Pthlh (parathyroid hormone-like hormone) - Rat Genome Database

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Gene: Pthlh (parathyroid hormone-like hormone) Rattus norvegicus
Analyze
Symbol: Pthlh
Name: parathyroid hormone-like hormone
RGD ID: 3441
Description: Enables hormone activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in brachydactyly type E2. Orthologous to human PTHLH (parathyroid hormone like hormone); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH 1-Oleoyl-2-acetyl-sn-glycerol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: parathyroid hormone-like peptide; parathyroid hormone-like protein; parathyroid hormone-related protein; parathyroid-like peptide; PLP; PTH-rP; PTHrP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84181,919,400 - 181,930,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4181,919,400 - 181,930,454 (-)EnsemblGRCr8
mRatBN7.24180,188,792 - 180,199,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4180,188,792 - 180,199,847 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4186,472,387 - 186,483,481 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04182,256,935 - 182,268,028 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04180,877,368 - 180,888,461 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04181,663,425 - 181,674,181 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04245,811,895 - 245,822,651 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44184,887,702 - 184,898,841 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4168,675,915 - 168,686,473 (-)NCBICelera
RGSC_v3.14185,132,825 - 185,143,965 (-)NCBI
RH 3.4 Map41091.1RGD
Cytogenetic Map4q44NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium carbonate  (ISO)
candesartan  (EXP)
ceruletide  (EXP,ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
enalapril  (EXP)
ethanol  (EXP,ISO)
fentanyl  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (ISO)
losartan  (EXP)
manganese(II) chloride  (EXP)
mercury dichloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentane-2,3-dione  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
quinapril hydrochloride  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
styrene  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
thiamethoxam  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichostatin A  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Alvarez J, etal., Development. 2002 Apr;129(8):1913-24.
2. Parathyroid hormone-related protein induction in focal stroke: a neuroprotective vascular peptide. Funk JL, etal., Am J Physiol Regul Integr Comp Physiol 2003 Apr;284(4):R1021-30.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue. Karaplis AC, etal., Mol Endocrinol 1990 Mar;4(3):441-6.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Expression of parathyroid hormone-related peptide and insulin-like growth factor I during rat fracture healing. Okazaki K, etal., J Orthop Res. 2003 May;21(3):511-20.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
17. Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. Tfelt-Hansen J, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E329-37. Epub 2003 Apr 15.
18. Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Thiede MA and Rodan GA, Science 1988 Oct 14;242(4876):278-80.
19. Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Yasuda T, etal., Mol Endocrinol 1989 Mar;3(3):518-25.
Additional References at PubMed
PMID:90087   PMID:8314082   PMID:8895385   PMID:9008714   PMID:9477327   PMID:9832460   PMID:9921650   PMID:11606467   PMID:12647298   PMID:15162506   PMID:15579504   PMID:16007342  
PMID:16672315   PMID:16940239   PMID:17200368   PMID:17328886   PMID:17435078   PMID:18048500   PMID:18401831   PMID:19574446   PMID:19674967   PMID:19910689   PMID:21073445   PMID:22093939  
PMID:22508055   PMID:23038778   PMID:23546599   PMID:24253735   PMID:25159845   PMID:25278090   PMID:25645361   PMID:26538570   PMID:26859332   PMID:30504697   PMID:31311343   PMID:31471966  


Genomics

Comparative Map Data
Pthlh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84181,919,400 - 181,930,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4181,919,400 - 181,930,454 (-)EnsemblGRCr8
mRatBN7.24180,188,792 - 180,199,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4180,188,792 - 180,199,847 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4186,472,387 - 186,483,481 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04182,256,935 - 182,268,028 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04180,877,368 - 180,888,461 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04181,663,425 - 181,674,181 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04245,811,895 - 245,822,651 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44184,887,702 - 184,898,841 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4168,675,915 - 168,686,473 (-)NCBICelera
RGSC_v3.14185,132,825 - 185,143,965 (-)NCBI
RH 3.4 Map41091.1RGD
Cytogenetic Map4q44NCBI
PTHLH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381227,958,084 - 27,972,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1227,958,084 - 27,972,755 (-)Ensemblhg38GRCh38
GRCh371228,111,017 - 28,125,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,002,284 - 28,016,183 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341228,002,283 - 28,014,161NCBI
Celera1233,256,594 - 33,270,557 (-)NCBICelera
Cytogenetic Map12p11.22NCBI
HuRef1227,880,337 - 27,894,279 (-)NCBIHuRef
CHM1_11228,076,045 - 28,089,944 (-)NCBICHM1_1
T2T-CHM13v2.01227,829,831 - 27,844,463 (-)NCBIT2T-CHM13v2.0
Pthlh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396147,153,607 - 147,165,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6147,153,599 - 147,165,681 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386147,252,109 - 147,264,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6147,252,101 - 147,264,183 (-)Ensemblmm10GRCm38
MGSCv376147,200,632 - 147,212,607 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366147,209,270 - 147,221,371 (-)NCBIMGSCv36mm8
Celera6150,289,180 - 150,301,102 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map678.19NCBI
Pthlh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555056,834,533 - 6,847,335 (+)Ensembl
ChiLan1.0NW_0049555056,834,533 - 6,846,909 (+)NCBIChiLan1.0ChiLan1.0
PTHLH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21068,846,032 - 68,858,167 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11268,842,410 - 68,854,564 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01258,341,361 - 58,355,804 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11260,959,327 - 60,973,749 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1260,960,071 - 60,973,750 (+)EnsemblpanPan2panpan1.1
PTHLH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12719,781,557 - 19,795,078 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2719,781,557 - 19,795,078 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2726,604,753 - 26,729,826 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02719,869,742 - 19,989,315 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2719,975,781 - 19,989,312 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12719,676,917 - 19,795,837 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02719,703,486 - 19,822,427 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02726,761,823 - 26,881,419 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pthlh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494581,724,063 - 81,735,818 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936760197,525 - 209,518 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936760197,525 - 209,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTHLH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl545,751,292 - 45,763,415 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1545,750,968 - 45,763,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2549,159,951 - 49,172,393 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTHLH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11127,682,300 - 27,694,808 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1127,682,338 - 27,694,898 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660697,351,760 - 7,364,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pthlh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247788,008,056 - 8,019,612 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247788,007,358 - 8,019,538 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pthlh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v164,929,100 - 4,940,124 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pthlh
81 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4176806581181925369Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
D4Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24180,200,975 - 180,201,064 (+)MAPPERmRatBN7.2
Rnor_6.04181,675,452 - 181,675,540NCBIRnor6.0
Rnor_5.04245,823,922 - 245,824,010UniSTSRnor5.0
RGSC_v3.44184,899,968 - 184,900,058RGDRGSC3.4
RGSC_v3.44184,899,969 - 184,900,057UniSTSRGSC3.4
RGSC_v3.14185,145,092 - 185,145,182RGD
RH 3.4 Map41091.9UniSTS
RH 3.4 Map41091.9RGD
RH 2.0 Map41106.7RGD
Cytogenetic Map4q44UniSTS
RH94501  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24180,188,895 - 180,189,095 (+)MAPPERmRatBN7.2
Rnor_6.04181,663,529 - 181,663,728NCBIRnor6.0
Rnor_5.04245,811,999 - 245,812,198UniSTSRnor5.0
RGSC_v3.44184,887,806 - 184,888,005UniSTSRGSC3.4
Celera4168,676,019 - 168,676,218UniSTS
RH 3.4 Map41091.1UniSTS
Cytogenetic Map4q44UniSTS
RH130039  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24180,188,864 - 180,189,084 (+)MAPPERmRatBN7.2
Rnor_6.04181,663,498 - 181,663,717NCBIRnor6.0
Rnor_5.04245,811,968 - 245,812,187UniSTSRnor5.0
RGSC_v3.44184,887,775 - 184,887,994UniSTSRGSC3.4
Celera4168,675,988 - 168,676,207UniSTS
Cytogenetic Map4q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 18 2 70 30 10 17 33 32 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000112037   ⟹   ENSRNOP00000078983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4181,919,400 - 181,930,454 (-)Ensembl
mRatBN7.2 Ensembl4180,188,792 - 180,199,847 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168791   ⟹   ENSRNOP00000108520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4181,922,227 - 181,930,454 (-)Ensembl
RefSeq Acc Id: NM_012636   ⟹   NP_036768
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84181,919,400 - 181,930,454 (-)NCBI
mRatBN7.24180,188,792 - 180,199,847 (-)NCBI
Rnor_6.04181,663,425 - 181,674,181 (-)NCBI
Rnor_5.04245,811,895 - 245,822,651 (-)NCBI
RGSC_v3.44184,887,702 - 184,898,841 (-)RGD
Celera4168,675,915 - 168,686,473 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036768 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41889 (Get FASTA)   NCBI Sequence Viewer  
  AAA41980 (Get FASTA)   NCBI Sequence Viewer  
  AAA41981 (Get FASTA)   NCBI Sequence Viewer  
  EDM01395 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078983
GenBank Protein P13085 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036768   ⟸   NM_012636
- Peptide Label: preproprotein
- UniProtKB: P13085 (UniProtKB/Swiss-Prot),   A0A8I5ZLU3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000078983   ⟸   ENSRNOT00000112037
Ensembl Acc Id: ENSRNOP00000108520   ⟸   ENSRNOT00000168791

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13085-F1-model_v2 AlphaFold P13085 1-177 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3441 AgrOrtholog
BioCyc Gene G2FUF-42415 BioCyc
Ensembl Genes ENSRNOG00000069267 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000112037 ENTREZGENE
InterPro PTH-rel UniProtKB/Swiss-Prot
  PTH/PTH-rel UniProtKB/Swiss-Prot
KEGG Report rno:24695 UniProtKB/Swiss-Prot
NCBI Gene 24695 ENTREZGENE
PANTHER PARATHYROID HORMONE-RELATED PROTEIN UniProtKB/Swiss-Prot
  PTHR17223 UniProtKB/Swiss-Prot
Pfam Parathyroid UniProtKB/Swiss-Prot
PhenoGen Pthlh PhenoGen
PROSITE PARATHYROID UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000069267 RatGTEx
SMART PTH UniProtKB/Swiss-Prot
UniProt A0A8I5ZLU3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LCT5_RAT UniProtKB/TrEMBL
  A6IN44_RAT UniProtKB/TrEMBL
  P13085 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-20 Pthlh  parathyroid hormone-like hormone  Pthlh  parathyroid hormone-like peptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Pthlh  parathyroid hormone-like peptide    parathyroid-like peptide  Name updated 629478 APPROVED
2002-06-10 Pthlh  parathyroid-like peptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may be a hormone for the mobilization and/or transfer of calcium to milk  
gene_process plays a role in lactation  
gene_process regulates epidermal development.  
gene_process may have intracrine effects in the nucleus of cells that produce it in addition to having juxtacrine, paracrine, and possibly endocrine effects after secretion 61489