Sele (selectin E) - Rat Genome Database

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Gene: Sele (selectin E) Rattus norvegicus
Analyze
Symbol: Sele
Name: selectin E
RGD ID: 3654
Description: Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in leukocyte migration and response to cytokine. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E); PARTICIPATES IN eicosanoid signaling pathway; malaria pathway; sleeping sickness pathway; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD62 antigen-like family member E; E-selectin; ELAM-1; endothelial leukocyte adhesion molecule 1; LECAM2; leukocyte-endothelial cell adhesion molecule 2; selectin, endothelial cell
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp329
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81378,935,997 - 78,945,905 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1378,936,036 - 78,945,903 (+)EnsemblGRCr8
mRatBN7.21376,402,841 - 76,412,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,403,304 - 76,412,741 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1379,021,472 - 79,031,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,325,949 - 80,335,341 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,580,536 - 77,589,930 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,355,234 - 82,365,323 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,355,471 - 82,365,341 (+)Ensemblrn6Rnor6.0
Rnor_5.01387,234,842 - 87,244,746 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41379,813,455 - 79,822,845 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1376,136,932 - 76,146,318 (+)NCBICelera
RGSC_v3.11379,827,642 - 79,837,033 (+)NCBI
Cytogenetic Map13q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-linalyl acetate  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
1,10-phenanthroline  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-phenanthrol  (ISO)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
asbestos  (ISO)
aspalathin  (ISO)
atorvastatin calcium  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
biotin  (ISO)
bisphenol A  (EXP,ISO)
budesonide  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
chrysin  (ISO)
clobazam  (ISO)
clopidogrel  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cordycepin  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP)
D-glucose  (ISO)
D-mannitol  (ISO)
dabrafenib  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
desflurane  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
enalapril  (ISO)
Enterolactone  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
farnesyl diphosphate  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fluticasone  (ISO)
furan  (EXP)
galangin  (ISO)
gallic acid  (ISO)
gastrin-17  (ISO)
gentamycin  (EXP)
geranylgeraniol  (ISO)
ginkgolide B  (ISO)
ginsenoside C-K  (ISO)
glucose  (ISO)
glutathione  (ISO)
griseofulvin  (ISO)
GW 3965  (ISO)
GW 501516  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (ISO)
ibuprofen  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
ketorolac  (EXP)
ketotifen  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lycopene  (ISO)
malvidin 3-O-beta-D-glucoside  (ISO)
mangiferin  (ISO)
methotrexate  (ISO)
Methylthiouracil  (ISO)
mevalonic acid  (ISO)
mevastatin  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
MitoTEMPO  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
naproxen  (EXP)
nebivolol  (ISO)
neocuproine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
notoginsenoside R1  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oleuropein  (ISO)
oxytocin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parthenolide  (ISO)
perfluorooctanoic acid  (EXP)
phenanthrene  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
polymyxin B2  (ISO)
polyphosphates  (ISO)
PR-39  (ISO)
probucol  (ISO)
progesterone  (ISO)
pyrene  (ISO)
quercetin  (ISO)
Quinupristin-dalfopristin  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rolipram  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
steviol  (ISO)
stevioside  (ISO)
sulfasalazine  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (EXP)
tebuconazole  (ISO)
tepoxalin  (ISO)
testosterone  (EXP)
thenoyltrifluoroacetone  (ISO)
tibolone  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valsartan  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vitamin E  (ISO)
wedelolactone  (ISO)
xanthohumol  (ISO)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. Abu-Amero KK, etal., BMC Med Genet. 2007 Jun 20;8:35.
2. Imaging E-selectin expression following traumatic brain injury in the rat using a targeted USPIO contrast agent. Chapon C, etal., MAGMA. 2009 Jun;22(3):167-74. Epub 2008 Dec 24.
3. [Inhibiting effects of interleuin-10 on expression of E-selectin and L-selectin in cerebral ischemia-reperfusion: experiment with rats] Du HW, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 6;89(1):59-62.
4. Expression of VCAM-1 and E-selectin in an in vivo model of endothelial activation. Fries JW, etal., Am J Pathol 1993 Sep;143(3):725-37.
5. P- and E-selectin blockade can control bacterial translocation and modulate systemic inflammatory response. Garcia-Criado FJ, etal., J Invest Surg. 2005 Jul-Aug;18(4):167-76.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Prediction of residual valvular lesions in rheumatic heart disease: role of adhesion molecules. Hafez M, etal., Pediatr Cardiol. 2013 Mar;34(3):583-90. doi: 10.1007/s00246-012-0501-7. Epub 2012 Sep 18.
9. A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia. Hattori H, etal., Brain Res. 2006 Sep 7;1108(1):221-3. Epub 2006 Jul 14.
10. Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. Hirashiki A, etal., J Am Coll Cardiol. 2003 Oct 15;42(8):1429-37.
11. Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats. Ishibashi S, etal., J Cereb Blood Flow Metab. 2009 Mar;29(3):606-20. Epub 2008 Dec 24.
12. Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China. Li Y, etal., Int J Cardiol. 2005 Aug 3;103(1):33-6. Epub 2004 Dec 16.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. Nowak M, etal., Clin Exp Med. 2008 Sep;8(3):159-64. Epub 2008 Sep 13.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. Accelerated development of arthritis in mice lacking endothelial selectins. Ruth JH, etal., Arthritis Res Ther. 2005;7(5):R959-70. Epub 2005 Jun 15.
24. Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients. Smadja DM, etal., Angiogenesis. 2020 May 27. pii: 10.1007/s10456-020-09730-0. doi: 10.1007/s10456-020-09730-0.
25. Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy. Takei T, etal., Am J Hum Genet. 2002 Mar;70(3):781-6. Epub 2002 Feb 1.
26. Intratracheal administration of endotoxin and cytokines: VIII. LPS induces E-selectin expression; anti-E-selectin and soluble E-selectin inhibit acute inflammation. Ulich TR, etal., Inflammation. 1994 Aug;18(4):389-98.
27. Demonstration of increased endothelial-leukocyte adhesion molecule-1 mRNA expression in rat ischemic cortex. Wang X, etal., Stroke. 1995 Sep;26(9):1665-8; discussion 1668-9.
28. Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacing. Yamazaki KG, etal., Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1387-93. doi: 10.1152/ajpheart.00496.2011. Epub 2012 Jan 20.
Additional References at PubMed
PMID:7680663   PMID:8609175   PMID:9290466   PMID:9312078   PMID:10894166   PMID:12960351   PMID:17114491   PMID:18029551   PMID:20735828   PMID:21194567   PMID:22664869   PMID:24289084  
PMID:24966906   PMID:25182537   PMID:27033411   PMID:28011641  


Genomics

Comparative Map Data
Sele
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81378,935,997 - 78,945,905 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1378,936,036 - 78,945,903 (+)EnsemblGRCr8
mRatBN7.21376,402,841 - 76,412,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,403,304 - 76,412,741 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1379,021,472 - 79,031,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,325,949 - 80,335,341 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,580,536 - 77,589,930 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,355,234 - 82,365,323 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,355,471 - 82,365,341 (+)Ensemblrn6Rnor6.0
Rnor_5.01387,234,842 - 87,244,746 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41379,813,455 - 79,822,845 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1376,136,932 - 76,146,318 (+)NCBICelera
RGSC_v3.11379,827,642 - 79,837,033 (+)NCBI
Cytogenetic Map13q23NCBI
SELE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,722,640 - 169,734,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,722,640 - 169,764,705 (-)Ensemblhg38GRCh38
GRCh371169,691,781 - 169,703,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,958,406 - 167,969,803 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341166,423,439 - 166,434,837NCBI
Celera1142,801,587 - 142,813,012 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,914,126 - 140,925,551 (-)NCBIHuRef
CHM1_11171,113,936 - 171,125,374 (-)NCBICHM1_1
T2T-CHM13v2.01169,078,428 - 169,089,853 (-)NCBIT2T-CHM13v2.0
Sele
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,867,200 - 163,886,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1163,875,773 - 163,885,246 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381164,039,614 - 164,058,487 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,048,234 - 164,057,677 (+)Ensemblmm10GRCm38
MGSCv371165,978,365 - 165,987,808 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361165,884,909 - 165,894,352 (+)NCBIMGSCv36mm8
Celera1166,489,844 - 166,499,312 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.35NCBI
Sele
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554627,564,437 - 7,575,297 (+)NCBIChiLan1.0ChiLan1.0
SELE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2180,034,813 - 80,046,272 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1179,703,217 - 79,714,676 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01145,205,684 - 145,217,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,927,333 - 148,938,781 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,930,437 - 148,938,313 (-)EnsemblpanPan2panpan1.1
SELE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,888,503 - 28,898,787 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,888,197 - 28,898,786 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha728,420,727 - 28,430,555 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0728,690,348 - 28,700,684 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl728,690,094 - 28,700,681 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1728,538,997 - 28,548,824 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0728,574,705 - 28,584,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0728,811,713 - 28,821,538 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sele
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,067,998 - 99,077,891 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648116,915,182 - 16,921,840 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648116,915,203 - 16,921,840 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SELE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1481,289,061 - 81,299,657 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2488,914,255 - 88,924,371 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SELE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,305,610 - 59,333,789 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,322,913 - 59,330,668 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605560,978,152 - 60,989,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sele
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248267,626,380 - 7,635,309 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248267,624,852 - 7,635,330 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sele
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11043,278,582 - 43,288,485 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sele
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000030677
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 62 141 71 70 39 40 39 6 269 135 11 113 73 87 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000030677   ⟹   ENSRNOP00000034797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1378,936,036 - 78,943,332 (+)Ensembl
mRatBN7.2 Ensembl1376,403,304 - 76,410,170 (+)Ensembl
Rnor_6.0 Ensembl1382,355,471 - 82,365,341 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076757   ⟹   ENSRNOP00000068171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1378,936,036 - 78,945,903 (+)Ensembl
mRatBN7.2 Ensembl1376,403,351 - 76,412,741 (+)Ensembl
Rnor_6.0 Ensembl1382,355,886 - 82,365,323 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098346   ⟹   ENSRNOP00000095247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1378,936,036 - 78,943,332 (+)Ensembl
mRatBN7.2 Ensembl1376,403,304 - 76,410,167 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154598   ⟹   ENSRNOP00000107229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1378,936,036 - 78,945,903 (+)Ensembl
RefSeq Acc Id: NM_138879   ⟹   NP_620234
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81378,936,514 - 78,945,904 (+)NCBI
mRatBN7.21376,403,351 - 76,412,741 (+)NCBI
Rnor_6.01382,355,933 - 82,365,323 (+)NCBI
Rnor_5.01387,234,842 - 87,244,746 (+)NCBI
RGSC_v3.41379,813,455 - 79,822,845 (+)RGD
Celera1376,136,932 - 76,146,318 (+)RGD
Sequence:
RefSeq Acc Id: XM_008769608   ⟹   XP_008767830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81378,935,997 - 78,945,905 (+)NCBI
mRatBN7.21376,402,841 - 76,412,733 (+)NCBI
Rnor_6.01382,355,234 - 82,365,299 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598678   ⟹   XP_017454167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81378,935,997 - 78,945,905 (+)NCBI
mRatBN7.21376,402,841 - 76,412,741 (+)NCBI
Rnor_6.01382,355,236 - 82,365,323 (+)NCBI
Sequence:
RefSeq Acc Id: NP_620234   ⟸   NM_138879
- Peptide Label: precursor
- UniProtKB: P98105 (UniProtKB/Swiss-Prot),   A6IDD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767830   ⟸   XM_008769608
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017454167   ⟸   XM_017598678
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000034797   ⟸   ENSRNOT00000030677
Ensembl Acc Id: ENSRNOP00000068171   ⟸   ENSRNOT00000076757
Ensembl Acc Id: ENSRNOP00000095247   ⟸   ENSRNOT00000098346
Ensembl Acc Id: ENSRNOP00000107229   ⟸   ENSRNOT00000154598
Protein Domains
C-type lectin   EGF-like   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P98105-F1-model_v2 AlphaFold P98105 1-549 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3654 AgrOrtholog
BioCyc Gene G2FUF-17605 BioCyc
Ensembl Genes ENSRNOG00000002723 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000076757 ENTREZGENE
  ENSRNOT00000154598 ENTREZGENE
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  Compl-Cell_Adhes-Reg UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  Selectin_CTLD UniProtKB/Swiss-Prot
  Selectin_superfamily UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
KEGG Report rno:25544 UniProtKB/Swiss-Prot
NCBI Gene 25544 ENTREZGENE
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot
  E-SELECTIN UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/Swiss-Prot
  Lectin_C UniProtKB/Swiss-Prot
  Sushi UniProtKB/Swiss-Prot
PhenoGen Sele PhenoGen
PRINTS SELECTIN UniProtKB/Swiss-Prot
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  SUSHI UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002723 RatGTEx
SMART CCP UniProtKB/Swiss-Prot
  CLECT UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
  SSF57535 UniProtKB/Swiss-Prot
UniProt A0A0H2UHU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP16_RAT UniProtKB/TrEMBL
  A0A8L2R0D5_RAT UniProtKB/TrEMBL
  A0ABK0LZ14_RAT UniProtKB/TrEMBL
  A6IDD1 ENTREZGENE, UniProtKB/TrEMBL
  A6IDD2 ENTREZGENE, UniProtKB/TrEMBL
  LYAM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Sele  selectin E  Sele  selectin, endothelial cell  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sele  Selectin, endothelial cell      Symbol and Name status set to approved 70586 APPROVED