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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpina3nincreases expressionISOSerpina3n (Mus musculus)6480464CTDDoxorubicin results in increased expression of SERPINA3N mRNAPMID:21040762 PMID:28608983 PMID:36227756
Serpina3nmultiple interactionsISOSerpina3n (Mus musculus)6480464CTD[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of SERPINA3N mRNA; Folic Acid inhibits the reaction [Doxorubicin results in increased expression of SERPINA3N mRNA]PMID:21040762 PMID:28608983
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