RGD Reference Report - Pnlip encoding pancreatic lipase is possible candidate for obesity QTL in the OLETF rat. - Rat Genome Database

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Pnlip encoding pancreatic lipase is possible candidate for obesity QTL in the OLETF rat.

Authors: Muramatsu, Y  Yamada, T  Taniguchi, Y  Ogino, T  Kose, H  Matsumoto, K  Sasaki, Y 
Citation: Muramatsu Y, etal., Biochem Biophys Res Commun 2005 Jun 17;331(4):1270-6.
RGD ID: 1358859
Pubmed: PMID:15883013   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2005.04.040   (Journal Full-text)

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat exhibits polygenic obesity, and one of quantitative trait loci (QTLs) responsible for a susceptibility to obesity in the OLETF, Nidd6/of, has been mapped to the approximately 10-cM genomic region between D1Rat166 and D1Rat90 on chromosome 1 in (OLETF x normal) F2 intercross. In this study, we have attempted to identify the causal gene for the Nidd6/of QTL. A Nidd6/of congenic strain, constructed by introgressing the OLETF allele on the mapped Nidd6/of region in the normal F344 rat strain, confirmed the existence of the Nidd6/of as obesity QTL. The Nidd6/of region was refined to a approximately 2.3-cM genomic region between D1Rat225 and D1Rat90, using informative recombinants selected from (Nidd6/of congenic x F344) F1 x Nidd6/of congenic backcross progenies. Among 46 genes located within the approximately 2.3-cM region, pancreatic lipase gene, Pnlip, was regarded as the most prominent and physiologically relevant positional candidate for the Nidd6/of QTL. We found that Pnlip possesses an OLETF allele-specific increase of mRNA levels in the pancreas, and that the OLETF allele is longer in variable number of tandem repeat (VNTR) within the 5'-flanking region than normal alleles. We further showed that the Nidd6/of QTL completely cosegregates with Pnlip VNTR in the informative recombinants from (Nidd6/of congenic x F344) F1 x Nidd6/of congenic backcross progenies. These results suggest that Pnlip is possible candidate for the Nidd6/of QTL.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  IAGP 1358859 RGD 
obesity susceptibilityISOPnlip (Rattus norvegicus)1358859; 1358859 RGD 
obesity susceptibilityIAGP 1358859 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal fat pad morphology  IAGP 1358859 RGD 
increased abdominal fat pad weight  IAGP 1358859F344/DuCrlCrljRGD 
increased abdominal fat pad weight  IAGP 1358859compared to F344/DuCrlCrljRGD 
increased body weight  IAGP 1358859 RGD 
increased body weight  IAGP 1358859F344/DuCrlCrljRGD 
increased body weight  IAGP 1358859compared to F344/DuCrlCrljRGD 
increased epididymal fat pad weight  IAGP 1358859F344/DuCrlCrljRGD 
increased epididymal fat pad weight  IAGP 1358859compared to F344/DuCrlCrljRGD 
increased mesenteric fat pad weight  IAGP 1358859F344/DuCrlCrljRGD 
increased mesenteric fat pad weight  IAGP 1358859compared to F344/DuCrlCrljRGD 
increased retroperitoneal fat pad weight  IAGP 1358859F344/DuCrlCrljRGD 
increased retroperitoneal fat pad weight  IAGP 1358859compared to F344/DuCrlCrljRGD 

Related Phenotype Data for this Reference

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Objects Annotated

Genes (Rattus norvegicus)
Pnlip  (pancreatic lipase)

Genes (Mus musculus)
Pnlip  (pancreatic lipase)

Genes (Homo sapiens)
PNLIP  (pancreatic lipase)

QTLs
Bw54  (Body weight QTL 54)

Strains
F344.OLETF-(D1Rat166-D1Rat90)/Tj  (NA)
OLETF/Got  (Otsuka Long Evans Tokushima)

Objects referenced in this article
QTL Bw115 Body weight QTL 115 Rattus norvegicus
QTL Niddm24 Non-insulin dependent diabetes mellitus QTL 24 Rattus norvegicus

Additional Information