Slc25a1 (solute carrier family 25 member 1)

Gene: Slc25a1 (solute carrier family 25 member 1) Rattus norvegicus

Analyze

Symbol:

Slc25a1

Name:

solute carrier family 25 member 1

RGD ID:

3703

Description:

Enables citrate secondary active transmembrane transporter activity. Involved in mitochondrial citrate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1); INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

Cic; citrate carrier; citrate transport protein; citrate transporter) member 1; citrate transporter, member 1; Ctp; MGC93247; mitochondrial tricarboxylate carrier; Slc20a3; solute carrier family 25 (mitochondrial carrier, citrate transporter) member 1; solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1; solute carrier family 25, member 1; tricarboxylate transport protein, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC25A1 (solute carrier family 25 member 1)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc25a1 (solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc25a1 (solute carrier family 25 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC25A1 (solute carrier family 25 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC25A1 (solute carrier family 25 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc25a1 (solute carrier family 25 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC25A1 (solute carrier family 25 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC25A1 (solute carrier family 25 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc25a1 (solute carrier family 25 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Slc25a1 (solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SLC25A1 (solute carrier family 25 member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc25a1b (slc25a1 solute carrier family 25 member 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-178e17.1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	CTP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	K11H3.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y37B11A.3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	sea	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YFR045W	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	slc25a1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	96,560,054 - 96,563,071 (+)	NCBI		GRCr8
mRatBN7.2	11	83,055,764 - 83,058,781 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,055,748 - 83,058,781 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	91,784,347 - 91,787,364 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	84,445,481 - 84,448,498 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	83,499,096 - 83,502,113 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	87,204,248 - 87,207,265 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	87,204,175 - 87,207,264 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	90,295,813 - 90,298,829 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,043,902 - 85,046,919 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	85,084,587 - 85,087,515 (+)	NCBI
Celera	11	81,831,785 - 81,834,802 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

2-hydroxyglutaric aciduria (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

chromosome 22q11.2 microduplication syndrome (ISO)

combined D-2- and L-2-hydroxyglutaric aciduria (ISO)

Congenital Myasthenic Syndrome 23 (ISO)

DiGeorge syndrome (ISO)

epilepsy (ISO)

genetic disease (ISO)

immunodeficiency 51 (ISO)

intellectual disability (ISO)

megacolon (ISO)

Neurodevelopmental Disorders (ISO)

Polyarteritis Nodosa, Childhood-Onset (ISO)

primary immunodeficiency disease (ISO)

schizophrenia (ISO)

velocardiofacial syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trimethylbenzene (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

afimoxifene (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (EXP,ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (EXP)

dexamethasone (EXP,ISO)

dibutyl phthalate (EXP,ISO)

doxorubicin (ISO)

elemental selenium (ISO)

fenthion (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

glucose (EXP)

heptachlor (EXP)

hydrogen cyanide (ISO)

hydrogen peroxide (EXP)

hypochlorous acid (ISO)

indometacin (ISO)

ivermectin (ISO)

ketamine (EXP)

ketoconazole (EXP)

L-methionine (ISO)

mercury dichloride (EXP)

methotrexate (ISO)

monosodium L-glutamate (ISO)

nefazodone (EXP)

obeticholic acid (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

potassium cyanide (ISO)

quercetin (ISO)

rotenone (EXP)

selenium atom (ISO)

selenomethionine (ISO)

streptozocin (EXP)

sulindac sulfide (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

trichostatin A (ISO)

Triptolide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

vitamin E (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial citrate transmembrane transport (IBA,IDA,IEA,ISO,TAS)

transmembrane transport (IEA)

Cellular Component

membrane (IEA)

mitochondrial inner membrane (ISS)

mitochondrion (IBA,IEA,ISO)

Molecular Function

antiporter activity (IEA)

citrate secondary active transmembrane transporter activity (IBA,IDA,IEA,ISO)

citrate transmembrane transporter activity (TAS)

tricarboxylic acid transmembrane transporter activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification and purification of the tricarboxylate carrier from rat liver mitochondria.	Bisaccia F, etal., Biochim Biophys Acta. 1989 Nov 23;977(2):171-6. doi: 10.1016/s0005-2728(89)80068-4.
2.	Normalization and subtraction: two approaches to facilitate gene discovery.	Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
3.	The N- and C-termini of the tricarboxylate carrier are exposed to the cytoplasmic side of the inner mitochondrial membrane.	Capobianco L, etal., FEBS Lett 1995 Jan 9;357(3):297-300.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.	Nota B, etal., Am J Hum Genet. 2013 Apr 4;92(4):627-31. doi: 10.1016/j.ajhg.2013.03.009.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	Mitochondrial carrier proteins.	Palmieri F FEBS Lett 1994 Jun 6;346(1):48-54.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Starvation-induced posttranscriptional control of rat liver mitochondrial citrate carrier expression.	Siculella L, etal., Biochem Biophys Res Commun 2002 Dec 6;299(3):418-23.
14.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	Biogenesis of rat mitochondrial citrate carrier (CIC): the N-terminal presequence facilitates the solubility of the preprotein but does not act as a targeting signal.	Zara V, etal., J Mol Biol 2003 Jan 10;325(2):399-408.

Additional References at PubMed

PMID:8132490	PMID:8514800	PMID:12865426	PMID:14651853	PMID:15060089	PMID:15589833	PMID:16129883	PMID:17001083	PMID:18614015	PMID:18775783	PMID:19056867	PMID:21630459
PMID:22249025	PMID:23376485	PMID:24625528	PMID:29031613

Genomics

Comparative Map Data

Slc25a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	96,560,054 - 96,563,071 (+)	NCBI		GRCr8
mRatBN7.2	11	83,055,764 - 83,058,781 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,055,748 - 83,058,781 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	91,784,347 - 91,787,364 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	84,445,481 - 84,448,498 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	83,499,096 - 83,502,113 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	87,204,248 - 87,207,265 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	87,204,175 - 87,207,264 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	90,295,813 - 90,298,829 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,043,902 - 85,046,919 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	85,084,587 - 85,087,515 (+)	NCBI
Celera	11	81,831,785 - 81,834,802 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

SLC25A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	19,175,581 - 19,178,736 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	19,175,581 - 19,178,739 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	19,163,094 - 19,166,249 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	17,543,095 - 17,546,285 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	17,537,648 - 17,540,839	NCBI
Celera	22	3,015,039 - 3,018,281 (-)	NCBI		Celera
Cytogenetic Map	22	q11.21	NCBI
HuRef	22	2,784,165 - 2,787,414 (-)	NCBI		HuRef
CHM1_1	22	19,162,601 - 19,165,887 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	19,551,495 - 19,554,686 (-)	NCBI		T2T-CHM13v2.0

Slc25a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	17,743,075 - 17,746,083 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	17,743,087 - 17,746,083 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	17,925,211 - 17,928,219 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	17,925,223 - 17,928,219 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	17,925,304 - 17,928,312 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	17,838,786 - 17,841,726 (-)	NCBI		MGSCv36	mm8
Celera	16	18,498,276 - 18,501,284 (-)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	11.11	NCBI

Slc25a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	18,804,319 - 18,808,900 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	18,804,319 - 18,807,353 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC25A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	28,797,278 - 28,800,600 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	31,344,710 - 31,348,304 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	1,931,623 - 1,934,850 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	17,609,157 - 17,612,463 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	17,609,157 - 17,612,463 (-)	Ensembl	panpan1.1		panPan2

SLC25A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	30,002,732 - 30,006,696 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	30,002,861 - 30,005,444 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	29,956,809 - 29,960,686 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	31,403,987 - 31,407,864 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	31,403,949 - 31,407,414 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	29,452,587 - 29,456,464 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	29,076,886 - 29,080,763 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	30,164,721 - 30,168,599 (+)	NCBI		UU_Cfam_GSD_1.0

Slc25a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	139,573,117 - 139,576,194 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	3,177,871 - 3,181,099 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	3,177,868 - 3,181,095 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC25A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	50,974,617 - 50,978,039 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	50,974,616 - 51,002,970 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	54,541,583 - 54,544,449 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC25A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	6,569,627 - 6,572,872 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666085	360,112 - 363,347 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc25a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624945	155,604 - 159,667 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624945	155,596 - 159,042 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc25a1
2 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	97
Count of miRNA genes:	77
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000000306
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
2302043	Pia27	Pristane induced arthritis QTL 27	18.6	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	11	82566545	83440803	Rat

Markers in Region

Es2el

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	83,056,519 - 83,057,529 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	87,205,004 - 87,206,013	NCBI	Rnor6.0
Rnor_5.0	11	90,296,568 - 90,297,577	UniSTS	Rnor5.0
RGSC_v3.4	11	85,044,658 - 85,045,667	UniSTS	RGSC3.4
Celera	11	81,832,541 - 81,833,550	UniSTS
Cytogenetic Map	11	q23	UniSTS

UniSTS:547032

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	26,235,298 - 26,236,350 (+)	MAPPER	mRatBN7.2
mRatBN7.2	11	83,057,242 - 83,058,752 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	26,663,524 - 26,664,575	NCBI	Rnor6.0
Rnor_6.0	11	87,205,727 - 87,207,236	NCBI	Rnor6.0
Rnor_5.0	11	90,297,291 - 90,298,800	UniSTS	Rnor5.0
Rnor_5.0	11	30,285,908 - 30,286,959	UniSTS	Rnor5.0
Celera	11	81,833,264 - 81,834,773	UniSTS
Celera	11	26,024,113 - 26,025,164	UniSTS
Cytogenetic Map	11	q23	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	20	55	41	10	41			73	35	41	11
Low		23	2		9		8	11	1				8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC100077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI277974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB758644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000000306 ⟹ ENSRNOP00000000306

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,055,748 - 83,058,781 (+)	Ensembl
Rnor_6.0 Ensembl	11	87,204,175 - 87,207,264 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109053 ⟹ ENSRNOP00000088250

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,055,826 - 83,058,781 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113816 ⟹ ENSRNOP00000091375

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,055,792 - 83,058,779 (+)	Ensembl

RefSeq Acc Id:

NM_017307 ⟹ NP_059003

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	96,560,054 - 96,563,071 (+)	NCBI
mRatBN7.2	11	83,055,764 - 83,058,781 (+)	NCBI
Rnor_6.0	11	87,204,248 - 87,207,265 (+)	NCBI
Rnor_5.0	11	90,295,813 - 90,298,829 (+)	NCBI
RGSC_v3.4	11	85,043,902 - 85,046,919 (+)	RGD
Celera	11	81,831,785 - 81,834,802 (+)	RGD

Sequence:

show sequence

CGGGACCAGAATTGGTCGCGGTCTCTGTAGCCTCCGGCCCCGTTGCTTTCCGAGTGCCCCGCGC
CGGAGGCTCGGACCCGAGGTCGACGCCGGGCGCCCCTCCTCCTGCCCGCCATGGCTGCGCCTCG
CGCACCCCGCGCTCTGACGGCTGCCGCTCCCGGGTCCGGGAAAGCCAAACTGACGCACCCCGGG
AAGGCGATCCTAGCAGGCGGCCTGGCTGGAGGCATCGAAATCTGCATCACCTTCCCGACCGAAT
ACGTGAAGACTCAACTACAGCTAGATGAACGCGCGAACCCACCGCGGTACCGGGGCATTGGGGA
CTGCGTGCGGCAAACTGTCCGCAGCCATGGCGTCCTGGGCCTGTACCGCGGCCTCAGCTCCTTG
CTCTACGGCTCCATCCCCAAGGCGGCTGTCAGGTTTGGGATGTTCGAGTTCCTCAGCAACCACA
TGCGGGATGCCCAAGGTAGACTGGACAGCAGGAGAGGACTGCTGTGCGGTCTGGGTGCCGGCGT
GGCAGAGGCAGTGGTAGTCGTGTGCCCCATGGAGACCGTGAAGGTGAAATTCATCCATGACCAG
ACTTCCTCCAATCCAAAGTACCGAGGATTTTTCCATGGGGTTAGAGAGATTGTTCGGGAACAAG
GGCTAAAGGGGACATACCAAGGCCTCACAGCTACTGTACTGAAGCAGGGCTCAAACCAAGCCAT
CCGATTCTTCGTCATGACCTCCCTACGCAACTGGTACCAAGGAGACAACCCCAACAAGCCTATG
AACCCACTGATCACCGGGGTCTTTGGAGCTGTCGCAGGTGCAGCCAGTGTCTTTGGGAACACAC
CCTTGGATGTGATCAAGACCAGGATGCAGGGCCTGGAGGCACACAAATACCGGAACACCCTGGA
CTGTGGAGTGCAGATCCTGAAGAATGAGGGGCCCAAGGCATTCTACAAGGGCACCGTTCCCCGG
CTGGGCCGAGTCTGCCTGGACGTGGCCATCGTATTCGTCATCTATGATGAAGTGGTGAAGCTGC
TCAATAAAGTGTGGAAGACGGACTAACCCTGGAGGGTGCAATGGGGCGTCCCAGCTCCTCCAGG
CCACCTACTCTTGACGATTCCAGTGCAGTAGTGCCAAAAGGCCCCTTCCTTTGTCCCTCAAGTT
CTGTGGCCTGGTGTGTCATAGTGACTGTCATGTGTTCCTTAGTACTGTACTCCCATGTGGTCTA
TGTGTAACACTACTATTGTATCTGTGTCCAGCCTGGCCGTGGCTGGGTGTCTCTTTGGCCTGTG
AAGACGTGCTCACTTACCCATGTGCTTGCTTGTGAGCCATGTGCCTGTTTCATGTTCTATGTCA
TGTGACCCTGTGCCCCACTTCCTGGGGTGCCTATGTGCCCTGGTCCATGGCCTTGGAGCCATGG
TCAGGTCACAGTCCGGTGCCTTCCACCCCCTATGGCAAGGGCGCCCTGCCCTGGCCTACCACAG
CTGCCTCTGGGCTTCGGCCTGGCTTCACCGCATTCCAGGGGCTATAGGCCCCCCTGCTTCTCCC
GCCATTGGCCTTAAATGGCCCTCGGGCCCTCCCTCTGCCCGGAACAGGGTGGCACCAGCCACTC
TCAGGACCACCTTGCCAAGGAGAATAAACCGGATCCTGTTGCAAAAAAAAAAAAAAAAAAAAAA
AAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_059003	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00078	(Get FASTA)	NCBI Sequence Viewer
	EDL77913	(Get FASTA)	NCBI Sequence Viewer
	EDL77914	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000306
	ENSRNOP00000000306.5
	ENSRNOP00000088250.1
	ENSRNOP00000091375.1
	ENSRNOP00055004374
	ENSRNOP00060017276
	ENSRNOP00065008831
GenBank Protein	P32089	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_059003 ⟸ NM_017307
- Peptide Label:	precursor
- UniProtKB:	Q498T8 (UniProtKB/Swiss-Prot), P32089 (UniProtKB/Swiss-Prot), A6JSJ3 (UniProtKB/TrEMBL), A0A8I6AEC6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAPRAPRALTAAAPGSGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERANPPRY RGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSRRGLLCG LGAGVAEAVVVVCPMETVKVKFIHDQTSSNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQG SNQAIRFFVMTSLRNWYQGDNPNKPMNPLITGVFGAVAGAASVFGNTPLDVIKTRMQGLEAHKY RNTLDCGVQILKNEGPKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKTD hide sequence

RefSeq Acc Id:

ENSRNOP00000000306 ⟸ ENSRNOT00000000306

RefSeq Acc Id:

ENSRNOP00000088250 ⟸ ENSRNOT00000109053

RefSeq Acc Id:

ENSRNOP00000091375 ⟸ ENSRNOT00000113816

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P32089-F1-model_v2	AlphaFold	P32089	1-311	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698312

Promoter ID:

EPDNEW_R8837

Type:

initiation region

Name:

Slc25a1_1

Description:

solute carrier family 25 member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	87,204,255 - 87,204,315	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3703	AgrOrtholog
BioCyc Gene	G2FUF-20622	BioCyc
Ensembl Genes	ENSRNOG00000038001	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055003706	UniProtKB/Swiss-Prot
	ENSRNOG00060012833	UniProtKB/Swiss-Prot
	ENSRNOG00065007735	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000000306	ENTREZGENE
	ENSRNOT00000000306.6	UniProtKB/TrEMBL
	ENSRNOT00000109053.1	UniProtKB/TrEMBL
	ENSRNOT00000113816.1	UniProtKB/TrEMBL
	ENSRNOT00055005826	UniProtKB/Swiss-Prot
	ENSRNOT00060021831	UniProtKB/Swiss-Prot
	ENSRNOT00065012100	UniProtKB/Swiss-Prot
Gene3D-CATH	1.50.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7126394	IMAGE-MGC_LOAD
InterPro	Mit_carrier	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mitochondrial_sb/sol_carrier	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mt_carrier_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TXTP-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29743	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:112694	IMAGE-MGC_LOAD
NCBI Gene	29743	ENTREZGENE
PANTHER	SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Mito_carr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc25a1	PhenoGen
PRINTS	MITOCARRIER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	SOLCAR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000038001	RatGTEx
	ENSRNOG00055003706	RatGTEx
	ENSRNOG00060012833	RatGTEx
	ENSRNOG00065007735	RatGTEx
Superfamily-SCOP	SSF103506	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A7P5_RAT	UniProtKB/TrEMBL
	A0A8I6AEC6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2PY12_RAT	UniProtKB/TrEMBL
	A6JSJ3	ENTREZGENE, UniProtKB/TrEMBL
	A6JSJ4_RAT	UniProtKB/TrEMBL
	P32089	ENTREZGENE
	Q498T8	ENTREZGENE
	TXTP_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q498T8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc25a1	solute carrier family 25 member 1	Slc25a1	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-15	Slc25a1	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	Slc25a1	solute carrier family 25, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Slc25a1	solute carrier family 25, member 1			Name updated	70584	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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