Shbg (sex hormone binding globulin) - Rat Genome Database

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Gene: Shbg (sex hormone binding globulin) Rattus norvegicus
Analyze
Symbol: Shbg
Name: sex hormone binding globulin
RGD ID: 3671
Description: Predicted to enable steroid binding activity. Involved in primary spermatocyte growth. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in endometrial cancer and type 2 diabetes mellitus. Orthologous to human SHBG (sex hormone binding globulin); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ABP; Abpa; androgen binding protein; SBP; Sex hormone binding globulin or androgen-binding protein; Sex hormone binding globulin or androgen-binding protein (other gene product from ABP gene); sex hormone-binding globulin; sex steroid-binding protein; testis-specific androgen-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   WKY.SHRSP-(Shbg-Atp1b2)/Bbb  
QTLs:   Bp106  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,831,716 - 54,849,162 (-)NCBIGRCr8
mRatBN7.21054,332,939 - 54,350,409 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,332,941 - 54,351,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,995,368 - 58,998,537 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,483,914 - 58,487,083 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,991,608 - 53,994,780 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,219,861 - 56,237,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,219,858 - 56,223,245 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,965,499 - 55,983,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,432,474 - 56,435,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,446,096 - 56,449,277 (-)NCBI
Celera1053,487,385 - 53,490,565 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (EXP)
2,4-Dihydroxybenzophenone  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-sec-butylphenol  (ISO)
3'-hydroxyflavanone  (ISO)
3-Deoxyestrone  (ISO)
4'-hydroxychalcone  (ISO)
4'-hydroxyflavanone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxychalcone  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7-hydroxyflavanone  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alcohol  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (EXP)
apigenin  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
Aurin  (ISO)
benzo[a]pyrene  (ISO)
Benzyl parahydroxybenzoate  (ISO)
beta-Zearalanol  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
carbamazepine  (ISO)
cerulenin  (ISO)
chalcone  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
clomiphene  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
delta-hexachlorocyclohexane  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
dienestrol  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
Dimethylstilbestrol  (ISO)
Droloxifene  (ISO)
drospirenone  (ISO)
elcometrine  (ISO)
equol  (ISO)
estra-1,3,5(10)-trien-3-ol  (ISO)
estriol  (ISO)
estrone  (ISO)
ethylparaben  (ISO)
fenvalerate  (ISO)
flavanone  (ISO)
fructose  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (ISO)
gestodene  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hesperetin  (ISO)
letrozole  (EXP)
levonorgestrel  (ISO)
Licochalcone B  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
masoprocol  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP)
methylparaben  (ISO)
Mitotane  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
Moxestrol  (ISO)
Nonylphenol  (EXP,ISO)
Norethynodrel  (ISO)
norgestimate  (ISO)
olanzapine  (ISO)
oxandrolone  (ISO)
oxcarbazepine  (ISO)
palmitoyl-CoA  (ISO)
paracetamol  (EXP)
pentachlorophenol  (EXP,ISO)
perfluorononanoic acid  (EXP)
phenolphthalein  (ISO)
phloretin  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
quercetin  (EXP,ISO)
quinoxyfen  (ISO)
raloxifene  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
spironolactone  (EXP)
stilbene-4,4'-diol  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetramethrin  (ISO)
thioacetamide  (EXP)
toremifene  (ISO)
trans-chalcone  (ISO)
trans-stilbene-4,4'-diol  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
Triphenylethylene  (ISO)
triptonide  (ISO)
wortmannin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
protein binding  (IPI,ISO)
steroid binding  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study. Chubb SA, etal., Eur J Endocrinol. 2008 Jun;158(6):785-92.
2. Sex hormone-binding globulin and testosterone in individuals with childhood diabetes. Danielson KK, etal., Diabetes Care. 2008 Jun;31(6):1207-13. Epub 2008 Mar 17.
3. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
4. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. Ding EL, etal., N Engl J Med. 2009 Sep 17;361(12):1152-63. Epub 2009 Aug 5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Co-expression of vasopressin and androgen-binding protein in the rat hypothalamus. Jirikowski GF, etal., J Chem Neuroanat. 2005 Jun;29(4):233-7. Epub 2005 Mar 17.
8. The gene structure of rat androgen-binding protein: identification of potential regulatory deoxyribonucleic acid elements of a follicle-stimulating hormone-regulated protein. Joseph DR, etal., Mol Endocrinol 1988 Jan;2(1):3-13.
9. Rat androgen-binding protein: evidence for identical subunits and amino acid sequence homology with human sex hormone-binding globulin. Joseph DR, etal., Proc Natl Acad Sci U S A 1987 Jan;84(2):339-43.
10. Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene. Kataoka N, etal., Cancer. 2007 Apr 1;109(7):1296-302.
11. Molecular analysis of the sex hormone-binding globulin gene in the rat hypodactylous mutation (Hd). Liska F, etal., Folia Biol (Praha). 2004;50(2):63-8.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Mori H, etal., Biochem Biophys Res Commun. 2007 Aug 10;359(4):952-8. Epub 2007 Jun 4.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Serum sex hormone-binding globulin, a determinant of cardiometabolic disorders independent of abdominal obesity and insulin resistance in elderly men and women. Onat A, etal., Metabolism. 2007 Oct;56(10):1356-62.
16. Hormonal regulation of rat androgen-binding protein (ABP) messenger ribonucleic acid and homology of human testosterone-estradiol-binding globulin and ABP complementary deoxyribonucleic acids. Reventos J, etal., Mol Endocrinol 1988 Feb;2(2):125-32.
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Estrogen receptor beta expression and apoptosis of spermatocytes of mice overexpressing a rat androgen-binding protein transgene. Selva DM, etal., Biol Reprod. 2004 Nov;71(5):1461-8. Epub 2004 Jun 23.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1701136   PMID:1702422   PMID:1855466   PMID:12477932   PMID:12573823   PMID:12831397   PMID:14625054   PMID:15112319   PMID:21033444   PMID:21079794   PMID:21734262   PMID:23376485  
PMID:23533145   PMID:24681170   PMID:37392803  


Genomics

Comparative Map Data
Shbg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,831,716 - 54,849,162 (-)NCBIGRCr8
mRatBN7.21054,332,939 - 54,350,409 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,332,941 - 54,351,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,995,368 - 58,998,537 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,483,914 - 58,487,083 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,991,608 - 53,994,780 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,219,861 - 56,237,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,219,858 - 56,223,245 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,965,499 - 55,983,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,432,474 - 56,435,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,446,096 - 56,449,277 (-)NCBI
Celera1053,487,385 - 53,490,565 (-)NCBICelera
Cytogenetic Map10q24NCBI
SHBG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,614,064 - 7,633,372 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,613,946 - 7,633,382 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,517,382 - 7,536,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,474,216 - 7,477,395 (+)NCBINCBI36Build 36hg18NCBI36
Build 34177,474,215 - 7,477,395NCBI
Celera177,543,810 - 7,563,117 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,411,426 - 7,430,707 (+)NCBIHuRef
CHM1_1177,526,291 - 7,545,881 (+)NCBICHM1_1
T2T-CHM13v2.0177,518,285 - 7,537,563 (+)NCBIT2T-CHM13v2.0
Shbg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,501,108 - 69,508,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,505,630 - 69,508,731 (-)EnsemblGRCm39 Ensembl
GRCm381169,610,282 - 69,618,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,614,804 - 69,617,905 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,428,318 - 69,431,407 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,198,988 - 70,201,975 (-)NCBIMGSCv36mm8
MGSCv361169,431,011 - 69,434,063 (-)NCBIMGSCv36mm8
Cytogenetic Map11B3NCBI
cM Map1142.86NCBI
Shbg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554679,301,173 - 9,305,010 (-)NCBIChiLan1.0ChiLan1.0
SHBG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,221,821 - 15,235,544 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,187,912 - 17,193,499 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,658,831 - 7,664,631 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,645,188 - 7,650,552 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,645,187 - 7,650,552 (+)Ensemblpanpan1.1panPan2
SHBG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,535,738 - 32,540,627 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,537,138 - 32,540,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,674,555 - 32,679,801 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,640,395 - 32,645,639 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,642,122 - 32,645,637 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,608,086 - 32,613,336 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,564,351 - 32,569,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,743,466 - 32,748,710 (+)NCBIUU_Cfam_GSD_1.0
Shbg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,419,255 - 47,423,061 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595894,040 - 897,733 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595894,048 - 897,249 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHBG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11252,914,711 - 52,919,092 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,255,233 - 55,259,078 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SHBG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,002,380 - 7,012,170 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,008,682 - 7,012,764 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,395,808 - 14,399,825 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shbg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478610,234,484 - 10,239,034 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Shbg
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:90
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000015248, ENSRNOT00000048350
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
631652Bp106Blood pressure QTL 106arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105432493354332939Rat

Markers in Region
D10Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,333,375 - 54,333,470 (+)MAPPERmRatBN7.2
Rnor_6.01056,220,298 - 56,220,392NCBIRnor6.0
Rnor_5.01055,965,936 - 55,966,030UniSTSRnor5.0
RGSC_v3.41056,432,906 - 56,433,000UniSTSRGSC3.4
Celera1053,487,817 - 53,487,911UniSTS
Cytogenetic Map10q24UniSTS
D10Arb8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,333,376 - 54,333,620 (+)MAPPERmRatBN7.2
Rnor_6.01056,220,299 - 56,220,542NCBIRnor6.0
Rnor_5.01055,965,937 - 55,966,180UniSTSRnor5.0
RGSC_v3.41056,432,906 - 56,433,150RGDRGSC3.4
RGSC_v3.41056,432,907 - 56,433,150UniSTSRGSC3.4
RGSC_v3.11056,446,529 - 56,446,773RGD
Celera1053,487,818 - 53,488,061UniSTS
SHRSP x BN Map1046.5699UniSTS
SHRSP x BN Map1046.5699RGD
Cytogenetic Map10q24UniSTS
UniSTS:498767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,335,520 - 54,335,782 (+)MAPPERmRatBN7.2
Rnor_6.01056,222,443 - 56,222,704NCBIRnor6.0
Rnor_5.01055,968,081 - 55,968,342UniSTSRnor5.0
RGSC_v3.41056,435,051 - 56,435,312UniSTSRGSC3.4
Celera1053,489,962 - 53,490,223UniSTS
Cytogenetic Map10q24UniSTS


Related Rat Strains
The following Strains have been annotated to Shbg


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4 1 17
Low 3 42 47 31 18 31 8 11 71 35 24 11 8
Below cutoff 1 6 6 1 6 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M62613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000015248   ⟹   ENSRNOP00000015248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,332,941 - 54,336,324 (-)Ensembl
Rnor_6.0 Ensembl1056,219,858 - 56,223,245 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095236   ⟹   ENSRNOP00000095897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,332,941 - 54,351,057 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102053   ⟹   ENSRNOP00000076817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,332,941 - 54,350,991 (-)Ensembl
RefSeq Acc Id: NM_012650   ⟹   NP_036782
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,831,721 - 54,834,901 (-)NCBI
mRatBN7.21054,332,944 - 54,336,125 (-)NCBI
Rnor_6.01056,219,866 - 56,223,046 (-)NCBI
Rnor_5.01055,965,499 - 55,983,036 (-)NCBI
RGSC_v3.41056,432,474 - 56,435,654 (-)RGD
Celera1053,487,385 - 53,490,565 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246586   ⟹   XP_006246648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,831,716 - 54,837,227 (-)NCBI
mRatBN7.21054,332,939 - 54,337,708 (-)NCBI
Rnor_6.01056,219,861 - 56,223,890 (-)NCBI
Rnor_5.01055,965,499 - 55,983,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246592   ⟹   XP_006246654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,831,716 - 54,849,162 (-)NCBI
mRatBN7.21054,332,939 - 54,350,409 (-)NCBI
Rnor_6.01056,219,861 - 56,237,354 (-)NCBI
Rnor_5.01055,965,499 - 55,983,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767771   ⟹   XP_008765993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,831,716 - 54,849,150 (-)NCBI
mRatBN7.21054,332,939 - 54,350,376 (-)NCBI
Rnor_6.01056,219,861 - 56,237,241 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597013   ⟹   XP_017452502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,831,716 - 54,849,148 (-)NCBI
mRatBN7.21054,332,939 - 54,350,374 (-)NCBI
Rnor_6.01056,219,861 - 56,237,292 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085221   ⟹   XP_038941149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,831,716 - 54,847,950 (-)NCBI
mRatBN7.21054,332,939 - 54,347,339 (-)NCBI
RefSeq Acc Id: XM_039085222   ⟹   XP_038941150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,831,716 - 54,849,148 (-)NCBI
mRatBN7.21054,332,939 - 54,350,374 (-)NCBI
RefSeq Acc Id: XM_039085224   ⟹   XP_038941152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,831,716 - 54,834,116 (-)NCBI
mRatBN7.21054,332,939 - 54,350,281 (-)NCBI
RefSeq Acc Id: XM_063268425   ⟹   XP_063124495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,831,716 - 54,839,520 (-)NCBI
RefSeq Acc Id: NP_036782   ⟸   NM_012650
- Peptide Label: precursor
- UniProtKB: Q4QR94 (UniProtKB/Swiss-Prot),   P08689 (UniProtKB/Swiss-Prot),   A6HFS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246654   ⟸   XM_006246592
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AMK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246648   ⟸   XM_006246586
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765993   ⟸   XM_008767771
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y0E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452502   ⟸   XM_017597013
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y0E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015248   ⟸   ENSRNOT00000015248
RefSeq Acc Id: XP_038941150   ⟸   XM_039085222
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038941152   ⟸   XM_039085224
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038941149   ⟸   XM_039085221
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000095897   ⟸   ENSRNOT00000095236
RefSeq Acc Id: ENSRNOP00000076817   ⟸   ENSRNOT00000102053
RefSeq Acc Id: XP_063124495   ⟸   XM_063268425
- Peptide Label: isoform X2
Protein Domains
Laminin G   Laminin G-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08689-F1-model_v2 AlphaFold P08689 1-403 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3671 AgrOrtholog
BioCyc Gene G2FUF-24538 BioCyc
Ensembl Genes ENSRNOG00000011357 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015248.5 UniProtKB/TrEMBL
  ENSRNOT00000095236.1 UniProtKB/TrEMBL
  ENSRNOT00000102053 ENTREZGENE
  ENSRNOT00000102053.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7453185 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24775 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114346 IMAGE-MGC_LOAD
NCBI Gene 24775 ENTREZGENE
PANTHER LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEX HORMONE-BINDING GLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Laminin_G_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Shbg PhenoGen
PROSITE LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011357 RatGTEx
SMART LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC231308
UniProt A0A0H2UHJ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y0E6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMK2 ENTREZGENE, UniProtKB/TrEMBL
  A6HFS0 ENTREZGENE, UniProtKB/TrEMBL
  P08689 ENTREZGENE
  Q4QR94 ENTREZGENE
  SHBG_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4QR94 UniProtKB/Swiss-Prot
  Q63029 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Shbg  sex hormone binding globulin      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Shbg  sex hormone binding globulin      Name updated 70585 PROVISIONAL