Scg2 (secretogranin II) - Rat Genome Database

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Gene: Scg2 (secretogranin II) Rattus norvegicus
Analyze
Symbol: Scg2
Name: secretogranin II
RGD ID: 3626
Description: Predicted to enable chemoattractant activity and cytokine activity. Predicted to be involved in several processes, including eosinophil chemotaxis; induction of positive chemotaxis; and negative regulation of apoptotic process. Located in secretory granule. Orthologous to human SCG2 (secretogranin II); INTERACTS WITH (S)-nicotine; 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Chcg; Chromogranin C (Secretogranin II); chromogranin-C; secretogranin 2; secretogranin II (chromogranin C); secretogranin-2; sgII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8988,251,531 - 88,257,208 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl988,251,354 - 88,269,598 (-)EnsemblGRCr8
mRatBN7.2980,803,074 - 80,808,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl980,803,075 - 80,821,097 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx989,232,915 - 89,238,224 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0994,361,806 - 94,367,115 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,744,332 - 92,749,641 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0985,237,460 - 85,243,024 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,237,458 - 85,243,001 (-)Ensemblrn6Rnor6.0
Rnor_5.0984,991,667 - 84,997,231 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4978,762,661 - 78,767,970 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera978,291,442 - 78,296,748 (-)NCBICelera
RGSC_v3.1978,946,079 - 78,951,389 (-)NCBI
Cytogenetic Map9q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
baclofen  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
captan  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fentanyl  (EXP)
fenvalerate  (EXP)
flavonoids  (EXP)
folpet  (ISO)
glyphosate  (ISO)
lead(0)  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
Oxotremorine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
potassium chloride  (EXP)
prednisolone  (EXP)
progesterone  (EXP)
propanal  (ISO)
pyrethrins  (EXP)
reserpine  (EXP)
rotenone  (EXP,ISO)
Rutecarpine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
thapsigargin  (EXP,ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons. Blanco EH, etal., Neuropeptides. 2011 Aug;45(4):273-9. doi: 10.1016/j.npep.2011.05.002. Epub 2011 May 31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The primary structure of rat secretogranin II deduced from a cDNA sequence. Gerdes HH, etal., Nucleic Acids Res 1988 Dec 23;16(24):11811.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment. Marksteiner J, etal., Neuroscience 2001;104(2):325-33.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Expression of chromogranin/secretogranin mRNA in spontaneous mammary tumors in aging Fischer-344 rats. Umemura S, etal., Pathol Int 2001 Sep;51(9):667-70.
Additional References at PubMed
PMID:1918927   PMID:8321414   PMID:9473216   PMID:9654353   PMID:12534970   PMID:12581877   PMID:12969248   PMID:14622145   PMID:14970115   PMID:15257142   PMID:17962349   PMID:18299326  
PMID:20061385   PMID:20495819   PMID:22655045   PMID:22682498   PMID:24360019   PMID:28902709  


Genomics

Comparative Map Data
Scg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8988,251,531 - 88,257,208 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl988,251,354 - 88,269,598 (-)EnsemblGRCr8
mRatBN7.2980,803,074 - 80,808,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl980,803,075 - 80,821,097 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx989,232,915 - 89,238,224 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0994,361,806 - 94,367,115 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,744,332 - 92,749,641 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0985,237,460 - 85,243,024 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,237,458 - 85,243,001 (-)Ensemblrn6Rnor6.0
Rnor_5.0984,991,667 - 84,997,231 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4978,762,661 - 78,767,970 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera978,291,442 - 78,296,748 (-)NCBICelera
RGSC_v3.1978,946,079 - 78,951,389 (-)NCBI
Cytogenetic Map9q34NCBI
SCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,596,940 - 223,602,361 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,596,940 - 223,602,361 (-)Ensemblhg38GRCh38
GRCh372224,461,658 - 224,467,079 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,169,902 - 224,175,365 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342224,287,231 - 224,292,584NCBI
Celera2218,227,485 - 218,232,948 (-)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2216,313,475 - 216,319,034 (-)NCBIHuRef
CHM1_12224,468,089 - 224,473,648 (-)NCBICHM1_1
T2T-CHM13v2.02224,080,034 - 224,085,455 (-)NCBIT2T-CHM13v2.0
Scg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39179,412,083 - 79,417,743 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl179,412,386 - 79,417,837 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38179,434,366 - 79,440,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl179,434,669 - 79,440,120 (-)Ensemblmm10GRCm38
MGSCv37179,431,244 - 79,436,665 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36179,313,693 - 79,319,114 (-)NCBIMGSCv36mm8
MGSCv36180,309,596 - 80,315,017 (-)NCBIMGSCv36mm8
Cytogenetic Map1C4NCBI
cM Map140.89NCBI
Scg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,364,607 - 10,366,466 (+)Ensembl
ChiLan1.0NW_00495545310,361,440 - 10,366,956 (+)NCBIChiLan1.0ChiLan1.0
SCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213126,223,219 - 126,228,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B126,238,188 - 126,243,628 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B110,849,262 - 110,854,770 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B229,427,169 - 229,432,731 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B229,424,536 - 229,429,510 (-)EnsemblpanPan2panpan1.1
SCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13729,435,038 - 29,440,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3729,435,041 - 29,437,333 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3730,270,420 - 30,275,988 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03729,459,286 - 29,464,858 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3729,459,232 - 29,464,827 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13729,370,476 - 29,376,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03729,304,406 - 29,309,978 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03729,314,146 - 29,319,716 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Scg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,024,421 - 179,029,787 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365695,367,206 - 5,373,017 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365695,367,270 - 5,372,627 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15125,419,847 - 125,426,278 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115125,420,773 - 125,426,303 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SCG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110109,505,344 - 109,510,830 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604089,869,948 - 89,875,489 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248231,659,431 - 1,661,290 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248231,656,195 - 1,661,779 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Scg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14152,528,718 - 152,534,192 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Scg2
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:128
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000020219
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)98672213292642305Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
D9Wox33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,809,229 - 80,809,441 (+)MAPPERmRatBN7.2
Rnor_6.0985,243,608 - 85,243,817NCBIRnor6.0
Rnor_5.0984,997,815 - 84,998,024UniSTSRnor5.0
RGSC_v3.4978,768,736 - 78,768,945UniSTSRGSC3.4
Celera978,297,514 - 78,297,723UniSTS
Cytogenetic Map9q34UniSTS
Scg2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8988,252,220 - 88,253,159 (+)Marker Load Pipeline
mRatBN7.2980,803,814 - 80,804,754 (+)MAPPERmRatBN7.2
Rnor_6.0985,238,201 - 85,239,140NCBIRnor6.0
Rnor_5.0984,992,408 - 84,993,347UniSTSRnor5.0
RGSC_v3.4978,763,325 - 78,764,264UniSTSRGSC3.4
Celera978,292,106 - 78,293,045UniSTS
Cytogenetic Map9q34UniSTS
RH139367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,803,262 - 80,803,449 (+)MAPPERmRatBN7.2
Rnor_6.0985,237,649 - 85,237,835NCBIRnor6.0
Rnor_5.0984,991,856 - 84,992,042UniSTSRnor5.0
RGSC_v3.4978,762,773 - 78,762,959UniSTSRGSC3.4
Celera978,291,554 - 78,291,740UniSTS
RH 3.4 Map9734.2UniSTS
Cytogenetic Map9q34UniSTS
Scg2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,808,475 - 80,808,577 (+)MAPPERmRatBN7.2
Rnor_6.0985,242,854 - 85,242,955NCBIRnor6.0
Rnor_5.0984,997,061 - 84,997,162UniSTSRnor5.0
RGSC_v3.4978,767,982 - 78,768,083UniSTSRGSC3.4
Celera978,296,760 - 78,296,861UniSTS
Cytogenetic Map9q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 7 61 156 59 58 27 26 27 5 225 113 7 137 62 87 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020219   ⟹   ENSRNOP00000020219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,251,481 - 88,256,904 (-)Ensembl
mRatBN7.2 Ensembl980,803,075 - 80,808,502 (-)Ensembl
Rnor_6.0 Ensembl985,237,458 - 85,243,001 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105728   ⟹   ENSRNOP00000078659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,251,527 - 88,257,021 (-)Ensembl
mRatBN7.2 Ensembl980,803,075 - 80,811,332 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112421   ⟹   ENSRNOP00000089801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,251,481 - 88,269,598 (-)Ensembl
mRatBN7.2 Ensembl980,803,075 - 80,821,097 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125596   ⟹   ENSRNOP00000100352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,251,354 - 88,269,598 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142296   ⟹   ENSRNOP00000100467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,251,480 - 88,257,226 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147411   ⟹   ENSRNOP00000111363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,251,355 - 88,264,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166173   ⟹   ENSRNOP00000104795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,251,480 - 88,269,598 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167100   ⟹   ENSRNOP00000099975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,251,481 - 88,269,598 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168776   ⟹   ENSRNOP00000102163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,251,480 - 88,269,598 (-)Ensembl
RefSeq Acc Id: NM_022669   ⟹   NP_073160
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,251,557 - 88,256,866 (-)NCBI
mRatBN7.2980,803,151 - 80,808,464 (-)NCBI
Rnor_6.0985,237,537 - 85,242,842 (-)NCBI
Rnor_5.0984,991,667 - 84,997,231 (-)NCBI
RGSC_v3.4978,762,661 - 78,767,970 (-)RGD
Celera978,291,442 - 78,296,748 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245148   ⟹   XP_006245210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,251,531 - 88,257,208 (-)NCBI
mRatBN7.2980,803,074 - 80,808,646 (-)NCBI
Rnor_6.0985,237,460 - 85,243,024 (-)NCBI
Rnor_5.0984,991,667 - 84,997,231 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767195   ⟹   XP_008765417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,251,531 - 88,256,974 (-)NCBI
mRatBN7.2980,803,125 - 80,808,606 (-)NCBI
Rnor_6.0985,237,511 - 85,243,012 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266647   ⟹   XP_063122717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,251,531 - 88,256,983 (-)NCBI
RefSeq Acc Id: NP_073160   ⟸   NM_022669
- Peptide Label: precursor
- UniProtKB: P10362 (UniProtKB/Swiss-Prot),   A0A8I6A821 (UniProtKB/TrEMBL),   A6JW74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245210   ⟸   XM_006245148
- Peptide Label: isoform X2
- UniProtKB: P10362 (UniProtKB/Swiss-Prot),   G3V7X2 (UniProtKB/TrEMBL),   Q6P7R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765417   ⟸   XM_008767195
- Peptide Label: isoform X1
- UniProtKB: P10362 (UniProtKB/Swiss-Prot),   A0A8I6A821 (UniProtKB/TrEMBL),   A6JW74 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020219   ⟸   ENSRNOT00000020219
Ensembl Acc Id: ENSRNOP00000078659   ⟸   ENSRNOT00000105728
Ensembl Acc Id: ENSRNOP00000089801   ⟸   ENSRNOT00000112421
RefSeq Acc Id: XP_063122717   ⟸   XM_063266647
- Peptide Label: isoform X2
- UniProtKB: P10362 (UniProtKB/Swiss-Prot),   G3V7X2 (UniProtKB/TrEMBL),   Q6P7R4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100352   ⟸   ENSRNOT00000125596
Ensembl Acc Id: ENSRNOP00000100467   ⟸   ENSRNOT00000142296
Ensembl Acc Id: ENSRNOP00000104795   ⟸   ENSRNOT00000166173
Ensembl Acc Id: ENSRNOP00000102163   ⟸   ENSRNOT00000168776
Ensembl Acc Id: ENSRNOP00000111363   ⟸   ENSRNOT00000147411
Ensembl Acc Id: ENSRNOP00000099975   ⟸   ENSRNOT00000167100

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10362-F1-model_v2 AlphaFold P10362 1-619 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696790
Promoter ID:EPDNEW_R7314
Type:multiple initiation site
Name:Scg2_1
Description:secretogranin II
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0985,242,893 - 85,242,953EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3626 AgrOrtholog
BioCyc Gene G2FUF-27015 BioCyc
Ensembl Genes ENSRNOG00000015055 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020219 ENTREZGENE
  ENSRNOT00000105728 ENTREZGENE
  ENSRNOT00000167100 ENTREZGENE
IMAGE_CLONE IMAGE:6919444 IMAGE-MGC_LOAD
InterPro Chromogranin_CS UniProtKB/Swiss-Prot
  Granin UniProtKB/Swiss-Prot
  ScgII UniProtKB/Swiss-Prot
KEGG Report rno:24765 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72816 IMAGE-MGC_LOAD
NCBI Gene 24765 ENTREZGENE
PANTHER PTHR15119 UniProtKB/Swiss-Prot
  SECRETOGRANIN-2 UniProtKB/Swiss-Prot
Pfam Granin UniProtKB/Swiss-Prot
PhenoGen Scg2 PhenoGen
PROSITE GRANINS_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015055 RatGTEx
UniProt A0A8I6A821 ENTREZGENE, UniProtKB/TrEMBL
  A6JW71_RAT UniProtKB/TrEMBL
  A6JW74 ENTREZGENE, UniProtKB/TrEMBL
  A6JW75_RAT UniProtKB/TrEMBL
  G3V7X2 ENTREZGENE, UniProtKB/TrEMBL
  P10362 ENTREZGENE
  Q6P7R4 ENTREZGENE
  SCG2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Scg2  secretogranin II  Scg2  secretogranin II (chromogranin C)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Scg2  secretogranin II (chromogranin C)  Scg2  secretogranin II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-20 Scg2  secretogranin II  Scg2  secretogranin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Scg2  secretogranin 2      Symbol and Name updated 629477 APPROVED
2003-03-06 Scg2  secretogranin 2  Chcg  Chromogranin C (Secretogranin II)  Data merged from RGD:2337 628472 PROVISIONAL
2002-06-10 Chcg  Chromogranin C (Secretogranin II)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Scg2  Secretogranin II      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is expressed in some mammary tumors 727329