium  (EXP)
ethanol  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
flecainide  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycidol  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
graphene oxide  (ISO)
GW 4064  (ISO)
haloperidol  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
imipramine  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
loratadine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
olanzapine  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentamidine  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (ISO)
phenacetin  (EXP)
phenylhydrazine  (EXP)
phosgene  (ISO)
phytoestrogen  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rofecoxib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
selenium atom  (EXP)
senecionine  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotalol  (ISO)
sotorasib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichlorfon  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vitamin E  (EXP)
zimeldine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (ISO)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells. Baumann H, etal., J Biol Chem. 1987 Jul 15;262(20):9756-68.
2. IL-1beta induces serine protease inhibitor 3 (SPI-3) gene expression in rat pancreatic beta-cells. Detection by differential display of messenger RNA. Chen MC, etal., Cytokine. 1999 Nov;11(11):856-62.
3. Protein abnormalities in adult respiratory distress syndrome, tuberculosis, and cystic fibrosis sera. Emmett M, etal., Proc Soc Exp Biol Med. 1987 Jan;184(1):74-82.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Alpha-1-antichymotrypsin expression in lung adenocarcinoma and its possible association with tumor progression. Higashiyama M, etal., Cancer. 1995 Oct 15;76(8):1368-76.
6. Accelerated evolution in the reactive centre regions of serine protease inhibitors. Hill RE and Hastie ND, Nature 1987 Mar 5-11;326(6108):96-9.
7. Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe alpha1-antitrypsin deficiency. Hollander C, etal., BMC Pulm Med. 2007 Jan 29;7:1.
8. Association between alpha-1-antichymotrypsin polymorphism and susceptibility to chronic obstructive pulmonary disease. Ishii T, etal., Eur J Clin Invest. 2000 Jun;30(6):543-8.
9. Activation of the rat serine proteinase inhibitor 3 gene by interferon gamma via the interleukin 6-responsive element. Kordula T and Travis J, Biochem J. 1995 Jul 1;309 ( Pt 1):63-7.
10. The role of Stat and C/EBP transcription factors in the synergistic activation of rat serine protease inhibitor-3 gene by interleukin-6 and dexamethasone. Kordula T and Travis J, Biochem J. 1996 Feb 1;313 ( Pt 3):1019-27.
11. Association of alpha(1)-antichymotrypsin deficiency with milder lung disease in patients with cystic fibrosis. Mahadeva R, etal., Thorax. 2001 Jan;56(1):53-8.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Cardioprotection by a novel recombinant serine protease inhibitor in myocardial ischemia and reperfusion injury. Murohara T, etal., J Pharmacol Exp Ther. 1995 Sep;274(3):1246-53.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Effect of cytokines, dexamethasone and the A/T-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease. Nilsson LN, etal., Neurochem Int. 2001 Nov-Dec;39(5-6):361-70.
16. Alpha-1-antichymotrypsin is an effective inhibitor of pancreatitis-induced lung injury. O'Donovan DA, etal., Eur J Gastroenterol Hepatol. 1995 Sep;7(9):847-52.
17. Molecular cloning and characterization of rat contrapsin-like protease inhibitor and related proteins. Ohkubo K, etal., J Biochem (Tokyo) 1991 Feb;109(2):243-50.
18. Molecular characterization of three rat liver serine-protease inhibitors affected by inflammation and hypophysectomy. Protein and mRNA analysis and cDNA cloning. Pages G, etal., Eur J Biochem 1990 Jun 20;190(2):385-91.
19. Primary structure and assignment to chromosome 6 of three related rat genes encoding liver serine protease inhibitors. Pages G, etal., Gene 1990 Oct 15;94(2):273-82.
20. A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease. Poller W, etal., Genomics. 1993 Sep;17(3):740-3.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. [Some acute phase proteins in children suffering from recurrent laryngeal papillomatosis]. Szydlowski J, etal., Otolaryngol Pol. 2005;59(4):505-9.
26. Expression of serine protease inhibitor 3 in ocular tissues in endotoxin-induced uveitis in rat. Takamiya A, etal., Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2427-33.
27. Inflammation induces serine protease inhibitor 3 expression in the rat pineal gland. Takamiya A, etal., Neuroscience. 2002;113(2):387-94.
28. Inflammation inhibitors were remarkably up-regulated in plasma of severe acute respiratory syndrome patients at progressive phase. Wan J, etal., Proteomics. 2006 May;6(9):2886-94.
29. Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-alpha-stimulated HT-29 cells. Yanaka N, etal., Mol Nutr Food Res. 2011 Apr;55(4):635-43. doi: 10.1002/mnfr.201000282. Epub 2011 Jan 5.
30. Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-alpha-stimulated HT-29 cells. Yanaka N, etal., Mol Nutr Food Res. 2011 Jan 5.
Additional References at PubMed
PMID:15489334   PMID:15638460   PMID:15795238   PMID:18078237   PMID:23007996   PMID:23012479   PMID:24006456   PMID:25915831  


Genomics

Comparative Map Data
Serpina3n
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,088,392 - 129,095,950 (+)NCBIGRCr8
mRatBN7.26123,323,623 - 123,331,181 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,323,629 - 123,332,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,454,436 - 123,462,011 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,749,728 - 123,757,302 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,120,847 - 123,128,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06128,073,344 - 128,080,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,941,526 - 128,080,889 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06137,283,367 - 137,290,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,461,775 - 128,469,309 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,465,521 - 128,473,056 (+)NCBI
Celera6120,800,865 - 120,808,399 (+)NCBICelera
Cytogenetic Map6q32NCBI
SERPINA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,612,391 - 94,624,053 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,612,384 - 94,624,055 (+)EnsemblGRCh38hg38GRCh38
GRCh371495,078,728 - 95,090,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361494,148,467 - 94,160,143 (+)NCBINCBI36Build 36hg18NCBI36
Build 341494,148,479 - 94,160,142NCBI
Celera1475,134,849 - 75,146,525 (+)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,259,097 - 75,270,773 (+)NCBIHuRef
CHM1_11495,016,470 - 95,028,146 (+)NCBICHM1_1
T2T-CHM13v2.01488,842,378 - 88,854,040 (+)NCBIT2T-CHM13v2.0
Serpina3n
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,372,967 - 104,380,588 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,372,988 - 104,380,588 (+)EnsemblGRCm39 Ensembl
GRCm3812104,406,646 - 104,414,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,406,729 - 104,414,329 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712105,644,918 - 105,652,539 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,807,805 - 104,815,375 (+)NCBIMGSCv36mm8
Celera12105,637,386 - 105,645,008 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1254.17NCBI
SERPINA3-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,976,397 - 115,987,453 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17115,978,453 - 115,987,392 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27123,110,551 - 123,119,612 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7qNCBI

Variants

.
Variants in Serpina3n
140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:156
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000014073
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat

Markers in Region
RH128585  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26123,330,917 - 123,331,101 (+)MAPPERmRatBN7.2
Rnor_6.06128,080,630 - 128,080,813NCBIRnor6.0
Rnor_5.06137,290,653 - 137,290,836UniSTSRnor5.0
RGSC_v3.46128,469,061 - 128,469,244UniSTSRGSC3.4
Celera6120,808,151 - 120,808,334UniSTS
RH 3.4 Map6822.9UniSTS
Cytogenetic Map6q32UniSTS
RH142440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26123,322,867 - 123,323,045 (+)MAPPERmRatBN7.2
Rnor_6.06128,072,580 - 128,072,757NCBIRnor6.0
Rnor_5.06137,282,603 - 137,282,780UniSTSRnor5.0
RGSC_v3.46128,461,011 - 128,461,188UniSTSRGSC3.4
Celera6120,800,101 - 120,800,278UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 12 12 12
Medium 15 13 13 4 1
Low 3 8 26 12 19 12 8 9 48 19 29 9 8
Below cutoff 35 4 4 4 2 26 16 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013961   ⟹   ENSRNOP00000013961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,300,439 - 123,312,529 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078064   ⟹   ENSRNOP00000070684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,300,371 - 123,312,529 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082680   ⟹   ENSRNOP00000074930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,300,538 - 123,312,486 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087017   ⟹   ENSRNOP00000070308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,298,437 - 123,305,803 (+)Ensembl
RefSeq Acc Id: NM_031531   ⟹   NP_113719
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,088,392 - 129,095,950 (+)NCBI
mRatBN7.26123,323,623 - 123,331,181 (+)NCBI
Rnor_6.06128,073,344 - 128,080,878 (+)NCBI
Rnor_5.06137,283,367 - 137,290,901 (+)NCBI
RGSC_v3.46128,461,775 - 128,469,309 (+)RGD
Celera6120,800,865 - 120,808,399 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_113719   ⟸   NM_031531
- Peptide Label: precursor
- UniProtKB: P09006 (UniProtKB/Swiss-Prot),   Q03312 (UniProtKB/Swiss-Prot),   A6JEQ8 (UniProtKB/TrEMBL),   A0A0H2UHI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070684   ⟸   ENSRNOT00000078064
RefSeq Acc Id: ENSRNOP00000013961   ⟸   ENSRNOT00000013961
RefSeq Acc Id: ENSRNOP00000070308   ⟸   ENSRNOT00000087017
RefSeq Acc Id: ENSRNOP00000074930   ⟸   ENSRNOT00000082680
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09006-F1-model_v2 AlphaFold P09006 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694808
Promoter ID:EPDNEW_R5331
Type:multiple initiation site
Name:LOC299282_1
Description:Serine protease inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5330  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06128,073,341 - 128,073,401EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3747 AgrOrtholog
BioCyc Gene G2FUF-36379 BioCyc
Ensembl Genes ENSRNOG00000010478 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000029949 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055031674 UniProtKB/Swiss-Prot
  ENSRNOG00060004529 UniProtKB/Swiss-Prot
  ENSRNOG00065014139 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013961.7 UniProtKB/TrEMBL
  ENSRNOT00000014073 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000014073.6 UniProtKB/Swiss-Prot
  ENSRNOT00000077517.2 UniProtKB/TrEMBL
  ENSRNOT00000078064.2 UniProtKB/TrEMBL
  ENSRNOT00000082680.2 UniProtKB/TrEMBL
  ENSRNOT00055054855 UniProtKB/Swiss-Prot
  ENSRNOT00060007613 UniProtKB/Swiss-Prot
  ENSRNOT00065023367 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129287 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24795 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93363 IMAGE-MGC_LOAD
NCBI Gene 24795 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR A3A-RELATED UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR A3N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpina3n PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010478 RatGTEx
  ENSRNOG00000029949 RatGTEx
  ENSRNOG00055031674 RatGTEx
  ENSRNOG00060004529 RatGTEx
  ENSRNOG00065014139 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYK0_RAT UniProtKB/TrEMBL
  A0A0G2K9B1_RAT UniProtKB/TrEMBL
  A0A0G2KB85_RAT UniProtKB/TrEMBL
  A0A0H2UHI5 ENTREZGENE, UniProtKB/TrEMBL
  A6JEQ8 ENTREZGENE, UniProtKB/TrEMBL
  F1LM05_RAT UniProtKB/TrEMBL
  P09006 ENTREZGENE
  Q03312 ENTREZGENE
  SPA3N_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q03312 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Serpina3n  serine (or cysteine) peptidase inhibitor, clade A, member 3N  Spin2c  Serine protease inhibitor  Symbol and Name updated 1299863 APPROVED
2002-06-10 Spin2c  Serine protease inhibitor      Symbol and Name status set to approved 70586 APPROVED