Rgs3 (regulator of G-protein signaling 3) - Rat Genome Database

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Pathways
Gene: Rgs3 (regulator of G-protein signaling 3) Rattus norvegicus
Analyze
Symbol: Rgs3
Name: regulator of G-protein signaling 3
RGD ID: 3566
Description: Predicted to enable GTPase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of signal transduction. Predicted to be located in cytoplasm and membrane. Predicted to be active in nucleus and plasma membrane. Biomarker of bladder disease and lesion of sciatic nerve. Orthologous to human RGS3 (regulator of G protein signaling 3); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC93233; regulator of G-protein signalling 3; SRB-RGS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8581,037,588 - 81,177,446 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl581,056,068 - 81,177,445 (+)EnsemblGRCr8
mRatBN7.2576,022,038 - 76,161,895 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl576,022,001 - 76,161,894 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx578,478,060 - 78,561,409 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,295,183 - 80,378,540 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,270,680 - 80,354,040 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,429,017 - 78,567,281 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,428,669 - 78,567,288 (+)Ensemblrn6Rnor6.0
Rnor_5.0582,550,757 - 82,690,343 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4579,624,388 - 79,709,035 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera575,018,488 - 75,101,807 (+)NCBICelera
RGSC_v3.1579,629,500 - 79,714,147 (+)NCBI
Cytogenetic Map5q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-timolol (anhydrous)  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Ampullosporin  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl malate  (ISO)
dopamine  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ketamine  (EXP)
menadione  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
monosodium L-glutamate  (EXP)
N-nitrosodimethylamine  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
valsartan  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
membrane  (IEA)
nucleus  (IBA,IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons. Costigan M, etal., Mol Cell Neurosci. 2003 Sep;24(1):106-16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular cloning and characterization of a steroid receptor-binding regulator of G-protein signaling protein cDNA. Ikeda M, etal., Gene 2001 Aug 8;273(2):207-14.
5. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells. Wang Q, etal., J Biol Chem 2002 Jul 12;277(28):24949-58.
12. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
Additional References at PubMed
PMID:10702309   PMID:11034339   PMID:12062898   PMID:12477932   PMID:15458844   PMID:15489334   PMID:17541154   PMID:25931508  


Genomics

Comparative Map Data
Rgs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8581,037,588 - 81,177,446 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl581,056,068 - 81,177,445 (+)EnsemblGRCr8
mRatBN7.2576,022,038 - 76,161,895 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl576,022,001 - 76,161,894 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx578,478,060 - 78,561,409 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,295,183 - 80,378,540 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,270,680 - 80,354,040 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,429,017 - 78,567,281 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,428,669 - 78,567,288 (+)Ensemblrn6Rnor6.0
Rnor_5.0582,550,757 - 82,690,343 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4579,624,388 - 79,709,035 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera575,018,488 - 75,101,807 (+)NCBICelera
RGSC_v3.1579,629,500 - 79,714,147 (+)NCBI
Cytogenetic Map5q24NCBI
RGS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389113,444,730 - 113,597,738 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9113,444,731 - 113,597,743 (+)Ensemblhg38GRCh38
GRCh379116,207,010 - 116,360,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,246,832 - 115,399,839 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349113,435,753 - 113,439,571NCBI
Celera986,854,611 - 87,007,602 (+)NCBICelera
Cytogenetic Map9q32NCBI
HuRef985,813,933 - 85,966,662 (+)NCBIHuRef
CHM1_19116,353,638 - 116,506,463 (+)NCBICHM1_1
T2T-CHM13v2.09125,643,547 - 125,796,339 (+)NCBIT2T-CHM13v2.0
Rgs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,478,079 - 62,621,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl462,478,084 - 62,622,238 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38462,559,835 - 62,703,019 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,559,847 - 62,704,001 (+)Ensemblmm10GRCm38
MGSCv37462,220,881 - 62,364,053 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36462,046,208 - 62,188,696 (+)NCBIMGSCv36mm8
Celera461,227,755 - 61,366,061 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.19NCBI
Rgs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541913,919,051 - 14,056,521 (-)Ensembl
ChiLan1.0NW_00495541913,918,274 - 14,042,090 (-)NCBIChiLan1.0ChiLan1.0
RGS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,779,028 - 25,933,046 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1925,781,387 - 25,935,478 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0984,561,302 - 84,696,534 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19112,929,604 - 113,065,746 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9112,927,407 - 113,065,746 (+)EnsemblpanPan2panpan1.1
RGS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11167,781,832 - 67,878,153 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1167,781,962 - 67,920,075 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1166,186,531 - 66,324,166 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01168,906,019 - 69,044,294 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1168,923,206 - 69,044,285 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11167,424,053 - 67,562,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01167,455,234 - 67,593,195 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01168,210,062 - 68,330,325 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rgs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947183,085,781 - 183,161,654 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936559109,690 - 182,331 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936559112,375 - 180,737 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,067,492 - 254,211,805 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11254,078,618 - 254,211,805 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21284,875,313 - 284,953,037 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11225,985,782 - 26,118,393 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1225,985,723 - 26,117,343 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603516,686,032 - 16,825,304 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476021,514,359 - 21,636,684 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rgs3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1190,824,171 - 90,946,971 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rgs3
1358 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:356
Count of miRNA genes:200
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000059183
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
D3Rat120  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8581,099,114 - 81,099,371 (+)Marker Load Pipeline
Rnor_5.0582,611,942 - 82,612,198UniSTSRnor5.0
RGSC_v3.4579,629,453 - 79,629,709UniSTSRGSC3.4
RGSC_v3.4579,629,452 - 79,629,709RGDRGSC3.4
Celera575,023,580 - 75,023,822UniSTS
RGSC_v3.1579,634,565 - 79,634,822RGD
Cytogenetic Map5q24UniSTS
D5Uwm20  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8581,161,836 - 81,162,025 (+)Marker Load Pipeline
mRatBN7.2576,146,283 - 76,146,472 (+)MAPPERmRatBN7.2
Rnor_6.0578,551,671 - 78,551,859NCBIRnor6.0
Rnor_5.0582,674,733 - 82,674,921UniSTSRnor5.0
RGSC_v3.4579,693,426 - 79,693,614UniSTSRGSC3.4
RGSC_v3.4579,693,425 - 79,693,614RGDRGSC3.4
Celera575,086,215 - 75,086,395UniSTS
RGSC_v3.1579,698,538 - 79,698,727RGD
Cytogenetic Map5q24UniSTS
RH141488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2576,118,076 - 76,118,265 (+)MAPPERmRatBN7.2
Rnor_6.0578,523,465 - 78,523,653NCBIRnor6.0
Rnor_5.0582,646,665 - 82,646,853UniSTSRnor5.0
RGSC_v3.4579,663,973 - 79,664,161UniSTSRGSC3.4
Celera575,058,088 - 75,058,276UniSTS
RH 3.4 Map5559.0UniSTS
Cytogenetic Map5q24UniSTS
BE098515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2576,159,438 - 76,159,588 (+)MAPPERmRatBN7.2
Rnor_6.0578,564,824 - 78,564,973NCBIRnor6.0
Rnor_5.0582,687,886 - 82,688,035UniSTSRnor5.0
RGSC_v3.4579,706,579 - 79,706,728UniSTSRGSC3.4
Celera575,099,351 - 75,099,500UniSTS
Cytogenetic Map5q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB055153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000059181   ⟹   ENSRNOP00000055954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl581,056,068 - 81,131,737 (+)Ensembl
mRatBN7.2 Ensembl576,022,001 - 76,116,179 (+)Ensembl
Rnor_6.0 Ensembl578,483,904 - 78,521,567 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000059183   ⟹   ENSRNOP00000055956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl581,093,947 - 81,177,445 (+)Ensembl
mRatBN7.2 Ensembl576,078,492 - 76,161,894 (+)Ensembl
Rnor_6.0 Ensembl578,483,893 - 78,567,279 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080744   ⟹   ENSRNOP00000071774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl581,056,068 - 81,177,445 (+)Ensembl
mRatBN7.2 Ensembl576,022,001 - 76,161,894 (+)Ensembl
Rnor_6.0 Ensembl578,428,669 - 78,567,288 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099793   ⟹   ENSRNOP00000093735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl581,173,868 - 81,177,445 (+)Ensembl
mRatBN7.2 Ensembl576,158,469 - 76,161,888 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107343   ⟹   ENSRNOP00000081496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl581,057,617 - 81,177,445 (+)Ensembl
mRatBN7.2 Ensembl576,041,973 - 76,161,894 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143652   ⟹   ENSRNOP00000109277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl581,056,068 - 81,177,445 (+)Ensembl
RefSeq Acc Id: NM_019340   ⟹   NP_062213
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,094,051 - 81,177,446 (+)NCBI
mRatBN7.2576,078,492 - 76,161,895 (+)NCBI
Rnor_6.0578,483,893 - 78,567,280 (+)NCBI
Rnor_5.0582,550,757 - 82,690,343 (+)NCBI
RGSC_v3.4579,624,388 - 79,709,035 (+)RGD
Celera575,018,488 - 75,101,807 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238260   ⟹   XP_006238322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,057,615 - 81,177,446 (+)NCBI
mRatBN7.2576,042,138 - 76,161,895 (+)NCBI
Rnor_6.0578,447,541 - 78,567,281 (+)NCBI
Rnor_5.0582,550,757 - 82,690,343 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238264   ⟹   XP_006238326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,057,673 - 81,139,312 (+)NCBI
mRatBN7.2576,042,119 - 76,123,754 (+)NCBI
Rnor_6.0578,447,527 - 78,523,819 (+)NCBI
Rnor_5.0582,550,757 - 82,690,343 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238265   ⟹   XP_006238327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,093,319 - 81,139,312 (+)NCBI
mRatBN7.2576,077,759 - 76,123,754 (+)NCBI
Rnor_6.0578,481,697 - 78,523,819 (+)NCBI
Rnor_5.0582,550,757 - 82,690,343 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763801   ⟹   XP_008762023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,146,386 - 81,177,446 (+)NCBI
mRatBN7.2576,133,480 - 76,161,895 (+)NCBI
Rnor_6.0578,538,902 - 78,567,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763802   ⟹   XP_008762024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,146,386 - 81,177,446 (+)NCBI
mRatBN7.2576,132,987 - 76,161,895 (+)NCBI
Rnor_6.0578,537,274 - 78,567,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593595   ⟹   XP_017449084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,037,730 - 81,177,446 (+)NCBI
mRatBN7.2576,022,167 - 76,161,895 (+)NCBI
Rnor_6.0578,429,042 - 78,567,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593597   ⟹   XP_017449086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,057,702 - 81,177,446 (+)NCBI
mRatBN7.2576,042,138 - 76,161,895 (+)NCBI
Rnor_6.0578,447,541 - 78,567,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110674   ⟹   XP_038966602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,037,602 - 81,177,446 (+)NCBI
mRatBN7.2576,022,038 - 76,161,895 (+)NCBI
RefSeq Acc Id: XM_039110676   ⟹   XP_038966604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,082,314 - 81,177,446 (+)NCBI
mRatBN7.2576,066,756 - 76,161,895 (+)NCBI
RefSeq Acc Id: XM_063288322   ⟹   XP_063144392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,037,602 - 81,177,446 (+)NCBI
RefSeq Acc Id: XM_063288323   ⟹   XP_063144393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,037,588 - 81,139,312 (+)NCBI
RefSeq Acc Id: XM_063288324   ⟹   XP_063144394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,037,588 - 81,130,942 (+)NCBI
RefSeq Acc Id: XM_063288325   ⟹   XP_063144395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,142,580 - 81,177,446 (+)NCBI
RefSeq Acc Id: XM_063288326   ⟹   XP_063144396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,149,040 - 81,177,446 (+)NCBI
RefSeq Acc Id: XM_063288327   ⟹   XP_063144397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,171,872 - 81,177,446 (+)NCBI
RefSeq Acc Id: XM_063288328   ⟹   XP_063144398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,171,872 - 81,177,446 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001416610 (Get FASTA)   NCBI Sequence Viewer  
  NP_062213 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238322 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238326 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238327 (Get FASTA)   NCBI Sequence Viewer  
  XP_008762023 (Get FASTA)   NCBI Sequence Viewer  
  XP_008762024 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449084 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449086 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966602 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966604 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144392 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144393 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144394 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144395 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144396 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144397 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144398 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52371 (Get FASTA)   NCBI Sequence Viewer  
  AAH85710 (Get FASTA)   NCBI Sequence Viewer  
  BAB63460 (Get FASTA)   NCBI Sequence Viewer  
  EDM10542 (Get FASTA)   NCBI Sequence Viewer  
  EDM10543 (Get FASTA)   NCBI Sequence Viewer  
  EDM10544 (Get FASTA)   NCBI Sequence Viewer  
  EDM10545 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055954
  ENSRNOP00000055956
  ENSRNOP00000071774
  ENSRNOP00000081496
  ENSRNOP00000093735
GenBank Protein P49797 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062213   ⟸   NM_019340
- UniProtKB: Q920Q9 (UniProtKB/Swiss-Prot),   Q5RKK6 (UniProtKB/Swiss-Prot),   P49797 (UniProtKB/Swiss-Prot),   A6J7W3 (UniProtKB/TrEMBL),   G3V9Q2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238326   ⟸   XM_006238264
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006238322   ⟸   XM_006238260
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006238327   ⟸   XM_006238265
- Peptide Label: isoform X10
- UniProtKB: P49797 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008762024   ⟸   XM_008763802
- Peptide Label: isoform X9
- UniProtKB: A6J7W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762023   ⟸   XM_008763801
- Peptide Label: isoform X9
- UniProtKB: A6J7W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449084   ⟸   XM_017593595
- Peptide Label: isoform X1
- UniProtKB: Q920Q9 (UniProtKB/Swiss-Prot),   Q5RKK6 (UniProtKB/Swiss-Prot),   P49797 (UniProtKB/Swiss-Prot),   A0A0G2K1B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449086   ⟸   XM_017593597
- Peptide Label: isoform X4
- UniProtKB: Q920Q9 (UniProtKB/Swiss-Prot),   Q5RKK6 (UniProtKB/Swiss-Prot),   P49797 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071774   ⟸   ENSRNOT00000080744
Ensembl Acc Id: ENSRNOP00000055954   ⟸   ENSRNOT00000059181
Ensembl Acc Id: ENSRNOP00000055956   ⟸   ENSRNOT00000059183
RefSeq Acc Id: XP_038966602   ⟸   XM_039110674
- Peptide Label: isoform X1
- UniProtKB: Q920Q9 (UniProtKB/Swiss-Prot),   Q5RKK6 (UniProtKB/Swiss-Prot),   P49797 (UniProtKB/Swiss-Prot),   A0A0G2K1B5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966604   ⟸   XM_039110676
- Peptide Label: isoform X5
- UniProtKB: Q920Q9 (UniProtKB/Swiss-Prot),   Q5RKK6 (UniProtKB/Swiss-Prot),   P49797 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000093735   ⟸   ENSRNOT00000099793
Ensembl Acc Id: ENSRNOP00000081496   ⟸   ENSRNOT00000107343
RefSeq Acc Id: XP_063144393   ⟸   XM_063288323
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QRC0 (UniProtKB/TrEMBL),   A6J7W2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144394   ⟸   XM_063288324
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063144392   ⟸   XM_063288322
- Peptide Label: isoform X2
- UniProtKB: Q920Q9 (UniProtKB/Swiss-Prot),   Q5RKK6 (UniProtKB/Swiss-Prot),   P49797 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063144395   ⟸   XM_063288325
- Peptide Label: isoform X9
- UniProtKB: A6J7W4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144396   ⟸   XM_063288326
- Peptide Label: isoform X9
- UniProtKB: A6J7W4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144397   ⟸   XM_063288327
- Peptide Label: isoform X11
- UniProtKB: A0A8I6AJG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144398   ⟸   XM_063288328
- Peptide Label: isoform X12
- UniProtKB: A6J7W5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109277   ⟸   ENSRNOT00000143652
Protein Domains
C2   PDZ   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49797-F1-model_v2 AlphaFold P49797 1-967 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693797
Promoter ID:EPDNEW_R4321
Type:single initiation site
Name:Rgs3_1
Description:regulator of G-protein signaling 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0578,483,872 - 78,483,932EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3566 AgrOrtholog
BioCyc Gene G2FUF-41084 BioCyc
Ensembl Genes ENSRNOG00000024501 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000059181 ENTREZGENE
  ENSRNOT00000059183 ENTREZGENE
  ENSRNOT00000080744 ENTREZGENE
  ENSRNOT00000099793 ENTREZGENE
  ENSRNOT00000107343 ENTREZGENE
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  1.10.196.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot
InterPro PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
  RGS_RGS3 UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdom1/3 UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
KEGG Report rno:54293 UniProtKB/Swiss-Prot
NCBI Gene 54293 ENTREZGENE
PANTHER REGULATOR OF G-PROTEIN SIGNALING 3 UniProtKB/Swiss-Prot
  REGULATOR OF G-PROTEIN SIGNALING 3 UniProtKB/Swiss-Prot
Pfam PDZ UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
PhenoGen Rgs3 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot
PROSITE PDZ UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024501 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF48097 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
UniProt A0A0G2K1B5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZT37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJG0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QRC0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LXR8_RAT UniProtKB/TrEMBL
  A6J7W2 ENTREZGENE, UniProtKB/TrEMBL
  A6J7W3 ENTREZGENE, UniProtKB/TrEMBL
  A6J7W4 ENTREZGENE, UniProtKB/TrEMBL
  A6J7W5 ENTREZGENE, UniProtKB/TrEMBL
  G3V9Q2 ENTREZGENE, UniProtKB/TrEMBL
  P49797 ENTREZGENE
  Q5RKK6 ENTREZGENE
  Q920Q9 ENTREZGENE
  RGS3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5RKK6 UniProtKB/Swiss-Prot
  Q920Q9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Rgs3  regulator of G-protein signaling 3  Rgs3  regulator of G-protein signalling 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rgs3  regulator of G-protein signalling 3    regulator of G-protein signaling 3  Name updated 1299863 APPROVED
2002-06-10 Rgs3  regulator of G-protein signaling 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds directly to the activated Ga subunits and pormotes GTP hydrolysis 625585
gene_process serves as a GTPase-activating protein (GAP) and inhibits G protein signaling; inhibits muscarinic m3 receptor signaling through MAP kinase (ERK) 625585