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Gene: Pnlip (pancreatic lipase) Rattus norvegicus

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Symbol:

Pnlip

Name:

pancreatic lipase

RGD ID:

3360

Description:

Enables triacylglycerol lipase activity. Involved in post-embryonic development; response to lipid; and response to peptide hormone. Located in extracellular space. Used to study obesity. Orthologous to human PNLIP (pancreatic lipase); PARTICIPATES IN glycerolipid metabolic pathway; retinol metabolic pathway; INTERACTS WITH (R)-noradrenaline; 6-propyl-2-thiouracil; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC108349706; pancreatic triacylglycerol lipase; pancreatic triglyceride lipase; PANLI; PL; uncharacterized LOC108349706

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PNLIP (pancreatic lipase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pnlip (pancreatic lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PNLIP (pancreatic lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PNLIP (pancreatic lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PNLIP (pancreatic lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PNLIP (pancreatic lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PNLIPRP1 (pancreatic lipase related protein 1)	HGNC	OrthoDB
Homo sapiens (human):	PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene))	HGNC	OrthoDB
Homo sapiens (human):	PLXDC1 (plexin domain containing 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PNLIP (pancreatic lipase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pnlip (pancreatic lipase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG34448	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5966	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5966	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6847	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG6283	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6271	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG17191	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6277	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10116	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pnliprp2	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pnliprp1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pnliprp3	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pnlip	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pnlip	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100488279	Alliance	DIOPT (OMA\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	LOC394967	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	LOC100486017	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100486161	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Bw54

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	267,760,073 - 267,797,797 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	267,784,724 - 267,797,795 (+)	Ensembl				GRCr8
mRatBN7.2	1	257,774,012 - 257,811,656 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	257,798,581 - 257,811,654 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	266,009,226 - 266,022,367 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	272,715,238 - 272,728,379 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	265,351,509 - 265,364,696 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	279,798,187 - 279,811,372 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	279,798,187 - 279,811,372 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	287,136,617 - 287,172,914 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	265,107,812 - 265,120,969 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	253,456,158 - 253,469,343 (+)	NCBI		Celera
RGSC_v3.1	1	265,318,856 - 265,332,014 (+)	NCBI
Cytogenetic Map	1	q55	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

obesity (IAGP)

Pancreatic Lipase Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-noradrenaline (EXP)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-didecanoylglycerol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

allethrin (EXP)

amitrole (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

carnosic acid (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

dichlorine (EXP)

doxorubicin (ISO)

fenvalerate (EXP)

flavonoids (EXP)

genistein (ISO)

iron atom (EXP)

iron(0) (EXP)

isoprenaline (EXP)

lead diacetate (EXP,ISO)

manganese atom (EXP)

manganese(0) (EXP)

manganese(II) chloride (EXP)

methamphetamine (EXP)

methotrexate (ISO)

monosodium L-glutamate (ISO)

oleuropein (EXP)

orlistat (EXP,ISO)

ozone (EXP)

p-hydroxybenzyl alcohol (ISO)

PCB138 (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

pluronic P-123 (ISO)

Poloxamer (ISO)

pyrethrins (EXP)

rotenone (EXP)

sodium dichromate (EXP,ISO)

Soman (EXP)

streptozocin (ISO)

taurocholic acid (EXP)

taurodeoxycholic acid (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

troglitazone (EXP)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol homeostasis (IBA)

fatty acid biosynthetic process (IBA)

high-density lipoprotein particle remodeling (IBA)

intestinal cholesterol absorption (ISO)

lipid catabolic process (IEA)

lipid metabolic process (IEA,ISO)

positive regulation of triglyceride lipase activity (ISO)

post-embryonic development (IDA,IEP)

response to lipid (IEP)

response to peptide hormone (IEP)

retinoid metabolic process (IEA,ISO)

retinol metabolic process (IEA)

triglyceride catabolic process (IBA)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IDA,IEA,ISO)

Molecular Function

all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity (IEA)

carboxylic ester hydrolase activity (IEA)

hydrolase activity (IEA)

lipase activity (IDA,IEA,ISO)

lipoprotein lipase activity (IBA)

metal ion binding (IEA)

phospholipase A1 activity (IBA)

protein binding (ISO)

retinyl-palmitate esterase activity (IEA,ISO)

triacylglycerol lipase activity (IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glycerolipid metabolic pathway (IEA)

retinol metabolic pathway (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Pancreatic lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the postnatal development of rats.	Birk RZ, etal., Pediatr Res. 2004 Aug;56(2):256-62. Epub 2004 Jun 4.
2.	Leptin directly regulates exocrine pancreas lipase and two related proteins in the rat.	Elinson N, etal., Br J Nutr. 2006 Oct;96(4):691-6.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids.	Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
6.	A structural domain (the lid) found in pancreatic lipases is absent in the guinea pig (phospho)lipase.	Hjorth A, etal., Biochemistry 1993 May 11;32(18):4702-7.
7.	Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase.	Jennens ML and Lowe ME, J Lipid Res. 1995 Nov;36(11):2374-82.
8.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
9.	Dexamethasone-regulated expression of pancreatic lipase and two related proteins in AR42J cells.	Kullman J, etal., Am J Physiol. 1996 May;270(5 Pt 1):G746-51.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Pnlip encoding pancreatic lipase is possible candidate for obesity QTL in the OLETF rat.	Muramatsu Y, etal., Biochem Biophys Res Commun 2005 Jun 17;331(4):1270-6.
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development.	Payne RM, etal., Am J Physiol 1994 May;266(5 Pt 1):G914-21.
15.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
16.	GOA pipeline	RGD automated data pipeline
17.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Comprehensive gene review and curation	RGD comprehensive gene curation
20.	Identification and cloning of GP-3 from rat pancreatic acinar zymogen granules as a glycosylated membrane-associated lipase.	Wishart MJ, etal., J Biol Chem 1993 May 15;268(14):10303-11.

Additional References at PubMed

PMID:9631512	PMID:12915407	PMID:19760487	PMID:21382969	PMID:21469501	PMID:24262094	PMID:25862608

Genomics

Comparative Map Data

Pnlip
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	267,760,073 - 267,797,797 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	267,784,724 - 267,797,795 (+)	Ensembl				GRCr8
mRatBN7.2	1	257,774,012 - 257,811,656 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	257,798,581 - 257,811,654 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	266,009,226 - 266,022,367 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	272,715,238 - 272,728,379 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	265,351,509 - 265,364,696 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	279,798,187 - 279,811,372 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	279,798,187 - 279,811,372 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	287,136,617 - 287,172,914 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	265,107,812 - 265,120,969 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	253,456,158 - 253,469,343 (+)	NCBI		Celera
RGSC_v3.1	1	265,318,856 - 265,332,014 (+)	NCBI
Cytogenetic Map	1	q55	NCBI

PNLIP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	116,545,931 - 116,567,855 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	116,545,931 - 116,567,855 (+)	Ensembl			hg38	GRCh38
GRCh37	10	118,305,443 - 118,327,367 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	118,295,418 - 118,317,357 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	118,295,448 - 118,317,356	NCBI
Celera	10	112,034,704 - 112,056,644 (+)	NCBI		Celera
Cytogenetic Map	10	q25.3	NCBI
HuRef	10	111,932,653 - 111,954,591 (+)	NCBI		HuRef
CHM1_1	10	118,588,590 - 118,610,538 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	117,439,962 - 117,461,884 (+)	NCBI		T2T-CHM13v2.0

Pnlip
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	58,658,797 - 58,670,231 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	58,640,930 - 58,670,220 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	58,670,365 - 58,681,799 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	58,652,498 - 58,681,788 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	58,744,855 - 58,756,278 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	58,723,615 - 58,735,038 (+)	NCBI		MGSCv36	mm8
Celera	19	60,867,340 - 60,878,784 (+)	NCBI		Celera
Cytogenetic Map	19	D2	NCBI
cM Map	19	54.46	NCBI

PNLIP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	128,391,967 - 128,445,865 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	128,428,918 - 128,451,163 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	113,067,443 - 113,158,473 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	116,568,110 - 116,589,729 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	116,568,273 - 116,589,729 (+)	Ensembl			panPan2	panpan1.1

PNLIP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	27,139,028 - 27,156,457 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	27,139,230 - 27,212,178 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	27,289,546 - 27,307,018 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	27,675,675 - 27,693,147 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	27,675,917 - 27,749,003 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	27,230,205 - 27,247,650 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	27,249,644 - 27,267,077 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	27,438,556 - 27,456,027 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

PNLIP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	126,772,911 - 126,790,001 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	126,771,920 - 126,789,097 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	138,017,775 - 138,032,310 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PNLIP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	109,330,050 - 109,375,687 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	109,352,806 - 109,375,670 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	70,600,324 - 70,623,276 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	52
Count of miRNA genes:	50
Interacting mature miRNAs:	52
Transcripts:	ENSRNOT00000024065
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	263946994	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1578775	Iddm21	Insulin dependent diabetes mellitus QTL 21	4.13		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	245782829	270518180	Rat
631837	Niddm35	Non-insulin dependent diabetes mellitus QTL 35		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	248619887	269633915	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	5e-06	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	247133834	270518180	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1600390	Niddm64	Non-insulin dependent diabetes mellitus QTL 64		0.003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	257624997	270518180	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	237995023	269633915	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
1598839	Rf56	Renal function QTL 56			renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	255849111	270518180	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	241569529	269633915	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	243953669	270518180	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Markers in Region

RH131157

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	257,807,548 - 257,808,665 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	279,807,267 - 279,808,383	NCBI	Rnor6.0
Rnor_5.0	1	287,168,807 - 287,169,923	UniSTS	Rnor5.0
RGSC_v3.4	1	265,116,864 - 265,117,980	UniSTS	RGSC3.4
Celera	1	253,465,238 - 253,466,354	UniSTS
RH 3.4 Map	1	1690.9	UniSTS
Cytogenetic Map	1	q55	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
8	9	16	122	38	29	10	19	10	4	96	51	111	19	56	19	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001439915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_013161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB038242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D88534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D88535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M58369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024065 ⟹ ENSRNOP00000024065

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	267,784,724 - 267,797,795 (+)	Ensembl
mRatBN7.2 Ensembl	1	257,798,581 - 257,811,654 (+)	Ensembl
Rnor_6.0 Ensembl	1	279,798,187 - 279,811,372 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103590 ⟹ ENSRNOP00000095754

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	267,785,161 - 267,797,795 (+)	Ensembl
mRatBN7.2 Ensembl	1	257,799,020 - 257,811,654 (+)	Ensembl

RefSeq Acc Id:

NM_013161 ⟹ NP_037293

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	267,784,610 - 267,797,795 (+)	NCBI
mRatBN7.2	1	257,798,469 - 257,811,654 (+)	NCBI
Rnor_6.0	1	279,798,187 - 279,811,372 (+)	NCBI
Rnor_5.0	1	287,136,617 - 287,172,914 (+)	NCBI
RGSC_v3.4	1	265,107,812 - 265,120,969 (+)	RGD
Celera	1	253,456,158 - 253,469,343 (+)	RGD

Sequence:

show sequence

GTCCATAGAACCCGACGGATCCGCCACGATGCTGATGCTGTGGACATTTGCAGTGCTGCTGGGA
GCAGTAGCTGGAAAAGAAGTTTGCTTTGACAAACTCGGCTGCTTCAGTGATGATGCCCCGTGGT
CAGGAACCATAGACAGACCCCTGAAAGCACTGCCCTGGAGCCCAGCACAGATCAACACCCGCTT
TCTCCTCTACACCAACGAGAACCAAGACAACTACCAGAAAATTACTTCAGATGCATCGAGTATC
AGAAACTCCAATTTCAAAACGAACAGAAAAACCCGCATCATTATCCACGGCTTCATTGACAAGG
GAGAGGAGAACTGGCTATCTGACATGTGCAAGAACATGTTCAAAGTGGAGAGTGTGAACTGCAT
CTGTGTGGACTGGAAAGGTGGCTCCCGGGCTACATACACCCAGGCTACCCAGAACGTCCGGGTC
GTGGGTGCAGAAGTGGCATTATTGGTTAACGTTCTGAAGTCTGACCTCGGTCATCCACCTGACA
ACGTCCACCTGATTGGCCACAGCCTGGGTTCCCACGTTGCTGGGGAGGCAGGAAAGAGGACATT
CGGAGCTATTGGGAGGATCACAGGGTTGGACGCGGCTGAACCTTACTTCCAGGGCACACCTGAA
GAAGTCCGTCTGGACCCCACCGATGCCCAGTTTGTGGATGCAATTCACACAGATGCTGCACCCA
TCATCCCCAACTTAGGATTTGGAATGAGCCAGACTGTGGGTCACCTAGATTTCTTTCCTAATGG
AGGGATGGAAATGCCTGGATGTCAGAAGAATATCCTTTCCCAAATCGTTGACATCGACGGGATC
TGGGAAGGAACTCGCGACTTTGCTGCCTGTAACCACTTGAGAAGCTACAAATATTACACCGACA
GTATCGTCAACCCGACTGGCTTCTCTGGCTTCTCCTGTAGCTCTTACAATGTTTTTTCTGCAAA
TAAGTGCTTCCCATGTGGGAGTGAAGGATGCCCACAGATGGGTCACTATGCTGACAAATACCCT
GGGAAGACAAAAGAACTCTACCAGAAATTTTACCTGAACACTGGTGACAAGAGCAACTTCGCAC
GTTGGCGGTACCAGGTGACTGTCACCCTCTCTGGACAGAAGGTCACTGGGCACATTCTAGTTTC
TTTGTTTGGAAATGGAGGAAACTCTAAACAGTATGAAGTTTTCAAGGGCTCTCTGCATCCAGGT
GACACTCATGTCAAGGAATTTGACTCTGATATGGATGTTGGAGATTTGCAGAAAGTTAAATTTA
TTTGGTACAACAATGTGATCAACCCAACTCTACCCAAAGTGGGAGCATCAAGGATTTCAGTGGA
ACGAAATGACGGCAGAGTGTTCAACTTCTGTAGTCAAGATACAGTGAGGGAGGATGTCCTGCTT
ACACTGTCTGCATGTTAGAAGGCTGCTGATGTGTGACCACCAAGTCCCACTGTAATAAAGTCTA
GTATCAAAGCCACCCGGAA

hide sequence

RefSeq Acc Id:

XM_039102162 ⟹ XP_038958090

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	267,760,073 - 267,797,797 (+)	NCBI
mRatBN7.2	1	257,774,012 - 257,811,656 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001426844	(Get FASTA)	NCBI Sequence Viewer
	NP_037293	(Get FASTA)	NCBI Sequence Viewer
	XP_038958090	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA79888	(Get FASTA)	NCBI Sequence Viewer
	BAA13637	(Get FASTA)	NCBI Sequence Viewer
	BAA13638	(Get FASTA)	NCBI Sequence Viewer
	BAA90789	(Get FASTA)	NCBI Sequence Viewer
	EDL94538	(Get FASTA)	NCBI Sequence Viewer
	EDL94539	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024065
GenBank Protein	P27657	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_037293 ⟸ NM_013161
- Peptide Label:	precursor
- UniProtKB:	P27657 (UniProtKB/Swiss-Prot), G3V8A7 (UniProtKB/TrEMBL), A6JI64 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLMLWTFAVLLGAVAGKEVCFDKLGCFSDDAPWSGTIDRPLKALPWSPAQINTRFLLYTNENQD NYQKITSDASSIRNSNFKTNRKTRIIIHGFIDKGEENWLSDMCKNMFKVESVNCICVDWKGGSR ATYTQATQNVRVVGAEVALLVNVLKSDLGHPPDNVHLIGHSLGSHVAGEAGKRTFGAIGRITGL DAAEPYFQGTPEEVRLDPTDAQFVDAIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGMEMPGCQK NILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPTGFSGFSCSSYNVFSANKCFPCGSEG CPQMGHYADKYPGKTKELYQKFYLNTGDKSNFARWRYQVTVTLSGQKVTGHILVSLFGNGGNSK QYEVFKGSLHPGDTHVKEFDSDMDVGDLQKVKFIWYNNVINPTLPKVGASRISVERNDGRVFNF CSQDTVREDVLLTLSAC hide sequence

Ensembl Acc Id:

ENSRNOP00000024065 ⟸ ENSRNOT00000024065

RefSeq Acc Id:	XP_038958090 ⟸ XM_039102162
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000095754 ⟸ ENSRNOT00000103590

Protein Domains

Lipase PLAT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P27657-F1-model_v2	AlphaFold	P27657	1-465	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3360	AgrOrtholog
BioCyc Gene	G2FUF-55270	BioCyc
Ensembl Genes	ENSRNOG00000017725	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000024065	ENTREZGENE
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot
	PLAT/LH2 domain	UniProtKB/Swiss-Prot
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot
	Lipase/vitellogenin	UniProtKB/Swiss-Prot
	Lipase_LIPH	UniProtKB/Swiss-Prot
	Lipase_N	UniProtKB/Swiss-Prot
	Lipase_panc	UniProtKB/Swiss-Prot
	PLAT/LH2_dom	UniProtKB/Swiss-Prot
	PLAT/LH2_dom_sf	UniProtKB/Swiss-Prot
	TAG_lipase	UniProtKB/Swiss-Prot
KEGG Report	rno:25702	UniProtKB/Swiss-Prot
NCBI Gene	25702	ENTREZGENE
PANTHER	PANCREATIC TRIACYLGLYCEROL LIPASE	UniProtKB/Swiss-Prot
	PTHR11610	UniProtKB/Swiss-Prot
Pfam	Lipase	UniProtKB/Swiss-Prot
	PLAT	UniProtKB/Swiss-Prot
PhenoGen	Pnlip	PhenoGen
PIRSF	Lipoprotein_lipase_LIPH	UniProtKB/Swiss-Prot
PRINTS	PANCLIPASE	UniProtKB/Swiss-Prot
	TAGLIPASE	UniProtKB/Swiss-Prot
PROSITE	LIPASE_SER	UniProtKB/Swiss-Prot
	PLAT	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017725	RatGTEx
SMART	LH2	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF49723	UniProtKB/Swiss-Prot
	SSF53474	UniProtKB/Swiss-Prot
UniProt	A0A8I6APT2_RAT	UniProtKB/TrEMBL
	A6JI64	ENTREZGENE, UniProtKB/TrEMBL
	A6JI65_RAT	UniProtKB/TrEMBL
	G3V8A7	ENTREZGENE, UniProtKB/TrEMBL
	LIPP_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9JM77_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Pnlip	pancreatic lipase	LOC108349706	uncharacterized LOC108349706	Data merged from RGD:11404496	737654	PROVISIONAL
2016-08-02	LOC108349706	uncharacterized LOC108349706			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Pnlip	Pancreatic lipase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expression is low in the fetal pancreas but rises rapidly during the suckling-weanling transition	728275
gene_function	digests lipids	728275

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)