(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRNP mRNA] CTD PMID:31150632 (1->4)-beta-D-glucan multiple interactions ISO Prnp (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRNP mRNA CTD PMID:36331819 (E)-thiamethoxam increases expression ISO Prnp (Mus musculus) 6480464 Thiamethoxam results in increased expression of PRNP mRNA CTD PMID:33533595 1,2-dichloroethane decreases expression ISO Prnp (Mus musculus) 6480464 ethylene dichloride results in decreased expression of PRNP mRNA CTD PMID:28189721 and PMID:28960355 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine multiple interactions ISO PRNP (Homo sapiens) 6480464 Copper affects the reaction [1 and 2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form] CTD PMID:20936829 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine affects folding ISO PRNP (Homo sapiens) 6480464 1 and 2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form CTD PMID:20936829 1,2-dimethylhydrazine decreases expression ISO Prnp (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of PRNP mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO Prnp (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PRNP mRNA CTD PMID:22206623 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of PRNP mRNA CTD PMID:25380136 17alpha-ethynylestradiol multiple interactions ISO Prnp (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRNP mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of PRNP mRNA CTD PMID:12075121 17beta-estradiol multiple interactions ISO PRNP (Homo sapiens) 6480464 [Estradiol co-treated with EGF protein] results in increased expression of PRNP mRNA CTD PMID:24758408 17beta-estradiol increases expression ISO PRNP (Homo sapiens) 6480464 Estradiol results in increased expression of PRNP mRNA CTD PMID:31614463 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of PRNP mRNA CTD PMID:32145629 17beta-estradiol affects expression ISO PRNP (Homo sapiens) 6480464 Estradiol affects the expression of PRNP mRNA CTD PMID:22574217 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO Prnp (Mus musculus) 6480464 Dihydrotestosterone results in decreased expression of PRNP mRNA CTD PMID:17023530 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO PRNP (Homo sapiens) 6480464 2 more ... CTD PMID:25305463 2,2,2-tetramine increases expression EXP 6480464 Trientine results in increased expression of PRNP mRNA and Trientine results in increased expression of PRNP protein CTD PMID:22362149 2,2,2-tetramine affects response to substance EXP 6480464 PRNP protein affects the susceptibility to Trientine CTD PMID:22362149 2,2,2-trifluoroethanol affects folding ISO PRNP (Homo sapiens) 6480464 Trifluoroethanol affects the folding of PRNP protein modified form CTD PMID:20936829 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Prnp (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRNP mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PRNP mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PRNP mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Prnp (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of PRNP mRNA CTD PMID:21570461 2-methoxyethanol increases expression EXP 6480464 methyl cellosolve results in increased expression of PRNP mRNA CTD PMID:21061450 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 3,4-dichloroaniline decreases expression ISO PRNP (Homo sapiens) 6480464 3 and 4-dichloroaniline results in decreased expression of PRNP mRNA CTD PMID:24172598 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of PRNP mRNA CTD PMID:25380136 4,4'-diaminodiphenylmethane decreases expression ISO Prnp (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of PRNP mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases expression ISO PRNP (Homo sapiens) 6480464 bisphenol S results in increased expression of PRNP protein CTD PMID:34186270 5-fluorouracil decreases response to substance ISO PRNP (Homo sapiens) 6480464 PRNP protein results in decreased susceptibility to Fluorouracil CTD PMID:15386405 acetamide increases expression EXP 6480464 acetamide results in increased expression of PRNP mRNA CTD PMID:31881176 acetylsalicylic acid increases expression EXP 6480464 Aspirin results in increased expression of PRNP mRNA CTD PMID:12800193 acrylamide increases expression ISO PRNP (Homo sapiens) 6480464 Acrylamide results in increased expression of PRNP mRNA CTD PMID:32763439 aflatoxin B1 decreases expression ISO Prnp (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of PRNP mRNA CTD PMID:19770486 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of PRNP mRNA CTD PMID:23630614 and PMID:25378103 aflatoxin B1 increases expression ISO PRNP (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of PRNP mRNA CTD PMID:22100608 aldehydo-D-glucose multiple interactions ISO PRNP (Homo sapiens) 6480464 [PRNP protein results in increased expression of SLC2A1 protein] which results in increased uptake of Glucose CTD PMID:21265952 all-trans-retinoic acid decreases expression ISO PRNP (Homo sapiens) 6480464 Tretinoin results in decreased expression of PRNP mRNA CTD PMID:15498508 and PMID:33167477 all-trans-retinoic acid increases expression ISO PRNP (Homo sapiens) 6480464 Tretinoin results in increased expression of PRNP mRNA CTD PMID:21934132 and PMID:23724009 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of PRNP mRNA CTD PMID:20488242 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PRNP mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO PRNP (Homo sapiens) 6480464 Antirheumatic Agents results in decreased expression of PRNP mRNA CTD PMID:24449571 arsenite(3-) multiple interactions ISO PRNP (Homo sapiens) 6480464 arsenite promotes the reaction [G3BP1 protein binds to PRNP protein] CTD PMID:32406909 arsenous acid multiple interactions ISO PRNP (Homo sapiens) 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PRNP protein] CTD PMID:26598702 atrazine decreases expression ISO PRNP (Homo sapiens) 6480464 Atrazine results in decreased expression of PRNP mRNA CTD PMID:22378314 bathocuproine disulfonic acid multiple interactions EXP 6480464 bathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein] CTD PMID:16148034 benzene increases expression ISO PRNP (Homo sapiens) 6480464 Benzene results in increased expression of PRNP mRNA CTD PMID:20359517 benzo[a]pyrene multiple interactions ISO Prnp (Mus musculus) 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to PRNP promoter] CTD PMID:19654925 benzo[a]pyrene increases methylation ISO PRNP (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of PRNP promoter CTD PMID:27901495 benzo[a]pyrene affects methylation ISO PRNP (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of PRNP 5' UTR CTD PMID:27901495 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PRNP mRNA CTD PMID:21839799 benzo[a]pyrene diol epoxide I increases expression ISO PRNP (Homo sapiens) 6480464 7 more ... CTD PMID:26238291 benzoates increases expression ISO PRNP (Homo sapiens) 6480464 Benzoates analog results in increased expression of PRNP mRNA CTD PMID:29472718 bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of PRNP mRNA CTD PMID:16648578 bisphenol A decreases expression ISO PRNP (Homo sapiens) 6480464 bisphenol A results in decreased expression of PRNP mRNA CTD PMID:20678512 bisphenol A increases expression ISO PRNP (Homo sapiens) 6480464 bisphenol A results in increased expression of PRNP mRNA and bisphenol A results in increased expression of PRNP protein CTD PMID:29275510 and PMID:34186270 bisphenol A affects expression ISO PRNP (Homo sapiens) 6480464 bisphenol A affects the expression of PRNP mRNA CTD PMID:30903817 bisphenol A affects methylation ISO Prnp (Mus musculus) 6480464 bisphenol A affects the methylation of PRNP promoter CTD PMID:27334623 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PRNP mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PRNP mRNA CTD PMID:12075121 and PMID:32145629 Bisphenol B increases expression ISO PRNP (Homo sapiens) 6480464 bisphenol B results in increased expression of PRNP protein CTD PMID:34186270 bortezomib increases expression ISO PRNP (Homo sapiens) 6480464 Bortezomib results in increased expression of PRNP mRNA CTD PMID:20977926 butyric acid increases expression EXP 6480464 Butyric Acid results in increased expression of PRNP mRNA CTD PMID:12800193 cadmium atom increases ubiquitination ISO Prnp (Mus musculus) 6480464 Cadmium results in increased ubiquitination of PRNP protein CTD PMID:22995398 cadmium atom multiple interactions ISO PRNP (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRNP mRNA CTD PMID:35301059 cadmium dichloride increases expression ISO PRNP (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of PRNP mRNA CTD PMID:12760830 cadmium dichloride multiple interactions ISO PRNP (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRNP mRNA CTD PMID:35301059 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of PRNP mRNA CTD PMID:16148034 caffeine decreases expression ISO PRNP (Homo sapiens) 6480464 Caffeine results in decreased expression of PRNP mRNA CTD PMID:18444173 calcitriol increases expression ISO PRNP (Homo sapiens) 6480464 Calcitriol results in increased expression of PRNP mRNA CTD PMID:16002434 carbamazepine affects expression ISO PRNP (Homo sapiens) 6480464 Carbamazepine affects the expression of PRNP mRNA CTD PMID:25979313 carbon nanotube increases expression ISO Prnp (Mus musculus) 6480464 Nanotubes and Carbon analog results in increased expression of PRNP mRNA CTD PMID:25554681 CGP 52608 multiple interactions ISO PRNP (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to PRNP gene] CTD PMID:28238834 chloropicrin decreases expression ISO PRNP (Homo sapiens) 6480464 chloropicrin results in decreased expression of PRNP mRNA CTD PMID:26352163 chlorpyrifos increases expression ISO Prnp (Mus musculus) 6480464 Chlorpyrifos results in increased expression of PRNP mRNA CTD PMID:32715474 cisplatin decreases response to substance ISO PRNP (Homo sapiens) 6480464 PRNP protein results in decreased susceptibility to Cisplatin CTD PMID:15386405 Congo Red decreases expression ISO Prnp (Mus musculus) 6480464 Congo Red results in decreased expression of PRNP protein alternative form CTD PMID:11994310 copper atom affects binding ISO PRNP (Homo sapiens) 6480464 Copper binds to PRNP protein more ... CTD PMID:16824036 more ... copper atom decreases response to substance ISO PRNP (Homo sapiens) 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:21537833 copper atom decreases response to substance ISO Prnp (Mus musculus) 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:12500977 and PMID:16787422 copper atom increases reduction ISO PRNP (Homo sapiens) 6480464 PRNP protein results in increased reduction of Copper CTD PMID:12572668 copper atom increases cleavage ISO PRNP (Homo sapiens) 6480464 Copper results in increased cleavage of PRNP protein CTD PMID:19597535 copper atom increases transport ISO Prnp (Mus musculus) 6480464 Copper results in increased transport of PRNP protein CTD PMID:21172064 copper atom affects folding ISO PRNP (Homo sapiens) 6480464 Copper affects the folding of PRNP protein modified form CTD PMID:20936829 copper atom increases uptake EXP 6480464 PRNP protein results in increased uptake of Copper CTD PMID:19957168 and PMID:22362149 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of PRNP mRNA more ... CTD PMID:22362149 and PMID:22465980 copper atom multiple interactions EXP 6480464 [PRNP protein results in increased uptake of Copper] which results in increased activity of SOD1 protein CTD PMID:22362149 copper atom increases uptake ISO Prnp (Mus musculus) 6480464 Copper results in increased uptake of PRNP protein CTD PMID:17155929 copper atom affects binding ISO Prnp (Mus musculus) 6480464 Copper binds to PRNP protein and PRNP protein binds to Copper CTD PMID:12500977 more ... copper atom multiple interactions ISO PRNP (Homo sapiens) 6480464 [[[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species] which results in increased cleavage of PRNP protein more ... CTD PMID:17112476 more ... copper atom multiple interactions ISO Prnp (Mus musculus) 6480464 [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein] promotes the reaction [PRNP protein binds to PRNP protein] more ... CTD PMID:15467011 more ... copper(0) affects binding ISO PRNP (Homo sapiens) 6480464 Copper binds to PRNP protein more ... CTD PMID:16824036 more ... copper(0) decreases response to substance ISO PRNP (Homo sapiens) 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:21537833 copper(0) decreases response to substance ISO Prnp (Mus musculus) 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:12500977 and PMID:16787422 copper(0) increases reduction ISO PRNP (Homo sapiens) 6480464 PRNP protein results in increased reduction of Copper CTD PMID:12572668 copper(0) increases cleavage ISO PRNP (Homo sapiens) 6480464 Copper results in increased cleavage of PRNP protein CTD PMID:19597535 copper(0) increases transport ISO Prnp (Mus musculus) 6480464 Copper results in increased transport of PRNP protein CTD PMID:21172064 copper(0) affects folding ISO PRNP (Homo sapiens) 6480464 Copper affects the folding of PRNP protein modified form CTD PMID:20936829 copper(0) increases uptake EXP 6480464 PRNP protein results in increased uptake of Copper CTD PMID:19957168 and PMID:22362149 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of PRNP mRNA more ... CTD PMID:22362149 and PMID:22465980 copper(0) multiple interactions EXP 6480464 [PRNP protein results in increased uptake of Copper] which results in increased activity of SOD1 protein CTD PMID:22362149 copper(0) increases uptake ISO Prnp (Mus musculus) 6480464 Copper results in increased uptake of PRNP protein CTD PMID:17155929 copper(0) affects binding ISO Prnp (Mus musculus) 6480464 Copper binds to PRNP protein and PRNP protein binds to Copper CTD PMID:12500977 more ... copper(0) multiple interactions ISO PRNP (Homo sapiens) 6480464 [[[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species] which results in increased cleavage of PRNP protein more ... CTD PMID:17112476 more ... copper(0) multiple interactions ISO Prnp (Mus musculus) 6480464 [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein] promotes the reaction [PRNP protein binds to PRNP protein] more ... CTD PMID:15467011 more ... copper(II) chloride multiple interactions ISO Prnp (Mus musculus) 6480464 [NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein] CTD PMID:16990274 copper(II) chloride multiple interactions EXP 6480464 bathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein] CTD PMID:16148034 copper(II) chloride increases expression EXP 6480464 cupric chloride results in increased expression of PRNP mRNA and cupric chloride results in increased expression of PRNP protein CTD PMID:16148034 copper(II) sulfate affects binding ISO PRNP (Homo sapiens) 6480464 PRNP protein binds to Copper Sulfate and PRNP protein polymorphism binds to Copper Sulfate CTD PMID:16847141 copper(II) sulfate multiple interactions ISO Prnp (Mus musculus) 6480464 Copper Sulfate results in increased uptake of and affects the localization of PRNP protein more ... CTD PMID:11994310 copper(II) sulfate multiple interactions ISO PRNP (Homo sapiens) 6480464 Copper Sulfate results in increased uptake of and affects the localization of PRNP protein more ... CTD PMID:11994310 copper(II) sulfate increases expression ISO PRNP (Homo sapiens) 6480464 Copper Sulfate results in increased expression of PRNP mRNA CTD PMID:19549813 copper(II) sulfate affects binding ISO Prnp (Mus musculus) 6480464 PRNP protein binds to Copper Sulfate CTD PMID:16787422 copper(II) sulfate decreases response to substance ISO Prnp (Mus musculus) 6480464 PRNP protein results in decreased susceptibility to Copper Sulfate CTD PMID:16787422 cyclosporin A increases expression ISO Prnp (Mus musculus) 6480464 Cyclosporine results in increased expression of PRNP mRNA CTD PMID:19770486 cyclosporin A increases expression ISO PRNP (Homo sapiens) 6480464 Cyclosporine results in increased expression of PRNP mRNA CTD PMID:20106945 and PMID:25562108 cytarabine decreases expression ISO PRNP (Homo sapiens) 6480464 Cytarabine results in decreased expression of PRNP mRNA CTD PMID:21198554 D-glucose multiple interactions ISO PRNP (Homo sapiens) 6480464 [PRNP protein results in increased expression of SLC2A1 protein] which results in increased uptake of Glucose CTD PMID:21265952 diarsenic trioxide multiple interactions ISO PRNP (Homo sapiens) 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PRNP protein] CTD PMID:26598702 dichloromethane increases expression ISO PRNP (Homo sapiens) 6480464 Methylene Chloride results in increased expression of PRNP mRNA CTD PMID:20359517 diethyldithiocarbamic acid increases expression EXP 6480464 Ditiocarb results in increased expression of PRNP protein CTD PMID:20452388 dioxygen increases expression ISO PRNP (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of PRNP mRNA and Oxygen deficiency results in increased expression of PRNP protein CTD PMID:17387271 dioxygen decreases expression ISO PRNP (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of PRNP mRNA CTD PMID:35883890 dioxygen multiple interactions ISO Prnp (Mus musculus) 6480464 Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of PRNP mRNA] CTD PMID:22629407 dioxygen increases expression ISO Prnp (Mus musculus) 6480464 Oxygen deficiency results in increased expression of PRNP mRNA CTD PMID:22629407 dioxygen multiple interactions ISO PRNP (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of PRNP mRNA] CTD PMID:17387271 diuron decreases expression ISO PRNP (Homo sapiens) 6480464 Diuron metabolite results in decreased expression of PRNP mRNA CTD PMID:24172598 dorsomorphin multiple interactions ISO PRNP (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases response to substance ISO PRNP (Homo sapiens) 6480464 PRNP protein results in decreased susceptibility to Doxorubicin CTD PMID:15386405 edaravone multiple interactions EXP 6480464 Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD1 protein] more ... CTD PMID:20806394 entinostat increases expression ISO PRNP (Homo sapiens) 6480464 entinostat results in increased expression of PRNP mRNA CTD PMID:26272509 entinostat multiple interactions ISO PRNP (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA CTD PMID:27188386 ethyl methanesulfonate increases expression ISO PRNP (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of PRNP mRNA CTD PMID:23649840 ethylbenzene increases expression ISO PRNP (Homo sapiens) 6480464 ethylbenzene results in increased expression of PRNP mRNA CTD PMID:20359517 ethylenediaminetetraacetic acid multiple interactions ISO Prnp (Mus musculus) 6480464 Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein] and Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein] CTD PMID:16595185 etoposide decreases response to substance ISO PRNP (Homo sapiens) 6480464 PRNP protein results in decreased susceptibility to Etoposide CTD PMID:15386405 fenthion decreases expression ISO Prnp (Mus musculus) 6480464 Fenthion results in decreased expression of PRNP mRNA CTD PMID:34813904 filipin III increases secretion ISO PRNP (Homo sapiens) 6480464 Filipin results in increased secretion of PRNP protein CTD PMID:11994310 filipin III multiple interactions ISO Prnp (Mus musculus) 6480464 [Copper co-treated with Filipin] results in increased cleavage of PRNP protein and Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein] CTD PMID:11994310 and PMID:19597535 filipin III multiple interactions ISO PRNP (Homo sapiens) 6480464 Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein] CTD PMID:11994310 filipin III decreases expression ISO Prnp (Mus musculus) 6480464 Filipin results in decreased expression of PRNP protein alternative form CTD PMID:11994310 filipin III increases secretion ISO Prnp (Mus musculus) 6480464 Filipin results in increased secretion of PRNP protein CTD PMID:11994310 flutamide increases expression EXP 6480464 Flutamide results in increased expression of PRNP mRNA CTD PMID:24793618 folic acid multiple interactions ISO Prnp (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PRNP mRNA CTD PMID:22206623 formaldehyde increases expression ISO PRNP (Homo sapiens) 6480464 Formaldehyde results in increased expression of PRNP mRNA CTD PMID:23649840 furan increases expression EXP 6480464 furan results in increased expression of PRNP mRNA CTD PMID:27387713 genistein increases expression EXP 6480464 Genistein results in increased expression of PRNP mRNA CTD PMID:12075121 genistein decreases expression ISO Prnp (Mus musculus) 6480464 Genistein results in decreased expression of PRNP mRNA CTD PMID:24967385 genistein increases expression ISO PRNP (Homo sapiens) 6480464 Genistein results in increased expression of PRNP mRNA CTD PMID:18444173 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of PRNP mRNA CTD PMID:22061828 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of PRNP mRNA CTD PMID:33387578 glucose multiple interactions ISO PRNP (Homo sapiens) 6480464 [PRNP protein results in increased expression of SLC2A1 protein] which results in increased uptake of Glucose CTD PMID:21265952 glutathione multiple interactions ISO Prnp (Mus musculus) 6480464 PRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione] CTD PMID:17483122 glyphosate decreases methylation EXP 6480464 Glyphosate results in decreased methylation of PRNP gene CTD PMID:31011160 graphene oxide decreases expression ISO PRNP (Homo sapiens) 6480464 graphene oxide results in decreased expression of PRNP protein CTD PMID:33219560 GW 1929 multiple interactions ISO PRNP (Homo sapiens) 6480464 GW 1929 inhibits the reaction [Melatonin results in increased expression of PRNP protein] and GW 1929 inhibits the reaction [Pioglitazone results in increased expression of PRNP protein] CTD PMID:29734669 heparan sulfate affects binding ISO Prnp (Mus musculus) 6480464 PRNP protein modified form binds to Heparitin Sulfate metabolite CTD PMID:18717736 hydrogen peroxide increases expression ISO PRNP (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of PRNP mRNA CTD PMID:12419474 hydrogen peroxide decreases response to substance ISO Prnp (Mus musculus) 6480464 PRNP protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:17483122 hydrogen peroxide increases response to substance ISO Prnp (Mus musculus) 6480464 PRNP protein results in increased susceptibility to Hydrogen Peroxide CTD PMID:12500977 hydrogen peroxide multiple interactions ISO Prnp (Mus musculus) 6480464 [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein] promotes the reaction [PRNP protein binds to PRNP protein] more ... CTD PMID:16595185 indoxyl sulfate multiple interactions ISO PRNP (Homo sapiens) 6480464 PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]] more ... CTD PMID:29734669 inulin multiple interactions ISO Prnp (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of PRNP mRNA CTD PMID:36331819 iron atom multiple interactions ISO Prnp (Mus musculus) 6480464 [Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein more ... CTD PMID:16595185 and PMID:23478311 iron atom decreases abundance ISO Prnp (Mus musculus) 6480464 PRNP gene mutant form results in decreased abundance of Iron CTD PMID:23478311 iron(0) decreases abundance ISO Prnp (Mus musculus) 6480464 PRNP gene mutant form results in decreased abundance of Iron CTD PMID:23478311 iron(0) multiple interactions ISO Prnp (Mus musculus) 6480464 [Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein more ... CTD PMID:16595185 and PMID:23478311 lead diacetate increases expression ISO Prnp (Mus musculus) 6480464 lead acetate results in increased expression of PRNP mRNA CTD PMID:29746905 lead tetraacetate decreases expression ISO Prnp (Mus musculus) 6480464 lead tetraacetate results in decreased expression of PRNP mRNA CTD PMID:20865013 lead(0) affects expression ISO PRNP (Homo sapiens) 6480464 Lead affects the expression of PRNP mRNA CTD PMID:28903495 lipopolysaccharide increases expression ISO Prnp (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of PRNP mRNA CTD PMID:19339665 lipopolysaccharide multiple interactions ISO Prnp (Mus musculus) 6480464 methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of PRNP mRNA] CTD PMID:19339665 luzindole multiple interactions ISO PRNP (Homo sapiens) 6480464 luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein] and luzindole inhibits the reaction [Pioglitazone results in increased expression of PRNP protein] CTD PMID:29734669 manganese atom increases stability ISO Prnp (Mus musculus) 6480464 Manganese results in increased stability of PRNP protein CTD PMID:20176619 manganese atom affects binding ISO Prnp (Mus musculus) 6480464 PRNP protein binds to Manganese CTD PMID:16595185 manganese atom multiple interactions ISO Prnp (Mus musculus) 6480464 [[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein] more ... CTD PMID:16595185 manganese(0) increases stability ISO Prnp (Mus musculus) 6480464 Manganese results in increased stability of PRNP protein CTD PMID:20176619 manganese(0) affects binding ISO Prnp (Mus musculus) 6480464 PRNP protein binds to Manganese CTD PMID:16595185 manganese(0) multiple interactions ISO Prnp (Mus musculus) 6480464 [[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein] more ... CTD PMID:16595185 manganese(II) chloride multiple interactions ISO Prnp (Mus musculus) 6480464 PRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione] more ... CTD PMID:17483122 manganese(II) chloride decreases response to substance ISO Prnp (Mus musculus) 6480464 PRNP protein results in decreased susceptibility to manganese chloride CTD PMID:17483122 melatonin increases expression ISO PRNP (Homo sapiens) 6480464 Melatonin results in increased expression of PRNP protein CTD PMID:29734669 melatonin multiple interactions ISO PRNP (Homo sapiens) 6480464 GW 1929 inhibits the reaction [Melatonin results in increased expression of PRNP protein] more ... CTD PMID:29734669 mercury dibromide increases expression ISO PRNP (Homo sapiens) 6480464 mercuric bromide results in increased expression of PRNP mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO PRNP (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA CTD PMID:27188386 metam multiple interactions ISO Prnp (Mus musculus) 6480464 methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of PRNP mRNA] CTD PMID:19339665 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of PRNP mRNA CTD PMID:30467583 methotrexate decreases expression ISO PRNP (Homo sapiens) 6480464 Methotrexate results in decreased expression of PRNP mRNA CTD PMID:17400583 methyl methanesulfonate increases expression ISO PRNP (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of PRNP mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO PRNP (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of PRNP mRNA CTD PMID:28001369 and PMID:29581082 methylseleninic acid increases expression ISO PRNP (Homo sapiens) 6480464 methylselenic acid results in increased expression of PRNP mRNA CTD PMID:18548127 mitomycin C increases expression ISO PRNP (Homo sapiens) 6480464 Mitomycin results in increased expression of PRNP mRNA CTD PMID:12760830 mono(2-ethylhexyl) phthalate increases expression ISO PRNP (Homo sapiens) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of PRNP mRNA CTD PMID:23360888 N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRNP mRNA CTD PMID:28659758 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of PRNP mRNA CTD PMID:19638242 N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of PRNP mRNA CTD PMID:25380136 NADP zwitterion multiple interactions ISO Prnp (Mus musculus) 6480464 [NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein] CTD PMID:16990274 NADP zwitterion multiple interactions ISO PRNP (Homo sapiens) 6480464 [Copper co-treated with NADP] promotes the reaction [PRNP protein binds to PRNP protein] and [Copper co-treated with NADP] results in increased susceptibility to [PRNP protein binds to PRNP protein] CTD PMID:19149680 NADP(+) multiple interactions ISO Prnp (Mus musculus) 6480464 [NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein] CTD PMID:16990274 NADP(+) multiple interactions ISO PRNP (Homo sapiens) 6480464 [Copper co-treated with NADP] promotes the reaction [PRNP protein binds to PRNP protein] and [Copper co-treated with NADP] results in increased susceptibility to [PRNP protein binds to PRNP protein] CTD PMID:19149680 nickel atom affects binding ISO PRNP (Homo sapiens) 6480464 Nickel binds to PRNP protein CTD PMID:17126907 nickel atom multiple interactions ISO Prnp (Mus musculus) 6480464 Nickel inhibits the reaction [PRNP protein binds to PRNP protein] CTD PMID:16595185 nickel sulfate decreases expression ISO PRNP (Homo sapiens) 6480464 nickel sulfate results in decreased expression of PRNP mRNA CTD PMID:22714537 nitroprusside multiple interactions ISO PRNP (Homo sapiens) 6480464 [Nitroprusside results in increased abundance of nitrosonium ion] which results in increased expression of PRNP mRNA CTD PMID:12393473 nystatin multiple interactions ISO PRNP (Homo sapiens) 6480464 Nystatin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein] CTD PMID:11994310 nystatin multiple interactions ISO Prnp (Mus musculus) 6480464 Nystatin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein] CTD PMID:11994310 o-xylene increases expression ISO PRNP (Homo sapiens) 6480464 2-xylene results in increased expression of PRNP mRNA CTD PMID:20359517 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PRNP mRNA CTD PMID:25729387 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of PRNP mRNA CTD PMID:25729387 ozone multiple interactions ISO PRNP (Homo sapiens) 6480464 [Air Pollutants results in increased abundance of Ozone] which affects the expression of PRNP mRNA CTD PMID:35430440 panobinostat multiple interactions ISO PRNP (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA CTD PMID:27188386 panobinostat increases expression ISO PRNP (Homo sapiens) 6480464 panobinostat results in increased expression of PRNP mRNA CTD PMID:26272509 paracetamol increases expression ISO PRNP (Homo sapiens) 6480464 Acetaminophen results in increased expression of PRNP mRNA CTD PMID:21420995 more ... paraquat decreases response to substance ISO Prnp (Mus musculus) 6480464 PRNP protein results in decreased susceptibility to Paraquat CTD PMID:15451062 and PMID:17896796 parathion decreases expression ISO Prnp (Mus musculus) 6480464 Parathion results in decreased expression of PRNP mRNA CTD PMID:34813904 perfluorohexanesulfonic acid increases expression ISO Prnp (Mus musculus) 6480464 perfluorohexanesulfonic acid results in increased expression of PRNP mRNA CTD PMID:37995155 perfluorooctane-1-sulfonic acid multiple interactions ISO Prnp (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRNP mRNA more ... CTD PMID:36331819 perfluorooctanoic acid increases expression ISO PRNP (Homo sapiens) 6480464 perfluorooctanoic acid results in increased expression of PRNP mRNA and perfluorooctanoic acid results in increased expression of PRNP protein CTD PMID:25868421 and PMID:26879310 permethrin multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRNP mRNA CTD PMID:28659758 phenylmercury acetate increases expression ISO PRNP (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of PRNP mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO PRNP (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA CTD PMID:27188386 pioglitazone multiple interactions ISO PRNP (Homo sapiens) 6480464 GW 1929 inhibits the reaction [Pioglitazone results in increased expression of PRNP protein] more ... CTD PMID:29734669 pioglitazone increases expression ISO PRNP (Homo sapiens) 6480464 Pioglitazone results in increased expression of PRNP protein CTD PMID:29734669 pirinixic acid decreases expression ISO Prnp (Mus musculus) 6480464 pirinixic acid results in decreased expression of PRNP mRNA CTD PMID:17426115 and PMID:23811191 progesterone increases expression ISO PRNP (Homo sapiens) 6480464 Progesterone results in increased expression of PRNP mRNA CTD PMID:18037150 Pyridostigmine bromide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRNP mRNA CTD PMID:28659758 reactive oxygen species multiple interactions ISO PRNP (Homo sapiens) 6480464 [[[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species] which results in increased cleavage of PRNP protein and [[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species CTD PMID:19697239 reactive oxygen species multiple interactions ISO Prnp (Mus musculus) 6480464 PRNP protein inhibits the reaction [manganese chloride results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:17483122 resveratrol multiple interactions ISO PRNP (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of PRNP mRNA CTD PMID:23557933 SB 431542 multiple interactions ISO PRNP (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silver atom affects expression ISO Prnp (Mus musculus) 6480464 Silver affects the expression of PRNP mRNA CTD PMID:19429238 silver atom increases expression ISO PRNP (Homo sapiens) 6480464 Silver results in increased expression of PRNP mRNA CTD PMID:26551752 silver(0) affects expression ISO Prnp (Mus musculus) 6480464 Silver affects the expression of PRNP mRNA CTD PMID:19429238 silver(0) increases expression ISO PRNP (Homo sapiens) 6480464 Silver results in increased expression of PRNP mRNA CTD PMID:26551752 sodium arsenite decreases expression ISO PRNP (Homo sapiens) 6480464 sodium arsenite results in decreased expression of PRNP mRNA CTD PMID:22714537 sodium arsenite affects expression ISO PRNP (Homo sapiens) 6480464 sodium arsenite affects the expression of PRNP mRNA CTD PMID:29319823 sodium arsenite increases expression ISO PRNP (Homo sapiens) 6480464 sodium arsenite results in increased expression of PRNP mRNA CTD PMID:12760830 and PMID:28229933 tamibarotene affects expression ISO PRNP (Homo sapiens) 6480464 tamibarotene affects the expression of PRNP mRNA CTD PMID:15498508 tert-butyl hydroperoxide increases expression ISO PRNP (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of PRNP mRNA CTD PMID:15336504 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRNP mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of PRNP mRNA CTD PMID:31150632 tetracycline affects binding ISO PRNP (Homo sapiens) 6480464 Tetracycline binds to PRNP protein CTD PMID:10903871 tetracycline multiple interactions ISO PRNP (Homo sapiens) 6480464 Tetracycline inhibits the reaction [PRNP protein binds to PRNP protein] CTD PMID:10903871 thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of PRNP protein CTD PMID:35544339 thiamethoxam increases expression ISO Prnp (Mus musculus) 6480464 Thiamethoxam results in increased expression of PRNP mRNA CTD PMID:33533595 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of PRNP mRNA CTD PMID:23411599 and PMID:34492290 toluene increases expression ISO PRNP (Homo sapiens) 6480464 Toluene results in increased expression of PRNP mRNA CTD PMID:20359517 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of PRNP mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PRNP mRNA CTD PMID:25729387 trichloroethene decreases expression ISO Prnp (Mus musculus) 6480464 Trichloroethylene results in decreased expression of PRNP mRNA CTD PMID:19448997 trichloroethene increases expression ISO PRNP (Homo sapiens) 6480464 Trichloroethylene results in increased expression of PRNP mRNA CTD PMID:20359517 trichostatin A increases expression ISO PRNP (Homo sapiens) 6480464 trichostatin A results in increased expression of PRNP mRNA CTD PMID:24935251 and PMID:26272509 trichostatin A multiple interactions ISO PRNP (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA CTD PMID:27188386 tunicamycin increases expression ISO PRNP (Homo sapiens) 6480464 Tunicamycin results in increased expression of PRNP mRNA CTD PMID:22378314 urethane increases expression ISO PRNP (Homo sapiens) 6480464 Urethane results in increased expression of PRNP mRNA CTD PMID:28818685 ursodeoxycholic acid decreases expression EXP 6480464 Ursodeoxycholic Acid results in decreased expression of PRNP mRNA CTD PMID:15885361 valproic acid multiple interactions ISO PRNP (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA CTD PMID:27188386 valproic acid increases expression ISO PRNP (Homo sapiens) 6480464 Valproic Acid results in increased expression of PRNP mRNA CTD PMID:19101580 more ... vincristine decreases response to substance ISO PRNP (Homo sapiens) 6480464 PRNP protein results in decreased susceptibility to Vincristine CTD PMID:15386405 zinc atom affects localization ISO Prnp (Mus musculus) 6480464 PRNP protein affects the localization of Zinc CTD PMID:19486831 zinc atom decreases response to substance ISO Prnp (Mus musculus) 6480464 PRNP protein results in decreased susceptibility to Zinc CTD PMID:19486831 zinc oxide increases expression ISO PRNP (Homo sapiens) 6480464 Zinc Oxide results in increased expression of PRNP mRNA CTD PMID:19755143 zinc(0) affects localization ISO Prnp (Mus musculus) 6480464 PRNP protein affects the localization of Zinc CTD PMID:19486831 zinc(0) decreases response to substance ISO Prnp (Mus musculus) 6480464 PRNP protein results in decreased susceptibility to Zinc CTD PMID:19486831